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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

MDMA Chemistry/Pharmacology Thread

This debate has gone down an unproductive route. Just to differentiate what is being said;

The original question I had circa Sept 2015 was how do we know if MDMA is MDMA and could MDMA vary batch to batch even if it were tested by GC / MS. The better in the 90s has been flogged continuously and the result only returns to anecdotal experience.

My question was based on a considerable variance in CURRENT pill effects - having two different pills tested as MD but having a very differing experience on each.

An experience repeated and repeated and found the same. One pill being. Dutch 200+mg banger. One pill being reported "Manc crew". The one I found closer to the original effects aka Shulgin were the "Manc crew". The Dutch although considerably stronger on paper delivered a more Mongy high. I can still dance I can still socialise but not in the way of the Manc.

Reference to prior experience indeed was reflected on but honestly it is as andy777 says personal and anecdotal.

I considered dose so I reduced the dosage repeated and found both did not alter in the effects just the intensity. In fact if you read posts I went a lot further to test out dose theories.

Yes I did pills 88 - 96, briefly in 98 - 2002 then a big gap until circa 2012. Not because of tolerance but due to life. No I don't believe that all today's pills and powders are crap just the effects do seem to vary, yes I do agree set setting age etc but the fact remained that the pills seemed to vary more so than any period I've experienced prior when all the evidence suggested I had pure product as verified by GC/MS.

If I compare to prior experience (anecdotal absolutely agreed) the Dutch appears to be significantly a step further from my memories. BUT I certainly don't expect to gain that period back. Just the wish to not waste 2 months of serotonin on a meh experience. It's a search for the best chance to find MY preference.

What I presume is, as small town casual has said constantly, this is all about the money backed up by Biscuit and his very clear summary.

This view is reinforced within literature of then and today regarding the market and manufacture. Not simply from videos of blokes doing the super gurn although this is some of the only historic evidence of actual effects we now have.

What has been proven without any argument the quality of MD can and does vary even if the product is classed by CURRENT test methods as pure. Set and setting, dose, tolerance obviously have effect but ultimately there is variance in quality and GC / MS method is flawed and does not identify quality% just a quantity%.

We then set about trying to see if there was a way to self identify by reagent. That's where we are at?

My point - lots of views all very important and no one should be decried for posting their opinion or result. We can't hope for a scientific outcome as we don't have the equipment or access.

What's most important is that we carry on alerting to what are good bad and possibly dangerous. We are a community created by legislation. Let's keep it community value the opinion of others and realise, as biscuit keeps telling us, the only people who actually know are LE who have and will continue to fingerprint any seizure to identify the manufacturer.

Certainly I don't take one person report posted here as green light but I certainly appreciate them. Only when multiples shout that I would consider this to be the time for personal test. Until then I'm happy with the pipe and slippers.

thanks for all the fish Boa
 
This debate has gone down an unproductive route. Just to differentiate what is being said;

The original question I had circa Sept 2015 was how do we know if MDMA is MDMA and could MDMA vary batch to batch even if it were tested by GC / MS. The better in the 90s has been flogged continuously and the result only returns to anecdotal experience.

My question was based on a considerable variance in CURRENT pill effects - having two different pills tested as MD but having a very differing experience on each.

An experience repeated and repeated and found the same. One pill being. Dutch 200+mg banger. One pill being reported "Manc crew". The one I found closer to the original effects aka Shulgin were the "Manc crew". The Dutch although considerably stronger on paper delivered a more Mongy high. I can still dance I can still socialise but not in the way of the Manc.

Reference to prior experience indeed was reflected on but honestly it is as andy777 says personal and anecdotal.

I considered dose so I reduced the dosage repeated and found both did not alter in the effects just the intensity. In fact if you read posts I went a lot further to test out dose theories.

Yes I did pills 88 - 96, briefly in 98 - 2002 then a big gap until circa 2012. Not because of tolerance but due to life. No I don't believe that all today's pills and powders are crap just the effects do seem to vary, yes I do agree set setting age etc but the fact remained that the pills seemed to vary more so than any period I've experienced prior when all the evidence suggested I had pure product as verified by GC/MS.

If I compare to prior experience (anecdotal absolutely agreed) the Dutch appears to be significantly a step further from my memories. BUT I certainly don't expect to gain that period back. Just the wish to not waste 2 months of serotonin on a meh experience. It's a search for the best chance to find MY preference.

What I presume is, as small town casual has said constantly, this is all about the money backed up by Biscuit and his very clear summary.

