It's never to late, you aren't dead yetThe more I learn about chemistry in my free time, the more I regret not having studied it. I'd be sitting in a lab after working hours, isolate all the alkaloids of the poppy plant and study them, try to find ways to synthesize novel opioids, enhancing qualities such as euphoria and duration of action, etc.
Such a fascinating science.
Instead I studied bland finance
Some labs are researching mitragynine analogs as potential painkillers, and I’ve come across a few recent publications. One issue with natural Kratom alkaloids is their inhibition of CYP450. But IMO, the key point is that these are natural products that would compete with modern, fully synthetic opioids, as well as with more traditional semi-synthetic opioid pharmaceuticals (such as morphine and thebaine derivatives). That 'situation' is clearly not be ideal for pharmaceutical companies, even if they have the distinct advantage of not inducing β-arrestin recruitment.
psychedelicreview.com
Where can I find info about those opioids that don't induce beta arrestin? That's interestingIf they are producing analogs, I would presume they are synthesizing them and so they would still require the same stringent testing as any other medicine. Their are already opioids undergoing clinical trials that do not produce beta-arrestin recruitment,
It doesn't mean the study of mitragynine might not still produce something of utility because the pharmacore is so unusual:
The Structure-Activity Relationship of Two Kratom Compounds
Even slightly modifying the chemical structure of the compounds in kratom can significantly alter their effects.
Yeah I don't know if a mitragynine analog will ever be commercialized by pharmaceutical companies. But it's definitely an interesting compound that probably has a lot to teach us.If they are producing analogs, I would presume they are synthesizing them and so they would still require the same stringent testing as any other medicine. Their are already opioids undergoing clinical trials that do not produce beta-arrestin recruitment,
It doesn't mean the study of mitragynine might not still produce something of utility because the pharmacore is so unusual:
The Structure-Activity Relationship of Two Kratom Compounds
Even slightly modifying the chemical structure of the compounds in kratom can significantly alter their effects.
Yeah I'm currently contacting different labs to see if there is a passionate chemist who would be willing to teach me chemistry in his free time. Ideally learning by doing. I'd even pay money if he wants. Unfortunately there is no such thing as Citizen Science here in Germany. Let's see if one of those labs answers me back...
You might get lucky if you know someone but I doubt a regular lab would let you do experiments if you haven't learned the basics (for obvious security reasons).
Oh wow, I wasn't aware this existed. Thank you!
Was going to mention this. I believe you actually get a certificate for completing the course as well. Doesn't mean much obviously, but still cool.
www.udemy.comThe more I learn about chemistry in my free time, the more I regret not having studied it. I'd be sitting in a lab after working hours, isolate all the alkaloids of the poppy plant and study them, try to find ways to synthesize novel opioids, enhancing qualities such as euphoria and duration of action, etc.
Such a fascinating science.
Instead I studied bland finance
Any urinary retention?