I just did my first dose of 2C-E on friday, and let me tell you it was crazy. I had some uneasyness and nausea at about the 1hour point but it quickly faded by the second hour. I have noticed that all psychedelic drugs ive tried start out kindof uneasy but it dissipates. Also Id like to throw out some respect to Fizzycyst, who told me to stay around 12 mgs for the first time last week. He was def. right, I decided to go with 12.5 mg, rather than 16. even though I cant wait to try 16mg, Im very glad I went with a lower dose 12.5 had some crazy visuals with some mind fuck, but Id love to get some ego loss with this chemical