Dissociatives [Methoxetamine Subthread] Combinations - 2nd experiment
- Thread starter Thorns Have Roses
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FlawedByDesign
Bluelighter
I believe another poster reported a seizure after using mxe before or after 25c.
ebola?
Bluelight Crew
That's a rather difficult question (though it is likely that MXE inhibits SERT rather than acting as a releaser), and I'm not exactly sure if we have a good answer yet. Empirically, it seems that 'complex' combinations of drugs that enhance serotonin's activity relatively directly pose increased risk of serotonin syndrome. Eg, you see higher incidence of serotonin syndrome when combining reuptake inhibitors with vastly different selectivities (eg, DXM + an SSRI). I don't think that we yet have a coherent theory of why some combinations are more dangerous than others, beyond clear-cut exceptions, eg with the combination of SSRIs and MDMA (where the high binding affinities of clinically used SSRIs at SERT attenuate's MDMA's effects).
ebola
farmacista
Bluelighter
anyone knows if this molecule is still legal in italy?
Obsidius
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further experiments with dissociative combinations:
MXE + 3-meo-pcp - as many in this thread suggested, and i confirm this MXE synergizes VERY activly with 3-meo-pcp and one should watch the dose. i pushed it quite a bit, never felt a health risk, tho the trips themself got really intense, ego deathening, chaotic and confusing, sometimes even up until total impairment to comprehend, move or perceive reality, especially when further combined with 2c-d.
MXE + 3-meo-pcp + 2C-D is a sacred combo! however i had difficulties you have to keep the trip "stable" in a positive manner i must admit that this combo is one of the more profound experiences of my life. NOT a party thing. you NEED a tripsitter. take a very close and good friend or at best your loved one. very emotional, lots of tears of joy but also (past) pain, very deep introspective and soultouching. healing on a different level. i "came back" in tears (of every emotion) EVERY time with this combo, quite regardless the dose. i however always pushed the MXE towards m-hole level. 2C-D was quite stable at 25mg and 3-meo-pcp i reduced over time (from 25 to 20 to 15). i also only took once all at once (which is chaotic) and usually stagger things up in 15 minute steps 25mg at one step. just 2c-d was often taken 1-2 hours before and was already developed and post-comeup bodyload when the rest was taken. most ROA was nasal, except 2c-d was mostly taken oral. i once took the PEA nasal with the rest in one go, but it resulted in shakes and uncalm body. i'd stick with oral or plugging. absolutely love this combination for its serious potential! i'd put my second lifechanging +4 in here.
MXE + 2-meo-ketamine is nothing special. 2MK seems to be a bit a "wonkyness booster" but i could not find any synergies there unfortunately.
MXE + N-ethyl-norketamine does nothing but block your nose from NENK and basically stop your nasal consume for the rest of the night (which is quite therapeutic on a different level)
MXE + n2o is indeed adventurous. lots of fractal time looping in itself. funny and mindfucking.
Question of the day: are there any difficulties regarding the combination if MXE and NDRIs? dont intent to combo in one go, but would lower doses of like a-PVP hours before MXE get health risky? there is still so much unconfirmed speculation of MXE's stimulant activity.
MXE + 3-meo-pcp - as many in this thread suggested, and i confirm this MXE synergizes VERY activly with 3-meo-pcp and one should watch the dose. i pushed it quite a bit, never felt a health risk, tho the trips themself got really intense, ego deathening, chaotic and confusing, sometimes even up until total impairment to comprehend, move or perceive reality, especially when further combined with 2c-d.
MXE + 3-meo-pcp + 2C-D is a sacred combo! however i had difficulties you have to keep the trip "stable" in a positive manner i must admit that this combo is one of the more profound experiences of my life. NOT a party thing. you NEED a tripsitter. take a very close and good friend or at best your loved one. very emotional, lots of tears of joy but also (past) pain, very deep introspective and soultouching. healing on a different level. i "came back" in tears (of every emotion) EVERY time with this combo, quite regardless the dose. i however always pushed the MXE towards m-hole level. 2C-D was quite stable at 25mg and 3-meo-pcp i reduced over time (from 25 to 20 to 15). i also only took once all at once (which is chaotic) and usually stagger things up in 15 minute steps 25mg at one step. just 2c-d was often taken 1-2 hours before and was already developed and post-comeup bodyload when the rest was taken. most ROA was nasal, except 2c-d was mostly taken oral. i once took the PEA nasal with the rest in one go, but it resulted in shakes and uncalm body. i'd stick with oral or plugging. absolutely love this combination for its serious potential! i'd put my second lifechanging +4 in here.
