Respectfully, the "interference with monoamine transporters" specifically refers to DAT, SERT, and NET.No need to reinvent the wheel.
All these possibilities have already been listed in this post.
My post proposes INTERMITTENT dampening of the DA/5HT/NE response - caused by modulation of the ENTIRE system by something not in the meh-MDMA and not expected, LIKE GABAPENTIN which supposedly doesn't DIRECTLY AFFECT the systems specific to MDMA.
For example, the endocannabinoid receptors modulate the serotonin system.
Modulation of the Serotonin System by Endocannabinoid Signaling
The cannabinoid CB[1] receptors and their endogenous agonists, endocannabinoids (eCBs), are ubiquitously distributed throughout the central nervous system (CNS), where they play a key role in the regulation of neuronal excitability. As such, CB signaling ...
www.ncbi.nlm.nih.gov
It has only been recently that THC content of marijuana has consistently exceeded 25%, or that it has been legalized recreationally.
It is a comparatively TINY number of people that have experienced "meh-MDMA" that has been lab tested and confirmed as actual MDMA. It's not widespread.
Furthermore, I personally know people who take Gabapentin and experience MDMA just fine.
What I am proposing is that some people have an intermittent dampening of their response to MDMA that has nothing to do with what's in the pill and everything to do with mindset, nutritional status, and other Rx and non-prescription drugs consumed. These responses may only apply to individuals or a small percentage of people.
As another example, ceftriaxone (omnicef) a beta-lactam antibiotic restores the levels of depleted DA/5HT if given post METH usage.
Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine - PubMed
Repeated exposure to high doses of methamphetamine (METH) is known to alter several neurotransmitters in certain brain regions. Little is known about the effects of ceftriaxone (CEF), a β-lactam antibiotic, known to upregulate glutamate transporter subtype 1, post-treatment on METH-induced...
pubmed.ncbi.nlm.nih.gov
If an antibiotic can elicit such a change to the DA/5HT system POST METH USE, what effect could it have pre or concurrently.
I think only an extremely small number of people are even aware of the effects of gabapentin on the response to 5HT releases/agonists, or the effects of CEF on DA/5HT levels post METH.
Or that weed modulates the response to 5HT.
I would also wager that the number of people who experienced meh-MDMA (lab confirmed) and were not concurrently or very recently using another or many other drugs of any type is ZERO.
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