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Nootropics The Big & Dandy Nootropics Thread (Stack 2)

My 2nd attempt at combining 5-MeO-MiPT with Coluracetam was a massive success, although I'd like to think it had nothing to do with these two at all. For the first time, I've decided to combine PRL 8-53 with a psychedelic. To my amazement, my own kitchen floor became an endless complex of branches, swaying elegantly back and forth, almost as if performing some sort of a dance. I absolutely never get visuals, period (although, I haven't tried Salvia, Ibogaine, or DMT as of yet.) I decided to take a walk across the neighbourhood, as with most trips. My inebriation was far less obvious than on, say, dissociatives, although I certainly wasn't doing a good job hiding my current state. At times, I had trouble keeping my balance or walking in a straight line - I'm very fortunate everyone in this neighbourhood is so drug tolerant. ;) At some point during the walk, I found myself looking into the glass door of some house or other, and what did I see? Samuel L. Jackson, with an afro, staring me straight in the face. I was pretty neutral at the time, but at this point, it's fucking hilarious. Upon finishing my walk throughout the neighbourhood, I decided to go to my room and introspect for a bit. Staring at my carpet, I noticed once again - I was getting visuals, somehow! Fractals slowly spinning, almost like a hurricane in a sense. After this, the fractals turned into a being - something was trying to get out of the carpet. I could see its red eyes staring straight into my soul, yet I couldn't help but be amused. Just seconds later, I realized that what I had assumed were eyes were, in actuality, just a few simple carpet stains. I continued focusing in on certain objects in the room - namely, the base of my bed. A few seconds into this charade, and the bed starts shaking violently, like some sort of demonic possession. Was I going to have to exercise this table? Nah, he'll come back to his senses soon enough. I feel as though there's someone trapped under the bed during this violent shaking. In a panic, I lift up the bed to find...nothing, nothing at all. This realization brings me back to reality, and kills any further (pronounced) visuals. Soon after this incident, I find myself coming down, back to the usual stimulant stage - bored and restless as ever.

This was certainly a surprise, being my first time ever to experience visuals. I was under the impression that, due to my severe myopia, any type of visuals would be impossible for me to experience. I'm glad to say this is not the case after today. Melting visuals similar to acid, fractal patterns, breathing walls, shifting of spatial perception (objects appearing much larger or smaller than they really are, straight lines turning into slopes leading up or down), and the constant presence of these "heat waves" were some of the most common visual experiences throughout the trip. Visual phenomena aside, I'm more interested in what might've caused me to spontaneously go from getting no visuals at all to getting some fairly vivid visuals throughout the experience this time around. Was it the Coluracetam causing all this? Given that I never spent any time introspecting in my last trip, and the fact that I'd only experience visuals when introspecting this time around, I'd say it's a fair bet Coluracetam is the culprit for these visuals. To confirm, I'll be sure to test the 5-MeO-MiPT Coluracetam combination *without* PRL 8-53 in the next attempt. I do remember reading something about Coluracetam permanently improving eyesight. I wonder if this has something to do with my newfound ability to perceive visuals during trips? It's always nice getting surprises like this, and this was the best I could've hoped for. Every single trip in the past resulted in not a single visual to speak of, yet here I am today, getting tons of visuals, some of which were indistinguishable with reality. Visuals aren't everything, but they should never be taken for granted. I only hope this'll last. :)
 
I don't think it's very good as a nootropic, but it's awesome as a wakefulness promotor which is also usually the way it is used.

Agreed. I read the neurochemical profile it provides and it sounded similar to adderall, so I was excited at it's potential. But in reality I found it harder to study, even when I combined with caffeine. Not to mention my piss spelt horrible...

Big waste of money for me unfortunately.
 
A list of cognitive enhancers, anti anxiety, stimulants, nootropics, and others.

