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Opioids Tianeptine Megathread v1

No I dont intend to get high from it only to use it therapeutically for depression and not every day just for acute as required usage. Ive always avoidedanti depressants because i hate the idea of the schtick they tell you that you have to take it 24/7 indefinitely. which is why tianeptine has appealed to me because I believe depression can be beaten if you can blast yourself in to a motivated socially outgoing state at specific times rather than being drugged up constantly.
 
I don't know who has been giving you information, but anti-depressants are not a life time sentence. Nor are they being "drugged up constantly". There's a big range of drugs given legally for depression in varying dosages. Taking an opiate is not the best way of approaching the problem
 
Can someone tell me if detoxing off tianeptine is worse than suboxone? Like, 10 days of 300-400mg/day of tianeptine, or a month of 1mg/day sub? Please PM me, I really need some good advice from anyone with some experience!..
 
peolpe like you taking stupid doses and then going to the er when the shit hits the fan are what will get this substance banned quicker. taper down and suck it up.
 
Hey guys,

I quit my big nasty dilaudid abuse/addiction about six months ago. I am having rather a lot of trouble functioning when I need to get things done. I just don't have any energy.

So, tonight I took 45mgs hydrocodone, and lo and behold, I was able to get the house clean! It had really deteriorated, and I used the lovely energy boost to get it clean!

I do more or less need an antidepressant, at least some of the time, so occasionally taking a dose of tianeptine, which I have never tried, just seems like it might be helpful to me when I really need to function.

Believe me, I have no intention of getting hooked on opies again. I did not go on bupe or methadone, despite the fact that they were offered to me. I just had far, far too many horrid side-effects from my long, nasty IV dilaudid addiction, and it made me absolutely miserable. Not able to sleep right, I was sweating constantly(disgusting crotch sweat, UGH!), was constantly hot and freezing at the same time, horrifically depressed, etc.

So please don't warn me about getting addicted again. I'm just not willing to get myself into that position again.

I do have more hydro, but have no urge to redose.

So, opinions?

Also, if anyone has a good bit of experience with it, what is the dose equivalency of tianeptine compared to hydro or oxy?

Thanks a ton in advance for any useful replies.

Much love,

-Nicholai
 
Well the issue here is the fact that theyre not equipotent at any dose to hydrocodone or oxycodone because the antidepressant qualities tend to show up near 12.5 to 25mg, whereas the opioid qualities tend to show up near the 60-100mg range. Still not a bad option for you if you really want to try it, but i think itd be a lot easier for you to try something with no opioid qualities at all, such as kanna or a true SSRI/SNRI
 
Ahh, thanks for the useful info.

Yeah, I've been on Cymbalta, till I ran out anyway(and I'm between doctors). It was useful...I've trialed pretty much all the antidepressants, and Cymbalta is the only one I can tolerate. Helps with depression, and a little bit with my chronic pain, but doesn't help with energy whatsoever.

Been meaning to try Kanna for a long time, thanks for reminding me!
 
If youre having some serious troubles with energy AND want something opioidergic, i would say kratom BUT the addiction potential is definitely there. I am currently addicted to kratom and have stopped twice before and keep coming back to it. Dont fool yourself, but it does work and ive stayed at the exact same dosage for over a year now.
 
tianeptine is a horrible substitute for oxy or hydro. The high sucks and is very short lived plus tolerance seems to build rapidly. If you can get oxy or hydro I'd stick with those.

That being said I used to get a buzz off of 100mg of tianeptine when I first started and had little tolerance.
 
I would not suggest getting on getting on Tianeptine.
I have had horrible withdrawals, I would say it was worse then oxycodone withdrawals.
Find something else, what helped me was gabapentin. Even those have withdrawals after long use,
it can be easy to get off with a taper. It helps with my anxiety, depression, chronic pain, and even energy.
For me, it makes my coffee 5 times stronger, which is a plus in the morning.
 
If I really wanted to get high I'd just get some dope, heh.

Thanks for the quality info, guys. Going to give this chem a miss.
 
I started with 100mgs tianeptine which gave me a buzz and moved onto 1g 2x a day very, very quickly. I was replacing an opiate habit. Just don't do it.
 
I realize that, perhaps using racetams was a poor metaphor, but what I'm trying to say is many of them are downplaying the opioid agonist mechanism as I've actually seen a couple vendors who post on reddit say that there aren't any appreciable effects at MOR - which is just flat out wrong. I know of no other drug that can completely remove classic opioid withdrawal symptoms and trigger classic opioid withdrawal upon cessation without having an appreciable binding affinity at MOR and/or DOR.

EDIT: See this vendor's post:

NSFW:
tianeptine.jpg


That vendor is a bit off base. The Ki and EC50 determine the concentration that a drug will be active at, not how efficacious it is. Just because tianeptine has lower affinity then morphine doesn't mean that it couldn't produce just as strong an effect, as long as it is present in the brain at a high enough concentration to occupy mu receptors.


One can say (truthfully) that tianeptine has low affinity for the MOR. I think the reason why it can have very significant and obvious opiate effect is due to the dosage. While it has a low affinity, its doseage is 12.5mg/day, or ~38mg/day. When it comes in powder form, it is NOT hard to dose crazy amounts of it (like me, i used to do 10g/day at my worst). I think that taking so much at once allows enough stimulation at the MOR as to get opiate like effects despite low affinity. Totally just an educated guess.......my "theory" if you will.
 
I went through around 7grams of this in about 3 weeks. It was best right after waking up, It would wake me up like nothing else and get me moving. It's hard not to continue dosing throughout the day, and you definitely feel a bit of a comedown after a couple of hours. Still a good experience.
 
has anyone here thought of getting the sulfate form of tianeptine as opposed to the sodium salt.

its less hygroscopic so its easier to store and encapsulate.

also i think its half life is longer and it is absorbed more slowly into the bloodstream, so instead of dosing 3x a day, 1x a day is enough. i think i read that you might just need 25mg as opposed to 12.5mg
Anyone tried the TIANEPTINE SULFATE? The problem with tianeptine is the short duration, this could solve the problem
 
Anyone tried the TIANEPTINE SULFATE? The problem with tianeptine is the short duration, this could solve the problem

I've had the sulfate form. It seems to have a much less intense peak of effects, but lasts longer. If I'm doing 500mg/day of the sodium then I'd need about 1g/day of the sulfate version, but I'd only need to dose once. still doesnt quite have the "super happy pick me up" feeling of the sodium though. Would be a better choice for use as an A.D, but not so useful for recreation.
 
Ok, so how similar is the Tianeptine high to Kratom and is it more, less or equally addictive and more or less harmful than Kratom??

Also, can it be safely mixed with SSRIs and Klonopin?

Cause I mixed Kratom with my Lexapro and Klonopin quite a few times with no problems at all.
 
In my experience, Tianeptine is lacking in fullness to kratom. Sure, it hits the opiate receptors but it's just not the same.

It's also far more compulsive, more addicting, the withdrawals from opiate level doses (high doses) rival herion and it can greatly increase ones tolerance level pretty quickly.

People who are currently on kratom and looking for an alternative should think twice before switching to Tianeptine. It's a step in the wrong direction.

Kratom is easy to maintain, has the added benefit of a ceiling dose, is easy to taper and somewhat easy to withdrawal from. Tianeptine has none of these aspects. It's very easy to to start taking more and more. Tolerance rises quickly. Addiction sets in fast. Withdrawals are awful.

Now, if one sticks to therapeutic doses, it's a great antidepressant! But be warned, if you are an addict (especially an opiate addict) then having a tub of this stuff around may be asking for trouble... Even with the best of intentions.
 
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