The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

[Sun Drugs]

The only way of making sure I won't go overboard is to only order it in small quantities. 1 to 2 grams. Any more that than and I just won't have any control. It just becomes so easy to rationalize taking another dose.

 

[Xorkoth]

I want to add that sometimes you can responsibly use again after you quit. My guess is that you will be able to do this with MXE, I don't see any harm in trying once you have given yourself a sufficient break to reset your mentality. And it helps it's not physically addictive. Also, dissociatives do not mess with the areas of your brain responsible for giving pleasure and reward. If you were addicted to opiates or stimulants I would probably say you shouldn't use them in the future.

I know for me, I can never use opiates again in my life, even once, because every time I have quit and tried to use responsibly I fell back into addiction faster than I could blink, literally after the first time. I have a friend who was addicted to opiates who took a very long break and now occasionally uses without problems, but I know me, and that will not happen for me.

 

[Chris Timothy]

Any advice?

Maybe switch to psychedelics?

 

[spacejunk]

If you want to literally create a block, I found that taking a nootropic called noopept completely negated all effects of an mxe dose if taken in the day or so leading up to the trip.
Not like dosing an opiate addict with naloxone etc - just a whole lot of nothing, really.

If you are finding the psychological pull too much (I don't believe dosing like that would be good for your mental or physical health in the long term) - it might be worth considering.

As xorkoth points out - addiction is a powerful thing indeed.

 

[Asante]

Day 1. So far, no real craving to speak of, just tiredness and general boredness. I wouldnt be as bored if I wasnt too tired to do something though.

 

[phuckingnutz]

^ I feel you dude. Honestly, I was the same way.. until I ran out. Once I didn't have access to anymore it was relatively easy to stop dosing, but having grams sitting around the house led to compulsive dosing everyday...



MXE can be quite habitual in all honesty, not quite addictive in the classic sense but it is very easy to ignore the negatives that everyday dosing causes.

I've never done MXE, but a buddy and I got "hooked" on old school PCP...similar, no?... and finally had to run out to stop.

Getting "small" felt more normal than normal.

Actually,my friend quit when he became convinced he could change the traffic signals with his mind...scared the shit out of him.

Good Luck

 

[Ballz_Trippington]

Day 1. So far, no real craving to speak of, just tiredness and general boredness. I wouldnt be as bored if I wasnt too tired to do something though.

You can do it brother! After an extended break, I do believe its possible to be a responsible MXE user. I only dose once a month or rarely twice a month. If it's kept within that kind of use I don't think it's harmful in fact I think MXE can be very beneficial this way.
The key I think to get through this initial period is to occupy yourself with something else that you enjoy. There is much in life that's awesome besides MXE!
Remember that MXE is only a tool and it's meant to be utilized by you not for you to be utilized by it. You are strong and can do this!

 

[Sweetshare]

Hi all!

Did anyone notice a negative impact on cognitive function in the long term?

 

[dezz]

Well I have been using MXE on and off for a pretty long time now, regarding language and writing I notice that MXE actually IMPROVES the way I communicate. It's like I understand the purpose of words better or something and language just turns into a playground of witty remarks and puns. This is on a low dose by the way. When you go too far it all turns into one giant confusing pile of WTF lol. IME overall cognitive function decreases if you use too much. It just gets too confusing, it kind of feels like your walking on a cloud and everything is a little fuzzy. But to be honest I think ANY substance can have a negative impact on cognitive function if used in excess. Long-term however I have personally not experienced any changes in cognitive functioning. After the initial haze brought on by abuse my mind will get clear again just as it was before..

 

[THCified]

^ Exactly!

 

[osla4n]

I totally understand your problem with getting into tv and movies. It's like you don't see the characters in the movie, all you see is a bunch of actors trying to act. It can be very unsettling, like you're peeling off the outer layer of "movie" and you see how fake it really is. Often because of these effects I get stuck trying to figure out what kind of relationships there are between the actors instead of looking at the characters and following the actual movie. Sometimes they have milk-cartons for faces.

