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The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

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Folley said:
I'd be very surprised if MXE did not affect dopamine in someway..
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vortech said:
Folley I've been compiling lots of resources, basically everything I find I have been cataloging. I have been discussing the dopamine factor with some other researchers, and yes while it doesn't directly affect the dopamine reuptake transport system (but it does definitely effect the serotonin reuptake), there are other ways in which the effects can lead to increases in dopamine levels.
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Well, considering that both PCP and ketamine are DIRECT dopamine d2H agonists, i guess it's safe to say that mxe is also a DIRECT agonist at the d2H receptor (especially because it's more stimulating than ketamine).

http://www.ncbi.nlm.nih.gov/pubmed/15852061
 
Right off the bat, I'm not sure but personally I have good experiences with coming down a bit then taking a single drink of alcohol before retiring. This tends to make the mind less chaotic and more conductive to sleeping. Don't drink more though.
 
I like to combo alcohol, MXE and cannabis. These 3 create great synergy but careful with the amount of alcohol. Never had a negative reaction but I try to drink slowly when dosing MXE.
 
Ballz_Trippington said:
What's the maximum ammount you'd drink alcohol with MXE?
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I think a bottle of wine and a few beers over the night is the maximum I've done. But that's more than enough. I usually stick with just a few beers. I think spirits could cause problems.
 
xammy said:
I think a bottle of wine and a few beers over the night is the maximum I've done. But that's more than enough. I usually stick with just a few beers. I think spirits could cause problems.
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You must have a hefty alcohol tolerance! I would not recommend nearly that much as a safe amount to combine with MXE. For me, a person who drinks alcohol only a few times a year, I can have no more than 1 drink per hour or two or things go downhill.
 
vortech said:
You must have a hefty alcohol tolerance! I would not recommend nearly that much as a safe amount to combine with MXE. For me, a person who drinks alcohol only a few times a year, I can have no more than 1 drink per hour or two or things go downhill.
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Yep I didnt recommend it, its just max amount i've done. It was actually when I had drank 4 days in a row so yep, there was certainly some tolerance. Usually 2-4 beers is enough with MXE for me. And I always dose MXE first and then drink slowly, I think taking MXE while drunk would be a very bad idea. Everyone should tread with caution when combining MXE with anything. Cannabis also potentiates it very much.
 
I miss MXE so much :( tonight would be the perfect night to get wonky..


WSH said:
Well, considering that both PCP and ketamine are DIRECT dopamine d2H agonists, i guess it's safe to say that mxe is also a DIRECT agonist at the d2H receptor (especially because it's more stimulating than ketamine).

http://www.ncbi.nlm.nih.gov/pubmed/15852061
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Well, MXE doesn't share all the same receptors as MXE and PCP. So, maybe not. It's hard to say without more information on hand (or the ability to reliably decipher that information :sus: )
 
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getting wonky <3

I'm so glad that is a term used by other people. all my friends like to call it that we want it to catch on lol
 
I did 35-40mg last night nasally with a few beers and a few bowls of ganja. Oh wow, that was intense. Almost hole, definitely sub-hole. Its amazing how I feel like I'm moving when I'm laying still on my bed, and if I check if I move only my finger moves but it feels like my whole body is fucking flying around with the music. Sometimes it feels like I'm melting into the bed.. extremely euphoric. Can't achieve that state without cannabis I'm afraid.

Cool stuff.
 
I want to share all the references I've collected so far relating to methoxetamine studies, whether it be relating to pharmacology, phenomenology, case reports of toxcity etc. Also articles relating to the other arylcyclohexylamines. I've also started a list of articles that may provide insight into the psychedelic mind, this is definitely not a complete list so please inform me if you know any good ones!

http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs
http://www.justice.gov/dea/pr/microgram-journals/2012/mj9-1_3-17.pdf
The Characterization of 2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone (Methoxetamine) (Microgram Journal 2012;9(1):3-17)
http://www.ncbi.nlm.nih.gov/pubmed/24574323
Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine.
http://www.ncbi.nlm.nih.gov/pubmed/23774830
Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn.
http://www.ncbi.nlm.nih.gov/pubmed/23552616
From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices.
http://www.ncbi.nlm.nih.gov/pubmed/23527166
The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
http://www.ncbi.nlm.nih.gov/pubmed/24580056
Clin Toxicol (Phila). 2014 Mar;52(3):176-80. doi: 10.3109/15563650.2014.892605.
Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice.
http://www.medical-hypotheses.com/article/S0306-9877(12)00312-X/abstract
Methoxetamine: From drug of abuse to rapid-acting antidepressant
http://onlinelibrary.wiley.com/doi/10.1111/cns.12063/abstract
From “Special K” to “Special M”: The Evolution of the Recreational Use of Ketamine and Methoxetamine
http://www.tandfonline.com/doi/abs/10.1080/02791072.2013.803647#.U1L2v1f4L78
Methoxetamine (MXE) – A Phenomenological Study of Experiences Induced by a “Legal High” from the Internet
http://www.ncbi.nlm.nih.gov/pubmed/23349353
Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK's first Temporary Class Drug Order).
http://onlinelibrary.wiley.com/doi/10.1002/hup.1242/abstract
Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine.
Hum Psychopharmacol. 2012 Mar 05;27(2):145-9.

