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The Big & Dandy N-Ethyl-Norketamine Thread

Just a thought, but is it not feasible that when ketamine was first developed as an anaesthetic (by Parke-Davis back in the 60s?) it was one of several related compounds being considered?

I would suspect that both N-Ethyl-Norketamine and N-Methyl-Norketamine were developed and tested alongside each other for their potential pharmaceutical use. Safety-profile, potency, duration and cost-effectiveness would, amongst others, have been likely criteria for these tests . If this is the case then I would I imagine that there are good reasons why N-Methyl-Norketamine was chosen as the compound to ultimately become pharmaceutical Ketamine.

Anyone else have any thoughts or knowledge on this?
 
People have been looking for the unabridged Park-Davis trials for a long time, and to the best of my knowledge only snippets have been recovered. Some valuable info in there for sure.. .

Good to see some reason and logic in this thread Hamilton, unfortunately in these threads of the "the next big thing" that swell to 100 pages overnight reason and logic fall on deaf ears. I'm just waiting for the awful "meow-meow" name equivalent to come along. . .this signals scheduling haha. Or is it already "ethylketamine"?

As far as bladder damage, ketamine induced ulcerative cystitis is believed to be the result of an acidic metabolite, possibly due to n-dealkylation, possibly not. methoxetamine, as well as n-ethylnorketamine, are also subject to this dealkylation, producing the nor metabolite. Could be some other metabolite as well, or something else entirely. we just don't know yet. So hearing that the current "version" of this drug requires a Higher dose, lasts shorter, and has some other unforeseen effects, makes alarm bells ring in my head. Could be an even better candidate for problems! personally, I believe the higher dose is because of a shitty synthesis, as well as the excessive " burn", but who knows, maybe PD knew something we don't, or that our projected SAR is off. people really seemed to misinterpret FnB in regards to to the n-ethyl on MXE making it less of a candidate for bladder issues. This altered kinetics, and a lower dose being required, but from what I've seen people sure push it often and frequently with MXE as well. We'll see what the tide brings in. Personall, I wouldn't touch this n-ethylnorketamine until a lot more "data", and a more refined synth come out, and who knows even then. Don't trust these folks with my best interests in heart, and I don't applaud their motives - profit, at the cost of everything else, one bit.

Cheers, be safe
 
So we can agree that the substance in question is indeed an analog of the ketamine metabolite, not ketamine itself? That would explain a lot of things imo. First of all, unless I'm mistaken, orally taken ketamine is metabolized in the liver to norketamine before it reaches the brain. It's commonly accepted that when you ingest ketamine this way, it's a lot less psychedelic and you need a much bigger dose to achieve the same effects, even as much as 4-5x (source: erowid) the dose as you would need nasally or IM. So, this substance sold as n-ethyl-ketamine should be compared to the ketamine metabolite norketamine instead of ketamine itself. Now the marketing speeches sort of make more sense, I think this substance being sold is more potent than regular norketamine, but still quite a bit less potent than ketamine itself. God, the nomenclature is indeed very confusing.
 
So we can agree that the substance in question is indeed an analog of the ketamine metabolite

I bought this fact up earlier in the thread, but I was shot down by Hammilton and his squad of chemistry police. But you are correct, it does explain alot of things. I'm also rather disturbed at the amount of RC's that have been emerging, that are simply liver metabolites that come from the original chemicals (Ethylphenidate for one). There seems to be a trend with these, in that they have many undesireable effects (with the exception of 4-HO-MET, which was lovely)
 
So we can agree that the substance in question is indeed an analog of the ketamine metabolite, not ketamine itself?
no - and this is a further reason that I am against insisting on the cumbersome correct nomenclature, it is misleading to this wrong conclusion.

in ethylketamine, the n-methyl group of regular ketamine has been replaced with an n-ethyl group, whereas norketamine has no n-substitution at all. so the n-alkyl substitution has been lengthened in the step from ketamine to ethylketamine, so in a certain sense ethylketamine is further away from norketamine than ketamine itself. when one orders according to the length of the side chain, one gets the following series:

