Nootropics The Big & Dandy Nootropics Thread (Stack 2)

[Solipsis]

So I haven't touched my noopept in a week or so. It's in a jar and its pure powder.

It has developed an odd smell...like its going bad or something... I feel like it has a hint of garbage to the scent now. It has the normal scent with like garbage added (sorry I don't know what else to compare it to). What the fuck? Anyone experience a change in smell? Could it be unsafe to ingest now?

It also seems to be more clumpy.

I just store it in the jar in a cabinet if that matters.

I'm thinking moisture. I don't know why it would be unsafe now, but I figure it doesn't hurt to ask.

Maybe some hydrolysed? I'd say it tastes and smells a like musty, in the dank direction of rotting stuff, but garbage seems overstating it.

I've really been studying and reading up on racteams. There's really a few I'd love to give a try in the way of my anxiety, a motivation syndrome, and depression. My top wish-list for racetams would be: Aniracetam, Piracetam, Phenibut (as a nootropic to increase GABA for anxiety), and Noopept bc it's classic.

Phenibut does not release GABA, I think. It's a GABAb agonist.

 

[psychonautical420]

Maybe some hydrolysed? I'd say it tastes and smells a like musty, in the dank direction of rotting stuff, but garbage seems overstating it.

Yeah, so I assume it's safe to use? I mean, its the same noopept I've taken, just has an odd scent to it now.

 

[JWills20]

Too long; Don't want to read; this post is about trying to recreate the adderall experience, by stacking nootropics, without adderall itself.

Hey guys, just wanted to check in here and provide an interesting nootropic stack I came across that nearly reproduces the adderall experience. Basically, I've been experimenting with various nootropics for about a year now. I started off with just piracetam, where I'd just keep popping them all day while working on my dissertation (this was last year, around this time). Certainly noticed the improvements in memory and general capability to learn. Piracetam alone doesn't provide much in terms of an acute boost though, so I wanted to search for other nootropics which might do so. Moved onto aniracetam which I liked, but I don't think it is as good for studying. It certainly got me very drunk though, more than any other nootropic (I've tried them all with alcohol). Anyways, after aniracetam I brought some noopept which is certainly a great nootropic, however, it is only when I tried combining the nootropics that I found much of an acute effect. That is, I got hold of some piracetam recently and have been combining it with noopept daily. The combination alone is a mild motivational and mood boost, but still rather subtle and easily ignorable if you don't apply yourself to something productive. So, I moved onto to combining it with caffeine (usually energy drinks) and this is where I found the near-to-adderall experience. I've always combined nootropics with caffeine, but it was not until trying noopept, piracetam and caffeine that I found the awesome combination. For those of you who have tried adderall, you'll know what I mean by the tremendous clarity of thought and ability to focus and work for just hours. This nootropic stack really isn't all that far off, it just misses the massive motivational push and duration that adderall has. But, if you apply yourself to some work you'll soon find yourself in a state near to the adderall. It even has me sweating alot, which is always a good sign for me, shows me that I'm stimulated and in the zone. I usually take about 20mg noopept, 2.4grams of piracetam and 150mg caffeine (one big energy drink). I've tried more noopept/piracetam and found it to be a little anxiety provoking and/or causes a nagging headache. So around 20mg noopept and 2.4g's of piracetam seems to be the sweet spot for me. Adding a little more caffeine is also cool, but over-stimulation is not always great for studying either. One redbull (or 75mg) extra, with the aforementioned nootropic dosages, adds a nice amount of bonus intensity. The only problem is that it doesn't last as long as adderall (2-3 hours max) and also doesn't have the massive motivational push - you have to contribute more there.

Anyways, I'm sure you could reproduce the adderall experience by trial & error with dosages of either drug that work for you. I'm also sure that you could use different nootropic combinations, but the caffeine is the key ingredient. I'm going to try and stack different nootropics, and at different dosages, to see just how close to adderall I can get.

Hope someone finds this useful.

 

[SkyblueMolly]

Too long; Don't want to read; this post is about trying to recreate the adderall experience, by stacking nootropics, without adderall itself.

