• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

☛ Official ☚ The Big & Dandy Solubility & Stability Thread

Adding acid is more common when trying to extract alkaloids from plant material. Perhaps this is what you heard? To store pure chemicals, all I've ever done was to dissolve them in distilled water, or ethanol, or a combination of both.
 
Nope, it wasn't for extractions. eg on the previous page David Woodmont said:

"Therefore, try dissolving your compound in water (maybe with a little lemon juice or vitamin C to help it dissolve)"

And there are lots of other examples on BL.
 
^^Sure, but is "your compound" the freebase? Probably, if adding an acid makes it water soluable. The only RC's I'm aware of being sold as the freebase are 5meo-dmt (meant to be smoked), and DPT (the place that sold it that way is out of business). Everything else seems to dissolve well in ethanol, which I prefer to water, because it prevents bacterial growth.
 
2c-E

I was planning on buying 100mgs of 2c-E and dissolving it in 50ml of distilled water, so that each drop would be 2mgs. Has anyone done this, and how long would it remain stable for before it starts losing potency? I would be keeping it in an amber bottle, so light wouldn't effect it much, and probably keep it in the fridge, but I doubt I'd have this for any longer than 3 or 4 months; 5 tops.

Would it remain stable that long?
 
Yes, but make sure to store it in a cool, dark place. The fridge works well.

And I assume you meant "...so each mL would be 2mg." This is the way I store most of mine as well, and it works well for me.
 
Xorkoth said:
Yes, but make sure to store it in a cool, dark place. The fridge works well.

And I assume you meant "...so each mL would be 2mg." This is the way I store most of mine as well, and it works well for me.
Click to expand...


Ah yeah, that's what I meant. Thanks man, sounds good.
 
How long do you guys think salted 4-HO-DET would take to degrade in an H2O solution? Does it begin almost immediately? Additionally, what is the approximate solubility of 4-HO-DET hcl in water?
 
http://www.erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det_article1.shtml

I don't think it's very soluble in water (maybe a little heat would help). It's more soluble in alcohol. Also, 4-HO-DET should degrade faster than 4-Aco-DET, which is the topic in the link above.

I've only had experience with 4-Aco-MIPT in an alcohol solution (i think 10 mg/mL??). It would not dissolve in water even when I added some HCL. In the case of 4-Aco-MIPT, the solution started changing colors in a matter of days and was black within a week. The good news is that it's probably just a very small amount of degradation going on resulting in a colored product.
 
This might give an idea (note:this was the freebase.I assume the salts are somewhat more stable)

"I was curious how stable this 4-HO stuff really is.5-MeO-DIPT.HCl,DPT.HCl,DMT freebase and such stuff can be stored unchanged for years at RT when protected from light.

4-Acetoxi-indol itself,storing at 0° in a brown container for about 7 years showed still a pure product according to HPLC.I've recently checked freshly obtained 4-HO-DIPT which were grey crystals with a purity >99%.The methanolic HPLC solution (2mg/ml) was let standing at RT in the light and reassayed:after 6h,it was still unchanged and colorless.4 days later a slight discoloration towards a grey/violetbrown got apparent but HPLC looked still fine,only a very little noise in the baseline starting to stick its head out.
15 days later,the solution has turned brown and the content has fallen to about 92%.As a general rule,discoloration is a valid indicator of degradation but usually overstates the degree.

I would not store unfreezed solutions of these compounds (maybe only in degassed liquid and with VitC or BHT added at 0° with no light present) for longer periods.As pure crystals I'm confident they will hold purity rather long if kept in freezer/light protected.The hydrochlorides are probably considerably more stable.Will check the 4-HO-MIPT as well now."

I have the data for Miprocin as well now,just have to search it.
 
Thanks hugo, please do post that miprocin data! It's exciting to think that many years hence these might be pulled out of the freezer intact. Maybe they'll still be good when the kids I haven't had yet are grown up. I'm saving a large percentage of my collection for old age!
 
Dondante said:
http://www.erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det_article1.shtml

I don't think it's very soluble in water (maybe a little heat would help). It's more soluble in alcohol. Also, 4-HO-DET should degrade faster than 4-Aco-DET, which is the topic in the link above.

