The Big & Dandy Methoxetamine Thread - The 3rd Dose

[3rdEyeSeer]

I'll probably do some more research with this compound on the weekend at a higher initial dose and maybe take some EEG readings for fun.

EEG readings! This is real research. What next, 24 hour EKG, blood pressure & heart rate monitoring, with functional MRI before, during and after SWIM doses?

Taking a TR to another level

 

[twelvesevndi]

can i mix mxe with 2c-e? i read that it's dangerous to mix mxe with drugs that act on serotonin receptors. does 2c-e fall under that category?

ive done it a few times and it always feels really really good.

admittedly that could be an indication that its really bad for you but it does not seem to be dangerous in the short term.

in fact i can only assume its similar to what people get out of amt + mxe

 

[e1evene1even]

I'm still enjoying a very noticeable anti-depressant effect 24+ hours after dosing. :D

The constant pressure in my pre-frontal cortex is gone. I'm not only less depressed, but much less stressed and had a lot more patience today at work.

I'm curious to see how long this will last. This really gives me good reason not to abuse MXE as it feels like it could be a very effective medicine for me, used similarly to Jamshyd's Medicinal Ketamine Regimen.

If MXE continues to be this effective it could really make a positive impact on my life and social interactions.

Another thing is I've been using kratom regularly for a while now (mostly lower doses for energy/focus, 3-4x/week) and MXE seems to have eliminated any cravings as well as the the irritability and other withdrawal symptoms I get when not taking it.

In the other B&D threads there have been similar reports of MXE reducing dependance with other substances and this seems to be supported by the existing literature on NMDA antagonists. This 'dependance blocking action' might also help explain some of the negative interactions people have reported, specifically with other monoamine releasers and re-uptake inhibitors they may already have some tolerance to.

Modification of Drug Tolerance and Dependence

PCP, or other PCP-like NMDA antagonists such as dizocilpine, given repeatedly in combination with other drugs of abuse, can block or reduce development of tolerance and dependence [e.g., to opioids (74)] and sensitization [e.g., to effects of amphetamines, cocaine, and nicotine (32, 63)]. Competitive as well as noncompetitive NMDA antagonists are able to block tolerance development (72). Although the neural basis by which NMDA antagonists modify tolerance and dependence development is not known, it is possible that their interference with NMDA-receptor-mediated neuroadaptive processes is involved.

http://www.acnp.org/g4/gn401000171/ch167.html

Treatment of addiction

The Russian doctor Evgeny Krupitsky (Clinical Director of Research for the Saint Petersburg Regional Center for Research in Addiction and Psychopharmacology) has claimed to have encouraging results by using ketamine as part of a treatment for alcohol addiction which combines psychedelic and aversive techniques.[44][45] This method involved psychotherapy, controlled ketamine use and group therapy, and resulted in 60 of the 86 alcoholic males selected for the study remaining fully abstinent through one year of treatment. For heroin addiction, the same researcher reached the conclusion that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence from heroin during one year without any adverse reactions...

Jovaisa et al. from Lithuania demonstrated attenuation of opiate withdrawal symptoms with ketamine.... Ketamine group presented better control of withdrawal symptoms, which lasted beyond ketamine infusion itself.

https://secure.wikimedia.org/wikipedia/en/wiki/Ketamine#Treatment_of_addiction

Another insight I had during my MXE 'afterglow' was how little sense it makes for millions to be taking SSRI's which take weeks or months to even have an effect (which is often barely better than placebo anyway) when single low dose treatments with NMDA antagonists provide such immediate and long lasting results.

But then again, why would Big Pharma want people to be able to effectively treat depression for pennies a month when they're making billions every year on SSRI's which are taken daily and chronically??? The best thing they could hope for is some reactionary scheduling of this because some kid does something stupid...

 

[Ralt]

Well, I can throw in a little advice on the MXE+2ce. I got a 15mg sample of MXE about a month ago and recklessly mixed it with 20mg 2c-e, 1 hit of LSD, and 200mg of Methylone. Looking back, probably dumb, but it added a interesting tactile response and added even more tracers.

I just did my first solo run with MXE last night, snorting ~70mg in 5 piles of about 15 each over two hours. I had unspeakable ecstasy. This is coming from a lover of DXM though, it was my first psyche and I've done it over 70 times. The come-up was a bit confusing and took about two hours, I plan on doing more all at once next time.

But once the hallucinations started taking hold I poped on the LOTR soundtrack and had incredible hallucinations. I saw a giant flaming red demon reach his hands into my mind, grab a cloud, lift himself up to the gates of heaven, and battled with angels wilding swords for like an hour. Incredible epic type battle too, every time their swords would clash sprays of fire would jet from the demons sword, and white lightning would spark from the angels. He killed a lot of them, but after a while it changed to pulsating lights so I switched the music to techno and my face contorted into an open mouth grin of retarded happiness for three hours. Like, I just sat there going like this, .

