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The Big & Dandy Nootropics Thread

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Cthulhu said:
complete abstinence from psychoactives.
personally I found that even spinach and whatnot is psychoactive, so it probably depends on you definition of psychoactive.
Water perhaps? 8)
 
Ptah said:
personally I found that even spinach and whatnot is psychoactive, so it probably depends on you definition of psychoactive.
Water perhaps? 8)

yeah yeah glucose itself is psychoactive according to the most technical definition.
I guess you could say that a real period of purity would be one of fasting - however, fasting is generally unhealthy for the body, which depends on continuous nourishment, whereas one can be healthy with or without drugs. (of course there are exceptions, such as schizophrenics and medication). I recognize the value of mind altering substances, I'm just saying regular periods of abstinence can do a lot of good, in a grounding/integrating sort of way.
 
hey last night had a kind of uncomfortable scary experience.

This is the combination with the order of drugs as far as I can remember:

T+0: 1.5 grams piracetam, 350mg DMAE
T+1:00: 200mg L-Theanine
T+5:00: copious amounts of marijuana smoked (eyes dilated from nootropics and theanine wearing off causing a slight stimulant like rebound effect)
T+6:00: heart started to RACE, I tried timing it but I was way too stoned. It was about 100BPMs as far as I could tell. My resting heart rate is usually VERY LOW.
T+6:30: .5mg xanax and 2.5mg melatonin to stop heart racing.
T+7:00: sleep like a babyfor 12 hours.

Anyways, I wouldn't recommend even combining marijuana with piracetam (not even remotely around the same time). And I think the theanine had something to do with it too.

Of course, I have been slightly psychologically addicted to xanax the past couple weeks since I was going through a rough spot and was using it to even out my emotional state. So, the possibility that this was entirely psychological (providing an excuse to take xanax) was certainly there. I don't know...there is so much about my own mind I do not know still.
 
Deprenyl, l-seligiline, is a great PEA(Phenethylamine) smart drug. Definite cognitive enhancement. Not necessarily psychedelic, but lengthened a 2CB experience to 12+ hours. :)
 
Glad you're okay s_s. Marijuana can cause a racing heart, although you use it enough that it's kind of surprising it would have such a strong reaction. Personally I find piracetam to make marijuana a more enjoyable experience, but I have never had it become all intense like that.

Have you ruled out the possibility of some sort of light xanax withdrawal? I know you've been using it pretty frequently... I don't know how frequently though. Had you not taken it for a while? I ask because you were able to calm down and sleep after some was taken.
 
yes, the xanax definitely got me back to normal.

Possibly I am going through a light xanax withdrawl. Very light though. So light that I only notice it when I smoked. I've used it maybe 75% of the nights in the last 10 days. Only ever .5mg-2mg, never crazy high doses. Too much though I know.

I'm stopping while I still can.
 
I would be suspicious of the xanax in that situation as well. Thats been long enough that you should probably be getting some mild w/d effects.

I have smoked pot probably thousands of times on piracetam without any adverse effects. In fact it seems to help keep me from getting the brain fog quite as bad.

Had you switched to a more sativa-based strain of pot lately or anything? That sort of change (unexpectedly) can make me kind of nervous if I was already prone to being set off (taking xanax or whatever).

Maybe give CP55940 a shot at some point if you are having the panic/spaz issues with weed.
 
fizz, is cp55940 known for being less anxiety inducing than good ol' mary jane?

s_s, id also be weary of the xanax. I also went into a short period (1 or 2 months) of frequently dosing on benzos. I didnt get a physical dependance but definately felt a psychological addiction. I even convinced myself that i actually need it to get through the day, was considering getting a prescription for it.
I think benzos are better off left for bad trips or perhaps the occasional xanax bar with a couple beers. Unless ofcourse you have real anxiety issues, in which case i would advise seeing a physicican.
 
So I've been taking about 2,000mg of piracetam 2-3 times daily for a little over a week and have noticed a bunch of positive effects!

