Just my two cents on anti-depressants qualities of MXE : (I'm not a native english-speaker, so sorry for my mystakes)
I am a fervent reader of bluelight, the kind that read everything but never post a thing. That being said, I have a bipolar disorder, which means among other things that I often experience several months of depression associated with generalized anxiety. Knowing the MXE since a year, I started to realize that several persons high-lighted its so-called "anti-depressant afterglow". I have been on escitalopram (an SSRI) during a year and a half, it did the job during a time, but then it just started to fade, and the anxiety started to overwhelm me again. So at a moment, I stopped taking it. Several months from now.
Then, I was asking myself if MXE couldn't help me handle with those very handicapping days of generalized anxiety, and depression that made me feel like my brain couldn't work anymore (studying sciences and mathematics, the best indicator of an incoming depression for me is when I can't understand the theories that I study anymore, or when the theory that I learned a day ago seems to be a complete puzzle for me).
So, all in all, I said to myself that it was worth trying, especially that at a low dosage (5-10 mg), there was little to no dissociative effects. I started by snorting 5 mg of MXE, daily. The effects where very mild, I would describe them as : opiate-like during the first 30 minutes after the beggining of the effects (roughly between 45 minutes and an hour after snorting), the feeling that you are still in your mother's womb (I would compare it to a mild dose of morphine, and/or tramadol). Pretty pleasant, but not my main reason of taking MXE.
Then, for 2-3 hours, there is some mild anti-depressant effect, not the manic effect you could experience when on SSRI, but more the two-hours-ago-I-was-anxious-and-surprisingly-now-I'm-not.
Lastly, for the next 2-3 days after taking it, and that's the purpose of my use, my incapacity to get out of the bed, to try to make my brain fuction vanishes. To put it in a nutshell, it makes me euthymic (for a bipolar, that would mean you are neither depressed, nor into a manic state), that is to say functional.
I also tried to take it sub-lingually, and since several weeks, it's my only way of taking it. I find that it is even more effective (takes less time to feel the effects, and it seems more "clear headed", even if at those dosages, 5-10 mg, there is no mindfuck at all) than snorting. But then, again, the best ROA varies from person to person.
All in all, my only goal is to share my experience, and to emphasize the possiblity of using MXE as an anti-depressant. For a person like me, prone to regular phases of depression and anxiety, it works like a charm. So for now, the only side-effect is a very mild head-ache the day after I snorted (which doesn't appear when I take it sublingually), but I wonder if it is safe on bladder on the long time, knowing the damages Ketamine can do.
Thanks for reading me, and I only hope that this could help other persons.
P.S. : There are more and more scientific articles published recently, talking about using Ketamine as a quick anti-depressant. Why not doing the same kind of research with MXE, which is pretty similar to Ketamine, to some extent. For those interested :
http://bipolarnews.org/index.php?s=ketamine