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Opioids The Ultimate Opiate Potentiation Thread v2.0

Shoot, I may try this DXM thing, but I do know that the grapefruit juice thing does work for some opiods. For sure, no placebo effect.
 
dokomo said:
^Promethazine and similar antihistamines don't bind to opioid receptors, though. They 'potentiate' opioids because of their own inherent sedative effects.
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You sir, are correct :) My bad!

dokomo said:
Theoretically, DXM does have the potential to block certain opioids from binding at kappa or delta sites, freeing them to bind to mu receptors. However (as far as I'm aware) this has not been clearly characterized in the research. Most of what I've read about DXM's potentiating effects is related to its NDMA activity.
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I've already heard/read conflicting reports also.
 
vvvvvvvveeeery tired and sleepless

I use only fentanyl patches and only this(and one other i don't wanna say because i'm afraid that someone could have an OD)works.And of course always be careful with fuckin fent.

MartinFn
 
Lately I have been plugging my meds (morphine and dihydocodeine) due to their low bioavailability. I have good results with grapefruit juice in the past, will it still work with plugging? or should I shoot some up my bum ? lols.
 
brighton said:
Lately I have been plugging my meds (morphine and dihydocodeine) due to their low bioavailability. I have good results with grapefruit juice in the past, will it still work with plugging? or should I shoot some up my bum ? lols.
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Don't plug the grapefruit juice! :) It will still work drinking the juice and plugging the morph/diphydro.
 
My favorite opiate potentiators are wine and xanax/klonopin, the benzos by themselves feel "cleaner" but together with alcohol (a sensible amount like a large glass of wine or a 40oz of beer) and H they pack a punch.. Its that line of not doing so much you black out and don't remember your rush/high, somehow if I can't remember it when I come to its much less satisfying..

Obviously you want to be careful with your proportions as too much can easily cause you to fall asleep and not wake up..
 
GlassAss420 said:
.... wine and xanax/klonopin, the benzos by themselves feel "cleaner" ....
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Funny you should mention the "cleaner" feeling when mixing/potentiating benzo with wine, because I've personally found that potentiating opies (such as Codeine, Oxy, Morphine*** - the CYP2D6 substrates!) with DXM - although it definitely potentiates said drugs, it find it makes - when compared with them straight - the high feel quite "dirty". I'm not entirely sure how to explain it correctly. However at a quick (without any research. Basically just going off a "very little [read: no :/] sleep over the past 24 hours(ish)"-stretched brain ;)) guess I'd say it'll be due to the (additional) dissociative - and to a lesser extent (since they doses required to potentiate said substances are no way near as much as what would be required for a straight DXM trip!) - the deliriant effects (of the DXM)!

Anyone else care to agree/disagree? :)

GlassAss420 said:
....
Obviously you want to be careful with your proportions as too much can easily cause you to fall asleep and not wake up
..
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Definitely good advice! I'm putting a +1 for this basically because I had a situation whereby I, took too much DXM (with a 4pk, 30tablet, CWE of a "12.5mg-ea tablet generic brand") and was in a state of "dissociative-ness" (I'm making this word up! You all get what I mean! 8() and basically in my, err, "inebriated" state I came to the conclusion that I was an alien, and the whole world was more or less here only because I was concious! And my life had to consist of basically; living in my room, watching movies, and only get up and out of bed to get food/fluids .... otherwise the world would cease to exist (if I didn't exist)!

Was an, umm, how would I put it? An extreme experience!* Probably the only time after a trip (whether that be anything from weed, to MDx, to MXE, to LSD trips!) that I kind of feel like I need to/should (in order to, I guess, possibly learn from, or just to make sense of, said trip and) write a trip-report!


***Quick edit (so I don't get flamed! =D) re Morph being a substrate of CYP2D6, just double checked (admittedly only on wiki just yet) and it confirms the cytochrome P450 (CYP) family of enzymes involved in phase I metabolism however nothing specifically on the former (specific) enzyme...so don't quote me on that! ;)

*Note that I say extreme since that's what it was for me! I'm sure this would/might/always be the "norm" for those majorly into their psych's/dissociatives but like I said, for me, this was a very new (and somewhat frightening**) experience.

** Note 2 that when I say "frightening" I found it was initially, but within, I dunno, say about 15mins (at wild guess considering obviously my temporal cognition was way out the window!) of kinda "hitting that wall" I guess I just kinda "went with it" and "accepted it as truth".
 
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King Hop Head said:
Phenibut and Chlorphenamine(amti histamine) really potentiates a Poppy Pod Tea high.
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I have also heard the Phenibut suggestion for potentiating, basically any other depressant - considering it is a metabotropic* GABA(B) (and to a lesser extent LGIC GABA(A) ) receptor agonist.

Opiates, weed, benzos (although i'd personally be a little hesitant/cautious mixing two GABAergic drugs but tbh I'm not entirely sure how much they would potentiate each other! Basically just going on gut feeling here! ;) :) ) to name just a few!