I don't usually get this effect though, only when I do too much for what's really mentally comfortable. I usually do several low doses untill I get "sucked into" the movie with the lights off and sparkly spacey-time tunnelvision.
MXE has enhanced movies and tv-shows alot for me, I now have special mxe-movies, mxe-tvshows and mxe-games that only make sense and are fun when I'm on MXE. Entertainment that in retrospect seem tailor made for the mxeican state of mind that I'd never get into if I was sober. Kinda odd stuff like Lexx or Wild Palms

Watch some old cheap or improvised movies, they might be easier to get into. Like Easy Rider or Goin' South. It's not reality, but it's more sincere, people are drunk and fucked up and do not follow the script so closely.

One movie suggestion, check out Johnny Mnemonic! It's an awesome ride that in my opinion really fits the wierdness of mxe. Also fun without drugs, Keanu Reeves' wooden acting actually benefits the film as the character Johnny. In the future where everything is hackable, smuggler Johnny carries 80 gigs of data in his head, and everyone wants a piece.
Don't watch Tetsuo

Y'all need to check out The Wrong Ferarri, I won't go into detail much but I will say that Ketamine was both a huge influence and major plot device, and it's also McCauley Culkin's best role. And I'm pretty sure it's the first film made with an iPhone.

 

[THCified]

Since discussing batches is something Mods don't want to see here @ BL which i respect and understand and so won't go into detail, i, out of curiosity, recently tried the said to be outstanding good, floury slightly off-white Stuff which lead me to just two possibilities regarding expectation and results, which are as following:

a. me being just too blessed by solely using two slightly different looking but potency-wise identical UK-Preban Variations or
b. everyone else saying the floury one being 'outstanding' applies only for those, unfortunately never had the chance to try those two specified in point a.

As said, i was just curious because at some point people were speculating about different synths probably having somewhat, even if slight different effects, but tbh i'm more than disappointed of this expected to be 'good stuff', especially because of the horrible, never ever before experienced side-effects the day after and the experience itself, which was lacking almost if not even every good thing i (we) love when speaking about this truly unique and phantastic substance.

Yeah, that's what i wanted to say and share with you and i honestly really hope it's ok with the rules.

As a sidenote i should add, that i'm sure that this is exactly what others are referring to as 'floury slightly off-white' MXE. At least it was a free Sample, even though that doesn't changes anything about my conclusion, of course.

 

[thikal]

Also, dissociatives do not mess with the areas of your brain responsible for giving pleasure and reward.

In my understanding, this is totally incorrect and dissociatives mess a lot with reward circuits of your brain!

 

[FlawedByDesign]

So my domestic source for mxe just received new stock but are not selling it yet due to a "concerning odor". Anybody have any guesses on what would cause this? Mabey some unreacted precusors or just a failed synth? I'm surprised as their usual mxe is the second best I've ever had.

 

[Delsyd]

Sometimes different batches of MXE can produce different effects. My most recent batch was the most anesthatizing that I've had, even small doses made me slur my words, walking was more difficult than usual and it made want to just lay there and soak it in kind of like ketamine. It was not the social MXE I'm used to. It was not psychosomatic, I've had enough MXE to know the difference.
I don't have any way of explaining the differences other than possibly there are some active byproducts left from the synth.
I used to believe all MXE is MXE, but a few batches have made me feel otherwise.

 

[Delsyd]

Also, dissociatives do not mess with the areas of your brain responsible for giving pleasure and reward. If you were addicted to opiates or stimulants I would probably say you shouldn't use them in the future.

I don't know too much about the neurochemistry of MXE but I would guess it does hit some pleasure centers, at least for myself and many others. The feeling I get when MXE starts kicking in is similar to how you feel when you take a piss after holding it in for hours. A feeling that makes you go "aaaaaahhhhhhhh."
But i agree that an MXE addict can end up using it responsibly. As someone that used it on a nearly daily basis except for breaks in between batches, these days I buy a gram every 2-3 months and use it all within one week than wait a couple months till I do it again. If the circumstances are right I'll usually achieve 1-2 hole like experiences and the rest of it goes to giving me a pleasant dissociative buzz. My tolerance builds almost immediately and holes become inachievable, and the euphoric buzz becomes more stupifying than anything else, and that's what makes me want to wait a couple months till next time.

