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The Old and Overgrown DOC thread (fixed)

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How about their ability to inhibit MAO A & B? By inhibiting the breakdown of catecholamines (all the amphetamines & 3C indoles being MAOI's to some degree, even if it's not clinically significant w.r.t. interactions with other drugs) they're stopping the synaptic cleft from being 'cleaned' of dopamine & noradrenaline.

Hey, I know it's not exactly a strong contender, but it may contribute. Also I'm not sure how an intergrated, concious response to the drugs might alter the response. The novelty of the situation the concious mind find itself in is likely to stimulate the RAS in the same way that any novel situation would (dopamine release in the nucleus accumbens etc). I know it's a leap from neuropharmacology to psychology & biochem of learning/novel processes, but as hugo24 said "WE HAVE OVERLOOKED SOMETHING" - I'm just grasping at straws (there, I'm being honest!).
 
fastandbulbous said:
Also I'm not sure how an intergrated, concious response to the drugs might alter the response. The novelty of the situation the concious mind find itself in is likely to stimulate the RAS in the same way that any novel situation would (dopamine release in the nucleus accumbens etc). I know it's a leap from neuropharmacology to psychology & biochem of learning/novel processes, but as hugo24 said "WE HAVE OVERLOOKED SOMETHING" - I'm just grasping at straws (there, I'm being honest!).

If I'm understanding you correctly, this would basically be the same as the placebo effect? The mind is a very amazing thing, while placebo may not be as powerful as the majority of medicines/drugs/etc... it still can have quite an effect on people. Look at pretty much any study and you'll see that there are always people who received only sugar pills or whatever and thought that the drug worked great. I'd be quite surprised if placebo didn't account for at least some of the effects of these substances.
 
Not quite - whenever you're in a novel situation you're always operating with a bit more adrenaline (for the want of a better word) flowing because you might suddenly have to deal with a situation that you've never dealt with before (a sort of precursor to the 'fight or flight' response). This involves raised levels of catecholamine neurotransmitters - hence the perceived stimulant effect (the same sort of stimulation felt after riding in a really fast car, fairground ride etc).

Like I said, it's just thinking out loud - I've got nothing spercifically to back that idea up
 
The other day they waited, the sky was dark and faded,
Solemnly they stated, "He has to die, you know he has to die."
All the children learnin', from books that they were burnin',
Every leaf was turnin' ; to watch him die, you know he had to die.

The summer sun looked down on him, his mother could but frown on him,
And all the others sound on him, but it doesn't seem to matter.

And when the day had ended, with rainbow colors blended,
His mind remained unbended, he had to die, you know he had to die.

Spanish lady comes to me, she lays on me this rose.
It rainbow spirals round and round it trembles and explodes.
It left a smoking crater of my mind I like to blow away.
But the heat came 'round and busted me for smiling on a cloudy day.

Comin', comin', comin' around, comin', around,
comin', around, in a circle
Comin', comin', comin' around, comin' around, in a circle,
Comin', comin', comin' around, comin' in a circle.

Skippin' through the lily fields I came across an empty space,
It trembled and exploded, left a bus stop in it's place.
The bus came by and I got on, that's when it all began,
There was cowboy Neal at the wheel of the bus to never ever land.

Comin', comin', comin' around, comin', around,
comin', around, in a circle
Comin', comin', comin' around, comin' around, in a circle,
Comin', comin', comin' around, comin' in a circle.

And when the day had ended, with rainbow colors blended,
Their minds remained unbended,
He had to die, Oh, you know he had to die.
 
DOC and drug screenings

Hey there!

1. Will DOC or other psychedelic amphetamines and their metabolites give a positive on a screening for amphetamine of the blood?
2. Will DOC or other psychedelic amphetamines and their metabolites give a positive on a screening for amphetamine of the urine?

Peace

crOOk
 
^^^

There was some discussion of this in the B&D DOC thread. Instead of directing you to it I thought I'd pull it out and merge it into your thread here so that we can have a focused discussion of the topic here.
 
I've looked into this and it will as it an amphetamine analogue much like methamphetamine will show up....

No, methamphetamine is just a simple N-alkyl amphetamine; one of the metabolites of meth is plain amphetamine. Once you've got a whole load of groups attached to the aromatic ring, they have different physical, chemical and pharmacological properties. They may test positive, but if so the test would be so broad ranging that I'd imagine you'd get a lot of false positives.
 
Preferred Ingestion Method for DOC?

I got some DOC, and I've done it twice now with very mild effects.
I did 4mg orally the first time (just swallowing the crystals) and the effects took a long time to come on (~3 hours) and were very mild, limited to pretty fun closed eye visuals, little to no open eye visuals, and mild intellectual variation. I ate them on a rather full stomach, to which I attested the subdued experience.

The second time I ingested 3mg that same way, and dissolved 3mg into water, and held the water under my tongue. The effects were similar to the first time, but more intellectual movement (difficult to maintain conversations), and eventually a headache. No open eye visuals other than mild enhancement of color and some color shifting. (I was on an oral steroid during this time, which may have affected it. )

Would putting it onto blotter really affect the experience all that much? I'm trying to find out a way to do it that would get me similar effects to the trip reports I've read on here. I got the DOC from a chemical supplier, so I'm fairly certain it's the real deal. What's going on here? Is having a full stomach really that influential on the outcome of the trip?

Which method of ingestion is recommended?
 
First off try too eat as little as you can before consuming your doc (at least 4hours before food) id usually stay away from food that day just incase or at least a light snack, it helps a lot to keep them stomache upsets at bay ;)

I'd recommend you put between 6-8mg onto your tongue, sit and wait and making your own blotter paper wont make any difference. I couldn't imagine going much beyond the 8mg mark there is only so far your mind is willing to go before you trully are GOD! 8)
 
I took 2mg on a full stomach and was peaking in 3 hours, and had fairly dramatic hallucinations.

You may have gotten a product that was contaminated. Its known that some of the early batches of DOC that went into wide circulation were either 2C-I or heavily adultered with 2C-I.

How sure are you that you took 4mg? How accurate was this scale? If you didn't use a scale accurate to less than a milligram, chances are decent that you may not have taken the amount you thought you took.
 
I used a scale accurate to .001g, so even accounting for range of error +-2mg, I took 3-5mg.

I took 5mg today at 5, and it's 730 now. No effects other than a sense of significance to everything, similar to the onset of a shroom trip. I think I'm going to smoke a J.


Despite the supposed reliability of the source, perhaps I just didn't get what I thought I did. I used a Japanese source.


There is some added appreciation of color, vivid hues seem more vivid, and duller ones seem to fade between their usual dullness and a more intense color.
 
Yeah, that doesn't sound right at all...4mg DOC had my friend rambling about amazonian geometric fractal warriors engaging in a battle for the universe within 3 hours. But maybe you're just insensitive?
 
well you are building up a tolerance to it now. wait 2 weeks to a month before doing it again and then up it to 6-8 mg.

A good intense trip on this will take nearly this long to integrate fully into your psyche anyways.
 
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