Eyes can be an indication that things are going very wrong in the brain. I once had one pupil dilated while the other was pinned to the point that I could barely see any black in my eye. Then they started to alternate. I thought I was just hallucinating it and asked a sober friend to confirm for me. He was an EMT and advised me to go directly to the ER because something was very wrong. I ignored his advice and in an hour or so my eyes returned to being the same size as each other. I've never had this happen before or since (that I know of). I don't know if this was caused by mixing to many things, taking higher doses of them casually, or just due to past brain damage. One of my major concussions had massive effects on the visual areas of my brain so I might just be an oddball. Or perhaps one eye decided it liked opioids that were in my system 24/7 more than the LSD I was peaking on. Who really knows.
I had a friend that was very experienced with all sorts of chemicals. To give you an idea we often traded 1,000+ doses of things between each other just to add them to our personal collections. He was far more liberal with experimenting than I was. Where I would carefully weigh doses and slowly try different routes he was always the type to look up the average dose, double it, then inject it directly into his arm and let the effects of an intentional overdose (still below the known LD50 or at least known to have not killed someone that posted a trip report). He was the type that would come over unannounced, ask for some of your MXE, mainline it, then stumble to your couch or bed to enjoy a hole for many hours. Sometimes it was annoying but he was such a lovable guy you'd never deny him a request. You knew whenever he came back he was going to make it up to you.
Anyway. One night he showed up with one of the PCP analogs after MXE was banned and became less common. I tried it with him. We were casually taking bumps out of a small bottle for that purpose. I called over another friend and had a second dose. The first was really nice and reminded me of a speedy MXE. The second sent me into dysphoria and after both my guests left I spent hours in bed waiting for it to wear off. During the course of those hours I managed to rub my penis raw with my hand. Never did manage to cum. The next day I had a blister and a bad hang over. I decided 3-meo-pcp or -pce, whatever it was, wasn't for me. My other less experienced friend felt the same way. "Nice at first then it turned horrible" was his description. He really liked MXE (who doesn't?) so that pretty much confirmed it wasn't a good drug in my personal opinion. At least not for me.
My friend that had the bottle of 3-meo-pcp had a bad habit of pushing things to far and not taking breaks between uses. As you've probably guessed he kept taking bumps of the stuff constantly until he got himself into a bad state. I'm not sure what he did, only three people know, but I do know whatever he did really scared the people he was hanging out with that night. They all said he wasn't himself and it was like a demon was inside him. The lights were on but he wasn't home. In his place was something evil. Something that attacked a girl he was in love with but afraid to confess his feelings to. He told me he remembers putting his hands around her throat and attempting to choke her to death. He had to be restrained by the other people that were there. No one present that night will talk about it. I only know what he told me and he wasn't even sure it happened. He just knew when he sobered up a bit everyone was really afraid of him and begged him to flush the rest of the shit.
This is AFTER he spent several hours looking for the vial which he'd dropped on the ground in the parking lot of an apartment complex. He said he searched for it for what seemed like hours only to find it laying where he'd first looked (on the ground next to the driver's side of his car).
He's dead now so who knows what really happened. I just know 3-meo-pcp(or pce) managed to take a very peaceful, fun loving, life of the party, friend of everyone type of dude and turn him into someone that would attempt to kill the girl he had a crush on. As you can imagine this really upset him and I have no doubt this contributed to his death a couple of years later. After this happened he became a very heavy drinker which combined with his past use of opioids and IVing research chemicals, pharmaceuticals, and street quality cocaine/heroin caused his liver to quit at the age of 26. He swelled up like a balloon and was dead within weeks. It was really sad. He'd been off the needle for two years by that point, clean of opioids, and had even quit using most psychedelics, pharmaceuticals, and weed. Yet his past use combined with attempting to replace those chemicals with alcohol ended his life in his mid-20s.
Sorry for rambling. I guess the point I'm trying to make here is even the most experienced can be overwhelmed. My friend was far from a lightweight but a few days of binging 3-meo-pcp changed him into an entirely different person. I am sure this incident lead directly to his death and he would probably still be alive today if he wouldn't have ordered that particular chemical.
It's not rambling. Just honest interesting experience.
That PCP analogue is reported for leading quickly to significant psychosis for some.
2012 I tried an insufflated pcp analogue, I forget it's name- MK...something maybe, another name too one word...di...z c? Back of my head.
Ex ketamine addicts were using it, all novel RC's fully legal in UK then.
It was presented to me as very very strong. Tiny lines. Stronger than the original Veterinary ketamine.
It was. Very mind taking. I didn't like it. It was like an intrusion, removal of my own power, witts, personality, ability too.
Not comfortable. Like, I like to enjoy my drugs, get as far out as, but not like a Joker Spray type no self awareness or comfort effect.
Sorry about the tragic path your friend's life took. He just, didn't pay enough consideration to draw that line. It is important.
Take a major bad turn, it's no quick turning back, you are on a whole new track and potentially bad one.
I also believe in soul or person posession. I don't exactly mean permanent.
Drugs can be dangerous there, open up channels.
Now my own perceptions really interested me, as I piped up a short thinktank here, about is there too much acid, and what, when, why, how.
I always have kept my own firm mind about me. It's just turbulent, and rocky at times.
I really believed, I could take more acid than I'd have physical capability for, and always retain my full personality and cognition.
Now, I believe, it just takes a certain very large amount, in whatever relative way, and you could suddenly drastically alter yourself in an irreversible way.
Syd Barrett demonstrated that. No Schizophrenia. Just a staggering amount of LSD. Changed him in enormous ways forever.
Thanks for your thoughts and experience
@HeadphonesandLSD glad you worked through so much and can still share your experience to this day.