2-Aminoindane
2-Aminotetralin
2C-Bu
2C-C(anti-anxiety)
2C-D(Sub-hallucinogenic dose, SHD)
2C-G-N
2C-I(Sub-hallucinogenic dose, SHD)
2C-Ph
2C-Se
2C-T-4(SHD)
2C-x
2-methyl-2-butanol, 2m2bOH(helps you socialize. Anti-anxiety.)
5-HTP
a-Et-2C-D
AceticBenzylPiperazine
Agomelatin
Alpha GPC
Amobarbital(possible hypermnesia agent)
Aniracetam
Arecoline
Atagabalin
Atomoxetine
Azacyclonol
B Vitamins
Baclofen (Body temperature regulator)
Bacopa
Benzodiezepines
Boron
Cannabidiol(CBD)
Cashews
Cayenne Pepper
Choline
Citalopram(Anti anxiety)
Clean healthy colon
Coluracetam
CRL-40,941(Fladrafinil)
Cotinine
CX-546
Daffodil
Desoxypipradrol
Dexanabinol
Diclazepam
Diphenidine
DM-235(Sunifiram)
DMAA(Geranamine, DiMethylAmylAmine[safe stimulant])
E-55888
EthylAmphetamine (N-EthylAmphetamine)
Flodafinil
Fluorenol
GABA
Galantamine
GHB(Anti anxiety)
Glaucine
GLYX-13
Haloperidol(anti-psychotic and trip/hallucination terminater)
HU-308
HU-331
Huperzine A
Hyacinth Flower Petals
Hydergine
Hydroxyzine
IAP(IndanylAminoPropane)
Indanetraline
Isopropylamphetamine (N-IsopropylAmphetamine)
Ispronicline
JWH-200
Kanna Fruit
L-arginine
L-Dopa
L-Lysine
L-Theanine
L-Tyrosine
Lanicemine
Lucidril(Causes temporary hypermnesia)
Magnesium
MDO-D
Methionine
Methylenedioxyethylamphetamine
Monolaurin (Glyceryl Laurate)
Mucuna pruriens (Velvet bean)
Nefiracetam
Nitrazepam
Nitrous Oxide(When Vitamin B12 is taken an hour before)
Norepinephrine
NRX-1074
NSI-189
Omega 3's
Periwinkle Flower Petals
Phenibut
Phenylpiracetam
Piracetam
Pitolisant
Probiotics
Propranolol
PropylAmphetamine(N-PropylAmphetamine)
Pramiracetam
Pterostilbene
Purslane plant
PWZ-029
Pyritinol
Quercetin
Racetams
Resveratrol
Robalzotan
S-17092
S-18,986
SAM-e
Selegiline
Serotonin
Sesamol
Silver
SR-59,230-A
Sulbutiamine
Sunflower seeds
Synephrine
Tamarind Leaves
Tametraline
Tetrahydropalmatine
Thiopropamine
Tranylcypromine
TriMethylGlycine(TMG)
UH-232
Unifiram
Vallium(anti-anxiety)
Vinpocetine
Vitamin B5(cofactor in the conversion of choline into acetylcholine)
Vitamin B6
Vitamin D3
Win-41,528-2 (Fezolamine)
WIN 55,212-2

Maybe the megalist would be better.

