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The Big & Dandy Methoxetamine Thread - 2nd Dissociation

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2-(2-methoxyphenyl)-2-(methylamino)cyclohexanone

Route/dose: 100mg intramuscularly of HCl salt
Report:
This is ketamine with chloro group substituted by methoxy group. Like predicted before synthesis they are really similar. With such a dose i.m. it was easy to go K-holing. What’s the difference here? Chlorine is very electronegative but not as much as flourine. This is yet to be examined what concrete impact has methoxy group here because from subjective effects it’s really hard to tell if it’s more potent or less potent. Actually I see no difference. Well, at least I can’t report on any. This is as good as plain ketamine and if ketamine is easier to synthesize – why bother?

From: here. ^ This compund, right?

Looks interesting, and from the quote above, quite similar in effects to K.
 
^^^ Most of that post i have since come to dismiss as SAR based speculation rather than first hand experience, for several reasons. I was speaking as to the data given by a someone responsible for synthing and testing several related compounds, some of which is available elsewhere on Bluelight if you search around. The N-ethyl group seems to have optimal potency, with either lengthening or shortening the alkyl chain resulting in diminished potency. The propyls were indeed made and tested as well.
 
It's not simple logic.. it's not that simple AT ALL... it would be simple logic if you had a choice.. he lives at home, he doesn't have multiple homes, he hadn't experienced mania from it before, he made the decision to do it thinking it was safe based on experience, and he got burned unexpectedly. I don't see the distinction, there would be a distinction if he knew that was going to happen, and if he had somewhere safer to do it... and I disagree with this idea that your parents would take you to hospitals and professionals quicker, a housemate/neighbor might call the police or doing somthing even more drastic, the risks are almost identical, and this is about where you feel safe doing these things.. his home was unfortunately his parents house. Also I don't think you've understood the posts so far about these drugs, a small dose could turn on you just as much as a large one, you seem to think this was a predictable event, haven't you read these posts? it was an as yet unknown side effect. It was not predictable, everything you said is based on the idea that he knew it was going to happen - he didn't, nobody here did... no guarantees - that's the whole point.

I'm not going to comment on this subject again..

its NOT an unknown side effect http://www.bluelight.ru/vb/showthread.php?t=545420 (note the date in this trip report)

i'll tell you what i read- a couple of days before the alleged incident a huge dose of mxe and mdai had been taken together and produced and very unpleasant experience for the bluelighter concerned- i mentioned to him on this thread that it was foolish to mix them as the only recorded death from methoxetamine was from a combination of mxe and mdai injected. he said he knew about that, and i said why did you mix them them? few days later he had the screaming incident. which explains my harsh viewpoint. enough said. maybe you should read this thread more thoroughly.

clearly no kind of harm reduction had been implemented. its not that unpredictable that a high dose level of a non sedating dissociative can cause wild crazy behaviour. its been reported already quite a bit for mxe, 3-meo-pcp/3-meo-pce and years of pcp video's on youtube display the behaviour quite well.

there never are any guarantees but you can guess that the possibility is there as its happened before. which is what you would do if you were responsible with your use. i have by the way already seen one person having an mxe freakout and it occured because he used greedy doses- no surprises there.

this is a drug that i love but all the dissociatives are needing of your respect
 
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Tolerance with daily use increases ten fold in a short space of time.

Things can reach the point where a 25mg dose has an effect of minutes rather than an hour or two.
 
its NOT an unknown side effect http://www.bluelight.ru/vb/showthread.php?t=545420 (note the date in this trip report)

i'll tell you what i read- a couple of days before the alleged incident a huge dose of mxe and mdai had been taken together and produced and very unpleasant experience for the bluelighter concerned- i mentioned to him on this thread that it was foolish to mix them as the only recorded death from methoxetamine was from a combination of mxe and mdai injected. he said he knew about that, and i said why did you mix them them? few days later he had the screaming incident. which explains my harsh viewpoint. enough said. maybe you should read this thread more thoroughly.

clearly no kind of harm reduction had been implemented. its not that unpredictable that a high dose level of a non sedating dissociative can cause wild crazy behaviour. its been reported already quite a bit for mxe, 3-meo-pcp/3-meo-pce and years of pcp video's on youtube display the behaviour quite well.

there never are any guarantees but you can guess that the possibility is there as its happened before. which is what you would do if you were responsible with your use. i have by the way already seen one person having an mxe freakout and it occured because he used greedy doses- no surprises there.

this is a drug that i love but all the dissociatives are needing of your respect

I guess that all drugs need respect, from heroin to paracetamol. I kind of knew this, but now I fully understand why. It's one thing to know that people overdose on drugs, but another thing completely to experience an overdose yourself. Chances are only the latter is going to teach you to respect a drug properly.
 
