there is such a thing as too much perspective
I know, right?
http://xkcd.com/6/ (be sure not to miss the image alt text).
As far as MXE goes, I think I'm in love. I've always had quite the soft spot for dissociatives.
It all started more than ten years ago. As a mere teenager, I discovered that I happened to be one of those people who really liked DXM.
And this wasn't just because I was some suburban white kid who couldn't get "real" drugs. I was comparing it to things like oxycodone, LSD, MDMA, and pot among other things.
Ketamine was great in the early 2000s, but I never had enough money to have more than a little bit. All but one time I had it, it was at a rave or a club. I still find it funny that a drug like K can be such a good club drug. It just doesn't make sense without actually experiencing it.
Nitrous was good too, but its short duration, anoxia risk and vitamin B12 depletion make it impractical to use very much.
DXM was always available for obvious reasons. It's probably important to note that I'm pretty sure I'm a CYP-2D6 "poor metabolizer." >300mg DXM for me is massively too much. 600mg won't kill me or anything, but it would be way too much for me to have a good time. For my body, DXM makes me feel different for *days* after I take it. Its primary effects last a long time too. Along with pretty much unavoidable nausea and malaise as a very common side-effect, DXM is nice but not great. The only reason I take it now is some half-assed idea about how DXM might help reduce or reverse tolerance to opioids.
Now, along comes MXE. Well. Isn't this a nice, new and wonderful surprise. It reminds me the most of ketamine. Primarily because of my primary ROA (insufflation) and its duration. I'm not sure if this is good or not, but MXE lacks that really easy "hole" barrier K has. I've seen other people and personally experienced unintentional K holes from more casual bumping of K throughout the night. In a heartbeat, things go from a really fun, recreational experience to incredibly powerful and disorienting, but in the best way imaginable. I've felt ways and experienced things most people could not even imagine or think of at all. I still don't know if the possibility of an "m-hole" exists, but it seems much less likely to to achieve unintentionally.
I think the most important thing to consider with MXE is moderation. I keep track of when, how much and how often I use it. I pre-defined what was excessive usage, and stayed well below that. I did this for two reasons. Unless otherwise disproved, I must assume regular, high doses of MXE could damage your kidneys and bladder. The other reason is, no matter what sort of thing I take, I will avoid building a tolerance to anything (except alcohol). I hate the idea of needing to take twice as much as the average person to barely feel anything.