The extreme megalist. Over 140 nootropics.
1-Cyclopentyl-2-AminoPropane (CAP. CyclopentylAminoPropane, cyclopentylaminopropane, Norcyclopentamine.)
1-CycloHexyl-2-AminoPropane (cyclohexylaminopropane, CycloHexylAminoPropane,norpropylhexedrine, CHAP)
2-Amino-1,2-dihydronapthalene (2-ADN, 2-Aminodilin, 2-AD)
2-Aminoindane
2-Aminotetralin
2-Fluoroamphetamine
2-Phenyl-3,6-dimethylmorpholine
2C-2P (2C-IP, sub-hallucinogenic doses)
2C-Bu
2C-C(anti-anxiety)
2C-D(Sub-hallucinogenic dose, SHD)
2C-G-N(2C-NPH)
2C-I(Sub-hallucinogenic dose, SHD)
2C-Ph
2C-Se
2C-T-4(SHD)
2C-x
2-methyl-2-butanol, 2m2bOH(helps you socialize. Anti-anxiety.)
3-Fluoroamphetamine
4-Fluorophenylpiperazine
4-Methylaminorex
5-HTP
a-Et-2C-D
a-PVP
a-PHP
AceticBenzylPiperazine
Agomelatin
Alpha GPC
Alvameline
Aminorex
Amobarbital(may help create selective false memories and experiences you choose with great and vivid memory of the events. May also cause temporary hypermnesia.)
Amphetamine?
Aniracetam
Arecoline
Atagabalin
Azacyclonol
B Vitamins
Baclofen (Body temperature regulator)
Bacopa
Benzodiezepines
Benzofuranylpropylaminopentane
Benzothiophenylcyclohexylpiperidine (BTCP)
Benzhydryl Thioacetamide
Beta-Phenyl-Amphetamine
Boron
Bretazenil
Bromantane
Caffeine(Fatigue perception reducer)
Cannabidiol(CBD)
Cashews
Cayenne Pepper
CGS-15943(Fatigue perception reducer)
Choline
Chloral Hydrate(anti anxiety and sleeping aid)
Clean healthy colon
Coluracetam
Creatine
CRL-40,941(Fladrafinil)
Cotinine
Cyclazodone
Cyclopentamine
Daffodils
Dexanabinol
Diclazepam
Diphenidine
DM-235(Sunifiram)
DMAA(Geranamine, DiMethylAmylAmine[pre-work out stimulant])
Donepezil
E-55888
Emoxypene
EthylAmphetamine (N-EthylAmphetamine)
Flodafinil (Fluoromodafinil. Flmodafinil. CRL-40,940)
Fluorenol(Hydrafinil)
GBL(prodrug to GHB. Use responsibly)
GABA
Galantamine
GHB(Anti anxiety)
Ginkgo Biloba
Glaucine
Gluten Free
GLYX-13
Haloperidol(anti-psychotic and trip/hallucination terminater)
HU-308
HU-331
Huperzine A
Hyacinth Flower Petals
Hydergine
Hydroxyzine
IAP(IndanylAminoPropane)
Igmesine
Indanetraline
Isopropylamphetamine (N-IsopropylAmphetamine)
Ispronicline
ISRIB, trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
Istradefylline (KW-6002. Fatigue perception reducer)
ISX-9 http://www.biovision.com/isx9-8397.html
JWH-200
KA-672
Kanna plant(contains mesembrine)
L-arginine
L-Dopa
L-Lysine
L-Theanine
L-Tyrosine
Lanicemine
Lefetamine(combination stimulant and mild pain killer)Loxapine (anti-psychotic that induces the growth of new neurons)
Lucidril(Causes temporary hypermnesia)
Magnesium
MCOPPB (anti-anxiety) http://en.wikipedia.org/wiki/MCOPPB
MDEA (3,4-MethyleneDioxyEthylAmphetamine. Use no more than once a month.)
MDO-D
Memorimax
Methionine
Methiopropamine
Methylphencyclayte (Flynnalin)
Methylenedioxyethylamphetamine
Modafiendz (N-Methyl-Flodafinil. N-Methyl-Flmodafinil)
Monolaurin (Glyceryl Laurate)MT-45 (Pain killer)
Mucuna pruriens (Velvet bean)
N-acetyl-L-tyrosine
Nefiracetam
Nepetalactone
NESS-0327
Nitrazepam
Nitrous Oxide(When Vitamin B12 is taken an hour before)
Nooglutyl
Norepinephrine
NRX-1074
NSI-189
O-2172
Omega 3's
Oxiracetam
Oxolinic acid
Periwinkle Flower Petals
Phenibut
Phenobarbital (combined with a stimulant, it allows you to change your subconsciousness and beliefs and believe the most fictional stories experiences with cartoons and mythical creatures be true.)
Phenylpiracetam
Phenylpiracetam Hydrazide
Phenylpropylaminopentane (PPAP)
Piracetam
Pitolisant
PP-028
PRE-084
PRX-03140
Probiotics
Prolintane
Propranolol (anti-anxiety nootropic that may also treat PTSD)
PropylAmphetamine(N-Propyl-Amphetamine)
Propylhexedrine
Propylhexedrinsomfinil
Pramiracetam
Psilocybin(SHD, induces neuron growth)
Pterostilbene
Purslane plant
PWZ-029
Pyritinol
Quercetin
Racetams
Radequinil(The cure for Altzeimer's)
Resveratrol
Rivanicline
Robalzotan
S-17092
S-18,986
SAM-e
SCH-58261
Selegiline
Serotonin
Sesamol
Silver
SR-59,230-A
Stiminsomfinil
Stimvector
Sulbutiamine
Sulfer
Sunflower seeds
Sunifiram
Tamarind Leaves
Tametraline
Terbequinil
Tetrahydropalmatine
Thiopropamine
Tolazoline(fatigue perception reducer)
Tranylcypromine
TriMethylGlycine(TMG)
UH-232
Unifiram
Vallium(anti-anxiety)
Vinpocetine
Vitamin B6
Vitamin D3
Walnuts
WAY-317,538
Win-41,528-2 (Fezolamine)
WIN 55,212-2
Xenon
Yogurt
Z-17
Zinc
Zylofuramine

Like 200 nootropics!

