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Whats the hardest drug you can think of?

And I’m going to go with Crack being the worst hard drug out there. It just causes people to constantly fiend for the stuff like no other…
 
ChemicallyEnhanced said:
Viagra (geddit? :p)
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austin powers balloon GIF
 
acklac7 said:
And I’m going to go with Crack being the worst hard drug out there. It just causes people to constantly fiend for the stuff like no other…
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Yeah, meth users certainly don't fiend for the stuff in the worst way possible 🤔
 
deficiT said:
Yeah, meth users certainly don't fiend for the stuff in the worst way possible 🤔
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I guess some do? I didn’t? The people I know who use it don’t? Here again I’ve only really ever ingested the stuff, I’ve never smoked it nor shot it (I have snorted it about a half dozen times, however).

When I run out of Meth all I want to do is sleep.
 
Sweet Jane78 said:
Gracias. Sí, bien por ti por mantenerte alejado de eso. Mi novio me lo presentó hace unos 10 años para realzar nuestras experiencias sexuales. Me encantó por más que eso. Sigo haciéndolo porque me hace sentir viva y motivada. Me ocupo de la depresión, para que puedas ver dónde está la atracción. También me quita la ansiedad. A lo largo de los años he tenido períodos de tiempo que lo hice todos los días. De alguna manera me escapé de eso. En los últimos años, tal vez una vez al mes, mi novio y yo íbamos de fiesta. Estoy bastante bien si es solo una noche de libertinaje. Cuando tengo acceso a más de esa noche es cuando sigo haciéndolo todos los días hasta que se acaba. Ahí es cuando estoy en problemas con el accidente traicionero. A menudo me quedo en cama durante 3 días y, a veces, falto al trabajo. Estoy totalmente deshidratado y sin nutrientes y todavía no tengo ganas de comer. ¿Recuerdas que dije anteriormente que trato la depresión y la ansiedad? Eso es lo que realmente me jode mucho. Así que sonrío y lo soporto y vuelvo a sentirme bien y, a veces, dejo de tomarlo durante un par de semanas y luego aparecen los antojos y vuelvo por más, diciéndome a mí mismo que lo mantendré más bajo control con la dosis. comer y dormir para que una vez que salga de nuevo el bajón no sea tan malo. Nunca termina así. Es un ciclo predecible. La otra cosa es que mi novio apenas se ve afectado y puede tomarlo o dejarlo. Le gusta ir de fiesta a veces, pero no sufre ninguna consecuencia. Odia cuando lo hago en nuestras noches sin fiesta porque sabe lo que me llevará. Entonces él se enoja conmigo y me siento juzgado y avergonzado. como si fuera genial, pero yo soy el adicto a los perdedores. Si pudiera mantener mi uso únicamente para las noches de fiesta, estaría bien.🤦‍♀️
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I Dont know of what drug youre talking about
 
moreso than MDPV? I had thought APVP was not quite as likely to make me blatantly take out my coke shovel at the bar and offer the bartender "insight"
On top of combos like "rubber bands" in Chicago, maybe Serotoni (4-MMAR).

New unknown "chef's choice" like TuCi
 
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pcplease said:
moreso than MDPV?
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when vaped it is pure evil, nothing comes close to these pyrrolidines, no crack, no other stimulant. for me it was one hit every 5 minutes until i fell into the bed totally devasted after 3-4 days with a massive overdose. standard is 20mg, i did 3-4g in one session. and after the first hit your receptors are screaming because of the steric strain of the pyrrolidine. intense rush but not worth it. you absolutely need benzos with it.
 
I never tried RCs so for me its IV coke and IV ket.
IV coke its like an orgasm but only the first shoot. After you have to redose and trying to get the same rush. With high purity coke you ha r to be carefull with the dosage. It can be really dangerous. Redosing before 30 minutes off each shoot can be a OD too.
IV ket only tried a few times but its really powerful. A very little dose can take you to a k hole, really frighten. First time I thought I was dying.
IVing drugs is pottentially a real form to have a hard experience
 
pcplease said:
maybe Serotoni (4-MMAR).
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Oh you did Serotoni as well?
I got one of these sample pills with an order of research chemicals, did half of the pill and was in love with that substance. Got then 50g very cheap of which unfortunately my ex flushed the majority but it is among my top 3 of drugs.
 
Yep and I was naive to what it was. Perfect setting (sunset at a festival, was coming down during daybreak