Hey guys, just wanted to check in here and provide an interesting nootropic stack I came across that nearly reproduces the adderall experience. Basically, I've been experimenting with various nootropics for about a year now. I started off with just piracetam, where I'd just keep popping them all day while working on my dissertation (this was last year, around this time). Certainly noticed the improvements in memory and general capability to learn. Piracetam alone doesn't provide much in terms of an acute boost though, so I wanted to search for other nootropics which might do so. Moved onto aniracetam which I liked, but I don't think it is as good for studying. It certainly got me very drunk though, more than any other nootropic (I've tried them all with alcohol). Anyways, after aniracetam I brought some noopept which is certainly a great nootropic, however, it is only when I tried combining the nootropics that I found much of an acute effect. That is, I got hold of some piracetam recently and have been combining it with noopept daily. The combination alone is a mild motivational and mood boost, but still rather subtle and easily ignorable if you don't apply yourself to something productive. So, I moved onto to combining it with caffeine (usually energy drinks) and this is where I found the near-to-adderall experience. I've always combined nootropics with caffeine, but it was not until trying noopept, piracetam and caffeine that I found the awesome combination. For those of you who have tried adderall, you'll know what I mean by the tremendous clarity of thought and ability to focus and work for just hours. This nootropic stack really isn't all that far off, it just misses the massive motivational push and duration that adderall has. But, if you apply yourself to some work you'll soon find yourself in a state near to the adderall. It even has me sweating alot, which is always a good sign for me, shows me that I'm stimulated and in the zone. I usually take about 20mg noopept, 2.4grams of piracetam and 150mg caffeine (one big energy drink). I've tried more noopept/piracetam and found it to be a little anxiety provoking and/or causes a nagging headache. So around 20mg noopept and 2.4g's of piracetam seems to be the sweet spot for me. Adding a little more caffeine is also cool, but over-stimulation is not always great for studying either. One redbull (or 75mg) extra, with the aforementioned nootropic dosages, adds a nice amount of bonus intensity. The only problem is that it doesn't last as long as adderall (2-3 hours max) and also doesn't have the massive motivational push - you have to contribute more there.

Anyways, I'm sure you could reproduce the adderall experience by trial & error with dosages of either drug that work for you. I'm also sure that you could use different nootropic combinations, but the caffeine is the key ingredient. I'm going to try and stack different nootropics, and at different dosages, to see just how close to adderall I can get.

Hope someone finds this useful.

DMAA is very energetic. I just wish the government wouldn't have banned it in certain countries like they did. DMAA(Dimethylamylamine) is good for exercise and for studying. :D

 

[Solipsis]

I think DMAA is pretty horrible, but it's difficult to explain why. It just feels wrong and jittery to me.

The structure is vaguely related to amphetamine so it may not be a surprise that you link them, but I personally don't see the point in a derivative with some stim-like side-effects but an incomplete profile. I don't see how it's good for studying, unless your alternatives are very limited. Even then I'd prefer nothing.
And for exercise, why is it good for exercise? It is thermogenic, so maybe it means you are warmed up much more quickly, and it may get part of your metabolism nicely up and running, but I don't think it is particularly healthy to use anything stim-like to exercise and drop weight. I believe in rest and nutrition as adjunct to my home fitness routines and the sports I practice that are focused on explosive force, control, balance, attention...
though I don't know enough about the subject of exercise supplements to say what could be taken to help get a better condition or more mass / bigger press or lift. Well apart from creatine, simple and complex carbs and long vs. short degradable protein.

Also, I appreciate the question about adderall being answered but I do not consider DMAA nootropic.

 

[Solipsis]

Has anyone tried sunifiram? I am considering getting some...

 

[Xorkoth]

I think DMAA is pretty horrible, but it's difficult to explain why. It just feels wrong and jittery to me.

I agree, I hate how it makes me feel. Gross.

And I've never even heard of sunifiram... a piracetam relative?

 

[Incunabula]

Has anyone tried sunifiram? I am considering getting some...

I bought some, but lost all interest after realizing there might be a risk that it can cause brain cancer. I mean, it might not be true at all. But if I'm going to be consuming any unresearched chemical with any regularity, I want to be 110% sure that it's safe. I'm even getting second thoughts on my Coluracetam intake because it's still pretty unresearched too.

Sunifiram-%28DM235%29-structurally-novel-AMPAkine/page2

 

[Solipsis]

Interesting thanks.