I have so much more motivation to do things. I feel like I catch on quicker in school and that my memory has improved. Although when I don't take any, I feel very groggy and not really in the mood to do anything.
 
Pretty Diamonds, according to a lot of people on these forums 6 grams of Piracetam a day is a bit too much. I guess though since you're just starting out on Piracetam that "attack doses" (high doses) would be fine since you're body isn't yet sensitive to Piracetam.

People say once you've been on Piracetam a while to slowly decrease your dose as your body is now much more sensitive to it. A lot of long-time Piracetam users only take 500 milligrams to a gram or 2 once to twice a day. People also warn that overdoing Piracetam can actually cause a dumb drug effect of feeling sleepier and less sharp.

Also, be careful taking any stimulants now that you're on Piracetam as they might be strongly potentiated. Also, Tryptamine and Phenethylamine psychedelics might suddenly be much stronger for you on Piracetam. I highly recommend trying a mild to moderate dose of an Ergoline or 2CE while on Piracetam. The resulting trip is cleaner, clearer, more euphoric and visual.

You might want to take a Choline enhancing drug each day like DMAE or Lecithin to synergize with your Piracetam and it also may help decrease any Piracetam induced headaches.

Good luck with your introduction into the awesome world of smart drugs and supplements!

Some other good smart drugs to start with might be: Hydergine, Deprenyl

Or supplements like: SAM-e, DMAE, Lecithin, Acetyl L-Carnitine, Alpha Lipoic Acid, Rhodiola
 
The Wizard said:
Pretty Diamonds, according to a lot of people on these forums 6 grams of Piracetam a day is a bit too much. I guess though since you're just starting out on Piracetam that "attack doses" (high doses) would be fine since you're body isn't yet sensitive to Piracetam.

People say once you've been on Piracetam a while to slowly decrease your dose as your body is now much more sensitive to it. A lot of long-time Piracetam users only take 500 milligrams to a gram or 2 once to twice a day. People also warn that overdoing Piracetam can actually cause a dumb drug effect of feeling sleepier and less sharp.

Also, be careful taking any stimulants now that you're on Piracetam as they might be strongly potentiated. Also, Tryptamine and Phenethylamine psychedelics might suddenly be much stronger for you on Piracetam. I highly recommend trying a mild to moderate dose of an Ergoline or 2CE while on Piracetam. The resulting trip is cleaner, clearer, more euphoric and visual.

You might want to take a Choline enhancing drug each day like DMAE or Lecithin to synergize with your Piracetam and it also may help decrease any Piracetam induced headaches.

Good luck with your introduction into the awesome world of smart drugs and supplements!

Some other good smart drugs to start with might be: Hydergine, Deprenyl

Or supplements like: SAM-e, DMAE, Lecithin, Acetyl L-Carnitine, Alpha Lipoic Acid, Rhodiola
Ooh, that I didn't know! Maybe I should start lowering my dosage, then huh?

Thanks for all that extra info as well! =)
 
I wish people could describe to me how exactly Centrophenoxine feels better than DMAE. If it basically feels the same I don’t see a reason to buy it when DMAE is far cheaper. Is Centrophenoxine the same as DMAE in terms of one can only use it occasionally, as daily use quickly builds a tolerance?

Do you guys find that Fish Oil helps as much with depression and moodiness as I’ve heard?

I’ve never noticed withdrawals from quitting any smart drugs or supplements.

SAM-e was funny stuff to me. At first I could have sworn it was improving my mood and energy levels. But after using it for months I couldn’t tell anymore whether it was helping me at all and I discontinued it. What I’d been doing was using at least 400 mg of SAM-e with folic acid twice a day. I noticed clinical trials sometimes used 1,000 mg to 1,500 mg a day so I don’t know if my daily dosage of 800 mg was too low for the full therapeutic benefits. Does SAM-e boost Serotonin and Dopamine levels a lot or just slightly? Times I DID notice SAM-e to be strong was when I’d take high doses while rolling. 1,000+ mg of SAM-e while rolling is fucking incredible.