Case Reports/toxicology reports

http://www.ncbi.nlm.nih.gov/pubmed/22578175
Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation
http://www.ncbi.nlm.nih.gov/pubmed/22237166
Ketamine-like effects after recreational use of methoxetamine.
http://www.ncbi.nlm.nih.gov/pubmed/23111916
An accidental fatal intoxication with methoxetamine.
http://www.ncbi.nlm.nih.gov/pubmed/22993747
Out with the old, in with the new? Case reports of the clinical features and acute management of two novel designer drugs.
http://www.ncbi.nlm.nih.gov/pubmed/22205276
Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine.
http://www.ncbi.nlm.nih.gov/pubmed/24528118
J Forensic Sci. 2014 May;59(3):854-8. doi: 10.1111/1556-4029.12407. Epub 2014 Feb 15.
A polydrug intoxication involving methoxetamine in a drugs and driving case.
http://www.ncbi.nlm.nih.gov/pubmed/24466717
[Acute methoxetamine intoxication--a case report with serum and urine concentrations].
http://www.ncbi.nlm.nih.gov/pubmed/23243943
Accidental intoxication with high dose of methoxetamine (MXE)--a case report.

Articles relating to other arylcyclohexylamines and other relevant psychedelics studies (definitely not a complete list, add references of relevance)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952483/ (full article)
Ketamine as the prototype glutamatergic antidepressant: pharmacodynamic actions, and a systematic review and meta-analysis of efficacy
http://news.yale.edu/2014/04/13/new-finding-suggests-way-block-stress-damage
New finding suggests a way to block stress’ damage [ketamine]
By Bill Hathaway
April 13, 2014
http://www.jneurosci.org/content/33/38/15171.short
Broadband Cortical Desynchronization Underlies the Human Psychedelic State
and an article referencing the above article : http://embor.embopress.org/content/15/3/208.full
Mind‐altering drugs and research: from presumptive prejudice to a Neuroscientific Enlightenment?
http://www.ncbi.nlm.nih.gov/pubmed/24470121
New psychoactive substances as adulterants of controlled drugs. A worrying phenomenon?
http://www.ncbi.nlm.nih.gov/pubmed/24573920
An investigation of the stability of emerging new psychoactive substances.
http://www.ncbi.nlm.nih.gov/pubmed/22673201
Novel psychoactive substances: how to understand the acute toxicity associated with the use of these substances.
http://www.cell.com/neuron/abstract/S0896-6273(04)00608-7?cc=y?cc=y
LTP and LTD: An Embarrassment of Riches
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859735/ (full text)
Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089985
Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan

Edit: another interesting one:
http://www.cell.com/neuron/abstract/S0896-6273(14)00260-8
Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

I have the full text for most of these articles so if you want to read one and can't find it send me a PM.
 
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Can anyone expand on the "acute cerebellar toxicity" mentioned in "From Special K to Special M" above? Is this with prolonged high doses in lab animals?
[h=1][/h]
 
BillLee123 said:
Can anyone expand on the "acute cerebellar toxicity" mentioned in "From Special K to Special M" above? Is this with prolonged high doses in lab animals?
[h=1][/h]
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Nope, it was with human beings and the doses weren't very high (0.16-0.45mg/L in serum):

Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation

Methoxetamine may cause rapid onset of neurological impairment, characterised by acute cerebellar toxicity. Spontaneous recovery was observed, but the duration of recovery may extend to several days. Presentation with an acute cerebellar toxidrome should alert clinicians to the possibility of methoxetamine exposure.
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Two more patients aged 17 and 18 years presented with severe cerebellar ataxia, imbalance and reduced conscious level 40 minutes after nasal insufflation of methoxetamine (MXE). Both had slurred speech, incoordination and cerebellar ataxia that resolved within 24 hours.
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Sounds pretty normal effects of MXE. But how dangerous is temporarily cerebellar ataxia? Does this mean the same thing when u are drunk of alcohol, coordination problems? Or something else?

Isnt this the same thing that causes claudication that alcoholics often suffer?
 
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xammy said:
Sounds pretty normal effects of MXE. But how dangerous is temporarily cerebellar ataxia? Does this mean the same thing when u are drunk of alcohol, coordination problems? Or something else?

Isnt this the same thing that causes claudication that alcoholics often develope?
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Cerebellar ataxia apparently only means "an inability to coordinate balance, gait, extremity and eye movements", so yeah, that's definitely pretty normal for mxe.

Vortech, do you also have the full text for this study? It would be interesting how they diagnosed these things.
 
Ahh gotcha. Reminds me of the media bullshit "cannabis psychosis" where stoned people reported paranoia or that they felt a moment was imbued with special meaning...technically "psychotic symptoms," but most would call it "being high."
 
"Acute cerebellar toxicity" is just a more scary way of saying intoxication. The toxin is having an acute effect on the cerebellum, the area of the brain involved in motor coordination. Toxicity does not always mean damage.

Acute means short term so really the article just described the subjects as being intoxicated temporarily by MXE.
 
It is my understanding that the presumed acute cerebellar toxicity was established purely on clinical grounds and was not confirmed by MRI etc, so that no actual cellular impairment was observed. In such case, it is quite misleading to use this term IMO, since what sounds(to me) as histological diagnosis almost is in fact a speculative conslusion drawn merely from observational assessment.
 
A large percentage of the content in these articles published in scientific and medical journals is composed of technical and clinical-speak which isn't very translatable to the average user, as exemplified by the 'acute cerebellar toxicity' term. That's why I'm writing a guide for the average researcher that distills this information into a more comprehensive form.
 
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