Xorkoth, sunifiram is a raceRam, it is supposed to be more effective than racetams. It is also an AMPAkine, but besides that also promotes LTP (long term potentiation) between neurons which is considered a fundamental mechanism of memory and learning. I think Noopept does that but the regular racetams don't really.
Whereas racetams and even Noopept don't really improve my motivation much like stims and (/including) ADD meds like methylphenidate do, but sunifiram apparently does that and is a bit more stimulating.
There is also unifiram which is in the same series but at first glance seems structurally different despite the one letter difference, it is definitely a related molecule though. Maybe unifiram is slightly more researched or not even... but sunifiram is more available and is affordable. I'm tempted to put some in my freezer. Perhaps I'll fork the small amount over even if I have to sit on it until more research is done.
I wanna stash some of these novel nootropics before the patent guys start suing vendors

added:

But, Fagott... if you are talking about PKC-α activation, that relation to cancer has been strongly contradicted in the thread you linked to.

 

[Incunabula]

But, Fagott... if you are talking about PKC-α activation, that relation to cancer has been strongly contradicted in the thread you linked to.

Yes I know, but I don't think the suspicion is strongly contradicted. I mean, Tweex doesn't agree, but does he link any proof of what he claims? The info I'm quoting is from wikipedia, who writes the wiki articles and if they are to be trusted we don't know either. So what do we really know?

As I said, Sunifiram probably is very safe. But if there is just the slightest hint of any possibility of something being unhealthy about a chemical, I'm not going to consume it regularly.

When I said that Sunifiram was unresearched it wasn't really true, because it seems (just like with Coluracetam) that a lot is actually known about it's pharmacology, probably because they were invented and intended to be medicines. Still no authority has approved them for human consumption so they are still basically RC's.

My point is, that there's a big difference between trying some psychedelic RC a few times, and taking a RC nootropic everyday for weeks. You're putting your self in a much higher degree of danger of developing some kind of negative side effect.

I'm going to stick with stuff like Noopept, Piracetam and Aniracetam which thousands of people have been taking for years, months at the time, to no ill effect.

 

[Solipsis]

Hmm, anyway..

wanted to drop by because I just saw a racetam made available that I never heard about before: fasoracetam (NS-105).
However it is ridiculously expensive.

Would be cool if it has anxiolytic potential, but not sure if that is glutamate or glycine mediated or not at all.

 

[Incunabula]

Hmm

^ we all have to make our own research and draw our own conclusions when it comes to what we consume of chemicals which are not manufactured for human consumption. I'm just telling you mine conclusion in regards to Sunifiram, If you don't agree that's fine, it's your body.

 

[Shaal]

Anyone here using 2C-D as a nootropic? On a dose of 12,5 mg, I found that I was working much faster, going straight for the important stuff, being able to recall stuff much more easily, understanding concepts at first read (concepts at which I suck usually). Music didn't disturb me as it usually does. And I worked non-stop between 11 pm and 3 am. Motivation was increased.

 

[Ekscentra]

Finally, I've had the chance to combine IDRA-21 with benzos. No synergy, no interactions of any kind, just an additive effect. Good to know this is safe as well. Clonazepam at 250mcg, 500mcg, 1mg, 2mg, and 3mg all yield no negative interactions. I'll continue testing mid-way through next week, as I refuse to take benzos on a daily basis. Is there anything at all that interacts negatively with IDRA? Aside from a massive headache late in the day from combining with Coluracetam (PERFECT synergy otherwise), nothing. Next up, I'll attempt to combine IDRA with Moxy. Perhaps that'll help kill me (kidding ). It's good to know that, at least when it comes to interactions, this drug is almost entirely safe. I feel as though I've tried drugs from at least half the existing classes in combination with IDRA, yet I've run into nothing remotely worrying as of yet. Steroids sometime in the future, perhaps? What about MDMA or other strong serotonergics (I guess Moxy may count somewhat)? Neuroleptics (only willing to try Amisulpride for dopamine upregulation, everything else is off the table. Antipsychotics terrify me.) Kappa opioid agonists (Ibogaine and Salvia in general are some of the top drugs I'd like to try, so why not?) Now that I'm down to barely over 10mg left in my supply, I'll certainly be re-upping. The ability for IDRA to restore my cognition rapidly under difficult situations is more than enough to warrant a permanent place in my stash. Nothing has even come close when it comes to permanently eliminating cognitive deficits, whether drug-related, mood-related, sleep-related, or stress-related. Despite my initial negative opinion towards this drug after a simultaneous bout of psychosis and mania, it's been absolutely wonderful for the proper purpose it was made for - cognitive restoration, that is. And just to remind everyone once again, these extremely amplified moods can easily be alleviated through the use of racetams (or possibly racerams, assuming emotional-numbing effects are present in those substances as well) in tandem with the IDRA. Emotional numbness + IDRA does not necessarily result in emotional normality. SSRIs and dissociatives are NOT recommended in combination with IDRA, as for reasons I can't possibly explain, the typical emotional numbing effects of these two are amplified rather than canceled out. So SSRI users, stay away. The combination may not be dangerous, but it is quite disturbing being a complete robot. If you don't get the common side effect of apathy/emotional numbness with SSRIs, this may be a safe combo. Without having experienced anything but a zombie-like robotic feeling from drugs in this class, I couldn't give a definitive answer here. More combinations to come soon, folks.