I don’t find low grade, old Mexican MJ to be a smart drug particularly at all. If anything it can leave one feeling sleepy, sluggish, cloudy and apathetic. Now high grade Sativa strains of KB are another story. These can give me a nice upbeat, stimulated, clearheaded stone without side effects. I hear that high doses of Lecithin (5+ grams) can synergize really well with MJ. Anyone tried this? They also say Kanna synergizes great with MJ. And I know from experience that Kratom + MJ is a great time.

If you’re curious about Alpha Lipoic Acid (ALA) and Acetyl L-Carnitine (ALC) the combination can be great for depression, clearer thinking and more alertness. Wal-Mart sells a bottle of 30 capsules which are a combination of ALA and ALC for $8. I don’t remember the brand name.

I find myself again very curious about Yerba Mate. I’m def. tired of Coffee or straight Caffeine tablets with their unwanted side effects (the biggest side effect Caffeine gives me is when it wears off I suddenly feel sleepy as hell and I assume this is because it has depleted my adrenaline) and ability to quickly raise one’s tolerance. It’s true that Yerba Mate is much healthier, cleaner feeling and doesn’t cause a sharp rise in tolerance like Coffee/Caffeine? What all is contained in Yerba besides Caffeine? Do you brew it as a tea or toss n wash it? I wouldn’t recommend Chocamine; it’s pretty fucking weak and overpriced. I can eat 3 or 4 grams and still barely feel anything.

The best stimulating herbs I’ve tried so far are Rhodiola (in powder form) and Japanese Sweet Flag (the powdered 5X extract). I’d also like to find a source for high quality fresh Catuaba and Ginseng. Catuaba is purported to be a dopamine reuptake inhibitor, powerful aphrodisiac, and antidepressant and is actually related to Coca. Is it true that good fresh Ginseng is used daily for months can dramatically improve one’s mental and physical performance?

DL-Phenylalanine I still enjoy using once or twice a week as a mild, pleasant energy booster/mood elevator. I generally use 1.5 to 2 grams with some Vitamin C and B-Complex. DLPA (DL-Phenylalanine) also boosts Kratom or Opiates/Opioids realllly nicely.

If you want an alternative to the Benzos you were using try: Kava, Phenibut, Neurontin, GABOB, L-Theanine or Salvia miltiorrhiza.


Oh, lastly, I need you guys’ help on how I should use Hydergine. I got 30 4.5 mg tablets (Hydergina brand) yesterday and wanted to know if I should take 4.5 once a day or twice a day or what? And am I right that sublingual absorption will be best? How many days/weeks will it take before I’ll really notice the full effects or will it only take a few days? The longer I’m on Hydergine will my mind become more sensitive so I can lower the dose (such as happens with Deprenyl)?

I also would love to know how Hydergine will synergize with my usual psychedelics (HBW, blotter, Psilcoybe, Amanita, DXM, MDxx)? Am I right to assume that if I preloaded on Piracetam and Hydergine that I could get a lot more bang for my buck out of some blotter? Eventually, I want to try daily Deprenyl and then see how that influences trips.

What’s the current verdict on the usefulness of NADH, Vinpocetine, Vasopressin, Nicergoline, Bromcriptine, Amineptine?
 
If I use DMAE for more than 3 days in a row now it stops working as well as it usually does and actually has more negative effects I think.

Honestly, since I started really focusing on my diet, I can do without a choline donator (I still eat a couple tablespoons of soy lecithin oil a day).

Try it...you may find yourself pleasantly surprised.

Can't answer your last questions as I have never tried those (want to try vinpocetine though, I've heard good things).

I would be wary of messing about with vasopressin, personally.
 