0 norketamine
1 ketamine
2 ethylketamine

perhaps it makes this point even clearer when one remembers that ketamine could be also referred to as n-methyl-norketamine (as someone already mentioned in this thread).

btw, here is a picture of norketamine for your comparison:
norketamine.jpg
 
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perhaps it makes this point even clearer when one remembers that ketamine could be also referred to as n-methyl-norketamine

That just takes it to moronic lengths and doesn't prove anything aside from the fact that (A-B)+B = A. Fallacious reasoning.
Such (moronic) naming refers to one compound, and one compound only. That's why no one (with intelligence) would refer to it in such a way. N-E-NorKet MUST be referred to as such because otherwise you create potentially dangerous ambiguity.

no - and this is a further reason that I am against insisting on the cumbersome correct nomenclature, it is misleading to this wrong conclusion.

Wow... this is just getting retarded. It's a fucking analogue of both of them. And what relevance does this have to the naming of the compound? You could call it Ethetamine or anything and have a perfectly usable non-ambiguous trivial name. Either call it what is or come up with something new. Don't advocate for people's lives at risk because your ability to understand a truly simple naming process is impaired.

Honestly, this is like asking for the RC industry to get even more murky.

I can't believe that someone would admit to find the use of "nor" complicated, [proof that I'm capable of self censoring]

The whole reason for using the correct nomenclature is to account for the fact that the naming you're advocating refers to an entirely different compound. Here are just a few reasons not to use the moronic nomenclature you're advocating:

1. IT REFERS TO AN ENTIRELY DIFFERENT DRUG. If your naming system results in people being unable to tell the difference between two different drugs it is DANGEROUS.

2. WHAT DO WE NOW REFER TO THE REAL N-ETHYL-KETAMINE? Is that NEK-2? N-Ethyl-Ketamine version 2.0?

3. USING THIS MORONIC SYSTEM, AN RC VENDOR MAY PLACE AN ORDER FOR N-ETHYL-KETAMINE and actually receive N-Ethyl-Ketamine. You know, NEK-2 or N-Ethyl-Ketamine ver 2.0. I know, your system is supposed to be simpler right. Perhaps NEK-2 is actually toxic. Now people are dying. Perhaps it turns out to be much weaker (as it probably is) someone switches from high doses of that to high doses of NEK ver 1.0 without realizing it (because without pictures and analysis there's no way to actually tell) and they're talking to God face to face, in the undesired way.



The real, accepted nomenclature does not cause people to believe that it's an analogue of a metabolite or the more common drug. That's just people not understanding chemistry. That same misunderstanding occurs within all sorts of compounds for which there are no naming disputes (this isn't a dispute really- there's only one right answer. there's also a dumb answer, that's undeniable, but there's only one right one).

in ethylketamine, the n-methyl group of regular ketamine has been replaced with an n-ethyl group, whereas norketamine has no n-substitution at all. so the n-alkyl substitution has been lengthened in the step from ketamine to ethylketamine, so in a certain sense ethylketamine is further away from norketamine than ketamine itself. when one orders according to the length of the side chain, one gets the following series:

Yeah... so what? it's almost certainly closer in terms of pharmacology as well. That's irrelevant in naming the compound. Perhaps we should rename Dextromethorphan because people might get confused and think it's an opiate?
 
So we can agree that the substance in question is indeed an analog of the ketamine metabolite, not ketamine itself? That would explain a lot of things imo.

No. And...

But you are correct, it does explain alot of things. I'm also rather disturbed at the amount of RC's that have been emerging, that are simply liver metabolites that come from the original chemicals (Ethylphenidate for one). There seems to be a trend with these, in that they have many undesireable effects (with the exception of 4-HO-MET, which was lovely)

No.

Norketamine is also an analogue of ketamine, it makes no sense at all to suggest that N-ethyl-norketamine is somehow "closer" to norketamine. Nomenclature is no indication of effects.
 
