Did it seem like serotonin syndrome? Years ago I combined MXE with 4-FA as well as MDMA, and I think I may have combined it with MDA as well, but they never felt threatening. The 4-FA was actually extremely synergistic with MXE. I did keep the doses low but I wouldn't do combinations like that again.
Well, honestly... I don't really know. I'm not sure how I would tell. My heartrate was elevated, I was somewhat nauseous and got myself a bowl in case I threw up, I was sweating but did not have any bowel symptoms, ie, diarrhea, or however you spell that word. I actually own a blood pressure monitor and this would have been the ideal time to use it but I didn't unfortunately, so I can't report any definitive facts except subjective feelings. I was taking 1mg clonazepam at a time to see if it improved until 4 or 5mg just knocked me out. When I woke up I was seemingly fine. I'm not sure if there would be any need to be too worried about combining MXE, MDMA and 4-FA, serotonin syndrome as far as I understand it is usually a result of both a long-lasting serotonin transporter blocker (ie, an SSRI) and, usually, an MAOI of some kind, which I was not on. People combine MDMA and amphetamines all the time (intentionally or not, courtesy of the variety of mixtures sold in pills) and most ACH dissos even with serotonergic effects do not have strong enough affinities for the receptors to cause a problem when competing for binding with a highly serotonergic drug.
I mean I think most of the time honestly when people talk about getting serotonin syndrome, but they did not seek hospital treatment, and survived, actually most likely they just had some kind of anxiety attack or other bad reaction from overall bodily stress from taking too much drug(s). Serotonin syndrome, as far as I'm aware, is a medical emergency, and "mild" serotonin syndrome probably a nonexistent misnomer. Is it even possible to get serotonin syndrome purely from serotonin releasers? I would think, probably not, given that people have taken extremely heavy doses of strong releasers, and even in cases of fatality the cause of death is usually not serotonin syndrome, but some other peripheral effect of the drug. I could be wrong there of course, but the more I think about it... no, I think I did not have serotonin syndrome. But, DCK is relatively unstudied in humans and whatever happened, it did not feel good, and was possibly not safe, serotonin syndrome or not.
That's the way I am too. I only use them a handful of times a year anymore but when I do, it's usually days on end until I run out or flush what I ordered though. It's weird though because I only use certain ones like that (namely MXE, MXPr, MXiPr, and DCK), which come to think of it all have the beta-ketone functionality. Those 4 I couldn't really collect because they call out to me so strongly for whatever reason.
The only beta-ketones I've never had a problem using responsibly are ketamine (and 2F-DCK) as well as O-PCE. O-PCE mainly because I hate the feeling of it, whereas with ketamine using anymore than a couple days in a row becomes a case of diminishing returns with the huge doses needed. If I ever started IM'ing that might be a different story.
Yeah actually I do still have some 3-HO-PCP but I'm generally able to hold onto the PCP analogues far more sensibly, just because they're never reliably enjoyable. They do have a strange pull, I'll admit, in that their very strangeness makes me keep returning to them sometimes... but it's not a compulsion, really. MXE, sometimes I can hold onto it, for me that's borderline. But ketamine and DCK... yeah, those are a problem. I find it interesting that you don't have a problem using ketamine or 2F-DCK responsibly, but with DCK you do... to me they are all very similar, DCK coming out on top in many ways by a fairly large margin, and 2F-DCK, honestly, being fairly unimpressive.
I haven't yet tried the MXxx analogues, or O-PCE, although I do hope too, again, once I'm off this likely ill-advised train of being officially medicated by a relatively unfun and somewhat imperceptible drug.