I actually really like the combination of acid and alcohol in particular. I find myself much more able to relax and find the humor in the insanity. It is worth mentioning, though, that I am talking small to moderate doses of lyserg. At high dosages, I wouldn't even be able to find the fridge let alone force myself to drink enough.
On the flip side, I did have one circumstance about 8 years ago taking cubensis after having been drinking for several hours. The initial rush had me extremely panicked. It was a short-lived panic, however, and within an hour I forgot that I had even been drinking in the first place.