My mind turned to thoughts of my girlfriend and I started shaking with joy and ecstasy which would somehow turn into a white light that escaped from my body (eyes closed still, mind you) and would write love notes to her in my mind, slicing the blackness in my mind with glowing letters. I ended up texting her and surprisingly it made sense when I woke up.

After that it started subsiding a little and I just started thinking very random tangents, with no thought to previous thoughts. A very manic dissociative way to think, completely reminded me of my DXM trips, I was wallowing in utter joy.

I did have to do the one-eyed pirate trick to use a computer or phone, ala DXM.

Overall, I think I just fell in love with a drug. I can finally get my dissociative on without knowing I'm going to puke like a madman. I now MUST find ketamine, and for now, I have my MXE. Goddamn I was blown away.

Two billion hallucinatory thumbs up from me.

 

[foolsgold]

I think it's obviously better to try it without MXE .. That said, I realise it's hard not to when such an easy solution is available. Just try hanging in there first, get help if it lasts and go back to MXE is you can't handle it any other way.

Got my MXE yesterday, gonna try it out one of these days and post a report here

thanks for that. but im back to normal again to day it really was just more a come down now than anything i think but that innerpeace spring in my steps back

 

[Mitchi]

So I have been taking MXE 4 times now, with the highest dose been just over 40 mg. I have not "holed" on this before but I would like to, the next time.

So how would the dose be for that? I have no tolerance to speak of, I think.
ROA will be rectally, which is one of the reasons that I don't really know how much I should do (all the other times have been sublingual)

 

[foolsgold]

try 50mg

 

[Solide]

but im back to normal again to day it really was just more a come down now than anything

Good to hear



Just did ~25mg sublingual/oral (held it for 5 minutes till my mouth was to full of saliva to comfortably hold it and then swallowed) 10 minutes ago. I'm excited :D

 

[foolsgold]

cheers solide i say normal i mean back to how it feels to be mended by mxe . most likely going to mess it up tho cause im going to do a gram and half of 2-dpmp this weekend love that stuff maybe some baby wood rose and a nice smoke to

 

[Solide]

cheers solide i say normal i mean back to how it feels to be mended by mxe . most likely going to mess it up tho cause im going to do a gram and half of 2-dpmp this weekend love that stuff maybe some baby wood rose and a nice smoke to

Isn't 1.5g of 2-DPMP insanely much? I thought that you only needed about 0.01g for a 'medium' dose that lasts 12h.

 

[thedonsafc]

MXE Trip Report

-"CoCo" (Currently tripping and trying to type 13/04/2011)

-500mg of Methoxetamine (on me)

-On my own to test the recreational value of this compound.

-19y/o

-78kg

-experience (very little, mostly rc's) ; Cannabis, M-cat, speed, mdai, 6-apb, 5-apb, M-butylone(although its gone somewhere ???), DMC

-t7:45pm 30mg baseline of Methoxetamine

-t8:00pm Really feeling something ace is happening to my eyes. and very little tingling in extremities, i can almost link it with an m-cat "come on"...

-t8:15pm Gone with the wind, my eyes are like piss holes in the snow and my body is weightless but my head is heavy, it feels like i have lifted a great burden off myself. it feels like im looking through the eyes of someone else but only being able to see and hear what they feel although knowing reality is slowly slipping from me.

-t8:30pm Peaking, everything is tingling with mild-strong euphoria and slight jaw gurning with a mega dry mouth! Still feel like my eyes and ears are the only thing i have one me :S! I recall hearing a football match and can only compare hearing the fans in the backround to selecting 'bathroom' on 'realtek hd'. It was anoying me so i tried to float away (walked away).

-t10:10pm Still peaking pleasantly. I feel happy but i have decided i am going to try and smoke some cannabis resin through a bong.

-t10:30pm Ok good idea, the smoke increased evrything good about this compound and i now find myself at a stronger peak!

-t11:20pm Still peaking, although the smoke has decided to make me feel somewhat sedated now but the M-ket is still going strong. --- No More Jaw Gurning!

-t12:00am I am now physically tired but my mind is still going, all i can think about is the fact that i have 500mg and i only used 30mg :O! This is a v.good compound as i had no urge what so ever to re-dose (i think its because im physically tired or its the cannabis).

-tPresent,, Still feeling mild-strong effects of the M-ket and just beging to feel mentally and physically tired at the same time. Happy but im getting tired of typing and im needing my bed v.soon!