The Wizard said:
I wish people could describe to me how exactly Centrophenoxine feels better than DMAE. If it basically feels the same I don’t see a reason to buy it when DMAE is far cheaper. Is Centrophenoxine the same as DMAE in terms of one can only use it occasionally, as daily use quickly builds a tolerance?

Well, basically, centrophenoxine works every day. DMAE I can use for a few days and then it starts to feel counterproductive. I have read that DMAE isn't very safe to take by itself, whereas centro is because of what else is in it. But take that with a grain of salt because I can't remember exactly what I heard or where I heard it. Nevertheless I definitely prefer centro and use it daily without issue.

I’ve never noticed withdrawals from quitting any smart drugs or supplements.

Me neither. Phenibut, which isn't really a nootropic so much, can cause some rebound anxiety when you stop using it, but I don't really consider that withdrawal.

If you want an alternative to the Benzos you were using try: Kava, Phenibut, Neurontin, GABOB, L-Theanine or Salvia miltiorrhiza.

Indeed. I actually prefer phenibut to benzos because it produces an actual euphoria in me, as opposed to benzos which just remove stress.

Oh, lastly, I need you guys’ help on how I should use Hydergine. I got 30 4.5 mg tablets (Hydergina brand) yesterday and wanted to know if I should take 4.5 once a day or twice a day or what? And am I right that sublingual absorption will be best? How many days/weeks will it take before I’ll really notice the full effects or will it only take a few days? The longer I’m on Hydergine will my mind become more sensitive so I can lower the dose (such as happens with Deprenyl)?

I would definitely start with a 4.5mg tablet, once per day. They're too expensive to use more than you need. Whenever I use it now, I use like 1-2mg, so I would definitely say you get more attuned to it and need less the more you use it, like with piracetam. Sublingual is the best, yes. Fortunately hydergine has virtually no taste. I found hydergine to produce noticeable results pretty quickly. Actually the peak of effectiveness for me was around 1-2 weeks in.
 
Oh, lastly, I need you guys’ help on how I should use Hydergine. I got 30 4.5 mg tablets (Hydergina brand) yesterday and wanted to know if I should take 4.5 once a day or twice a day or what? And am I right that sublingual absorption will be best? How many days/weeks will it take before I’ll really notice the full effects or will it only take a few days? The longer I’m on Hydergine will my mind become more sensitive so I can lower the dose (such as happens with Deprenyl)?

On that note , i think caffeine affects absorption of ergoloid mesylates such as hydergine. If i have understood correctly it can raise plasma levels (quantity in the bloodstream). Here is the study documenting it

And here is the abstract,the bold is mine :

1. Following single oral doses of 3H-dihydroergocryptine (DHEC) to rats, most of the absorbed radioactivity was excreted in the bile, 18.5% +/- 3.2 SD after dosing with 3H-DHEC (0.1 mg/kg) and caffeine (1 mg/kg), and 15.1 +/- 4.6 SD after dosing with 3H-DHEC (0.1 mg/kg) alone. The exception data indicated that about 25% of a single oral dose of 3H-DHEC was absorbed. 2. During 7 h after the last of daily oral doses for 7 days, plasma concentrations of radioactivity were consistently significantly greater (P < 0.001 to < 0.01) in rats dosed with 3H-DHEC (0.1 mg/kg) and caffeine (1 mg/kg) than in those dosed with 3H-DHEC (0.1 mg/kg) alone. The extent of bioavailability of radioactivity was also signficantly greater during this time (P < 0.01) and during 24 h (P < 0.05) after the last of repeated oral doses of 3H-DHEC and caffeine than after 3H-DHEC alone.
 
Okay, so it's my third day on Hydergine. I took 9 mg sublingually Monday, 4.5 mg Tuesday and 4.5 mg just now. I've no idea how many days it's supposed to take for me to start noticing effects. Also, since I'm on other nootropics and a lot of supplements I don't know if I'll be able to distinguish the effects of the Hydergine from these other drugs at all.