This view is reinforced within literature of then and today regarding the market and manufacture. Not simply from videos of blokes doing the super gurn although this is some of the only historic evidence of actual effects we now have.

What has been proven without any argument the quality of MD can and does vary even if the product is classed by CURRENT test methods as pure. Set and setting, dose, tolerance obviously have effect but ultimately there is variance in quality and GC / MS method is flawed and does not identify quality% just a quantity%.

We then set about trying to see if there was a way to self identify by reagent. That's where we are at?

My point - lots of views all very important and no one should be decried for posting their opinion or result. We can't hope for a scientific outcome as we don't have the equipment or access.

What's most important is that we carry on alerting to what are good bad and possibly dangerous. We are a community created by legislation. Let's keep it community value the opinion of others and realise, as biscuit keeps telling us, the only people who actually know are LE who have and will continue to fingerprint any seizure to identify the manufacturer.

Certainly I don't take one person report posted here as green light but I certainly appreciate them. Only when multiples shout that I would consider this to be the time for personal test. Until then I'm happy with the pipe and slippers.

thanks for all the fish Boa

Good post...I'd agree with what you've said there mate.
 
Cant you guys just accept people have different opions? Would be nice if this thread went back to people reporting some actual experiences.

I've been doing pills since 2003, and I do think they've changed. And there is evidence to support that. The change in precursor, method, and as a result marquis reaction. But most of all, it is known PMK-Glycidate can be stereospecific, ie the precursor is only made up of one isomer, and yields and end product that way. If it's made up of a different mix of isomers then obviously the effects will be different. Much like racemic ketamine vs S isomer. I dont see how anyone who knows what they are talking about could say that a drug made up of a differnet mix of isomers wouldnt have a different effect? Each isomer has a completely different profile of effects, and a different mix of isomers will lead to different effects.

Agree with mr boa. Basically you have to take into account every chemist making it is doing things a little differently, some of us have better contacts than others where Dutch pills are concerned. ie people with access to the first batches or any level of insider knowledge will get the better batches. Ontop of that you have got set and setting, tolerance, and personal preferrences etc. It's very subjective. On the whole andy you cant deny there have been alot of people reporting mediocre experiences, I've seen it here, PR, reddit and a little bit on the deep web. The thing that got me with this thread though, is a couple of people posted what was good, and instead of anyone who seemed to be complaining the most and talking about how it's changed, they never actually seemed to try and seek out the good ones. Instead the "pills nowadays arent as good" debate on here continued.

If your really fussy either follow the marquis result theory. Or buy safrole MDMA from Canada and wash the impurities. If your having good nights on a nice batch of Dutch ones lets hear about it :)

Sid, out of curiosity is all the stuff from Canada (Safrole made stuff) full of impurities? I'm looking into this at the moment but have never washed anything down before (I'm hoping its not too difficult)
 
Alot of the canadian stuff is gc/ms testing much lower purity than the european. But the mdma is racemic. And it all seems to test purple. People report that its not very strong but i imagine the hit is still surely better. But tests only 50% territory arent very good people's doses could have been too low. If i knew something was only 50% i probably would wash it.

The uk pressers were the best bet for good pills. But it appears they're no longer pressing the same MDMA anymore.
 
http://www.ecstasy.org/testing/

Some results I've not found before. Only seen ones circa 98. Some good reminiscing for us old boys and interestingly (rolling eyes face plant) Sprout was right to highlight some many moons ago MDEA was rife. Some of those pills I could well of done and never realised!

They are interesting, shame they don't go back a little further. I've been ignoring all the arguing lately in this topic and at the risk of someone starting again:

I'll try and dig it out but i'm pretty sure I saw some results from the very early 90s "snowball" pills and "Dennis the Menace" capsules which were tested at round about 60-80MG MDMA. People report rocking in complete euphoria for 8 or 9 hours off those things and even taking the snowballs in quarters!!

In my personal opinion, yep the drug has changed. From reading peoples posts on here a select few are lucky enough to get a better buzz out of the current MDMA than the rest of us. I.E most of us are much more sensitive to the original synth but a few are still pretty sensitive to the new synth. This makes sense as everyone's body / DNA is different. For example depending on your genetics you may or may not be responsive to some blood thinners that doctors prescribe for heart problems etc.

I was lucky enough to have a saved mid 90's pill a couple of years back (sorry i'm not sure on the press). Probably one of the happiest nights of my life, easily lasted 6 hours at least!! Everything else I've taken just doesn't compare, started taking pills around 2005 for reference.
 