 

[JWills20]

What are people's thoughts on Modafinil? I've been trying it the past few days and I'm not overly impressed so far. I'm finding brain fog and lack of creativity. The only thing it seems to cause is doing something for ages. But the quality of that 'something' is just not brilliant IMO. I've tried combining it with nootropics and caffeine, the latter does help, but still doesn't give me any clarity of thought or pure focus. I kinda feel like it just sticks me into auto-pilot on whatever I'm doing.

I've only tried 200mg, so maybe I'll try a lower dose, which might improve the effects.

 

[SkyblueMolly]

I did, didn't see anything. Which is why I'm asking here, I guess, or there.
But likely it'll just get ignored and I'll remain in the dark about what exactly
this does.

It's sublingual validolum. It's an anti-anxiety type nootropic with few to no side effects. It's rarely heard of though.
Here's more information! I think I'm a bit of a studyaholic sometimes when it comes to bioactive molecules.
Validol (Validolum) produces a sedative effect and dilates (opens) blood vessels lowering blood pressure. Sublingual tablets work in under 5 minutes. Validol average dose is 60mg sublingual tablets.

Validol stimulates sensitive nerve receptors of the oral mucosa. This causes the release of endorphines, enkephalines and dinorphines which has a calming effect.

Symptoms Relieved:
Anxiety, Nervousness, Panic Attack, Hysteria
Rapid Heart Beat, Chest Pain, Hyperventilation
Nausea or Motion Sickness
Headache From Taking Nitrates

Benefits:
Calming, Relaxing Sedative Effect
Dilates (Opens) Blood Vessels
Fast Acting (Under 5 Minutes)
Non Habit Forming
Does Not Impair Motor Skills

 

[Solipsis]

What are people's thoughts on Modafinil? I've been trying it the past few days and I'm not overly impressed so far. I'm finding brain fog and lack of creativity. The only thing it seems to cause is doing something for ages. But the quality of that 'something' is just not brilliant IMO. I've tried combining it with nootropics and caffeine, the latter does help, but still doesn't give me any clarity of thought or pure focus. I kinda feel like it just sticks me into auto-pilot on whatever I'm doing.

I've only tried 200mg, so maybe I'll try a lower dose, which might improve the effects.

I don't think it's very good as a nootropic, but it's awesome as a wakefulness promotor which is also usually the way it is used.

 

[Ekscentra]

Combining 30mg 5-MeO-MiPT with 30mg Coluracetam yielded some interesting, though not necessarily surprising, results last week. Same effects as usual from the 5-MeO-MiPT, but the serotonergic effects and the euphoria were *significantly* more pronounced than usual. Subsequent serotonin burnout lasted much longer than expected - 2 to 3 days of sleeping 12-16 hours a day, and then back to baseline on the 4th day. I'll likely try this again tomorrow with 20mg of 5-MeO-MiPT and some Piracetam as well. 30mg of Moxy simply felt too taxing on the heart, and the only "benefit" was an increase in sexual effects (pure torture, considering I had planned to go through this trip entirely alone ). I still have yet to try MXE with Coluracetam, and although I'm certain the dissociation will be significantly weakened or cancelled, I still have to try this mix strictly for the sake of interest. After all, it's never been done before - that alone makes me very attracted to this idea.

