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Nootropics The Big & Dandy Nootropics Thread (Stack 2)

We've been over this, DMAA is not really a nootropic. What does it enhance exactly? Yes I've tried it and I know it can stimulate in some ways and be thermogenic, but I definitely don't see enhancement. (By the way MPA and DMAA would to me be expected as one of the dirties things ever 8( ). But I plain don't like DMAA anyway. Can't comment about functionality of MPA in lower dosages.

Bromantane is also really walking a fine line but IMO it's pretty novel in that it combines stimulation and anxiolysis and I've read nootropic-like things about it a while ago (cognitive enhancement). We can't just go including all anxiolytics and stimulants even if stimulants enhance cognition as part of their action, and 'enhancement of calmness' even less so, where does it end? It wouldn't make sense. For example I like phenibut, but I don't see a nootropic in it at all - I recall you do.

About other things, yes something like 2C-D or 2C-T-21 has nootropic potential in my experience... and I'm generally open to other things that are not strictly classified as nootropics to be used like that, but still.

Let's not dilute the mind expansion related discussion of nootropics by including so many drugs, alright? Especially if people are wondering how we are talking about this in PD to begin with.
 
Help with Nootropics needed, please!!!

I am trying to get opinions on a stack that SWIM has been taking for several weeks now. She is seeing good results, so far. Better cognition, reaction time, better memory, etc... SWIM has bipolar disorder, so her medications made her mental capacity decline. Importantly, she is looking to get the following through nootropic use.

Focus, clarity, help with social anxiety, motivation, drive, memory (short and long term), ability to be more creative, cognitive function, etc...

Currently SWIM is taking

Lecithan 1,200 mg in am
Acetyl L Carnitine 500 mg 3x's daily
CoQ10 100 mg in am
Lion's Mane 300 mg 3x's daily
Vinpocetine 5mg 3x's daily
Catuba 465 mg 3x's daily
Omega 3 1,500 mg 2x's daily
Aniracetam powder 750 mg 2x's daily
Oxiracetam powder 750mg 2x's daily
Bacopa Monnieri powder 150 mg 1 to 2x's daily
Picamilon powder 100 (maybe a bit more) mg 2x's daily
Sulbutiamine powder 200 mg 2x's daily
Rhodiola Rosea powder 500 mg 2x's daily
Ashwagandha root powder
Noopept 10 mg, if needed between other recetam doses
Uridine powder 150 mg 3x's daily

The following are SWIMs prescription medications...

Depakote 1,500 mg at bed
Lamictal 300 mg at bed
Risperdal 2 mg at bed
Klonopin 1 mg 1 to 2 x's daily

Please give me any information you can in regards to this stack. Is she overkill, anything suggested to add or take away, to do all that she is looking for, plus more? Do all of these work synergistically? How does this play with bipolar?

Any suggestions or comments are greatly appreciated.
 
please stop using swim. this is a forum where such things are not needed.

if you ask me (and im no expert) the list/stack is way overkill... im finding it hard to believe that you came to the stack by adding up things and instead just thought to take what seemed like a good idea at the time.
personally id just take the prescribed medication and perhaps discuss it with the prescribing doctor if changes are due because of the percieved decrease in mental capacity. perhaps he/she may help?

then i would perhaps try adding things one at a time and seeing what works....
 
kingme said:
please stop using swim. this is a forum where such things are not needed.

if you ask me (and im no expert) the list/stack is way overkill... im finding it hard to believe that you came to the stack by adding up things and instead just thought to take what seemed like a good idea at the time.
personally id just take the prescribed medication and perhaps discuss it with the prescribing doctor if changes are due because of the percieved decrease in mental capacity. perhaps he/she may help?

then i would perhaps try adding things one at a time and seeing what works....


SWIM I always found a safe bet to use. I am sorry to improperly use it in a forum, where it is not necessary.
As for the racetams, they were introduced very slowly, and I tried several. The aniracetam and oxiracetam together I found worked best for me. Ashwagadha and rhodiola is used for an overall sense of well being, considering I suffer from depression time to time. Uridine is known to help bipolar, and lion's mane is known to help with mental decline. Lecithan is used for a choline source. Picamilon, catuba, and the bacopa seems to mix well for my social anxiety. ALCAR & sulbutiamine are for energy, drive and motivation. Omega 3 for overall brain health. Vinpocetine isnt needed.
All were introduced slowly over the course of the past year.
Click to expand...
 
i dont know, like i said im no expert... but then, who is an expert on nootropics? :)

it seems to me that you re trying to also fight symptoms of your bipolar problem. again, it might be ebst to talk it over with your treating physician... perhaps a better mix for that might do away with these suppliments.
im not saying anything is bad in the stack, indeed it seems pretty complete. im just finding it hard to believe you find everything on it actually useful and active.

