Does anyone have any experience with using glucosamine and omega 3, 6 & 9 supplements for arthritic joints?
thanks
k
I have an autoimmune disease with symptoms that include pain and swelling of certain joints, in addition to arthritis symptoms. I find that astaxanthin helps a lot, and the only side effect I can find for this xanthophyll is that in an excessive amount beyond the theraputic range, your skin is prone to turning a reddish shade. There seem to be an okay amount of studies linking astaxanthin to be an efficient and wise choice in the treatment of a wide range of symptoms, including:
Astaxanthin exhibits a strong photoprotective effect
Astaxanthin increases cellular energy by protecting mitochondria
Astaxanthin is able to cross the blood-brain barrier to protect neurons
Astaxanthin keeps cataracts away
Astaxanthin protects against and treats ulcers
Astaxanthin combined with Flavangenol is powerful against diabetes complications
Astaxanthin keeps inflammation away
Some other claims:
Oxidative stress and inflammation are implicated in several different aspects of cardiovascular disease. Free radicals activate transcriptional messengers that contribute to endothelial dysfunction, initiation and progression of atherosclerosis, irreversible damage following stoke, and heart arrhythmia. Because of their ability to extinguish free radicals, researchers at the University of Hawaii, characterized the mechanism by which the carotenoid group works and reviewed preclinical data. They found that data from multiple species support the antioxidant/anti-inflammation properties of axtaxanthin, establishing it as an appropriate candidate for development as a therapeutic agent for cardiovascular oxidative stress and inflammation. (American Journal of Cardiology, May 22, 2008)
Astaxanthin boosts immune function
Earlier research has documented that astaxanthin significantly influences immune function. Several tests carried out at the University of Minnesota found it enhances antibody production in mouse spleen cells by exerting actions on T-cells, especially T-helper cells. It was able to restore decreased humoral immune responses in old mice, through immuno-modulating properties not related to provitamin A activity. Studies on human blood cells have demonstrated that astaxanthan enhances immunoglobulin production in response to T-cell dependent stimuli. The Minnesota group has also conducted studies on the mechanisms by which astaxanthan performs its actions. Astaxanthin has also shown in research to be effective against chronic viral and autoimmune diseases.
Summative interaction between astaxanthin, Ginkgo biloba extract
(EGb761) and vitamin C in Suppression of respiratory inflammation: a
comparison with ibuprofen.
Haines DD, Varga B, Bak I, Juhasz B, Mahmoud FF, Kalantari H, Gesztelyi R, Lekli I, Czompa A, Tosaki A.
Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
Abstract
In this study, combinations of Ginkgo biloba leaf extract (EGb761) plus the carotenoid antioxidant
astaxanthin (ASX) and vitamin C were evaluated for a summative dose effect in the inhibition of asthmaassociated inflammation in asthmatic guinea-pigs. Ovalbumin-sensitized Hartley guinea-pigs challenged with
ovalbumin aerosol to induce asthma, were administered EGb761, ASX, vitamin C or ibuprofen. Following
killing, bronchoalveolar lavage (BAL) fluid was evaluated for inflammatory cell infiltrates and lung tissue
cyclic nucleotide content. Each parameter measured was significantly altered to a greater degree by drug
combinations, than by each component acting independently. An optimal combination was identified that
included astaxanthin (10 mg/kg), vitamin C (200 mg/kg) and EGb761 (10 mg/kg), resulting in counts of
eosinophils and neutrophils each 1.6-fold lower; macrophages 1.8-fold lower, cAMP 1.4-fold higher; and
cGMP 2.04-fold higher than levels in untreated, asthmatic animals (p < 0.05). In conclusion,
EGb761, ASX
and vitamin C are shown here to interact summatively to suppress inflammation with efficacy equal to or
better than ibuprofen, a widely used non-steroidal antiinflammatory drug (NSAID). Such combinations of
non-toxic phytochemicals constitute powerful tools for the prevention of onset of acute and chronic
inflammatory disease if consumed regularly by healthy individuals; and may also augment the effectiveness
of therapy for those with established illness. Copyright (c) 2010 John Wiley & Sons, Ltd.
PMID: 20632299 [PubMed - as supplied by publisher]
On a side note, I have a mother who recently started that exact regimen for that exact reason. I'll chime in and see how she's doing with it. Hope this might be useful