MXE + 2-meo-ketamine is nothing special. 2MK seems to be a bit a "wonkyness booster" but i could not find any synergies there unfortunately.
MXE + N-ethyl-norketamine does nothing but block your nose from NENK and basically stop your nasal consume for the rest of the night (which is quite therapeutic on a different level)
MXE + n2o is indeed adventurous. lots of fractal time looping in itself. funny and mindfucking.
Question of the day: are there any difficulties regarding the combination if MXE and NDRIs? dont intent to combo in one go, but would lower doses of like a-PVP hours before MXE get health risky? there is still so much unconfirmed speculation of MXE's stimulant activity.
I can only make subjective comments regarding a-PVP & MXE together, rather than providing solid information on the risks or physiological actions.
IME: A bit of MXE after or during a-PVP usage makes for hyper-manic behaviour. Very enjoyable for the participant. Potentially very disturbing for sober bystanders.
I didn't notice much of an increase in blood pressure with the combo, but that doesn't mean a lot because a-PVP alone send my heart rate soaring and requires the use of atenolol.
GolemGolem
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Anyone give MXE + 4-ho-mipt a go? Think I'll do this in a few days.
Thorns Have Roses
Bluelight Crew
Some mxe and benzos (feel free to dose conservatively) is supposed to be pretty chill, and thoroughly enjoyable.
GolemGolem
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Just beware of blackouts. Low dose of each is awesome. Go to high in one or the other direction and your mates are gonna make fun of you the next day.
TheAppleCore
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^ Yes. IMO, there is no point in high dose benzodiazepines. After a certain point, the positive effects of benzos reach a plateau, and dosing higher only makes you increasingly retarded, in every sense of the word.
I personally have not, but it sounds amazing. Just keep in mind that psyches and dissociatives have shockingly extreme synergy. Do NOT take your usual doses of miprocin and MXE together. (I learned this the hard way with LSD + MXE).
I personally have not, but it sounds amazing. Just keep in mind that psyches and dissociatives have shockingly extreme synergy. Do NOT take your usual doses of miprocin and MXE together. (I learned this the hard way with LSD + MXE).
Right now I'm on about 10g of kratom made into a tea, 2 mg of etiz and 1 20 mg IM MXE shot. I'm feeling pretty good, but the MXE didn't come on nearly as strong as I was expecting. I will do another shot in twenty minutes or so (a little bit over an hour after the initial shot), maybe 30 mg this time.
Just adding to the data pool.
Just adding to the data pool.
Jesusgreen
Bluelight Crew
I've heard that while benzos can add to the fun factor they can cut down on how intense your trip is, and I know a lot of people who don't really enjoy MXE on its own who take benzos with it for this reason, so they can benefit from the other effects without it getting *too* weird.
If anything I'd recommend lowering the dosage of your chosen benzo rather than upping the dosage of the MXE.
RationalGaze
Greenlighter
Yep.
Friend of mine did 15mg Miprocin (fumarate i do believe) so it was a plenty mild dose, he wasn't noticeably fucked, very happy, very lucid, not jibbering random shit.
Coming off his peak he insufflated ~20mg MXE, and within 20 minutes he was properly gone.
A consistent effect for him on MiPT trips is a vibrational frequency that pervades the body (enhanced by music, other physical stimulations), and he said that the vibrations basically became too strong. Seemed like he was ready to burst with whatever energy, looked very uncomfortable and pretty ready to wig out, wasn't making a massive amount of sense and just generally looked like a bad time. I think it would've been maybe nicer if he was in a more comfortable environment (i.e. a free house, outdoors on a nice day, not at night in the winter) and with others tripping hard/or just no-one at all, sober company is often pretty lame when tripping.
another friend did ~20-25mg MiPT, then railed 30mg MXE (not sure how close to peak he was, no idea if it was before or after) but he ended up wigging out and hiding at his missus' place having her look after him/making sure he's not dying or w.e.