I bought this fact up earlier in the thread, but I was shot down by Hammilton and his squad of chemistry police. But you are correct, it does explain alot of things. I'm also rather disturbed at the amount of RC's that have been emerging, that are simply liver metabolites that come from the original chemicals (Ethylphenidate for one). There seems to be a trend with these, in that they have many undesireable effects (with the exception of 4-HO-MET, which was lovely)

Don't forget O-desmethyltramadol ;)
 
Although I completely agree that the name N-ethyl-norketamine is the most correct and should therefore be the one to be used (certainly on this site at least), I think its probably fair to say that the abbreviation N-EK is the one thats going to stick, especially with the vendors and therefore with the public.

I still find myself having to refer to the APBs as Benzo Fury around intelligent people so they know what I'm talking about. Instead of saying which particular 3-MeO-PCx I sniffed last night I find that everyone knows what I mean when I refer to it as "that PCP stuff". I know plenty of people who still struggle with the term RC in general. You start firing off relatively long chemical names or a load of numbers and letters and most people just get confused.

I would say that N-EK and ethylketamine are sufficient names to distinguish this stuff from the standard product in the eyes of the average Joe, regardless of whether they are technically correct. Ideally we would have a decent naming convention for all arylcyclohexylamines but that would almost certainly involve renaming ketamine, something thats not likely to happen. Perhaps though we could make some sort of list of names like:


Ketamine = N-methyl-norketamine = 2-Cl-2-Oxo-PCM
N-EK = N-ethyl-norketamine = 2-Cl-2-Oxo-PCE
2-MK = 2-methoxy-deschloroketamine = 2-MeO-2-Oxo-PCM


Anyone care to expand this list?
 
N-ENK

Seems easy enough as a compromise?

Anyway,

adder said:
Ethylketamine, 2-(2-chlorophenyl)-2-(ethylamino)cyclohexanone

Route/dose: 100mg intramuscularly of HCl salt
Report:
The name is obviously wrong but it’s easy to know what hides there. This is just ketamine with ethyl on amine (just like in case of PCE). This obviously had an impact on drug potency. It’s not stronger by a factor of 2 or 3 but 100mg i.m. knocked me out totally and I was EthylK-holing for about an hour. So it didn’t really alter duration of experience. It’s got already a broken piperidine ring, ethyl is known to be the best when it comes to potency so here it is, get an S-enantiomer and you’ve got a winner.
From here.

This is from someone who obviously has a bit of tolerance and really doesn't seem to resonate with the observations here.
 
N-ENK would be better, absolutely. I kinda think though that the vendors have decided their make-it-sound-as-close-to-ketamine-as-possible name and thats what will stick. No doubt there will be some variant on the rhino/dino theme in some areas too.
 
N-ENK

Seems easy enough as a compromise?

Anyway,


From here.

This is from someone who obviously has a bit of tolerance and really doesn't seem to resonate with the observations here.

Yeah, I had totally forgotten about that post, some valuable info in there,

I have had nowhere near those effects from this batch though. Tolerance is an issue undoubtedly but I can't imagine any amount of this substance could make me hole, I have gone through a gram in short order and felt almost nothing, tolerance or not thats unacceptable.
I doubt it's a poor synth. I just can't see a value if you can get ketamine it have any sort of tolerance, and certainly not at this price. It hurts my nose too much and it leaves me blocked up for 24 hours after a dose.

I seriously doubt this one, whatever it's called, is going to get popular. It's just Supermarket Value brand Diet Ket isn't it?

Suppose it could be a good intro for dissociatives for people scared of the k hole..
 
^
i'm not scared of holes, and like short, sharp trip.
What I am scared of is: blacking out and wandering the streets with no shirt on throwing things at passing cars PCP stylee.
So did think this stuff would fit the bill, but the chemistry confusion, nose bleeds and general air of dissappointment is making me wonder if its worth risking such a new compound.

but think its gunna take off, in the Uk if nowhere else....shoveling crappy over-priced powder is now as english as knotted hankies and a nice cup of tea in the morning
 
i had a free day so i gave this stuff a try 250mgs total. i started small with 10mg and built up to a 90mg line snorted. i dont have much experience with ketamine or mxe so didnt have any expectations and i dont know what its like to hole. it was a pleasant enough afternoon sitting about listening to music. i felt pretty relaxed.

it had a moderate anti-depressive and anxiolotic effect. it doesnt last that long though. afterwards now though i feel my mind is kind of foggy and a wee while ago i blew my nose and some blood came out which was a bit worrying.

overall id say its not really that worth it unless the price comes down and the purity goes up if it can.
 
