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Dissociatives [Methoxetamine Subthread] Combinations - 2nd experiment

I've read alot about people asking about this possible dangers of mxe an serotonergig drugs. I love mxe its my favourite of all the psychoactive substances. I've tried it in combination with a vareity of substances over the last 18 months. If im using mxe on its own I usually take around the 100-150 mg over 2 hours without any drama. I've mixed a vareity of substances with mxe. Here are some of my favourite and worst
150mg mxe and one and a half blotters of nice LSD once already in a m hole - this was horrendous it created a preasure in my head that just felt wrong and toxic I think I passed out about an hour after taking the LSD I spent the next day in bed and i took me a few days it feel better it put me off trying this combo for quite a while.

150 mg of mxe and probably 1/5 of a blotter of acid at the same time as the mxe - this was very very pleasant the methoxetamine hole but the hole was more colourful and i felt like i was being dragged into each visual instead of the floaty/merging of the normal mxe visuals.

40mg of mxe and 3 blotters of LSD. - This is how it feels to be completely insane i took the mxe about 3 hours after taking the LSD. I was in my bedroom for the duration of this but after 20 minutes i didnt have a clue where i was. I needed the bathroom but i couldn't find the door even though i was looking straight at it My mind couldn't recognise anything for what it was. I eventually decided to pee in a glass but when it come to it id forgot how to release the muscles I needed to release the pee once I did pee I couldn't close the muscles and for the duration of the rest of the trip pee just dribbled out out of my control. I spent the duration of the tri drifting in and out of consciousness with incredibly strong hallucinations. Mxe seems to significantly potentate the effects of LSD.
I've found the best ratio to be normal hole dose of mxe and just a tinyest ammount of LSD around 1/5 of a blotter or a normal dose of LSD and 10mg doses of mxe spread out untill you feel what you want.

cannabis, 40 mxe and 9mg 2cb - this is my favourite combo I had smoked quite a bit during day and i was lay on my bed and thought it might be nice to try a little mxe so i weighed out and took 40mg which surprisingly sent me into a hole I usually have to take uwards of 100mg to do that. After about an hour I was feeling adventurous so I had a think what I could do and decided on 2 CB I had it in my head I wanted to to take 15mg but I was finding it difficult to weigh and managed to weigh out 9 mg so decided that would be enough which I then snorted. Within 20 minutes I was feeling what I can only describe as all over body orgasms when I had my eyes open with minor 2cb type warpping but as soon as I closed my eyes I was instantly plunged into an out of body experience I can't compare to anything ive ever felt with floaty coloured orbs completely surrounding me with the warpy feeling of a high dose of mxe Absolutely amazing. I did spend the next 36hours asleep but it was worth it.

20mg amt and 50g mxe - quite unremarkable added a little colour to the mxe also stopped my nausia which I get really badly with amt id recomend it just for that. I always feel tired after mxe so it sort of detracted from the energy of the amt

150mg mxe 40mg Mdma - created preasure in my temples similar to LSD i passed out after around an hour I've never been tempted to experiment further with this as i really don't enjoy MDMA.

odd combinatios include

2000mg of gabapentin and 80mg of mxe - I had read once on one report that gabapentin helps potentate NMDA antagonists which it didn't. I didn't feel anything out of the ordinary.

2 grapefruits and 100mg of mxe - its well documented that grapefruit contains large amounts of naringin which inhibits the enzyme CYP3A4 I consumed 2 grappefruits a day 4 days prior to taking the mxe as there is some speculation that CYP3A4 may play some part in metabolizing mxe. I didn't feel any change in the intensity of the mxe. Was worth it though because I love grappefruit!

Buprenorphine (subtex) 100mg mxe - I took 2mg of sublingual subtex 15 hours before taking mxe I was no longer feeling the effects of the Buprenorphine but because of the long halflife it would have still been in my system to some extent. I didn't feel much difference maybe slightly more sudated and lethargic but I always use mxe while lay in bed wrapped in my duvet so it wasn't really notable.

500mg caffine 150mg mxe - im extremely tollerant to caffine I was driving home down the m6 after a 15 hour shift and popped 10 pro plus about an hour before I got home had a shower and dosed my mxe I didn't feel any notable difference.

Absinthe and 40mg mxe - just made me violently sick and I passed out I'll but that could have been the half bottle of absinthe I drank.

hope this helps someone

2cb and mxe is by far the best I've tried high dose lsd and mdma were quite uncomfortable but better when the doses were cut

My advice to anyone trying any combination is to take only 25% of your normal dose of mxe and an even smaller amount of the substance you're mixing and work up from that.