I make sure to use 1.5-2 grams of Piracetam once to twice a day, so this should synergize with my Hydergine, right? I assume I can get considerably more effect from a dose of Hydergine since the Piracetam will potentiate it, right?

Xorkoth, you say I will notice the full effects of Hydergine in 2 weeks and then they'll lessen or continue to intensify? Trying to understand if I need to worry about a tolerance to daily Hydergine. And why do people sometimes take time off from Hydergine occasionally? Is there a negative effect to long-term daily use of it? I wonder why the Europeans use a MUCH higher dose of Hydergine than Americans.

PM me if any of you know a cheap, reliable online source for Hydergine. Also, the brand I have, Hydergina, is it decent?
 
What dose of hydergine do Europeans use? I wasn't aware it was different.

I take time off because I feel that after using it for a few days it becomes counterproductive... it's just an intuition based on how I feel. This didn't occur at first... I took it every day for many months to great effect. After a certain point it was like I didn't need it anymore. In fact I've run out and am in no hurry to find more, although I will sometime.

As far as menufactured hydergine, I don't really know of any cheap ones. It's kind of an expensive thing. I once got a gram of pure ergoloid mesylates (hydergine) powder for $50, from a friend who got it from a chemical supply house. He talked to them and they sent it, but I don't really know the details. So it's evidently possible to get it in bulk, but it's still kind of expensive. However, $50 a gram is much cheaper than it is in pill form. Unfortunately I don't know any more details about that. But I bet if you searched around you could find something.

Oh, and I noticed the best effects around the 2 week mark and then it slowly lessened, but I think it may have been because I was depressed when I started taking it and feeling like I had lost my creativity, and when I started the hydergine it gave me a huge boost. So much of this stuff is subjective and situational, you know?
 
Eventually Hydergine simply stopped working or actually started feeling like it was hurting you mentally? I've heard of folks who eventually had to cut back or stop Hydergine because they mentally felt overwhelmed. I know there's tons of sites selling Hydergine, some much cheaper than others, but I hate risking it with sites I haven't heard people vouch for. The one I ordered from took over 2 weeks to come and that was 30 4.5 mg tablets which costed$33 as I recall. The box was for some reason already open when I got it yet the tablets were luckily still in their blister packs.

Doesn't Hydergine dilate the pupils? It's yet to do this to me at all. Hopefully the Kanna I used the last 2 nights isn't interfering with Hydergine's effectiveness. Is there any sort of body buzz component to Hydergine and how long does it take for the effects to kick in from a single dose? Have studies ever attempted to use Hydergine nasally or injected or no? I wonder if rectal administration would be more effective than sublingual...

When my order of Rhodiola arrives I'll stack that with my Piracetam and Hydergine. Any of you that doubt the effectiveness of Rhodiola as a stimulant/cognitive enhancer, either haven't used it long enough or got a weak product. The 5% Rosavin Rhodiola powder I was using only starting working after I'd used it consistently day after day. I found 1.5-2 grams twice a day to be optimal for me. Adaptogens like Rhodiola are great, as they balance your neurotransmitters.
 
Hydergine doesn't dilate my pupils... it does for some though (samadhi_smiles comes to mind). And when I say it felt like it was being counterproductive, I mean I felt like when I took it too much I was better off without it. It produced a feeling behind my eyes that I associate with having a cold or something... kind of hard to explain. I just felt a bit off. I still take it maybe once a week, and it's good for me that way.

I do like rhodiola... I use it when I'm feeling stressed and it it very calming. I don't really derive any benefits from it unless there is a specific reason for me to take it though. Likewise with L-theanine... I find it a big help when I've had too much caffeine or something, or I can't relax at night. Otherwise I leave it in my big box of supplements. The more I've gotten into nootropics, the more I have stopped taking most of them daily, because they work better for me when I save them for when I really need them. Otherwise I stop noticing them and I might as well just not be taking them at all. The exceptions are piracetam and centrophenoxine, and of course fish oil and a multivitamin. I take those daily.
 
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