Also I'd like to add that my "holes" after years of dissociative abuse have become far less deep and magical. They have become some sort of disjointed psychedlic recap of my life since my last experience.

 

[Folley]

I'd be very surprised if MXE did not affect dopamine in someway.. it was so euphoric when it first came out, people thought it had opioid activity! The fact that lower doses can be stimulating would also point to dopaminergic action, IMO. It's been said to be an SRI as well, hasn't it?



I'm looking around for the pharmacology of the drug now but I don't see any reliable sources.. I don't think any conclusion (based on proven fact) can be drawn for either side but it sure seams "pleasurable" and "rewarding" to me.

 

[vortech]

Folley I've been compiling lots of resources, basically everything I find I have been cataloging. I have been discussing the dopamine factor with some other researchers, and yes while it doesn't directly affect the dopamine reuptake transport system (but it does definitely effect the serotonin reuptake), there are other ways in which the effects can lead to increases in dopamine levels.
I brought up the question in this thread http://www.bluelight.org/vb/threads...istry-Pharmacology-and-More-Thread-V-2/page28

I'm confused why there is still so much confusion about the pharmacological actions of Methoxetamine. After this binding data was made public (http://www.bluelight.org/vb/threads/649843-Binding-data-for-popular-arylcyclohexamines/) people were scratching their heads because most had thought that it increased levels of dopamine in the brain, yet this binding data shows that there isn't any action that directly releases or inhibits dopamine reuptake. Is there some other way that it could increase dopamine levels? Maybe it only has an action at higher doses and this was tested with low doses? People were saying the same with the mu opioid affinity, that according to this it doesn't have an affinity, but maybe it does at higher doses (at least may be the case for ketamine).
Any clarification would be appreciated! Up until today I had thought MXE has DRI properties.

and this was the response I got:

Based on that evidence, we don't know whether MXE increases dopamine levels in the brain or not. All that we can say is that MXE doesn't increase dopamine levels by inhibiting the dopamine reuptake transporter. Or in other words we could say that MXE doesn't DIRECTLY increase dopamine levels.

There are plenty of INDIRECT ways that MXE could increase dopamine levels, none of which are ruled out by binding data. For example antagonism of NMDA receptors on GABAergic interneurons connected to the dopamine system could disinhibit dopamine release. In all likelihood the interaction is much more complicated than that. Here's a couple of reviews on the interaction between Glutamate and Dopamine signaling:

http://www.ncbi.nlm.nih.gov/pubmed/24735820
http://www.ncbi.nlm.nih.gov/pubmed/22763587
http://www.ncbi.nlm.nih.gov/pubmed/24409148

Also keep in mind, with the possible exception of 5-HT2A psychedelics, every single recreational drug increases striatal dopamine levels, and only a small proportion of those do so through a direct mechanism (see the 3rd review posted above). With that in mind it would be incredibly strange if MXE didn't increase dopamine levels in the brain, considering how readily people take it.

 

[Asante]

There is a balance in the brain between Serotonin and Dopamine so if a drug acts on serotonin it almost invariably has dopamine effects, if not directly then by altering the 5-HT/DA balance.

I ended up calling friends and handing my stash over with the agreement they'd "feed me" bitesized chunks twice a month for the moment. on the 30st I got my first chunk, 0.2gr MXE. The friend had brought some from my original stash from way back in the beginning, original euro MXE from 2011, first dose April 1 2011. I had had a tolerace break of several days and took 40mg rectally. Tolerance had reverted considerably, the dose was cutting edge! The scope of the effects was wider cause of tolerancec reversion which was beautiful but my point pertaining to the previous posts: the 2011 Euro MXE of my initial "virgin batch" was give or take almost identical in effects, potency and nature as the latest 2014 Asia MXE of the "maegashira batch" (these designations are personal ones which reveal nothing about vendors at all, so I think the mods will allow) that I did the end of my binge on and indeed throughout the 4.5 month binge I nibbled not just from them but also from my "Karma batch", "Big batch" and "God batch" which were bought from varied vendors throughout the years since beginning 2011 and I couldnt assign a specific nature to any of them that held up to scrutiny of repeat precision dosing.

