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The Big & Dandy 'Nausea and Psychedelics' Thread

I think you should be OK. It may cause a subtle qualitative change in the experience, but nothing major.
 
I was wondering the same thing. I get really nauseous so I have some Ondansetron (Zofran) wafers. Will they be ok too?
 
^^^^Dunno bout Ondansetron, but metoploclamide apparently is related to anti-psychotics, so it would have to dampen trips.
 
^ Well the receptors targetted by these drugs (D2, 5Ht3) are generally (and I use the word with caution!) related to negative physical side effects (such as nausea) rather than mental effects. There is a chance though that the effects may be altered.

Interesting. Are these two drugs australian? I have never come across them before today.

Though... I can really identify with your fear of nausea. I personally cannot handle nausea and almost certainly will always cry if I vomit. I have in the past successfully used Scopolamine patches (0.5mg/24h), I believe? to reduce nausea from AMT. I also used Ginger with rectal ayhuasca, though I cannot tell you if it was the ginger or the rectal admin. that curbed the purge...
 
^^^That its, i was going to try Hyoscine tablets (which I believe is scopolomine) but I'm sensitive to dipenhydramine, low dose gives me he ghost people pretty easily. Do NOT want that when on a seratonergic hallucinogen.

Metoplocamide is prolly Australian- it is incredibly effective against nausea: I recently had surgery, general anaethesia, plus loads of morphine, fentanyl, Oxycodone, and regular maxolon (metoplocacmfq- cant spell that word again) shots totally disabled nausea and allowed me to hold food in my stomachs.

Jamshyd, do you think by the activity of metaplocamide (sp??????!!!!1) would reduce euphoria or maybe evn help twitchy LSA or LSD muscles, or increase the twitch? I can't grasp the chemistry properly
 
Hahah :D
I can see how Metablah is effective against opioid-induced nausea, since it is dopaminergic, and Metablah, according to wiki at least, is a D2 antagonist.

LSA and LSD affect both Serotonergic and Dopaminergic receptors. In my expeirence, the way LSA nausea (LSD doesn't give me much nausea) manifested itself was in-line with other nauseating serotonergic psychedelics like AMT, 2C-T-7 or Iprocin.

The Dopaminergic-related nausea feels a bit different, it generally tends towards a more vertigo-type feeling and painful heaviness in the back of the head.

So your metwhatev. should work well for LSD. I don't think I know enough about receptor pharmacology to shed light on euphoria and twitches, so I'll leave it to someone more experienced... though, regarding the twitches, it might be possible that you have Magnesium deficiency? Try taking a Magnesium supplement to see how it goes.

From the wiki entry, I would guess Ondasetron to be more specific for nausea caused by serotonergic psychedelic like the simple tryptamines and phenethylamines.

Again, I could be wrong.

But yes, Hyoscine is the same as scopolamine :).
 
Zofran is a serotonin antagonist. It might negate some of the effects, though it is targeted to the 5ht4 receptor, while the 5ht2 receptor is the most psychedelic. It is not this simple, however.
Metoclopramide should work - please report whether it did. Unlike zofran, metoclopramide is inexpensive.
 
LvMkngFlwrChld said:
smoke pot. it will make you trip harder and sure as fuck cures nausea too.
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Bad advice.

Weed is a drug (and in some cases, psychedelic) in its own right. Adding it to something else does not allow you to experience the other for what it is. As for the nausea, some people (such as myself) find that weed actualy increases nausea.

ga: I believe 5HT3 and 5HT4 receptors are mostly peripheral. If someone more knowledgeable here can correct me, I'd appreciate it.
 
It would interesting to see- I think thhat this combo is 'safe', I have some cute little buttons spiking away for me over the coming days, if anythings gonna make sick its damn peyote. So we'll see.... thanks for responses.

Metawhatchamacallit rocks.
 
I know its a drug in itself and changes the trip, and ive seen higher doses of weed make people sick, but a puff really does settle ones stomach, and if one has a tolerance it wont affect the trip much. either way i was jsut tryin to help. also, dramamine can help with nausea and wont effect the trip in the doses that help with nausea. good luck.
 
I read in a paper that metoclopramide is the only antiemetic can completely clear ibogaine nausea. Although they are from a different class of psychedelics I would give it a try, it should be better than ondansetron which is an antagonist at serotonin receptors, therefore should be bad for the trip more than metoclopramide.(serotonin antagonist are said to stop trips in some papers)

Please do let us now if you ever try,

Good luck.
 
LvMkngFlwrChld said:
I know its a drug in itself and changes the trip, and ive seen higher doses of weed make people sick, but a puff really does settle ones stomach, and if one has a tolerance it wont affect the trip much. either way i was jsut tryin to help. also, dramamine can help with nausea and wont effect the trip in the doses that help with nausea. good luck.
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Nah, I apreciated the idea- I'mm a pot smoker, and have used it to that effect, but I really don't like smoking on a trip. As to dramamine, like I've said, small doses have randomly made me somewhat delerious, and I'm not cool with it.

Zimurgh, have you any link to that paper? I've found that metoclopramide eliminates opiate nausea.... I'll try this with peyote I believe, though as a PEA interacts more highly with dopamine, I'm wondering if the ibogaine story is only indicative of tryptamine/indole nausea.....

Come to think of it, the dopamine antagonism should 'reduce' or lessen affects of mescaline theoretically
 
Honestly, go with ginger or peppermint to reduce gastric distress. Metoclopramide is a pretty good zombie creator sort of drug. One of our cats used to need it when he'd get bouts of intractable vomiting (given IM - other half used to be a vet nurse) and he didn't look too happy afterwards except for not vomiting.

After he died, I tried a small dose of what was left out of interest (rectally, not by IM) and it was your classic antipsychotic zombie fuel. Dopamine is the vomit trigger in the CTZ (chemoreceptor trigger zone - vomit central), but reducing it's effects also buggers it's looked for effects in the limbic system. It will fuck up mescaline - honest

If you absolutely need an anti-emetic, go with a small dose of something like cinnarizine (Stugeron in the UK - it's OTC) that doesn't have too much impact on your state of mind

Dopamine vomiting is intriniscally linked to rapid administration of a hell of a lot of drugs of abuse - opioids, cocaine, amphetamines, nicotine etc - your brain gets a flash flood of dopamine, some of which happens in the CTZ
 
^^^^It doesn't appear to have anti-psychotic 'mental effects' at the dose used to counteract nausea, though a psychiatrist I see did mention muwscular effects- twicthing, cramping etc at high doses.

Thanks f&b, thats the response I wanted!. So phens seem out, but LSA seeds (ipomea mullieri) known as the Poison Moinging Glory, could be a candidate for nausea degradation, I only feel fucked and freaked by the physicao sensations of any LSA's. Does LSA share the structure of PEA that wouldmmake mescaline 'fucked up'? And in what way would it be fucked up, ie. no effect or unusual effects.
 
We found either metaclopramide or ondansetron to be useful for counteracting nausea from psychadelics, and they didn't really affect the trip much.

Depends on dose, and on how bad the nausea is...a friend had such bad nausea off LSA one time that even ondansetron didn't help much! Normally they will help to some extent though.

Metaclopramide may be a dopamine antagonist but its antiemetic effects are much stronger than its antipsychotic effects, we never noticed a normal antiemetic dose blocking the effects of psychadelics, although i suppose at a high enough dose it would start to.

Unfortunately both metaclopramide and ondansetron are prescription only, but prochlorperazine (stematil) is available over the counter in most countries and is similar to metaclopramide, just not so strong. Never come across cinnarizine myself but thats another good suggestion, different mechanism of action again.
 
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