Hey K_H_H, is Phenibut available OTC (here in Aus I am!). The wiki page says it's OTC in the US but not too sure about Aus! I think I've had it...but (if it is what I think I've had then) I definitely didn't get it OTC! >_<

Also, I had never heard of the AH - "Chlorphenamine" - ....but that's not all it is (apparently!)....it seems to have quite a few other (nicely beneficial!) side-effects! A brief wiki abstract;

In addition to being an histamine H1 receptor antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.[3] A similar antihistamine, brompheniramine, led to the discovery of the SSRI zimelidine.

Limited clinical evidence shows that it is comparable to several antidepressant medications in its ability to inhibit the reuptake of serotonin and also norepinephrine (noradrenaline). However, extensive clinical trials of its psychiatric properties in humans have not been conducted. It inhibits serotonin reuptake less than norepinephrine reuptake, however the literature is not consistent in this respect.
....
an allergy medication with both antihistamine and decongestant properties
....
it is also a potentiator of opioids, allowing enhanced suppression of cough, analgesia, and other effects from a given quantity of the drug by itself. I
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Although it does seem that there should be more clinical studies on this drug, ey?! =D

* just this evening learnt that word (additionally what, I guess you could say are, the "most common" cells are in the body - eukaryotic/prokaryotic cells plus certain receptors such as metabotropic/ionotropic (LGIC) receptor cells, blah blah blah! ^^)
 
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So I am taking oral Terbinafine (Lamisil) for a nail infection. Apparently terbinafine is a moderate CYP2D6 inhibitor. From what I understand, tramadol is converted to O-Desmethyltramadol through this enzyme. So this would lower the concentration of O-desmethyltramadol, correct? Also...could I make up for this by drinking grapefruit juice and thus inhibiting CYP3A4?
 
I have used toradol and diclofenac - acetic acid derivative NSAIDS - and they were extremely sedating. Lots of potentiation with opiates.

Keep in mind that these drugs are not safe to use frequently, and some people end up dying due to complications from extended toradol/diclofenac usage. However when I used them, they were surprisingly sedating, much moreso than a benzodiazepine in normal dosages.
 
I just recently heard of a drug called isoniazid which is used to treat tuberculosis but also inhibits CYP 450 3A4. I do not know if this would be a realistic way to potentiate opiates so I figured I would go ahead and see if anyone has any knowledge or experience with it.

Even if it is a viable potentiator, the fact that it is prescribed for treating tuberculosis means it is probably impossible to come by anyway. Besides, the list of side effects sound like a horror movie.

Another group of drugs which inhibit CYP450 are sulfonamides - any realistic potential for potentiation there?
 
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About chitosan with morphine. . . Will this work crushing up chitosan into powder, mixing 50/50 with a crushed MScontin pill and snorting the powder? Or is it necessary to CWE the morphine and mix chitosan into the solution? Is there some kind of binding that only happens in a liquid solution or will chitosan powder 'piggybacking' with the morphine in my nasal passage allow a higher bioavailablity that way? Despite what is said about the 10% BA of morphine taken nasally I can get a buzz from one 60mg MScontin snorted but for some reason it's not predictable. . . Sometimes I can snort one crushed pill and feel it just like if I had swallowed it, sometimes barely any feeling at all.
 
Captain.Heroin said:
I have used toradol and diclofenac - acetic acid derivative NSAIDS - and they were extremely sedating. Lots of potentiation with opiates.

Keep in mind that these drugs are not safe to use frequently, and some people end up dying due to complications from extended toradol/diclofenac usage. However when I used them, they were surprisingly sedating, much moreso than a benzodiazepine in normal dosages.
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Oh Diclofenac? By what MOA does this potentiate opiates? This is the first time I've ever heard of NSAIDs causing sedation. Unless my understanding of the pharmacodynamics of acetic acid derivative NSAIDs are wrong - inhibition of the COX-1/COX-2 (and possibly COX-3) enzymes preventing the formation of prostaglandins. From what I understand prostaglandins play many a role in the body but sedation? I'm really interested C.H! If you're able to point to a paper or two that'll rock man! =D
 
i started off today by taking 3 tums then 30 mins after that took 40mg of oxycodone and snorted 10mg of oxycodone 30 mins after that i snorted 10mg of morphine sulphate IR then took 50mg of Diphenhydramine approx 60 mins later the effects were very relaxing and i will finish it off later with 10mg of diazapam and sit and watch the first day of the English premiership on sky later

All an all a nice mellow Saturday night

Tele
 
RISKY and i don't recommend this as I overdosed and almost Died.........Xanax 6mg + 1 gram Black tar = OD


Safe ones that keep ur nod goin and prevent the itch......benadryl, Doxylamine. good.
 
Very dangerous when you take first the benzo's and then the opiates, i'm sure that benzo's are maybe the best potentiators, but i don't suggest it to anyone. Play more safe, you take the opiates first, and after some hours, you take the benzo's for relax...safer=better.;)


MartinFn
 
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