MXE doesn't seem to lend itself well to 4-HO-MiPT, although neither of them had any dis+psy experience before and were still semi-novice to MiPT+MXE. If you're going to do it, remember to start fuckin' small.
If i was doing it i'd go for ~20mg MiPT, wait until i'm getting comfortable at peak/plateau and then start small with no more than ~15mg MXE insuf.
Friend of mine did 15mg Miprocin (fumarate i do believe) so it was a plenty mild dose, he wasn't noticeably fucked, very happy, very lucid, not jibbering random shit.
Coming off his peak he insufflated ~20mg MXE, and within 20 minutes he was properly gone.
A consistent effect for him on MiPT trips is a vibrational frequency that pervades the body (enhanced by music, other physical stimulations), and he said that the vibrations basically became too strong. Seemed like he was ready to burst with whatever energy, looked very uncomfortable and pretty ready to wig out, wasn't making a massive amount of sense and just generally looked like a bad time. I think it would've been maybe nicer if he was in a more comfortable environment (i.e. a free house, outdoors on a nice day, not at night in the winter) and with others tripping hard/or just no-one at all, sober company is often pretty lame when tripping.
another friend did ~20-25mg MiPT, then railed 30mg MXE (not sure how close to peak he was, no idea if it was before or after) but he ended up wigging out and hiding at his missus' place having her look after him/making sure he's not dying or w.e.
MXE doesn't seem to lend itself well to 4-HO-MiPT, although neither of them had any dis+psy experience before and were still semi-novice to MiPT+MXE. If you're going to do it, remember to start fuckin' small.
If i was doing it i'd go for ~20mg MiPT, wait until i'm getting comfortable at peak/plateau and then start small with no more than ~15mg MXE insuf.
THCified
Bluelighter
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^ I'd take the disso (MXE in this case) before taking the psychedelic. 3-MeO-PCP and 4-HO-MiPT was an awesome combo!
Of course not, 2mg Etiz is way too much and dulls the effects of MXE.
Of course not, 2mg Etiz is way too much and dulls the effects of MXE.
Obsidius
Bluelighter
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a fairly reckless test, mixing a large dose of MXE (120 subcutanous, 100nasal) with 10mg 5-meo-dmt vaped resulted in a well.. 8-12 hour black hole or rather black out. i can only remember bits, nothing happend to. my roommate was carrying me around the house as i stumbled over quite everything. hit my head twice and have bruises. not recommend.
HofmannBlotter
Bluelighter
Hi,
Would be safe to combine Methoxetamine and a small dose of 2C-D ?
Thank yiu!
Would be safe to combine Methoxetamine and a small dose of 2C-D ?
Thank yiu!
Obsidius
Bluelighter
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^ if you lower your usual dose of MXE it certainly felt safe to me everytime i did it. 2C-D's tofu qualities synergized wonderfully with all kinds of dissociatives and certainly it does with MXE.
what you consider a "small dose of 2C-D"? around 20-25mg? should be no problem. i pushed it to 50mg once but that got too chaotic. up until 30mg and a slightly lower MXE dose always gave me a wonderful journey (if your normal m-hole dose of MXE is 100mg down the dose to 75mg).
i'd take the 2c-d first and let it develop and then stagger MXE in 20mg bumps until desired state is reached. bombing both at once can be chaotic if you never combined PEAs and dissocs.
what you consider a "small dose of 2C-D"? around 20-25mg? should be no problem. i pushed it to 50mg once but that got too chaotic. up until 30mg and a slightly lower MXE dose always gave me a wonderful journey (if your normal m-hole dose of MXE is 100mg down the dose to 75mg).
i'd take the 2c-d first and let it develop and then stagger MXE in 20mg bumps until desired state is reached. bombing both at once can be chaotic if you never combined PEAs and dissocs.
No. It's not a known dangerous combo in particular, but it's generally not advisable to mix two serotonergic substances. "Safe" it most definitely is not. Try Ketamine + 2C-D for something slightly safer. It's definitely never safe to combine recreational drugs and both classes carry some risks on their own already. It can be a very beautiful and intense experience though.