Nootropics: There are many sub-types. There are cholinergics, 5HT2a, serotonergics, stimulants, antianxiety, memory enhancers, critical thinking enhancers, among others. There are ecstasinergics(anti aggresion, mood lifting and serenics. They activate serotonin, dopamine, norephinephrine, and 5HT2a to a limited extent).

The classification of cognitive enhancers vs nootropics.
Hypranootropics(super nootropics)
Nootropics(permanent cognitive enhancement)
Quasinootropics(temporary cognitive increase, little or no brain damage)
Pseudonootropics(fake nootropics. The effect is temporary and there's extensive damage, toxicity, and a host of side effects including high addiction potential, blackouts and brain damage)

This is just a small stockpile of information. ;)

This information is for informational purposes only and does not constitute medical, professional, or legal advice.

Just for fun, here's a cool image. %)
3478r5e.jpg


I guess I'm a bit of a studyaholic.
 
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I think you posted the list before (page 12), and it was commented on.......
 
Thinking of starting to take nootropics but unsure of what to take and doses etc. I'm 19 years old medium build. Anyone help me out? Any comments of previous experience would be great also, thanks.
 
hydergine is my favorite nootropics (that I've tried). The basic racetams are also good, I used piracetam on and off for years and I enjoyed the subtle but real benefits. Also piracetam is about as safe and non-toxic as it gets, probably a good place to start. aniracetam and oxiracetram are more potent, and I like phenylpiracetam a little more than the others. Hydergine has a broad range of benefits that are much more noticeable than most other nootropics, but it's a pain to get (have to order from overseas or very expensively on eBay).
 
Couldn't agree more, the only thing is I am not really sure if that means that it is best to just start with piracetam or if it would be better to immediately go for a more effective one like aniracetam (which I certainly recommend but occasionally there are people who find the feeling it gives you unpleasant - still, the same might be true for piracetam?)... I would not immediately start out with potent and novel ones like noopept, personally.

For what reason or purpose are you interested in trying nootropics, Ety?
 
I've found phenylpiracetam & coluracetam pretty effective. Still haven't gotten around to messing with the other racetams & noopet I have laying around.

I usually take 100-125mg phenylpiracetam & 10-15mg coluracetam. I have yet to try the latter on its own, but it does seem to temper the stimulant effects of phenylpiracetam somewhat. Anyone else notice that?
 
I have noticed the (light) stimulant effects from phenylpiracetam (it's probably my favorite racetam so far) but I have yet to try coluracetam. I am very curious about it though, at some point I will give it a try. The research is intriguing to say the least. At least what I read on Wiki.
 
Combining a Racetam with Sunifiram and Noopept has rendered me a manic states of hypervigilant focus so intense I felt like a computer.
 
I'm posting this in the nootropics thread because it's classed as a nootropic conventionally. But reading some reports on a nootropics forum (not sure if linking to other forums is allowed? Sorry I'm new) has really piqued my interest in Sunifiram. Originally, I found this compound interesting because of its alleged activity on AMPA--ampakines seem like the future to me in terms of nootropic activity, and also possibly as novel antidepressants because of their alleged effect on BDNF and NGF. However, a consistent feature in reports for Sunifiram seems to be marked color enhancement. Especially warm tones like yellows. And especially at edges (eg. textures, object boundaries, walls).

This. Well. This sounds remarkably like my experience with psychedelics. Mushrooms have had an incredible effect for me in bringing out warm tones like reds, browns, yellows. And while they have some "texture enhancement" in my experience, I've noticed that feature more prominently while using hawaiian baby woodrose seeds.

The point being, these visual features seem to be distinctive traits of some psychedelic drugs I'm familiar with. While some people report color enhancement with nootropics in general, I'm wondering if the presence of these very specific characteristics indicates that Sunifiram actually has action at the 5ht2a receptor, or alternatively at a place downstream of the 5ht2a receptor?

For what it's worth, I have noticed remarkable color enhancement while taking noopept, on occasion. Racetams and nootropics in general are often thought of as good potentiators of psychedelics, but normally people cite the mechanism for this as something simplistic like "increased blood flow to the brain." I guess I'm suddenly wondering if they (or some of them--it doesn't necessarily make sense to group these drugs into one class) have mechanisms that are more closely related to the mechanisms of psychedelics than was previously thought.