in the adding department, i probably suggest a better choline source than lechitine. but, depending on your diet, that may not be actually neccessary. though most people say it is a good idea to supplement choline to racetams, going overboard can be counterproductive too...

what is it that you are trying to achieve is a better question to ask here
 
kingme said:
i dont know, like i said im no expert... but then, who is an expert on nootropics? :)

it seems to me that you re trying to also fight symptoms of your bipolar problem. again, it might be ebst to talk it over with your treating physician... perhaps a better mix for that might do away with these suppliments.
im not saying anything is bad in the stack, indeed it seems pretty complete. im just finding it hard to believe you find everything on it actually useful and active.

in the adding department, i probably suggest a better choline source than lechitine. but, depending on your diet, that may not be actually neccessary. though most people say it is a good idea to supplement choline to racetams, going overboard can be counterproductive too...



what is it that you are trying to achieve is a better question to ask here
Click to expand...


I agree, most of us only know through trial and error. I can sub Apha GPC, for the Lecithan. Yes I am trying to combat mybipolar. I am also trying to get the upper hand, on cognition, mental drive, energy, clarity, fast recall, combat social anxiety, intelligence that has been lost due to meds, , etc...
 
Alright everyone I have a question/concern...

Not long ago I started gaining an interest in various nootropics. Among them, Aniracetam is definitely one of my favorites. All of my research led to the conclusion that there is basically no dependency or withdrawal upon cessation of use of pretty much any nootropic, including Aniracetam, or any other racetam for that matter.

Well, I have an interesting observation that recently came into focus.

I have been using Aniracetam in pretty much the recommended dosage for the past several months, with only a couple of short periods where I didn't use it. I would split my dose into 2x 750-900 mg doses each day. This is only slightly higher than normal.

Well, I recently stopped again after almost daily use for a month and a half or so, and this time, I experienced "brain zaps", exactly what I experienced when I went through Zoloft (SSRI) withdrawal oh so many years ago. It happens mostly when I get up, or turn around, etc. Today is day 2, it feels slightly better than day 1, and it's not unbearable, just annoying, and I'm hoping it goes away soon, but I'm having a hard time believing it is because of the Aniracetam. I do know that Aniracetam has an effect on the 5HT2-A receptor, so this is really the only thing I can think of that could be causing it, as there isn't much else I have been using regularly, especially regarding serotonin. I did try taking Noopept (20 mg) and Rhodiola (~220 mg - a very low dose) yesterday, the same day I stopped, so I didn't take either of them today, but there haven't been any reports of Noopept or Rhodiola causing that as a side effect either, right? And as far as I know, Noopept at least isn't known to even affect serotonin at all. I also quit Kratom about a month ago, and was feeling just about 100% more or less until this, besides trouble sleeping.

Any thoughts/experiences/opinions on this? I tried researching and haven't found any other report of something like this happening anywhere on the web.

Strangely enough, I feel I should mention that I also experienced something similar for several days after a very strong Ayahuasca trip about a year ago. Could this all be a symptom of something else? Has anyone else experienced any of this?
 
Not sure how much is actually known and proven about brain zaps but afaik they involve unstable neurotransmitter levels, particularly ones changing while the brain is adapting such as with discontinuation of some drugs like SSRI's, sudden potent drug effects as occasionally with mushrooms, or restoration after heavy MDMA use. Particularly serotonin levels are thought to be relevant, although I am not quite sure what endogenous serotonin activity is like when you take a lot of mushrooms. Maybe it is better to think of it as a huge change in the system as a whole, and surely strong mushroom or ayahuasca trips involve temporarily having very altered brain chemistry.

Whatever the mechanism behind it, tapering instead of abrupt changes in your supplement or drug taking regimen should ease the changes going on in your brain, and it seems to me like that is the best chance you have at avoiding more brain zaps.
 
Haven't touched any of my noots in a few weeks now as I'd quite simply forgotten about them hahaha....so this morning I figured I'd dump a stack of sorts and see how I feel through the day, just as a bit of a one-off for the hell of it.

Pramiracetam 500mg
Alpha GPC 750mg
Noopept 40mg (sublingual)
Phenibut 2000mg

All taken at roughly 7:30am. Currently 9:00am

Have also had 3 shots of espresso, so somewhere around 200-240mg of caffeine.

Assessments so far: feel a little sharper yet relaxed, more motivated. Stomach felt a little off after parachuting the Phenibut, Prami, and Alpha GPC...though I hadn't (and still haven't) eaten anything solid yet.

See how I feel around midday :)
 
phenibut? no way would i ever feel sharper while under it's influence... if anything id maybe use it to relax at the end of a particularly stresful day but not in the morning

do people really find it improving their memery/attention/focus?
 