On a mildly off-topic note, I've noticed that timing seems to be very important with MXE, something I unfortunately neglected up until now. Taking 90mg followed by another 90mg at the peak should be an ideal dose for holing (I have a moderate tolerance at this point, though I've still had no trouble using too frequently; guess it's not much of an opiate after all, bloody fiend as I am! Hehe.) Given that I used 180mg followed by 90mg, I see no danger in attempting an even lower dose. That 90mg redoes somehow prolonged the trip to 16+ hours (!), whereas typically MXE lasts about 8 hours for me. This lower dose should allow for a trip that isn't overwhelming - of course, considering I'll be combining this with Coluracetam, I expect it to be *very* underwhelming. I'd only like to see if Coluracetam is any more effective in killing the effects of dissociatives compared to IDRA-21. It'd certainly be nice to have an "antidote" for NMDA antagonists laying around, in case of an overdose or severely bad trip, especially. AMPAkines could prove to be to dissociatives what benzos are to psychedelics, and perhaps antipsychotics to stimulants. Piracetam is fairly weak as an AMPAkine, and thus only moderately weakens the effects of dissociatives. IDRA-21 turned a 3rd plateau DXM trip into barely a 1st plateau, even with nicotine and white grapefruit juice potentiating the hell out of it. If that's not bloody impressive, I'm not sure what is. If Coluracetam can achieve similar results, it certainly wouldn't surprise me, but it's better to be sure. At the moment, I've used up my 500mg of IDRA, I'm afraid, so no comparison will be possible for a bit. As soon as Fasoracetam drops to a reasonable price and/or Unifiram is back in stock at my source, I'll be certain to include more IDRA in the order as well. It's been some time since I've used Colur, far too long in my opinion. I still recall this substance offering an incredible boost in my writing abilities, one unsurpassed by any substance to this day. Even psychedelics haven't allowed me to write so fluently as with Colur. I look forward to my next dose. This will be a fun test, to be certain. :D

 

[Solipsis]

How much of a difference is there between unifiram and sunifiram? I am expecting 2.5 g of the latter (it was rather affordable).

And yeah that dose of 5-MeO-MiPT sounds like it is too high.

 

[Ekscentra]

How much of a difference is there between unifiram and sunifiram? I am expecting 2.5 g of the latter (it was rather affordable).

And yeah that dose of 5-MeO-MiPT sounds like it is too high.

I'm afraid I don't have any experience with Unifiram or Sunifiram, but based on subjective evidence, Unifiram seems to be universally preferred as a cognitive enhancer. Some have combined the two at doses of 10mg or less each. Sunifiram both potentiates other substances fairly strongly and promotes LTP, two things that, as far as I'm aware, Unifiram does not do.

http://www.ncbi.nlm.nih.gov/pubmed/23295391

Studies confirming potentiation of other substances don't seem to exist at the moment, unfortunately. Sunifiram was thought to be carcinogenic at some point, but I'm fairly certain this was debunked. I'd definitely look on Longecity for reports of potentiation, especially if you're taking any sort of stimulant. 1/4th of your usual dose should be fine in combination; any more than that or you may become overstimulated, overdose, and/or die. Aside from lowering your dose of stimulants, Sunifiram seems to be relatively safe at doses of 10mg or lower. I've seen no such concerns with Unifiram, however. Given the lack of safety information out there regarding these substances, I'd take a bit more precaution than usual. All anecdotal reports I'm aware of are available either on Longecity or Brainmeta, with only vague mentions on Bluelight and Drugs-Forum.

And yes, while the dose of 5-MeO-MiPT used wasn't within the lethal range (reports exist of up to 60mg; given that the 5-MeO-MiPT was taken solo and the only symptoms were major sweating and tachycardia, 30mg shouldn't be enough, under any circumstances, to cause death with an acute dose; chronic doses, on the other hand, will almost definitely cause some serious heart problems and/or death in the long run), it was definitely too much - overstimulation, vasoconstriction and the like. Of course, you hardly notice these things when you're stuck in that wonderful state of mind. 20mg was my standard dose. Considering the psychedelic effects weren't any stronger for me at 30mg, I'll be reverting back to 20mg, my previous preferred dose. Coluracetam (and presumably all AMPAkines by extension) did an excellent job at increasing the serotonergic effects without causing any additional physical distress. I'll certainly need to try Unifiram and restock IDRA-21, as I imagine those two will offer even better synergy with 5-MeO-MiPT (wishful thinking, really, only based on these two being stronger AMPAkines than Coluracetam.) Ah, nootropics and psychedelics....what wondrous combos.