More specifically, though I certainly wouldn't suggest that sunifiram itself has potential as a novel hallucinogen, I can't help but wonder if there is potential for other chemicals based off of the same framework to make their way into the psychedelic community.

------

Besides the general colour saturation increase and increased shinyness on chromed surfaces, the other standard self-test I have developed after working with new racetams for so many years is the edge test.

Looking at high-contrast edges of things.

The higher racetams show it more than the lower ones.

Coluracetam shows a very strong edge effect - reported by others also and verified by me. High-contrast areas and edges are enhanced, with the brightness and also intensity difference boldened.

There is also an obvious edge effect caused by Sunifiram. However, instead of promoting highly attention-getting bright areas, it instead highlights a sub-effect I call the fine-edge effect.

Much like some of the really smart image-sharpening algorithms like WarpSharp, narrow lines and high-contrast gaps like in doorways show fine edges. It's hard to explain but likely due to the general contrast enhancement - double-sided edges become so much sharper. That's the difference between the fine-edge effect and the regular edge effect - the fine type is shown by enhancements to double-sided edges (like black lines or gaps against a light background), while the regular edge effect occurs on a single-contrast-transition gradient. The two are not mutex however.

And the heart: Aniracetam, Coluracetam and Sunifiram are the only racetams that have a heart. They generate a kind, peaceful texture to consciousness that could also be described as pro-social but it's far more than that. However, the sludgy side-effects of Aniracetam along with its low nootropic capacity limit the intelligence multiplier to the heart effect which prevents its full development. Like luminance, its intensity is the carrier for the other dimension of colour but by itself it is achromatic and dimensionless and thus alone unbalanced but together with the numerous qualitatives it provides them the energy to exist.

It is also becoming apparent that my ability to understand and come to large-scale synthetic conclusions and express them has increased significantly since the first dose of Sunifiram this morning. There may be enormous power awaiting within this molecule.

As for colour enhancement, I feel the need to be clear: the most enhancement so far has been in the warm region - the wonderful oranges and yellows really stand out! That includes the warm 3000K and 2700K compact and circline fluorescents in the washroom - whose edges also show the unigradient edge-effect - though when returning to my room illuminated solely by daylight and 6500K compact fluorescents with their strong aquamarine emission line I was also impressed by the increased perceptivity of colour saturation and a more difficult effect to qualify or quantify - colour fineness - not just the intensity of colour increasing but it being perceived more - as a more real totality.

It was rainy today and I looked out the kitchen window at the forest and grass and daffodils. The daffodils just stood out with so much more saturation - yet paradoxically pastellized as other higher racetams can do - while the greens of the forest and blue of the sky were more saturated but understated in comparison.

The chromatic enhancement is so relatively selective that the deciduous trees with yellower leaves stood out significantly more against the background of dark-green conifers and grayish-blue sky above.

Yes, the golden glow around things and the undefineable color and line effect of pretty much everything that you pay attention too.

Fortunately, this doesn't last forever, because "it's not supposed to!"

There is a need for rest, nourishment, and time to process these experiences. How could your brain possibly function that way for any length of time???

One of the things that I was able to do when the sunifiram was affecting me more strongly is do some fairly deep emotional processing, something that my perceived stress level (before sunifiram) prevented me from doing. Just having some of the mental clutter and distraction of anxiety removed, in addition to making the present moment much more enjoyable, made it possible to think, see, and thus conclude a little differently. So I am better than I was before. Much better, I have less baggage because I was able to solve some difficult dilemmas that I've had for years.
Meditation is more sustained and effective than normal.
The stimulant effect is still around, not as strongly, it was never invasive even when it was pretty strong. Now it's just energy and I can easily direct myself through what I need to do without procrastinating.
Sensory enhancement, though not apparent all the time, is still in the background and will fully resurface when I'm receptive. During a quiet period today I was looking at a painting I've had for years and the colors and shapes just started popping out, the picture took on a beautiful golden glow, super-saturated colors, higher contrast, the HDR effect. I saw much, much more in that picture than I'd ever seen before and I also saw it very sharply and clearly, as if I'd had a several diopter improvement in my eyesight. I have monovision normally, which means no real depth perception. I am an artist, ha ha!

