Like all of these things, 99% of the work was the dull stuff. ANYONE can download a free software package and happily scribble structures or use free online 'drug likeness' calculations but if you can't ACTUALLY make it, it's of no value whatsoever. Pyrazolam was only produced as a convenient precursor for pyeyzolam, pynazolam and pysylozam.
The only difference between those four is the 8-substituent.
8 Br- is pyrazolam
8- CHC- is pyeyzolam
8 NO2- is pynazolam
8-SiCH3 is pysylozam
The last one of these didn't get past animal studies so I cannot report on it's subjective effects. While the trimethyl silyl moiety has found it's way into a few drug candidates, I think I'm correct in saying that their is no medicine that contains an organo-silicon moiety. In this case we noted that it produced significant toxic symptoms in animal models and since the ethynyl had almost identical affinity data, it wasn't worth proceeding.
BTW that last one is pronounced si si lo zam. Obviously pyeyzam is pronounced pie eye zam.