I didn't get crazy compulsion from smoking MDPV or APVP. Then again, my first experience was mistakenly getting MDPV after ordering meph, did not read the chem name and assumed it was just crushed mephedrone. So finger dipped an attempted 150mgish, and bag still in my hand went to line up a rail to hit at the same time. Something was very wrong. I was an alcoholic, drank as much as I possibly could (maybe 0.5L of 80 proof) as it started to get worse. took an aspirin and naproxen, ate a big dose of weed coconut oil, laid down and successfully did not die. I wouldn't let my GF or myself take my BP/HR.
I redosed a few hrs later, but my lady had been doing it the whole time including after i realized i fuct up;

we finished the gram a couple hours after my first redosw
 
pcplease said:
I didn't get crazy compulsion from smoking MDPV or APVP. Then again, my first experience was mistakenly getting MDPV after ordering meph, did not read the chem name and assumed it was just crushed mephedrone. So finger dipped an attempted 150mgish, and bag still in my hand went to line up a rail to hit at the same time. Something was very wrong. I was an alcoholic, drank as much as I possibly could (maybe 0.5L of 80 proof) as it started to get worse. took an aspirin and naproxen, ate a big dose of weed coconut oil, laid down and successfully did not die. I wouldn't let my GF or myself take my BP/HR.
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Neither did I, not with sublingually nor intranasal, found alpha-PVP to be a nice stim, nicer than methylphenidate but once I seriously overdosed with 60-100mgs and ended up with psychotic stumbling through the nature for a whole night. Wow about your 150mg's. If anything then this speaks for the physical safety of the compound. A usual dose would be like 10mg for me.
 
Dreamflyer said:
I would say Fentanyl, since you can literally die just from handling a small amount of powder. Even in my darkest junkie days, it was one of the few drugs that I would never go anywhere near.

And considering the fact that clandestine labs are putting it in everything now, you can never be sure what you're taking. That's what killed Prince; he thought that he was just taking Vicodin. It's been found in everything from (fake) Xanax to cocaine.
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I was gonna say Fentanyl but wasn't sure if that was naive or not. You can't absorb it via skin like they thought but the shit's 50-100x stronger than morphine??

Did it really kill Prince? I have to investigate..
 
LSD, it being widespread in use and availability doesn't change the fact that it is an extremely powerful and somewhat dangerous drug.
 
Of all the drugs known to man, there is only one capable of raising five, sometimes six, of the eight neurotransmitters that shape the way we experience life. That drug is alcohol. We in the detoxification profession refer to it as the mother of all drugs or the kick-ass drug. The pharmaceutical industry has never produced a drug as all encompassing in its effect as alcohol. Most drugs will raise one or two neurotransmitters at a time.

Often antidepressant medications will raise serotonin and possibly a little noradrenaline. It is rare to find pharmaceutical agents that will raise two or three neurochemical systems. Wellbutrin (bupropion), the most powerful pharmaceutical agent out there, is an antidepressant medication that will actually raise three in somewhat of a reasonable manner: noradrenaline, dopamine, and acetylcholine.

Alcohol is the ultimate stimulant for the brain. To date, we know of no other agent that comes close to matching its power; alcohol’s effect on the human body is unprecedented. This influential drug is ultra-powerful as a neurotransmitter agonist. It moves the brain’s neurochemicals like no other drug on the planet.

Alcohol raises serotonin, GABA, endocannabinoid, glutamate, and at high dose, increases the release of opiates. It also has a significant end-result effect on dopamine (which is very euphoric), adding up to a total of six neurotransmitters being affected. All this stimulation makes alcohol a powerful anti-depressant (not to mention highly addictive) and an even more powerful depressant once it wears off, causing neurotransmitters to plummet.


When an active alcoholic suddenly stops drinking, they experience severe withdrawal. The GABA drops dramatically, creating a marked imbalance between GABA and glutamate. Glutamate, like race cars in the brain going hundreds of miles an hour with no stop signs, goes higher and higher, causing more and more agitation. This increases the severity of withdrawal symptoms and leads to delirium tremens.

By the second or third day of quitting, the alcoholic starts to experience confusion, agitation, and the shakes. The periphery of the body is a strong indicator of what is happening internally. Tremulousness, shakes, sweaty palms, and hyper-agitation of the body are all symptoms of the elevated glutamate’s effect in the brain.

At the 72-hour mark, the glutamate suddenly stops rising and begins to decrease over time while the GABA levels slowly increase..



Dr. Fredrick Von Stieff - Brain in Balance: Understanding the Genetics and Neurochemistry behind Addiction and Sobriety.
 
Jabberwocky said:
Of your common or garden variety of drugs I found the one that beat me up and defeated me the most was IV cocaine. It is horrendously compulsive although you only get a decent high from the first hit. You then spend all your available money scoring more and trying to hit yourself up through the vasoconstriction. You’ll probably vomit the first time but even as you chuck you are fiending for the second one. It brings out every stereotypical loser junkie behaviour you can imagine: except since it’s a stimulant you stay awake and just keep going at it hard. Something I hope I never ever do again.

Besides that. For difficult to stop, make you sick, and turn you into a giant fuckwit problems I rate alcohol as pretty hard. I wouldn’t touch that either.
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I had a serious problem with coke when I lived in Guatemala for four years. It was really strong stuff and when I was IVing coke I had to take xznax just to lower my heart rate cause I was so obsessed with redosing. I became a junkie off my first poke. I was selling my clothes and things just to buy more. I never want to be like that again. I had to go to treatment and after treatment I moved to Canada and became a meth junkie. My life fell apart in every way .
I lost my mind and ended up in psyche ward 6x …. It was insanity!!! I went to a year treatment finally and don’t use the needle anymore at all
 
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