Whoooooa had an awesome high dose experience last nigh. First time "holing" on anything :) Lots of realizations that have brought me peace, and not the crazy philosophical shit I used to cover up my emotions with, just observations on how my perception changes in a manner similar to the seasons, sometimes along with the seasons.

But, later in the trip I took ONE HIT of cannabis and had a panic attack that lasted hours. I dont know if my heart was actually racing, but once I "noticed it", my heart definitely really did start racing. Very fast. I was really scared that I was going to have a fucking heart attack. Was I actually in any danger? I didn't want to just tell myself it was fine because what if it wasn't? I was so ready to dial 911 if needed. Hard to differentiate real symptoms from tactile hallucinations, like feeling your arm go pins and needles. Heart attack symptom or just typical dissociative shit? Vision blacking out when you get up fast? Who knows lol.

Funny how high doses of obscure research chemicals had me doin just fine and a single hit of pot sends me off the deep end.
 
Whoooooa had an awesome high dose experience last nigh. First time "holing" on anything :) Lots of realizations that have brought me peace, and not the crazy philosophical shit I used to cover up my emotions with, just observations on how my perception changes in a manner similar to the seasons, sometimes along with the seasons.

But, later in the trip I took ONE HIT of cannabis and had a panic attack that lasted hours. I dont know if my heart was actually racing, but once I "noticed it", my heart definitely really did start racing. Very fast. I was really scared that I was going to have a fucking heart attack. Was I actually in any danger? I didn't want to just tell myself it was fine because what if it wasn't? I was so ready to dial 911 if needed. Hard to differentiate real symptoms from tactile hallucinations, like feeling your arm go pins and needles. Heart attack symptom or just typical dissociative shit? Vision blacking out when you get up fast? Who knows lol.

Funny how high doses of obscure research chemicals had me doin just fine and a single hit of pot sends me off the deep end.

Quite a few people now have reported alarming heart rates on MXE. Apparently myself included. It could be a self-induced panic that causes this, but since ketamine raises heart rates I wouldn't be surprised in MXE works in exactly the same way.

Could be dangerous if people try to mix this with cocaine, amphetamine, MPA and the like. Particular concern for MPA because that puts great strain on the heart and can be bought along with MXE in the same envelope.
 
Quite a few people now have reported alarming heart rates on MXE. Apparently myself included. It could be a self-induced panic that causes this, but since ketamine raises heart rates I wouldn't be surprised in MXE works in exactly the same way.
I've noticed faster heatbeat while on mxe, however im not sure if the heart is actually beating faster than normally, or are you just aware that you can feel your heart beating, and after that you start to listen it, and thus causing yourself panic attack. I've had this with weed also, i would end up making myself panic attack becouse you dont normally "feel" the pulse.. Anyway im gonna use fake excuse of starting to excercise to my parents this weekend and ask if they can lend me their BP machine, and test it myself.
 
Mixing with Mephedrone

Any word on mixing Methoxetamine (MXE, 50mg) with Mephedrone(say 100mg lines)?
 
I notice a lingering affect in the days after 'tripping' on MXE, slightly impaired congnitive function and also mild 'flashbacks' to intense experiences on the drug. Powerful stuff.
 
The incident was not unpredictable as similar reactions have been reported for other dissociatives and he was aware that he made involuntary noises on MXE in the past. Nevertheless, what's done is done and at the risk of insult he reported what happened for the sake of others when he didn't have to. Moreover, he admitted his mistake and committed to responsible behavior change. He's conducted himself as commendably as is realistic given the circumstances, and I hope others who make mistakes will follow suit. It's not really productive to chastise someone who has already done as much as can be expected.

here's a voice of reason i've ever seen one =D

well put!

What does MXE enhance for you?

my "thought patterns" ..!

altho my most memorable experience so far was while mountaineering in the north of norway, previous november, and squirting +-30mg of MXE under my tongue when i reached my bivouac at the end of the day (solo). i was camping on a flat plateau/snowfield, looking out over the fjords that led to the arctic sea, while the sun was setting. the spatial distortions of the geographical features around me were stunning, and my physical and mental exhaustion just melted into an unbelievable lucidity and relaxation.
 