I went through about 15mg of noopept a day for about 3 months until 2 months ago, I didn't feel any 'withdrawal' but did immediately start smoking bud frequently again, I felt tired regularly over the time when I stopped noopept but I think that's just the bud doing its job so I'm not stressing over anything.
 
kingme said:
phenibut? no way would i ever feel sharper while under it's influence... if anything id maybe use it to relax at the end of a particularly stresful day but not in the morning

do people really find it improving their memery/attention/focus?
Click to expand...

The Phenibut definitely wasn't contributing to any sharpening haha, I just chucked it in to help relax given it's Friday ;)
 
Phenibut doesn't improve my memory/recall or anything like that... however when dosed right it does tend to make me feel very motivated which depending on my previous state of mind can help me with tasks (if I was feeling low or unmotivated before). If you dose too much then it fucks your short term memory but if you dose it just right (which is hard to do) it doesn't really interfere with things mentally.
 
How do coluracetam, fasoracetam and nefiracetam compare?

I think phenibut's ability to enable people to do things should not be confused with nootropic potential. Pregabalin which I am prescribed is enabling me to do a lot of things being an anxiolytic, but should I call it a nootropic? I am personally against stretching the definitions and muddying the water. If you count indirect actions its hard to tell where to draw the line.
With say racetams or sunifiram I don't feel there is any indirect way in which they provide nootropic actions.
 
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Piracetam is the only nootropic I've dabbled with. Even taking it to fairly high doses like 5g/day I've found it (for me) to be pretty subtle most of the time, and maybe just placebo. However, I have noticed that it really helps me cope with sleep deprivation. If I've had a really poor sleep, piracetam helps me stay clear and it feels like my mind is operating almost the same as normal, in a way that coffee alone doesn't really accomplish.

The other day I heard a TED talk about how our brains lack a lymphatic system, and that mammals appear to have a different system to clear the brain tissue of metabolic waste. It seems that when we mammals sleep (well at least mice..) our neurons shrink a bit, opening up passages around our blood vessels which allows the cerebral spinal fluid to flow through our brains and essentially wash out our brains, cleaning it of things like beta-amyloids (which also seem to cause alzheimers). So I looked into this a bit further and sure enough found this abstract that says Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.

Here is an NPR article outlining this theory about sleep: http://www.npr.org/blogs/health/201...sweep-themselves-clean-of-toxins-during-sleep

So perhaps part of the story of how Piracetam works is that it shields our brains from the harms of beta-amyloids. This would explain why it helps me feel better after a really poor nights sleep, and why it seems to be so helpful to people with dementia and alzheimers.
 
I agree that phenibut is not a nootropic. In fact if I take a little too much it makes me decidedly cloudy and fucks with my short-term memory.
 
I'm curious about prolintane. It's supposedly safer and more motivating than caffeine while also increasing concentration. It's also supposedly less habit forming than caffeine. Prolintane is said to be a combination stimulant and nootropic.
 
I purchased 200g of adrafinil, betting on its effectiveness, and have used it for the last 22 days, 2 weeks on, 1 week off, 1 day on (so far) -- I usually dose 350mg. Forty five minutes later I can feel a heightened attention span, and slight widening of the field of senses, but it tends to last only four hours or so, and leaves me with a crash. However, sleep is easily attained, and I have since been waking very refreshed compared to normal... Well, I wake up an hour earlier than usual, and I'm not sleepy at all. Anyone report similar results?
 
Hello good people of Bluelight!

I am currently helping at a theoretical research project, where we are making a plan for treatment for Alzheimer disease pacients. Between the rest we are including that they will get nootropics.

Which nootropics would be most sufficient for Alzheimer disease pacients?
 
Just A Guy said:
I purchased 200g of adrafinil, betting on its effectiveness, and have used it for the last 22 days, 2 weeks on, 1 week off, 1 day on (so far) -- I usually dose 350mg. Forty five minutes later I can feel a heightened attention span, and slight widening of the field of senses, but it tends to last only four hours or so, and leaves me with a crash. However, sleep is easily attained, and I have since been waking very refreshed compared to normal... Well, I wake up an hour earlier than usual, and I'm not sleepy at all. Anyone report similar results?
Click to expand...

Well, yes, it's a stimulant. Your liver converts it to modafinil. You shouldn't take adrafinil regularly because of the extra load on your liver. Modafinil or armodafinil should work better & not cause (as much?) liver toxicity.

I've been having some modafinil & armodafinil (armodafinil is better) recently & it does work, but it causes a few side effects too, it makes me itch.

I really like noopept, I'm taking a tolerance break from it now, it seemed to lose some effectiveness after daily dosing for a long time. Not noticed any problems with using that daily yet, but it's a lot more subtle than modafinil.
 
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