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The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

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afer said:
It is my understanding that the presumed acute cerebellar toxicity was established purely on clinical grounds and was not confirmed by MRI etc, so that no actual cellular impairment was observed. In such case, it is quite misleading to use this term IMO, since what sounds(to me) as histological diagnosis almost is in fact a speculative conslusion drawn merely from observational assessment.
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Yeah all they did was ECG, blood work, etc. Here's the full text (click view below and to the right). I'll stress that I'm no doctor, but as far as I can tell using simple searches and some reading none of those readings is particularly worrisome, especially considering there's not that much consistency in the "atypical ranges" between the different MXE "overdoses," and all the levels returned to normal within hours to days. The high blood pressure is par for the course with the acute effects of stimulants as well as nearly harmless drugs like cannabis (not to mention panicking because you're freaking out in a hospital). As mentioned by others, the terms not associated with physiological measures are medical ways of saying "MXE works to fuck you up." They can indicate serious problems in the right contexts, but in the context of a dissociative related to another strong enough to use for field surgery I think you can expect a lot of behavioral incompetencies.

I think if MXE is a serious physical health threat to its typical users the substantial damage probably comes with long-term chronic use, or shorter term chronic use with extreme doses, as with ketamine.
 
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Hey all mexaholics and other heads. I've been on a 10-day run of daily use, and I will probably keep going (with small breaks) till I run out in a couple weeks. I'm amazed how my tolerance hasn't really grown much. The effects have changed a bit since the first day as my brain has adapted, but it's still fantastic. I've been working on my MXE guide book, a travel companion of sorts to help users get the most out of their journey. It is based on my years of travel to the holey land and the vast volumes of research and trip reports I'm finding on the Net. I'm inviting all others to contribute their nuggets of MXE wisdom if they so desire.

On a related note...I gave MXE to my cat last night. I know I know, it's stupid and unsafe to give drugs to cats, but at the time, in my MXE-colored judgement, I thought it was the best idea ever. So I dissolved 3-5 mg (I don't have the best scale) into his lactose-free milk, and he sipped it up. He didn't drink all of it, but about 20 minutes later he perked up a bit with a general interest in everything. He played with a laser pointer for a minute and then wanted to go outside. I followed him around the perimeter of the house to make sure he was all right, and then we chilled on my front porch for a few minutes. By this time I noticed his balance was starting to go off, and he was purring constantly. I took him inside and within a few minutes his balance really started to go wonky. His back legs seemed the most wobbly. I set him up on my bed and cuddled for a bit, but he got restless and ended up just wobbling around in circles for a few minutes. He was super docile though, so I picked him up and took him to his chair where he usually sleeps. He was very happy to find himself transported there, so he switched into chill mode and went off to sleep- Slept like a baby. He usually meows in the morning before I get up, but when I woke up at noon he was still asleep. When I woke him up he seemed to be feeling great, totally normal without any lingering side effects.
Please don't give MXE to your cat. This was purely for research.
 
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I've grown bored of MXE nowadays.. And I think that's not a bad thing. It's time to re-evaluate my drug use in general
 
Uh... Don't ever drug your cat again. They react very differently to medication than humans. Just look at morphine. Don't do that again. A cat cannot consent to the experience.

Here's some anecdotal information. Long story short, I have a full PSG available to me from time to time. Tried a 6 hour study with MXE taken about an hour before sleep onset. (25mg,normal dose rectal for me).

No S3 or NREM3 or whatever the AASM is denoting delta wave sleep as nowadays. Ultra short REM period of about 15 minutes towards the end. REM aborted for no discernible reason, returned right back to stage 2 sleep. No respiratory disturbance or limb movement precipitated it's termination.

Had no such issue when using ketamine in the same method.

Bear in mind this is one person, me, who is a poly drug user. Also keep in mind that an insane multitude of factors affect your sleep architecture.

I doubt anyone thought MXE improved their sleep and I'm sure taking it several hours before sleep onset would have made all the difference. Nonetheless, I present my findings.
 
JBrandon said:
Uh... Don't ever drug your cat again. They react very differently to medication than humans. Just look at morphine. Don't do that again. A cat cannot consent to the experience.
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I know, it was an utterly retarded act, and I will definitely never do it again, but if it makes it any better, I did do my research beforehand. Ketamine has been used clinically to anesthetize cats for a long time, so I was confident enough that I wasn't going to hurt him. Trust me, now that I am sober today I feel bad for doing it and taking the risk. Thankfully, my kitty is doing well today, happy and going about his cat ways.
 
If anyone hasn't seen this great article regarding MXE and the RC scene by a journalist who acted as a vendor and had a lab synth his compound hasn't read this, please do.

https://medium.com/p/19f753fb15e0

One of the reasons I bring it up is it states there have been atleast 2 deaths linked to MXE. If I recall one was someone who mixed it with MDAI or Methylone, possibly both. I'm just curious about the details as harm reduction.

Second, apparently there are a ton of states with legislation to ban MXE soon. Are we allowed to discuss what states are considering it? I can't seem to find the info on my own.

Regardless it's time everyone stocks up. Don't delay and it will be banned eventually (we all knew it was coming).

Really pisses me off as I really don't want to go back to Ketamine which I can get just as easy.