I kept these batches separate under -20'C freezer condition in glass vials. Some are more fluffy, others more dense. Some almost pure white, others offwhite. Some left a very few poorly soluble tiny crystals upon dissolving of one 40mg dose in about a ml of lukewarm water, others dissolved more readily and completely. But the relative potency and nature of the effects were almost identical to one another. I think people had bad luck with cut, impure or falsified batches, but in my experience the session-to-session effects of MXE of any batch vary more greatly than that I can discern tangible differences in the nature of the effects between distinct batches.

In case someone wonders where these off-the-wall batch names come from, whenever I got a new batch I had a few exploratory sessions and based on the nature of them, the batch got a name. I kept them separate on case if there were qualitative effects, but moreover in cases there should be differences in stability over longterm storage.
Here's a legenda of my fantasy batch names and explanations:

Virgin Batch / Small Batch this was my initial purchase, for my "virgin test" ie the first test of a new drug.
Karma Batch the vendor had sold me MDPV instead of MDAI and I ended up taking a 300mg oral dose of this. Whopping overdose, ambulance, ER, 1 day hospital stay nightmare. I told the vendor of my misadventure and he was very apologetic and because of his sense of guilt and I guess my lack of blame he offered me a sizable amount of an RC of choice, this was to be MXE which I christened "Karma Batch" because of the bad misadventure and good karma of the forgiveness and him paying it forward.
Big Batch I think thats rather obvious, MXE had gotten my drug of choice and I secured a larger batch thereof, the least imaginative name.
God Batch This particular batch initially and generally proved itself to be all about my quest for God. In the initial session I caught a glimpse of two Chinese chemists having a discussion in chinese next to a 20 liter roundbottom flask on a heating mantle where the heating of the last precursor rearranges it into MXE, the MXE this batch was from. Most doses I took I took from the God Batch and they have been rife with insights into the nature of the cosmos and a getting closer to the Godhead. The God Batch gave me strong communication with my higher self ("God consciousness") and this resulted in me walking out of a lifelong smoking habit without as much as a single craving, a miracle foretold and made to be by strong interaction between my God Self and me.
Maegashira Batch This last and final batch, like the God Batch, was an Asia batch. Upon the first session, after several doses, I had a vivid closed eye visual of a Maegashira sumo wrestler in mawashi stomping towards me with loud audible cracks of his wooden geta sandals on a stone floor and giving me an audible power talk in Japanese which my mind translated as: "I'm the spirit of this batch. I come in the guise of a Maegashira because you and I are going to tangle, I'm going to rough you up good, for your own good, and teach you many things with that, including how to lose weight and how to keep it off. For this I need your full commitment. ARE YOU WITH ME?" I affirmed strongly, he slapped the band of his mawashi hard with both hands and vanished. With that powerful vision, how could the batch get any other name than "Maegashira Batch" ?

I need to point out that the God Self makes house calls on any batch, and that two sessions of MXE are more different individually than there are tangible differences. Its one drug, its one mind. I don't buy into that normal syntheses produce serious differences in R/S ratio, if theres any difference in batches of MXE it has to be the influence of either the final precursor or the wrongly rearranged 3-methoxyphenyl-(1-methylaminocyclopentyl)ketone, the "weird methcathinone" reported to be found by the DEA in an impure sample. That could arguably be psychoactive in its own right, possibly a stimulant which would obviously alter the nature of the effect.

In my experience, with 90+% pure MXE, I saw no tangible differences.

Well, my early May MXE has been used, and the mid-May nibble is on its way. I must say there isnt much trouble at all with it, there was coming right off the binge but after my 200mg excursion, nope, it didnt arouse my inner glutton.

 

[xammy]

Is it safe to take 5-HTP the same night you've taken MXE? to get sleep