I've only had experience with 4-Aco-MIPT in an alcohol solution (i think 10 mg/mL??). It would not dissolve in water even when I added some HCL. In the case of 4-Aco-MIPT, the solution started changing colors in a matter of days and was black within a week. The good news is that it's probably just a very small amount of degradation going on resulting in a colored product.
Click to expand...

I was able to dissolve 100mg of 4-AcO-MiPT in 35mL of 95% ethanol and 65mL of distilled water. It took a while but eventually, and with a little heat, it all went into solution. I've been storing in my freezer and it has yet to change to any color but the very, very light grey that it turned immediately due to the color of the compound. I've had it for 2-3 months now.
 
djfriendly,I'm sure most RC's will last longer than you =D ...Only the 4-ho's need special care.

Here's the Miprocin stability data (HPLC).Again the same setup,a 2mg/ml solution in Methanol standing on the shelf unprotected.The material had a starting purity of 100% (freebase)

1 day: no change. 4 days,no change. 7 days,well you get an idea on where the degradation poducts will appear but its still 99% pure.The solution is now slightly brownish. 2 weeks,the purity has dropped to 98% but theres this bump in the baseline appearing.This looks like a statistical distribution of degradation products but I had this bump before from goo-like natural products so it might point to something similar,polymeric or fatty,and colored. Yeah the solution was now grey/brown.
At 3 weeks,the drop in purity got steeper,to 90%.

Note:HPLC is not an exact science,and theres the potential of stuff flying "under the radar".As theres was always the same solution and same inject volume used,the absolut mAU might give a hint of losing material "somewhere": 1857, 1794, 1800, 1738, 1572.

Six months later I discovered the solution still standing around,well it was all gone now,only this 2min. broad mountain left,exactly at the position of the earlier noted baseline-bump.

Two further notes:did once a TLC with Iprocin with a solvent containing Ammonia.You could literally watch the spot getting grey on the plate!So the 4-ho's degradation is drastically accelerated by any base present (could be the reason the Iprocin stability test in the other post showed a faster degradation)

Since HCl neutralizes the basic tert.amino group on the sidechain (if you have a salt) it will be a positive for the storage.Otherwise said amine will "fuck with himself",the acidic phenol at position 4 and form a zwitterion.No wonder it will get brown then...
 
Never did a stability on the acetyls,but its worth noting that solutions remain uncolored for a long time.BUT,the acetyl is very susceptible to hydrolysis.A solution in Methanol already split off a few % acetyl on the short way to the HPLC.

Avoided should all hydrolytic conditions like acids and bases.Plus alcohols (water is also an alcohol) which induce transesterification in the presence of small amounts of bases or acids (from the hydrochloride for example!)
 
I recently acquired some miprocin fumarate and when I added it to water it almost instantly turned green. I took 20mg soon after. In a few hours there was a layer of foam at the top of the bottle. I experimented with the substance 48 hours later and the results were very close to nill. I ended up taking over a period of 2 hours what should have been 40mg but felt like 5mg or less. Apparently this chemical broke down REAL quick when I dissolved it in water. Anyone else notice this? Are there other solvents I could use to prevent this? Real bummer, lost a lot of good product!
 
sdafsdfdsafasdfdsa said:
I recently acquired some miprocin fumarate and when I added it to water it almost instantly turned green...
Click to expand...

Did you use distilled water? If you used tap or bottled water, you probably had a lot of impurities in there.

The fumarate salt does degrage quickly (significant loss of potency within 3-4 weeks and discoloring within a day or two), but I can't imagine it would have died completely within 24 hours, unless your solution was really impure.

Maybe next time, try (drinkable) alcohol? I might just try that myself with a 100mg sample dissolved in 80 proof vodka.
 
No, I didnt use distilled water, so it may have been the problem. I also had miprocetin but that didnt react really at all to water. I could actually see the water turn green the instant I added miprocin fumarate to it, then foam up several minutes afterwords. I also dissolved some methylone in water too and that turned yellow and smelled like old fermented fruit in a couple days. I must have some crazy shit in my water or something...
 
Has anyone had experience with a more concentrated 5-MeO-AMT solution than 1ml/1mg? Say, 1ml/10mg, or small enough to drop on a sugar cube? [NOT SELLING. DO NOT FLAME. JUST NEED TO TRANSPORT].
 
You must log in or register to reply here.
Top