Happpy days everyone.
 
davesquirrel: does snorting 2cb not feel as terrible while on mxe? the pain and subsequent comeup is overwhelming and i thought the mxe might make it better. 2cb and weed gave me pretty bad anxiety but i reckon mxe would have the opposite effect
 
davesquirrel: does snorting 2cb not feel as terrible while on mxe? the pain and subsequent comeup is overwhelming and i thought the mxe might make it better. 2cb and weed gave me pretty bad anxiety but i reckon mxe would have the opposite effect

yep 2 cb it still feels like snorting battery acid even when mxe but the warm peacefull nature of mxe makes it more tollerable. I've been in tears before after taking 2cb on its own. as for the come up ive never been too bad with the come up on 2cb so couldn't really say. I can't imagine anyone having anxiety while on mxe though its just such a lovely warm comforting drug for me even while i was having a bad time when i mixed it with a too much LSD i never felt worried or fearful. It always surprises me when i read of people having a bad time on mxe but i supose drugs affect people in different ways and what i find enjoyable other people may not. What's your view of mxe on its own?
 
its amazing on its own. honestly all the cominations ive done were meh or made it worse in some way. but im gonna just man up and try with 2cb cause its gonna be awesome more than likely
(5-10mg snorted.... wouldnt push it lol)
 
its amazing on its own. honestly all the cominations ive done were meh or made it worse in some way. but im gonna just man up and try with 2cb cause its gonna be awesome more than likely
(5-10mg snorted.... wouldnt push it lol)

yeah Its my favourite of all the chemicals I've tried so far, it is one of shulgins favourites too, 2c t 7 is another of his favourites I've been waiting for what seems like forever to stumble upon it but good things come to those who wait so hopefully soon. when I eventually do mxe fill be the first combos I'll try with it. 25c nbome is something ive acquired recently once I feel comfortable with it I'll give it a whirl with mxe starting real low with just 50µg and get back to everyone Im hoping it goes as well as 2cb does as 2cb is like finding weapons of mass destruction in iraq round here at the moment. Lol. I don't think you'll regret it esecially you enjoy both substances on their own. You'll have to get back to us all when you do and let us know what you think. Out of curiosity what combinations have you already tried with mxe??
 
some people love it, especially the mellow and bliss feeling. but most people will advice against it. not because its much of a health-risk, but it will just dampen your experience (especially the stimulating mania that results in adventurous holes).
 
There shouldn't be interactions but the valium will make the experience a lot less defined and more vague. Not worthwhile unless you are getting overstimulated.
 
Thanks for the responses, guys! And how about for taking it to help you sleep?

-

There shouldn't be interactions but the valium will make the experience a lot less defined and more vague. Not worthwhile unless you are getting overstimulated.

I realised that pretty much answers my questions :)

INFINITE THANKS : D
 
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I think Valium goes well with MXE if you're going for the low dose, peaceful, contented state. Especially if you notice excess body tension from your day. It would probably be better to try to ease that through mindful relaxation, but if you can't or won't, go ahead and take it. I think it's a good combo for this purpose. For more psychedelic states, no, unless the state starts to create unease.

add - Looks like others have stated basically the same thing.
 
The not giving a fuck feeling with MXE and a benzo was almost too good to be true, that was both low dose and not trippy and very dissociating at all.

It was like disconnecting me from all my sorrows and it did only that and nothing else.
 
make sure to lock the door, disconnect your internet and remove the battery from your phone lol. ideally have someone present who isnt half as fucked up as you are. that being said, i hate mxe. its one of the maybe 5 drugs ive ever had laying around that i really dont feel like taking even if anything else is set for a "recreational drug experience". id even prefer hi-dose dxm over it lol. imho the only reason it is so popular is because most internet druggies cant get ahold of genuine pcp or ketamine these days. also, the suggested combination will probably lead to your forgetting about the whole experience aside from a few vague images. if thats your idea of a good time, i say go for it!
 
MXE + Wellbutrin

I had 300mg of Wellbutrin (XR) at around lunch time yesterday. Could having MXE this evening have a bad interaction with it?

And in general, anyone have any experience combining these two?
 
Haven't done it yet, but will do it next week.
I don't think they counteract each other so you're probably good to go.
 
In the end it was absolutely fine. I think I'd probably metabolised it by that point anyway, so I can't actually speak of interaction issues.

All I do know is that MXE is a dopamine reuptake inhibitor, and that Wellbutrin's (bupropion) "primary pharmacological action is thought to be norepinephrine-dopamine reuptake inhibition".

My experience of MXE last night seemed somewhat less euophoric than usual. My amateur guess is that the Wellbutrin from the day before had influenced the release (or something) of dopamine whilst on MXE.

As you can tell, I am no pharmacologist!

I should also say that the trip did feel a little different too. Although it was different in a way that I don't think I could actually describe..

EDIT:
Actually we're not so sure MXE is a DRI - you can see some binding data and the resulting discussion here.
 
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Actually we're not so sure MXE is a DRI - you can see some binding data and the resulting discussion here.

Since it seems like this question has been answered and this information could be useful, I'm going to merge it with the MXE combinations thread.
 
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