I revieced mine yesterday and started today. First I took 11mg at 8am. About 30-40 minutes in, I start to feel a tingling or slight thumping pressure on the left side of my brain. Soon this goes away and I start to feel somewhat euphoric and happy. As I was walking to class, I notice many random things in the landscape that I have never noticed for years. I also noticed that random ideas seem to come more often. I have yet to test how it effects memory.

Now for the debriefing.

At 11:42a I noticed while sweeping the floor that my palms were warm and sweaty.

At about the same time I noticed a slight physical discoordination and what seemed to be a slowing of mind.

At about 11:45a I moved on to sweeping the ceramic-tiled part of the floor. They are octagons tiled with squares.

Then the unexplained surfaced: I was feeling the texture of the tiles through the broom handle - it never happened before.

I continued sweeping for some time as I usually do in the mornings. The house is dark and there is not much noticeable whilst doing the dungeonesque chores. The cat's disgorged enteric contents on the floor didn't look much brighter than its usual shade of hardboiled egg-yolk yellow.

After the hour of morning chores I returned to my brighter daylit room and removed my glasses to sit at the computer. I glanced at the glasses as I was about to put them down - the carpet in this room is dark blue-green - and I saw the reflected lights and under it the dark blue-green, so very dark like a swamp.

The utter shinyness and smoothness of the glass startled me. It was so beautifully smooth, so absolutely shiny, gazing into a transparent solid smoothness; a liquid smooth pool. Then I realized that the perfectly shiny smoothness was so beautiful because inside me is now all shiny and smooth like the glass. My mind.

There is a silence there, some utter calmness, it is not like any other racetam.

I sat down and put on the desktop background - a scene of blue and white abandoned sea and sandy islet in the southern islands of Japan. The colours startled me in a way I have not been startled like for a long time if ever.

The black text is different somehow too - sharper and smoother too.

Overall visual dynamic range in chroma seems to have increased by about 20% while luma range by only about 10%.
(obviously his numbers about luma and chroma are unscientific, but regardless he's noticing a change)

Today is a very good challenge day for me for the possible "sunny" mood effects of sunifiram because it's probably gonna be a rough day by the nature of the activities coming up for me. Also it's very overcast today which is guarantee for some mood, energy and motivation depression.

This morning I took 10 mg of sunifiram around 6:30am then my usual large strong coffee. No oils, supplements, or other racetams at that time. About 45 minutes later I could feel the sunifiram starting up, a bit like coffee, much stronger, but not anxious. Decided to meditate to bring some peace and insight into what I have to deal with today. No problem meditating, in fact was interrupted a few times and was able to reset right into where I left off in the meditation which is not always easy for me.

It has not been as strong as yesterday, when I took a lot more: 5 mg and then a while later, 11 mg. Also took under very different external circumstances and mind/body state. I did have trouble sleeping last night, even though by bedtime more than 6 hours had passed since taking the sunifiram and there were no longer any discernable effects, other than a calm insomnia.

But even at the 10 mg I took this morning, sunifiram is pretty strong, causing definite thermogenisis and increased energy, as well as increased mental clarity.

3.5 hours later most of the obvious effects have worn off and I do not seem to be dropping below my normal baseline of mood, energy, and drive.

I would definitely say that a starting dose of maybe 1-2 mg is smarter than what I initially did. Everyone is different, but since this particular racetam seems fairly strong and there is less known about it for human use, test it carefully and slowly and test under different conditions. You'll get a better idea of how it works and maintain a higher level of safety.

Taking sunifiram has made me finally commit to quitting coffee, only using it "as needed" such as when I haven't had enough sleep or am driving long distances at night. I'm not replacing my morning coffee with any racetam but just noticed the difference between the stimulant effect of coffee versus sunifiram. Sunifiram has a much smoother, friendlier stimulant effect than coffee. Caffein is addictive in a physical sense, more so than any racetam I've taken. It is also more dangerous in high doses than most of the racetams, as far as we know right now. I'm not giving up green and white tea, just not consuming it in huge quantities every day.

Right now, for me, taking sunifiram alone (no other racetams or supplements) works pretty well at 10 mg. Thus far, I am not experiencing any adverse side effects, other than the insomnia last night. So it is going to be a racetam for the first half of the day, before late afternoon, unless there is some requirement where I need to stay awake late.

Mood and energy effects have mostly subsided 4.5 hours after taking sunifiram, but the thermogenisis is still pretty active, which means it is still doing something to me. Possibly my breakfast and supplements an hour ago boosted the last phase of the sunifiram.

