you know how SSRIs help people who may have serotonin deficiencies? can opioids help.

[Mr Blonde]

^

Yes it also sounds bullshit to me as well. Particularly that the 10% who are prone to abuse will experience stimulation, and as many people have posted in this thread that's just not the case.

Meh, doctors and pharmacists can come out with a lot of bullshit sometimes. Reminds me of a thread a while ago where a pharmacist warned someone not to take codeine with an SSRI, since the 'depressant' action of codeine would overpower the SSRI and make him depressed. 8)

In any drug/pharmaceutical text book (mainly thinking of mims here in Australia), both abuse and euphoria are listed as 'adverse reactions' and for this to occur, such reactions have to achieve statistical significance in clinical trials. In other words, 10% or below is not enough to achieve said significance and thus, would be considered rare.

What kind of levels would such an occurrence have to reach before it's statistically significant? 10% seems significant to me, but I don't work in the field so I wouldn't know.

 

[iameatingjam]

I'm on of the apparant 90% then, opiates make me feel like shit generally.

 

[KompelZ]

lol I've heard the whole CNS depressants make you 'depressed' thing before, I don't even bother correcting them. It's just too funny. I figure they will say it someone else that knows better in the future, and they'll get a laugh out of it as well.

Depends really, >10% be would considered significant, hence why both euphoria/abuse are listed. More than 10% of people experience these (not <10% or equal to 10% as his doctor implied). However if 10% feel euphoria then 90% wouldn't, and thus, dysphoria would be placed as a 'more common' effect, which simply isn't the case. Sorry, I got a bit mixed up but I think you get the gist of it. Additionally, the regular mims only lists the most common effects (usually around 5-10 per drug) and this is where abuse/euphoria appears in all drug opiates--even codeine and tramadol.

 

[Mr Blonde]

^ Yep, I get what you're saying.

Whaddya mean even codeine? I find it extremely pleasant!

 

[KompelZ]

my doctor said only a certain perfectage of people who use opioids get stimulated and a euphoric effect and i was thinking maybe it's because they natually don't have enough endorphins

You made a thread about that ages ago and I think we all came to the conclusion that your doctor is full of shit.

Seriously, saying only 10% of the human population receive a euphoric effect from opiates goes against every medical text book ever created. That, and like two-thousand years of human history. I'll be damned if 90% of the world receives a dysphoric reaction from taking morphine, codeine or any of their derivatives. 8)

I'm not saying this is the case for everyone. Sure, some people will naturally enjoy a certain class of drug more than others. That's a given. I just don't think the gap is as broad as your doctor previously implied. It's quite possibly the stupidest thing I've heard in relation to opiates/opioids. And I say that without hyperbole.

 

[johanneschimpo]

people who may have some sort of natural opioid (endorphin) deficiency? my doctor said only a certain perfectage of people who use opioids get stimulated and a euphoric effect and i was thinking maybe it's because they natually don't have enough endorphins... probably a stupid half-baked idea..but for some reason i keep thinking about it and think maybe it's a possilbility in some way.

EOJ

MERGED

Did you already forget you made this thread 2 weeks ago?
Its just as wrong now as it was then.
Here's what I recommend: stop thinking about it; its not a possibility in any way.

 

[enoughorangejuice?]

ok i'm stupid and my doctor is stupid and this thread is stupid ok great.

one question... do you think people who are depressed who respond well to anti-depressants (SSRIs, etc) have lower levels of serotonin than non-depressed people and the anti-depressants raise the level of serotonin to where it should be to help depressed people become happy again because of a serotonin deficiency or lowered level?

 

[johanneschimpo]

The serotonin-depression link still hasn't been proven. Yet the drugs keep coming...

 

[enoughorangejuice?]

do you take any antidepressants or anything like if i may ask?

 

[johanneschimpo]

Me? No, but I have been in the past.
Coincidentally, the one that I thought worked the best was buproprion (wellbutrin), which isn't even an SSRI. Of course dopamine reuptake inhibition is going to feel good though.

 

[enoughorangejuice?]

^ same here, that was the only anti-d i could tolerate, the rest made me too nauseous (had to get compazine, zofran & marinol Rx's for the nausea), or too sedated/lethargic.

but my point is if anti-d's are adjusting levels of serotonin, dopamine, NE, etc. and maybe some people need endorphin levels adjusted.... i'm not sure depression/anxiety is really from not enough serotonin or w/e, but if it is then it would kinda make sense that some people may need opiates to live normally. just an idea...