@Hammilton: while you're obviously correct on all points, I don't know if it's worth spending the effort renaming this when in all probability it's not going to be around much longer anyway. Sure, we could come up with a name, but that would even in the best case simply promote the use of yet another untested and unknown drug. Also, methylone, ethylone, butylone is kind of an ambiguous series, and eutylone just sounds awful.

Though, for clarity: this is not the very-likely-inactive compound that would be called "n-ethyl-ketamine", though it is valid IIRC to exclude the prefix nor- in forming an acronym NEK.
 
Snorted 250mg of this 5 days ago, have been away so havn't had the chance to post this earlier, this 250mg was consumed the day after my original trial of 100mg and I found myself fiending really badly for a re-dose all day so gave in.

This time the euphoric state acheived last time was not present, there were no hallucinations or CEV's even after smoking cannabis, my apologies for my original post claiming it to be potentially as good as ketamine i know do not think this is going to be the case.

250mg insuffulated didn't appear to have any much more of an effect than 100mg and I felt nowhere near a hole (bear in mind K can hole me at 130mg), im assuming it would have produced the visual state had I waited a few days before trying it again as I find that ketamine day after day doesn't really make me hole properly.
Once again though all I can say is AVOID SNORTING THIS STUFF!!! Nasal damage be fucked, I have never snorted anything that has messed my nose up so badly (And I sniff 2C-B and Ethylphenidate quite frequently with no complaints at all),
Its still fucked now, pain, blowing out reams and reams of snot for days after, it's all irritated and dry around the sides and my left nostril now produces a whistiling noise when I breath in and for about 2 hours after sniffing it I was sneezing and blowing my nose and focussing on how sore it was to be able to enjoy any of the miniscule effects that were present.

I will either be plugging or consuming orally the remaining 200mg I have and let you know whether it works for me or not as i have seen conflicting reports on this issue.
I very much doubt I will be purchasing this again its just not worth it unless it works orally and the price goes down drastically (£10-£15 a g perhaps to make it a viable option imo), its a real shame I cant seem to score any good quality ketamine as I would say its definately a better option although saying this my first trial of 100mg insufflated was more euphoric than k in a weird way, primarily in the body and it was certainly alot more moreish, I literally couldnt get it out of my head until i redosed, I find a similar thing with mephedrone. I got a bad feeling about this one despite my initial report, will be interesting to see how this develops.

Much love + Happy tripping =]
 
Well, I haven't tried this stuff yet and judging by the feedback I'm not so excited that I'll get some in this weekend. I do want to give it a go though, alongside 2-MK when that surfaces, but the prices aren't exactly endearing me, even moreso considering my general dissociative/anything tolerance means i'll have to get a whole gram and expect to clear it in a night.

I am curious in principle whether this one might interact well with 3-MeO-PCP, I don't expect anyone to recommend it here but I have a suspicion it could be quite interesting. I'll also be looking to try out my usual butylone combo aswell. So it seems I've already got several grams worth of experiments planned out here, maybe when the price comes down...
 
Well, I haven't tried this stuff yet and judging by the feedback I'm not so excited that I'll get some in this weekend. I do want to give it a go though, alongside 2-MK when that surfaces, but the prices aren't exactly endearing me, even moreso considering my general dissociative/anything tolerance means i'll have to get a whole gram and expect to clear it in a night.

I am curious in principle whether this one might interact well with 3-MeO-PCP, I don't expect anyone to recommend it here but I have a suspicion it could be quite interesting. I'll also be looking to try out my usual butylone combo aswell. So it seems I've already got several grams worth of experiments planned out here, maybe when the price comes down...

The good news is it does have some very nice sub hole euphoric ant-depressant effects.

The bad news is its very bad on the nose especially the day after, stings like a bitch when snorting it and it really is super short lasting, you'll be coming down in literally 10 minutes, you'll need to snort quite alot if you have any lingering tolerance and lastly of course the price is too high.

In all honesty IMO its just not worth it for the bad points above for the effects you get.
 
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