Some notes: People seem to be reporting color enhancement (specifically at edge lines and of warm tones), feeling (or illusion of) mental clarity, induction of a sort of meditative state or encouraging introspection, increased energy and the need to do something active, and even "thermogenesis" which I've interpreted to mean increased bodyheat.

All of these, as far as I can tell, seem symptomatic of drugs which affect the serotonin system. While this is perhaps "backyard pharmacology" I'm doing here, it would seem to me that sunifiram--if it truly acts primarily through its effect on AMPA (supposedly it's an allosteric modulator that prolongs the AMPAR signal, analogous to barbs for GABA, rather than increasing # of signals, analogous to benzos for GABA)--is either having an effect upstream of 5ht2a, or downstream of 5ht2a, but which mirrors some of the effects of 5ht2a agonists.

What do you guys think about all of this?
 
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I don't think so, not all color enhancement is necessarily mediated by the same mechanisms through which psychedelics act. Yes serotonin receptors throughout the neocortex are vital to higher consciousness functions including perception, but perception is also involved with processing of information which lies close to cognition. I don't presume to be an expert on that whatsoever, but effects from AMPAkines, cholinergics and action on the glutamatergic system can all influence the way information is processed in the brain. Obviously nootropics can have effects on memory and attention, but I think there are indirectly links to perception since processing data from the senses is what enables our cognitive faculties and they are closely involved with learning anything less than the absolutely abstract.

The point is not that I know how it works and can prove what other mechanism enables some nootropics (certainly some more than others) to have sensory enhancement effects, but rather that what we do know about psychedelics and 5-HT(2a) receptors and psychedelics shouldn't blind us about the complex going-ons of other receptors and drugs.
Noopept and aniracetam have also occasionally had visual sharpening effect on me (as if I suddenly gained HD vision), and I really doubt that that was because of action of 5-HT2a receptors. It is not known that they bind with appreciable affinity to that receptor type so why should there be psychedelic effects at those (normal) dosages, and why on earth are there no actual psychedelic effects, only ones that very vaguely and superficially are reminiscent of psychedelics?

Also let me remind you that there are countless other drugs acting on various completely different receptors like GABAr, NMDAr or opioid receptors and they can produce visual effects (even if they are not really psychedelic / hallucinogenic / trippy). The reason I think is that our consciousness depends on many parts of the brain and the actions of many many types of receptors and indirectly there is a lot of influence that can spread through layers of signal cascades.

my 0.02
 
I don't think so, not all color enhancement is necessarily mediated by the same mechanisms through which psychedelics act. Yes serotonin receptors throughout the neocortex are vital to higher consciousness functions including perception, but perception is also involved with processing of information which lies close to cognition. I don't presume to be an expert on that whatsoever, but effects from AMPAkines, cholinergics and action on the glutamatergic system can all influence the way information is processed in the brain. Obviously nootropics can have effects on memory and attention, but I think there are indirectly links to perception since processing data from the senses is what enables our cognitive faculties and they are closely involved with learning anything less than the absolutely abstract.

The point is not that I know how it works and can prove what other mechanism enables some nootropics (certainly some more than others) to have sensory enhancement effects, but rather that what we do know about psychedelics and 5-HT(2a) receptors and psychedelics shouldn't blind us about the complex going-ons of other receptors and drugs.
Noopept and aniracetam have also occasionally had visual sharpening effect on me (as if I suddenly gained HD vision), and I really doubt that that was because of action of 5-HT2a receptors. It is not known that they bind with appreciable affinity to that receptor type so why should there be psychedelic effects at those (normal) dosages, and why on earth are there no actual psychedelic effects, only ones that very vaguely and superficially are reminiscent of psychedelics?

Also let me remind you that there are countless other drugs acting on various completely different receptors like GABAr, NMDAr or opioid receptors and they can produce visual effects (even if they are not really psychedelic / hallucinogenic / trippy). The reason I think is that our consciousness depends on many parts of the brain and the actions of many many types of receptors and indirectly there is a lot of influence that can spread through layers of signal cascades.

my 0.02

Thanks Solipsis,

My point was not that sunifiram might bind to 5ht2a. I think that would have been discovered by now. Rather I was suggesting that it (and some other nootropics) might have an effect which mirrors the effects downstream caused by 5ht2a receptor activation. Eg. 5ht2a agonists affect AMPA downstream in some of their perceptual effects.