It's pretty simple. The precursor changed to a precursor which is an analogue, and often stereospecific; ie it only yields one isomer.

If you can't understand that taking a drug with a different mix of isomers will yield a completely different experience, based on the profile of each isomer and their differences, then you don't really understand the underlying chemistry effecting your experience re ecstasy, ketamine, meth, and various other drugs.
 
It's pretty simple. The precursor changed to a precursor which is an analogue, and often stereospecific; ie it only yields one isomer.If you can't understand that taking a drug with a different mix of isomers will yield a completely different experience, based on the profile of each isomer and their differences, then you don't really understand the underlying chemistry effecting your experience re ecstasy, ketamine, meth, and various other drugs.You said yourself you haven't done pills in how long? Yet you come here and rubbish pages of discussion based on an opinion which knows nothing. Pages which contained many opinions from people who understand more, have used recently, and as such opinions hold much more credibilty than your own.
Calm yourself. Look, I've seen this entire argument play out on this forum several times since 2008, and there have been all sorts of theories, but nobody has been able to conclusively explain why MDMA isn't always MDMA. As I understand it, all commercial MDMA is racemic, and no street MDMA has ever tested any differently. All the speculation in the world - however convincingly couched in scientific terminology - will not change that. Only real evidence will; not chatter on a bloody internet forum. Incidentally, I last took MDMA in 2012. It was the same as it ever was. I'm sorry. :)
 
It's pretty simple. The precursor changed to a precursor which is an analogue, and often stereospecific; ie it only yields one isomer.

If you can't understand that taking a drug with a different mix of isomers will yield a completely different experience, based on the profile of each isomer and their differences, then you don't really understand the underlying chemistry effecting your experience re ecstasy, ketamine, meth, and various other drugs.

Just to clarify then (as I get bored of sifting through all the arguments in this topic) which pre-cursor are we talking about here, Safrole or MxxxP ? Both appear to have been substituted for something else over the years.
 
Calm yourself. Look, I've seen this entire argument play out on this forum several times since 2008, and there have been all sorts of theories, but nobody has been able to conclusively explain why MDMA isn't always MDMA. As I understand it, all commercial MDMA is racemic, and no street MDMA has ever tested any differently. All the speculation in the world - however convincingly couched in scientific terminology - will not change that. Only real evidence will; not chatter on a bloody internet forum. Incidentally, I last took MDMA in 2012. It was the same as it ever was. I'm sorry. :)

Where are the test results for racemic MDMA? There's nobody doing any tests to prove this. But the marquis reaction has changed. Would the exact same drug synth'd differently but to the same mix of isomers give a different marquis reaction? No. Something has obviously changed. I guess a chemical reaction is not proof enough for you something changed?

There is PMK-Glycidate for sale which is stereospecific though. And we know it's being used as the main precursor in NL, the Dutch pill pressers themselves have said it.

Stereospecific precursor = stereospecific product. IE it's not racemic mix of the 2 isomers.

If you are unable to join the dots then your own your own. I'm glad to hear you enjoyed it.

Brenner, not sure. In my opinion it was still good until 2011. When the glycidate came about, I never had any issues with lacking stuff til around then. I'm not saying it didn't change before that, but I only started in 2003, and I'd say up until the drought it was all a similar buzz, some batches cleaner than others but of course that could be purity or quality of the chemist.

People thinking all MDMA is the same, where is the logic? When many batches will be a different purity, there's been lab results as low as 60% in Europe and as high as 90%, by GC/MS, on purity alone the experience from dropping 120mg of either would be very different.
Add to that changing the whole methods of synth, and of course IMO there would be a difference even when it was all still racemic. There will be a different effect from the different impurities associated with the synth surely
Then you make some with new precursor which is stereospecific, and there is an even bigger difference of course. If anyone here does ketamine how much difference do you feel between racemic and s isomer? A lot is the answer.
 
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Where are the test results for racemic MDMA? There's nobody doing any tests to prove this.
No tests are being conducted to support your argument either. Just anecdotal evidence and highfalutin' speculation. Yet chemist after chemist - some being respected posters on this very forum - have stated that it is extremely unlikely that any common synth route will produce anything other than racemic product. Until it's proven that stereospecific MDMA is on the streets (rather than talk about there being stereospecific precursors available) all of this is just so much twaddle. Give me hard facts and I'll be convinced. Give me mumbo-jumbo and I'll bow out of this thread with a sense of the frustration that many of its readers must be experiencing. :D
 
Marquis reaction is different. Can you explain that? If it's the same drug how would that happen?

