amapola
Bluelight Crew
^dextromethorphan
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OD Moderators: Keif’ Richards | negrogesic
Opioids The Ultimate Opiate Potentiation Thread v2.0
- Thread starter Captain.Heroin
- Start date
tyrael
Bluelighter
Please be careful if you're planning on using DXM to potentiate opiates! Often (in actual fact, all except one) OTC product in Australia (containing DXM) contains other ingredient which can in best case scenario just make you sick). If you plan to, make sure you get a product which contains only DXM (and generally artificial sweeteners or other non-active ingredient) - the one in Aus (and sold elsewhere in the world) is Robitussin Dry Cough Forte.
I generally ingest 20-40mg of the DXM, 45mins to 1hour before ingesting the opiate (codeine generally in my case), and then another 20mg-40mg at the same time as the opiate.
Play safe!
I usually takes 30-35mg of Oxycodone (percocet 10/325) for pain relief but is looking for a way to lower that dose. I have read this entire thread and wasn't able to find any concrete answers to te following question. How much should the oxy dose be lowered when potentiating with one or all of GFJ, DXM, Tums and Tagamet? I would really like to find a combination that allows for a lower dose of oxy but wants to experiment SAFELY. Also, will these method cause problems with the amount of APAP present in this dosage (roughly 1g)?
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Well first off "SWIM" shouldn't be taking that much APAP on a daily basis. More importantly, did YOU read the rules? There is NO FUCKING "SWIM"ing ON BLUELIGHT. I am sick and tired of seeing this bullshit. Are none of you smart enough to read the goddamn forum rules that you are required to agree to before you come here??? SWIM is strictly prohibited. Also, are you really gullible enough to think that using "SWIM" when you are obviously tlaking about yourself is going to help you avoid self-incrimination??? If they want you, they will fucking get you, because this magical "SWIM" doesn't exist and it is your IP address posting this bullshit.
So if YOU are asking me how to potentiate your oxy, I will help you, but I will NOT fucking give advice to you, on the basis of "SWIM". So learn to read, and quit being a goddamn tool.
Thank you. I normally wouldn't be so hostile, but this is the 4th time in the last week that someone has used that SWIM bullshit. And I hate SWIM, in fact I refuse to post on boards that make you do that stupid shit, because it does NOT PROTECT YOU!!!
Ok, on to "your" question.
First, if they are 10/325's, then the APAP should be no problem. Unfortunately, potentiating them will be a problem. You see, the liver breaks down oxycodone, like it breaks down all drugs, causing it to wear off. Unfortunately, the liver also metabolizes a portion of the dose into oxymorphone, which is much, MUCH more potent than oxycodone itself, and helps give it that kick that we love so much. Now, the enzyme that destroys oxy is CYP3A4; the enzyme that converts roughly 10% of the dose is CYP2D6.
Thus, your best bet would be to inhibit ONLY CYP3A4, and not CYP2D6, so that you can slow down the metabolism of the oxy, while still getting a full oxymorphone yield. Unfortunately, almost every drug that inhibits cyp3a4 also inhibits cyp2d6, which means there is not much you can do. But, some people have a malformed CYP2d6 anyway, which means they can inhibit enzymes, while still getting the same effect.
Your best bet is to take 600-800mg of Tagament with THE DOSE YOU WOULD NORMALLY take. This is becuase your dose will last longer, but most likely be a tad weaker, though not much. Remember to take it about 30-45 minutes before you dose. Preferably, you want around 37.5mg diphenhydramine hydrochloride and 15-30mg DXM, for synergy. Try it once, and report back.
(Also, I will post a couple of links for you, detailing the various CYP inducers/inhibitors/substrates, and some interesting stuff about oxy) If I remember...
Edit: In the name of harm reduction, IF you mix anything with your dose aside from the tagament, you should lower it by 5-10mg the first time, just to be safe, though if you have a tolerance it honestly shouldn't matter unless you get into some HARDCORE potentiation like I do!!!
Ok, on to "your" question.
First, if they are 10/325's, then the APAP should be no problem. Unfortunately, potentiating them will be a problem. You see, the liver breaks down oxycodone, like it breaks down all drugs, causing it to wear off. Unfortunately, the liver also metabolizes a portion of the dose into oxymorphone, which is much, MUCH more potent than oxycodone itself, and helps give it that kick that we love so much. Now, the enzyme that destroys oxy is CYP3A4; the enzyme that converts roughly 10% of the dose is CYP2D6.
Thus, your best bet would be to inhibit ONLY CYP3A4, and not CYP2D6, so that you can slow down the metabolism of the oxy, while still getting a full oxymorphone yield. Unfortunately, almost every drug that inhibits cyp3a4 also inhibits cyp2d6, which means there is not much you can do. But, some people have a malformed CYP2d6 anyway, which means they can inhibit enzymes, while still getting the same effect.
Your best bet is to take 600-800mg of Tagament with THE DOSE YOU WOULD NORMALLY take. This is becuase your dose will last longer, but most likely be a tad weaker, though not much. Remember to take it about 30-45 minutes before you dose. Preferably, you want around 37.5mg diphenhydramine hydrochloride and 15-30mg DXM, for synergy. Try it once, and report back.
(Also, I will post a couple of links for you, detailing the various CYP inducers/inhibitors/substrates, and some interesting stuff about oxy) If I remember...
