FutureReference
Bluelighter
- Joined
- Jul 15, 2019
- Messages
- 307
All correct, and there is indeed enough of a subjective and objective difference amongst, just to mention the strong opiates and semi-synthetics, the effects of morphine, 14-dihydromorphinones like hydromorphone and oxymorphone, morphine esters, dihydromorphine, and hydromorphinol that they really all should be available for medical use in all locales -- and then there are others like morphazones, halogenated morphine derivatives, and morphides which clearly have still different structure-activity relationships. And oxycodone and hydrocodone can be used up into the same range and have their own unique profiles of action and feelings.
The cleaner feeling (and scalability: I definitely think it can actually be used to kill more pain without causing unconsciousness than a lot of other narcotics) of oxymorphone, the pins and needles of morphine, and a dirtier, maybe more everything-but-the-kitchen-sink feeling with morphine esters are probably due to a number of things, with the more obvious ones the relative histamine release, the effect on other neurotransmitters and hormones, and the receptor-activation profile, and what if anything the drug does to other non-opioid receptors. Certainly the unusual stimulation of oxycodone probably has multiple causes too -- if it is not mixed with something it keeps me up like dextroamphetamine and has that methylphenidate-C-Jam dopaminergic stimulant feeling. There was another third element that I later pegged as being a little like pyrovalerone . . .
Both of the above also may have to do with the fact that there are other opioid receptors, and subtypes of the current four, thought to exist and the ζ opioid receptor was finally confirmed in 2017 I think it was, and also the nociceptive, NMDA, and Gaba systems may be more complex too and may have additional receptors in them as well.
Always enjoy the depth of your comments! I am glad to hear somebody has similar experiences with Oxycodone. I have no idea why, but it truly manages my pain better than anything. The only exception was Opana or Oxymorphone but unfortunately they won't even prescribe it in the United States anymore due to the potency.
As for the stimulating properties we seem to have the exact same effect. It makes socializing much more simple for me but without the addition of Clonazepam and/or Temazepam, I simply cannot sleep! I can have 500MG of caffeine and sleep fine but 20MG of Oxycodone and I literally cannot keep my eyes shut. Always found that extremely odd. Uses to be offputting but due to the relief I get I have come to expect and accept it