Well known fact that chemists now are using PMK-Glycidate. And anyone with some time to spare can find It online sold as stereospecific.

How could it possibly have the same effects if made with stereospecific precursor? Because chemist after chemist will tell you stereospecific precursor = stereospecific product.

Interesting you chose to ignore the rest of my post. I'll put you on ignore now to save me further wasting my time on someone who came to this thread with the sole intention of winding things up. While not answering any of the rest of my completely valid points.

I find it pretty funny your asking me for proof, I've certainly got more to back up what I'm saying than you do. Where was there ever any proof it was all racemic? There's not, yet you didn't question that.
 
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Why do you ask?

Look, you've just had me reading pharmacology for three hours based on a simple Google of your words. I suggest you do the same because the results of it are a discussion we aren't even allowed to have here.
 
My understanding is, MDMA has CH2O2 joined to the 3 and 4 positions on the ring via the oxygens; PMMA has CH3O joined to the 4 position and just the usual H at the 3 position. That end of PMMA gives it monoamine oxidase inhibiting abilities; while the other end is the kind of drug that must not be taken within 2 weeks of an MAOI (i.e., most drugs). This to me is evidence against a benevolent God.

Anyway, irrespective of the fine details of its mechanism of harm, it's bloody nasty stuff; unfortunately, the law fails to distinguish between supplying the mostly benign, enjoyable recreational drug MDMA and the deadly poison PMMA, and lets us all down as a consequence. And since Government policy is to prefer to blur the distinction between reasonably-safe recreational drugs and dangerous ones -- they'd rather you die than get high -- no change is likely anytime soon.
 
There were droughts before that. The original drought, that brought the original problems (of new synth/new precursors) was in 1997. Prior to that...



... True words spoken in jest etc. People who got crap pills between 1990-97 got really crap adulterated pills with caffeine and worse. All proper MDMA pills were MDMA and quality MDMA at that. The only exceptions were a spate of MDEA pills, the rare MDE pills and the "Latvian" snowballs which were MDA.

So yeah, it wouldn't have been like this in 1992.

There is a post in ecstasy discussion by Le Junk. It is written by someone who knows. Written by someone who was there and has had good access for years.

This debate has been going on much longer than ten years. I know. I started it. And I ended up convincing EVAD, through the sheer weight of those I attracted here at the time all saying the same thing. MDMA isn't MDMA isn't MDMA.

But I refuse to batter my head against this particular brick wall any longer. It's just nice to see more and more people coming round to our point of view along the way.

Good post. And it has been going on since my very first account on this site in 2006.

It did seem to me at one point a simple purity issue between batches was to blame. And that MDMA was MDMA no matter the precursor.

My view on all that changed when lab testing from places like Energy Control became possible, and batches of 92% MDMA (by GC/MS) weren't as good as stuff that was only 82% (but made with safrole oil).

Add to that the change in marquis reaction and it was a no brainier people like yourself, and I'll even say it MDMAhead who i argued the toss with here was right, and myself Evad and many others were wrong. The thing was back then it was harder for us to see, because MDMA made from PMK oil was still actually decent, and the marquis went purple; it was harder for anyone who hasn't been dropping since before the dinosaurs were extinct to see ;) but experience always knows best and we should have listened. Because now there is no doubt the older among us who have witnessed all these changes as time went by were right all along.

I've personally spent months posting information here, hopefully it has been of some use to some of you. To others if I've rubbed you up the wrong way then sorry but everything I've said here I've backed up with credible sources.

I think it's cool this debate continues. It was forums like these I believe that made the producers realise better to press MDMA than pips. It's not so simple for them to go back to PMK MDMA or safrole MDMA though because of precursor, it's basically an impossibility but for small specialist batches, usually not made by the major Dutch firms either.

I'll continue to post here if I have some actual MDMA, and review it so we know if there is anything good about. But the whole precursor debate it's getting to the stage I'm repeating myself and I'm fed up of explaining to trolls or people who won't just read back through the threads for themselves. If I actually find out anything new on the subject I will let you guys know.
 
I've got said 99% stuff made from PMK here. I'll post a pic, looks like glass. Do I think it is 99%? No. And will it be as good as the safrole stuff? I doubt it.

I'll be sending for lab tests. and I'll post the results here.

Here's a pic

http://anony.ws/i/2016/05/16/imageaddb8.jpg
 
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