Edit: In the name of harm reduction, IF you mix anything with your dose aside from the tagament, you should lower it by 5-10mg the first time, just to be safe, though if you have a tolerance it honestly shouldn't matter unless you get into some HARDCORE potentiation like I do!!!
trichomeinj
Greenlighter
- Joined
- Oct 3, 2011
- Messages
- 1
all I know is when I take 100mg methadone "normal dose" of methadone in morning I feel nothing just normal but not sick, although if I take 2 ultra strength tums then take those 8 10mg tabs I feel the methadone 3x stronger.
Tried normal dose with 30mg of DXM and 400mg of Tagament. Didn't notice a difference in effectiveness from this combo. The only difference is a spacey feeling from what I assume is the DXM, which I don't particularly like. I don't think I will be trying this combo again.
I tried searching the thread, but didn't find any definitive answers.
I've heard White Grapefruit works best, but what about Ruby Red, and why? What is it exactly that is in the Grapefruit that potentiates the Opiate? I'm curious to know chemical names, and specifics and how they effect the brain in such a way that allows the Opiate to potentiate itself.
I've heard White Grapefruit works best, but what about Ruby Red, and why? What is it exactly that is in the Grapefruit that potentiates the Opiate? I'm curious to know chemical names, and specifics and how they effect the brain in such a way that allows the Opiate to potentiate itself.
It's a flavanoid present only in white GFJ, er, a few chemicals. Bergamottin is the main one, IIRC.
@tripOr: 400mg tagament probably wouldn't make much of a difference. If you like nodding out, OTC anti-histamines d muscle relaxers??? And at 30mg DXM, you wouldn't have gotten any recreational effects, takes 50-100mg to break the threshold.
RunRunRun
Bluelighter
Grapefruit juice inhibits the cytochrome P450 liver enzyme system which is what breaks down or metabolizes a number of drugs. I believe it slows down or stops the enzyme activity which means an increase in the level of the medicine, for a longer time. It only affects a few types of opiates.
Some people swear by this, that they can tell a huge difference. Others beg to differ. But for the people that say it works, say it's only like the pure white grapefruit juice that will do the trick. It is probably mostly placebo. For me, the only thing that really worked was Tagamet(name brand) or Cimetidine. I noticed a slight difference/increase with my daily methadone dose. I think it pretty much does the same thing grapefruit juice does.
Some people swear by this, that they can tell a huge difference. Others beg to differ. But for the people that say it works, say it's only like the pure white grapefruit juice that will do the trick. It is probably mostly placebo. For me, the only thing that really worked was Tagamet(name brand) or Cimetidine. I noticed a slight difference/increase with my daily methadone dose. I think it pretty much does the same thing grapefruit juice does.
So Ruby Red Grapefruit Juice not from concentrate wouldn't chemically have any effect? I hear some people say it's actually counter productive in absorption of the chemical.
No, ONLY PURE 100% WHITE GRAPEFRUIT JUICE IS USEFUL. And to Runrunrun, it is not placebo, there is a remarkable difference IF you inhibit the enzyme enough with the proper drugs. I found it works best with methadone, as I am one of those weird people who prefers methadone over many other opiates(I mean extreme potency, killer half life, no fucking pro-drugs to worry about, and full agonism without overt drowsiness or speedy effect OR the requirement to bang the shit to get any effect) and man, I have taken so much klonopin and methadone with WGFJ and a handful of tagament(not to mention atarax) that I have fucking woke up high the next day!!! But he is 100% right about one thing: Tagament is superior to WGFJ, for most intents and purposes. I mean, WGFJ is technically considered a more potent inhibitor than cimetidine, but cimetidine covers a wider range of enzymes, not to mention that is is a helluva lot easier to pop a few tagament than it is to drink a liter of fucking juice.
Just remember, one glass of WGFJ won't help that much, just as 1 tagament won't. It takes a few glasses of WGFJ and/or 600-800mg of tagament to work. Just watch out though, becuase once you find the magic potentiation combo, you may very well end up like me, so dependent on the potentiators, that without them, your dose is almost useless, as you have to take higher doses AND dose more often if you don't have them.
(BTW, it would only be counter productive becuase of the acidity. Also, let me stress again it must be white!!!
RunRunRun
Bluelighter
lorne,
I guess I have just haven't tried enough pure wgfj. I am in mmt at the moment. I used to get a script for mdones though. And man I was like you, before I started banging, I preferred methadone. I could take 90-100mgs at one time and be high for 2 days. I always had an eye out for mdones before I got my script and then when I did, I was greedy as hell with them. But like I said, once I started the iv route, methadone just didn't do the same.
I guess I have just haven't tried enough pure wgfj. I am in mmt at the moment. I used to get a script for mdones though. And man I was like you, before I started banging, I preferred methadone. I could take 90-100mgs at one time and be high for 2 days. I always had an eye out for mdones before I got my script and then when I did, I was greedy as hell with them. But like I said, once I started the iv route, methadone just didn't do the same.
ryand123
Bluelighter
Best opiate euphoria potentiator???
This has definantly been asked before, but i cant find it...but i am wondering what to take to increase hydrocodones euphoric effects?
Im looking to increase the warmth and overall content feeling of my hydrocodone. so, any ideas?
This has definantly been asked before, but i cant find it...but i am wondering what to take to increase hydrocodones euphoric effects?
Im looking to increase the warmth and overall content feeling of my hydrocodone. so, any ideas?
paper planes
Bluelighter
- Joined
- Jul 6, 2011
- Messages
- 400
if you would search you find alot on this but try taking some dimenhydrinate
ryand123
Bluelighter
yeah i have done a few hours worth of research and i have found drugs that potentiate the sedative and relaxant effects of opiates but not the warmth and actual euphoria of them. is that otc or prescription?
mrflowers00
Ex-Bluelighter
soma