Definitely fast for at least 4-6 hours, 6 if possible before taking 2C-E. I have always done this with 2C-E, and I've never experienced any stomach discomfort with up to 16mgs. With 18mgs, I was only slightly nauseated. Cannabis helps alot.
However, as a warning, be careful with 2C-E. It can get intense, even at 10-12mgs. It is also the most visual compound I have ever ingested. I have had people that have used LSD and mushrooms plenty of times and told me they never really experienced good visuals. One day I decided to take 16mgs of 2C-E with this person (he took the same dose), and I told him that today he would experience it. He wasn't fully believing. By the end of the trip, he was afraid of his own shadow.
As for trying 2C-E as a first psychedelic other than entactogenics, I could go both ways. I guess it would depend on your personality and how confident you are about it. Never underestimate it. I will say that. 12mgs was my first dose, and when the peak came, it overwhelmed me a couple times and I was fully accustomed to LSA, LSD, high doses of mushrooms, and I had eaten Peyote before as well.
However, I did find something about it comfortable. It didn't seem to have the "edge" that LSD does. Just when I felt as if I could barely handle the intensity, it went away, whereas LSD will keep coming and coming and coming, especially when you get scared. LSD is quite hard to handle in that it seems quite threatening at high doses. 2C-E is intense, but there was something comfortable about it at 12-16mgs. Now 16mgs+ is a different story.