(Think I may have already mentioned this here, otherwise I've definitely mentioned it elsewhere): MXE, like Ket, is very very likely to be a fairly potent dopamine reuptake inhibitor. ANYTHING dopaminergic - either a releaser or an agonist? - would by its nature cause an interaction.

Presumably in some circumstances, the overall effect could be a multiplication of effect. For me, mixing MPA and MXE caused a very sudden, very serious acceleration of my heartrate. VERY unpleasant.

(Nb: everything here is speculative based on armchair interweb Googling. Everything I type should be ignored and deleted from the internet. Your pants may be repossessed if you do not keep up repayments, etc, yada yada yada...).

/dm
 
Does anyone have experiance of long term constant use? i've been using low dosages for past 4 days, around 300mg done, so far i don't really see anything bad going on. I know it aint very smart to do any drug for longer period's of time, but has anyone experianced any negative effects by using this substance for daily use? Tomorrow shall be the drug free day since im visiting my parents :) Will let ya know if i get any symptoms

So far i really like it on low doses, 20mg every 3hrs ish keeps me motivated for playing and doing random stuffs around the house. Only downside is that it doesn't really let me sleep that well, i find myself being up till 6am more often than before (my sleep pattern has been fucked up for years tho). Atm its 3am and i feel like staying up all night, will stop dosing altough, just to avoid any health issues with heart etc..
 
Whoooooa had an awesome high dose experience last nigh. First time "holing" on anything :) Lots of realizations that have brought me peace, and not the crazy philosophical shit I used to cover up my emotions with, just observations on how my perception changes in a manner similar to the seasons, sometimes along with the seasons.

But, later in the trip I took ONE HIT of cannabis and had a panic attack that lasted hours. I dont know if my heart was actually racing, but once I "noticed it", my heart definitely really did start racing. Very fast. I was really scared that I was going to have a fucking heart attack. Was I actually in any danger? I didn't want to just tell myself it was fine because what if it wasn't? I was so ready to dial 911 if needed. Hard to differentiate real symptoms from tactile hallucinations, like feeling your arm go pins and needles. Heart attack symptom or just typical dissociative shit? Vision blacking out when you get up fast? Who knows lol.

Funny how high doses of obscure research chemicals had me doin just fine and a single hit of pot sends me off the deep end.

I've found MXE doesn't raise my heartrate, at least not noticeably. But when I smoked a bowl right after redosing something like 30mg, it all hit me at once and I couldn't move. It was dysphoric, I felt so good that it wasn't good anymore. And my heart was racing as well. I don't think I'll ever feel the need to smoke a bowl while on MXE. It just wasn't enjoyable. The body sensations were what I would compare to something like 2g of psilocybin mushrooms.
 
The film was to be White Zombie, starring Boris Karloff,which, amazingly (given my taste for the genera) I had never seen.

I was just re-watching that few months back, it is available for free online from a number of places, it really is an incredible movie but is probably the last thing I would choose to watch while on methoxetamine.=D

EDIT: I was recently working in Vegas and took 5mg while in my hotel room along with 5mg of 4-AcO-DMT, more to attenuate potential toxicity than to potentiate the psychedelia. I normally find 4-AcO-DMT, at any dose, to be sharp and philosophical. There have been few occasions where I did not feel my speech pressured to the point that I found it difficult to stop speaking. But this combination was very soft and hedonistic and dumb. I had no desire to write or speak but simply to lay in a hot tub sloughing dead skin off my feet with a washcloth thoughtlessly for hours.

When I first tried 3-MeO-PCP several BLers were surprised by the profound effect it had on me at a low dose, but I think it is because many of these drugs have a seriously aliner dose-to-response curve, or rather several different curves occurring simultaneously. There is an initial euphoriant/stimulant effect that becomes apparent at a very low dose. I found that 60mg of MXE produced a euphoria comparable to 5mg, but then for the second curve of visual and perceptual distortions a much higher dose is required.
 
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Is anybody here currently taking Wellbutrin/Zyban (bupropion)? I am and it's an NDRI, adding to MXE's dopamine reuptake inhibiting properties. I feel like the Wellbutrin may have made MXE take longer to come up. It did this with MDMA (not related I know, but it affects other drugs in come-up time) as well. Even after an hour of 43mg sublingual I didn't feel much. After I redose (usually T+1hr), however, both doses seem to kick in at once. It's a nice rush, but it's a little disappointing if I don't have enough time to redose in a night.

Edit: Forgot to say, 150mg Wellbutrin SR once in the morning, usually at least 8 hours before my dose.
 
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