Summary - Overall this compound made me feel Happy, Euphoric, Empathy and Confused with reality. Its effects feel sedating but you could not sleep on this as your brain is in overdrive with your receptors going crazy! The only negetive effect i can come up with is the coldness of the hands, nose, lips and feet. This is not a compound you should drink with as i feel that might be a bit too much for the body to cope with and you might knock yourself out (sedate yourself), avoid this as your breathing could slow. As i was on my own it wasnt that ammusing (as you could immagine) but if you were with you friends then i bet you any money you would have a great time if you kept to low doses!!!


15/04/2011 - Still feeling the weak effects of MXE. This stuff stays in your system for a while!

 

[Mitchi]

try 50mg

Will do!

 

[farmaz]

I dont get why people are taking such small doses of this.

I got through 500mg in 1 day, It feels a very safe substance to me, there was no sign of being neuro-toxic or any negative physical aspect to me time with it.

This depression after a dose too is confusing to me. For days after & tbh even today in a milder way I feel kinda re-born. As I said in my report "As if God has dry cleaned my soul"

 

[farmaz]

1 last thing I forgot to say....This chemical goes very well with industrial techno.

A Sandy Warez Mix had me raving & dancing out of my body, 300% recomended

 

[Elinisti]

MXE seems to really "open up" if I make myself hyperventilate during the peak. Full body orgasm and total dispersion. Also I try to breath loudly so that my skull vibrates. Next I'll try playing a didgeridoo while under the influence.

Would smoking datura with MXE be possibly dangerous?

 

[Transform]

ive been feeling very depressed since it mxe on saturday. not saying it caused it but i think it probably did. it feels similar to post mdma depression.

A couple of friends reported the same thing, one hasn't bothered with it since, the other has had it a number of times and not had the depression again. Not sure what it is that causes it, the doses weren't unusual.

Both cases followed using with cannabis, but can't be replicated with or without.

Isn't 1.5g of 2-DPMP insanely much? I thought that you only needed about 0.01g for a 'medium' dose that lasts 12h.

0.005 g (5 mg) kept me awake for 36 hours without fatigue. I would not describe it as recreational.

Perhaps it has been cut to 10 mg/g for easier dosing :s

 

[knock]

I dont get why people are taking such small doses of this.

I got through 500mg in 1 day, It feels a very safe substance to me, there was no sign of being neuro-toxic or any negative physical aspect to me time with it.

People are taking smaller doses because they don't necessarily want or have time for total immersion lasting hours and hours on end and/or they don't have a dissociative tolerance.

I don't get why people keep asking why other people take small doses. Surely it's a good thing to have your drugs last longer. Or is it a race to get through them? Sorry, I sound like my mum (talking about food, not drugs!).

 

[Solide]

Small TR from last night:

00.00 ingestion

00.30: feeling relaxed and 'light'

00.34: body is getting numb

00.39: starting to feel lighter and a little spacy

00.45: Spacier. Everything seems far awa, not physically, but mentally. Feeling heavy (legs especially) too, lovely sedation.

00.51: all feelings increased, but nothing intense.

00.55: Walking feels strange, the air feels 'thick'. It's sort of like K-walking but less wobbly (slightly disappointed here, loved the wobblyness of K when I did it)

01.01: wobblier now. Dubstep sounds sweet and is fun to dance on. Tho i keep listening to 'Skinny Genes' too. It's such a happy song, it puts me in a happy mood.

01.05: When sitting still the sedation is very present, but when doing something it disappears almost completely.

01.11: smoke a little weed to enhance everything.

01.18: feels somewhat spacier and more 'confused', put the last part of 'how to train your dragon'. It feels very life like and im very engrossed into the movie

01.32: not any chances anymore, feels chill, space and dreamy but not very trippy or psychedelic. Less spacy then K aswell and more dreamy/sedating. I take a little bit more, now i'm at 25-30mg probably.

01.59: Effects increasing a little, smoking a cig is a strange experience.

02.01: texting is hard, gonna put on District 9 and after that go to sleep.

04.05: that movie was fucking wierd.

05.45: wake up with bloody nose, still slightly under influence and half asleep I manage to stop the bleeding and go back to sleep.

13.00: Wake up, feeling very sleepy but showering and breakfast helps. I have sort of a hangover: i'm mentally not completely sharp. Nothing bad but I couldn't do any studying or something.

 

[foolsgold]

Isn't 1.5g of 2-DPMP insanely much? I thought that you only needed about 0.01g for a 'medium' dose that lasts 12h.

im really use to the stuff went from half oz of speed that i was doing for years to ivory wave ultra to this stuff . never had any problems with it at all exsept for the typical rc take a week to return to normal . sorry it sounds like trupet blowing but im just trying to answer solide question . for the sake of it please dnt do what i and not study up on the stuff first or you will end up going through grams of it like me :D

 

[foolsgold]

sounds like you had fun solide