if youre talking about the worst drug to w/d from when it comes to the physical aspect - opiates (from heroin to opium to prescription opiate based painkillers like codeine, hydrocodone, oxycontin, morphine,etc), Alcohol (someone thats been drinking daily for a period of time longer than 4-5 months that tries to stop drinking all at once cold turkey can literally die from the withdrawl. Seizures will set in, etc), Benzos (valium, xanax, klonopin, ativan, etc. can also kill you when theyve been taken daily for a long period of time and stopping at once is attempted. Seizures set in, its horrible), GHB/GBL rapid withdrawl can also kill you.
When asked which is the worst its next to impossible to give an accurate answer due to everyone being different but opiate withdrawl is about as close u can get to experiencing a slow death with symptoms so horrid they cant be explained with words...
Alcohol and benzo withdrawl is pretty bad as well..
The mental aspect of withdrawl would include stimulants like cocaine hcl, crack cocaine and or base cocaine, amphetamine, methamphetamine, ice, and a long list of dirivitives like mephedrone, mdpv, etc. These drugs dont have much of a physical hold during withdrawl like the above listed do but they come with a completely different set of symptoms that play with you mentally which can be argued to be worse than the physical symptoms. Studies have shown that methamphetamine users that used 3 or more times a week over a period of more than 6months show permanant damage to their dopimine and seratonin receptors which before methamphetamine and ice was studied there were no cases of permanant un-doable damage to the brain with cocaine or amphetamine use. When ice popped up it everything. normal speed(amphetamine) is usually 10 to 40% Pure, 40 being very high and up to 3-4 years ago, methamphetamine purities were documented as high as 75%. roughly 4 or 5 years ago there was a noticable change in meth users. The psychosis that comes with prolonged use was getting much worse than ever seen, and meth began showing up at levels of purity up to and over 90%. "ICE" is basically methamphetamine in its pure form, its like speed on steroids and is hands down the most destructive drug mentally and physically that weve ever seen. It will take a perfectly healthy human with no health issues and turn them into a zombie in less than half a year. With cocaine a gram will last 1 user a day or night, or a couple users a night, a gram of ice which are now basically the same price will keep a user awake and going nonstop for days, and often weeeks. People are known to go weeks without sleeping or eating all the while in a state called tweaking which is a psychosis brought on by meth use. users will spend days taking electronical devices apart and putting them back together, known as Frankensteining. They become EXTREMELY paranoid - become convinced they are being watched, and will shave off all their body hair due to thoughts of aliens, police, bugs, etc. users will scrape, pick, scratch etc at their skin for days leaving them with huge open wounds.. with all other drugs the withdrawl and detox process the physical symptoms can last up to 3 or 4 months, mental symptoms with cocaine will last about the same, but with ICE users are reported to feeling barely any difference after being drug free for up to a year and a half...