fastandbulbous
Bluelight Crew
How about their ability to inhibit MAO A & B? By inhibiting the breakdown of catecholamines (all the amphetamines & 3C indoles being MAOI's to some degree, even if it's not clinically significant w.r.t. interactions with other drugs) they're stopping the synaptic cleft from being 'cleaned' of dopamine & noradrenaline.
Hey, I know it's not exactly a strong contender, but it may contribute. Also I'm not sure how an intergrated, concious response to the drugs might alter the response. The novelty of the situation the concious mind find itself in is likely to stimulate the RAS in the same way that any novel situation would (dopamine release in the nucleus accumbens etc). I know it's a leap from neuropharmacology to psychology & biochem of learning/novel processes, but as hugo24 said "WE HAVE OVERLOOKED SOMETHING" - I'm just grasping at straws (there, I'm being honest!).
Hey, I know it's not exactly a strong contender, but it may contribute. Also I'm not sure how an intergrated, concious response to the drugs might alter the response. The novelty of the situation the concious mind find itself in is likely to stimulate the RAS in the same way that any novel situation would (dopamine release in the nucleus accumbens etc). I know it's a leap from neuropharmacology to psychology & biochem of learning/novel processes, but as hugo24 said "WE HAVE OVERLOOKED SOMETHING" - I'm just grasping at straws (there, I'm being honest!).