Another thought, which I mentioned earlier but didn't connect the dots on until now: SSRIs are thought to work on depression by increasing BDNF. AMPAkines also allegedly increase BDNF. Isn't it possible that all or some of the effects of 5ht2a agonism are mediated by AMPA?

Of course, your point is well taken: Perception is very complex and, just because both 5ht2a ligands and AMPA modulators can affect perception, does not necessarily imply that one system is mediated through the other. And the fact that nootropics, even when megadosed, do not increase beyond this "threshold" of visual enhancement and/or introspective headspace, would seem to indicate that they probably are working to alter our perception through an entirely unrelated (well, distantly related, I suppose) mechanism. It just seems uncanny that their effects on perception at least subjectively seem to mirror the effects of psychedelics, rather than being distinctly different.
 
Been taking noopept daily for months now plus been taking phenylpiracetam and phenibut on and off but usually only once or twice a week just if I'm doing something really important.

I been learning to drive lately and have found the phenylpiracetam and phenibut together help loads in keeping me calm and focused when driving, in fact in general I'm much calmer, I used to have a short temper but that seems to have got a lot better.


Hard to tell if the noopept does anything anymore as been taking it for so long think it kinda feels like it emotionally blunts me sometimes but I'm not sure anymore as the feeling must be the norm. I think once I passed my test I'm gonna go completely cold turkey from everything and see if I notice any different.

Can't say these noots have made me feel smarter, just more relaxed and focused especially when I throw phenibut and phenylpiracetam in the mix which make me wonder if I'm wasting my money with noopept.
 
Yeah phenibut is not even really a nootropic, it's a straight up GABA-B agonist which, if dosed right, makes you feel very good, calm and euphoric. Good stuff, if you don't use it too often.
 
I see a lot of praise for phenylpiracetam here but honestly I was pretty disappointed with it. It doesn't feel like anything other than a mild stimulant to me, infact there's even a pinch of euphoria with it. My current stack is memantine + couleracetam + PRL-8-53 every other day. The memantine really smooths things out and helps for motivation and lethargy. I wanted to add centrophenoxine to the stack but it causes headaches and other symptoms probably from the combined cholinergic activity of PRL-8-53 and centro. I'll also add that this stack is remarkable as a mood stabilizer, I'm not emotionally blunted but it's quite difficult to get me truly upset.
 
Have any of you used Oxiracetam in conjunction with Sunifiram? I have both on the way and am really excited to start taking oxiracetam again, but after having read some speculatory comments in regards to possible long term excitotoxicity/neurotoxicity from combining sunifiram with other nootropics I thought I would ask around. The poster who had speculated about this has also used countless other nootropics which increases the amount of variables to account for when making such claims, so its hard to say they are legitimate concerns at this point. Aside from that, of those of you who have used Sunifiram, have you found it necessary to stack anything with it? Is it effective enough as a nootropic along with its stimulating and motivating effects on its own?
 
At risk of being flamed for responding to a forum posting that's coming up on 5 years old, here we go!:
Cerebrolysin seems to be the NKOB, anecdotal stuff on da weeb says that all others shy to compare. It also sounds as though it was "discovered" or "created" in 1987 (I have no references to substantiate this, please do your own research.).

My disclaimer:
This stuff is not for kids, or, people who are not stable by the sounds of it. Please have an adult, medical doctor, or, other trusted resource assist you if you're not capable of this on your own. In light of the recent movies "Limitless" and the soon to be released movie "Lucy" and my military friends/family: Hooah!
 
I'm interested in stacking 20mg of IAP(IndanylAminoPropane) and 30mg of DMAA(DiMethylAmylAmine). In the future, I hope I can try the new nootropic, AcBZP(AceticBenzylPiperazine). AcBZP is structurally similar to sunifiram. I might just try some 2m2bOH(2-methyl-2-butanol) though. 2m2bOH has anti-anxiety properties. It also affects dopamine and reports describe it as clear headed. Maybe I'll stack 2m2bOH with DMAA in the future. Vitamin D is pretty good to combine in nootropic stacks or use alone. It's like it works in the background or something. 2C-x at low doses are cool too. PWZ-029 seems interesting because it has nootropic properties and may counteract the mind dulling effects of benzodiazepines without reversing the relaxing effects of benzodiazepines. Imagine if the benzo and PWZ-029 stack could provide the perfect way to relax without losing a single ounce of cognition. The first thing I might try is 2m2bOH.
 
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