I thought you said you had a question. I see the statement, and then more declarative statements, but no inquisitive ones, lol. I'm just bustin' yer chops though; I got the gist of what you're wondering.
So if racemic (±)-MDMA is being resolved to a single isomer, how come all the seizure data shows an overwhelming amount of just the racemic MDMA? I hear what you're saying regarding the MDMA-(bi)tartrate and all, but still, you'd think we'd see more enantiospecific, confiscated, contraband MDMA than we do in the published reports from e.g. the DEA, Interpol, and those sorts.
Check out this Hamilton Morris podcast; it's pretty relevant to the topic:
Hamilton Morris Podcast 48: Interview with a clandestine MDA enantiopurifier. This guy details how amazing R-MDA is compared to racemic MDA. Now this stands in contrast to what Sasha had to say about R-MDA.
Also worthy of note:
Swim in the Chiral Pool: MDMA and MDA Enantiomers from Alanine-Derived Precursors EDIT: oops, just noticed you had already posted this link
@snmfmy … my bizzle.
Firstly, let me be CLEAR: I think meh-MDMA is bullshit. MDMA is the same REGARDLESS how you get to MDP2P, with the exception of TRACE impurities.
So what could be causing meh-MDMA?
1. ITS NOT MDMA - meaning it wasn't tested, or it can't be differentiated from MDMA even using NMR spectography - which is far-fetched to say the least.
2. An impurity exists (unidentified) that is active at the low single mg level, that diminishes the empathogenic action of MDMA, yet ONLY DIMINISHES THE ACTION OF MDMA, without any other deleterious effect on the body or brain. -- Sounds like a wonder drug, or an MDMA chemist's worst nightmare.
I MEAN IMAGINE THERE IS THIS BOOGEYMAN IMPURITY THAT CAUSES YOUR MOLLY TO BE JUNK.
3. The dose is small.
4. It's an issue with enantiomeric ratio.
We know multiple psychoactive drugs that have vastly different actions between/across enantiomers/stereoisomers.
Methamphetamine, MDMA, and the Aminorex group (with 2 chiral centers they have 4 isomers) - to name a few quickly.
We have also seen stereo-isomer separation processes implemented in clandestine drug production.
It's the only reasonable theory I can propose except this one:
Dopaminergic+Serotonergic+NE dampening due to
(A) intermittent idiopathic physiologic phenomenology, or
(B) unexpected pharmacological interference.
There are many physiological processes that can intermittently dampen the DA/5HT/NE response to drugs like MDMA. Age is the first on the list. Long-term drug use is the second. Nutritional state is third (a diet low in vitamin c and tryptophan will cause a lessened norepinephrine and serotonin response because they are necessary for synthesis)
But I recently (about a year ago) came upon a phenomenon that I had not experienced previously.
I had taken a break from street drugs b/c of unrelated health reasons
I took a known (subjectively by someone) good molly pill that tested MDXX and something - a mix with likely a benzofuran. And it was rubbish.
Took some powder from the baggy a week later, rubbish - although the length of effects were comparable to 5/6-(*)APB(*) and MDXX combo.
Took some mushrooms that everybody else was tripping balls on -- nothing but mild visuals.
A little bump of crystal -- dampened euphoria and shittier sympathomimetic effects than normal.
I thought I was fucked.
Then I realized there was something different:
I WAS CURRENTLY AND HAD BEEN ON 1600-2000 mg/day of GABAPENTIN for the last year.
So I tapered down, did a 2-week washout, and tried again.
Molly --Yay
Mushrooms -- woohoo
Crystal -- smooth and euphoric
Gabapentin isn't supposed to have that type of action. Although it is known to affect DA/5HT/NE levels in the brain and body, it is a calcium channel blocker and also an extra-synaptic GABAp receptor agonist.
It wasn't until yesterday that I realized my personal almost nightmare might be the reason for what is wrong with MDMA.
DIFFERENTIAL subjective experience because of UNEXPECTED PHARMACOLOGICAL INTERFERENCE.
Gabapentin didn't become widely prescribed or abused by poly-drug users until after it became a generic in 2004.
What OTHER seemingly innocuous pharmaceuticals (especially newer antidepressants) or even RCs have unknown effects of unknown duration on the response to MDMA and other psychoactive drugs?
OR MAYBE YOU ARE JUST OLD, AND/OR HAVE TAKEN TOO MANY DRUGS, AND/OR HAVE BAD NUTRITION