P.S. DO NOT PM ME FOR SOURCES; YOU WILL BE INGNORED
 
Isnt it banned already in most countries? Well, that doesn't make any difference to me whether it's legal or not. Of course I would prefer it to be legal to possess like any other drugs. But I'm certain there will be plenty of MXE around despite its legal status.
 
From the article: "“The guy had faceplanted in a quantity of white powder,” he says. “It was everywhere, all over his face. Like Scarface. The patient was out of it, but very happy.'. LOL!

Regarding the legislation to ban MXE, I know that Arizona has recently banned it. Source: http://legiscan.com/AZ/text/HB2453/2014
Something odd I noticed though is that there is an apparent error in the chemical name.
From the bill:
(xliii) 2-(methoxyphenyl)-2-(ethylamino)cyclohexanone(Methoxetamine).
(xliv) 2-(methoxyphenyl)-2-(methylamino)cyclohexanone(Methoxyketamine).
(xlv) Methoxyphencyclidine(MeO-PCP).

Isn't MXE 3-(methoxyphenyl)-2-(ethylamino)cyclohexanone?

Despite this, they also added this to apparently cover ALL PCP analogues:
(lvi) Phencyclidine mimetic substances that are any substances derived from phenylcyclohexylpiperidine by any substitution at the phenyl ring, any substitution at the piperidine ring, any substitution at the cyclohexyl ring, any replacement of the phenyl ring or any combination of the above.� Substances in the phenylcyclohexylpiperidine generic definition include Amino-PCP, BCP, Bromo-PCP, BTCP, Chloro-PCP, Fluoro-PCP, HO-PCP, MeO-PCP, Methyl-PCP, Nitro-PCP, Oxo-PCP, PCE, PCM, PCPY, TCP and TCPY.�
 
It's banned in most countries, been banned in Denmark for 2 years. Hasn't stopped me from ordering it.
 
As a general harm reduction statement, if you use MXE with any regularity, cannabis should be used with extreme moderation. Looking around in my research (and also including my anecdotal evidence), things often go south for people who are not very careful about combining the two. Cardiac effects such as rapid heart rate, high blood pressure, heart skipping beats, panic attacks, anxiety, delusions, all of these reports are from people who combine MXE with cannabis (and especially synthetic cannabanoids) too casually. The reverse statement should also be said, that if you use cannabis or synthetic 'noids with any regularity, MXE should be used with extreme moderation.
 
^ I never had any problems and I never once did MXE without smoking weed. Some people are prone to getting anxiety from cannabis.. some just aren't. It's the same with every other drug. Some people can't handle weed on psychedelics, while some people like myself can't handle psychedelics without weed.
 
Different strokes for different folks. As a rule, increasing the number of variables increases the chances of unexpected results. Discretion is advised when combining these classes of drugs.
 
Some people are prone to getting anxiety from cannabis.. some just aren't.
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Thats not the whole story. Most people who are prone to anxious cannabis reactions werent prone to that at all, until they used it together with a psychedelic or a dissociative, or had a long abstinence, and POW! Anxiety issues, often to the point of having to quit.

If you want to remain enjoying your weed don't combine it with psychedelics or dissociatives and dont use it too erratically. You may permanently ruin weed for you.
 
^Yeh, weed potentiates the FUCK out of dissos. I can't tell you the amount of times where I've dosed MXE or K, started to come up, feeling wonky but very in control....until I smoked weed, which blasted me off into "what the fuck" land.

But don't get me wrong...I enjoy "what the fuck" land ;) just not everyone does. And that's totally okay. Most psy/dis users that I know also smoke cannabis regularly, and as far as I know there's nothing PHYSICALLY unsafe about the combo. But yeah, if you're sensitive to weed, or prone to anxiety on weed or psychedelics or whatever else, then tread with extreme caution when combining the two. As for me personally, I couldn't imagine MXE WITHOUT weed, the two synergize in such a beautiful way for me. I've yet to have an MXE trial where I haven't smoked weed....maybe I should, for the sake of science, but god damn do I love my weed.
 
Alright. this was a big decision.
(Lots-a organic Primo weed & hash vaped throughout hourly). Low tolerance (post-rehab 120 days)
I spent the night researching a simultaneously, 1 each 150mcg LSZ and AL-LAD, Quite experienced, come up felt like forever, for the longest time, when will that psychedlic barrier, this embryonic psychic membrane somehow that officially bookends the trip the ego loss Oh god please don’t let me be stranded sub-threshhold…
……..OKAhhhh…
Now enter tha MXE.
I Don’t think this is necessarily safe or recommended, but, maybe neuro-plasticity will create some new branches or whatever….but…not good…. for 2 hours or so, racy, just scattered & stimmy pretty clear headed, a few gastric anomalies with the Al-LAD, which is rare; get, after 2mg Xanax helped immensely (recommended), Then, I entered a state of zen. very nice and personal. Just a visitor, but I had access to a wondrous arrangement of just the dust and bones of the earth at the end.
Where all that is or ever was or will ever be Exists.
Does anyone wanna know what I saw?
Heres what i Reckon. The Earth right? It was supposed to be a perfect life and energy creating and storage device, perhaps a “battery” for lack of a better term, the magnetic molten urn core, Pyramids as some type of terminal connections, silly gum ball, perfect bit of life, From some grand design, or maybe organic nature of the earth that life occurs in the universe. The moon is the most likely culprit, a cataclysmic collision. We are all living on a smashed up version of whatever terrra-formed or naturally perfect planet/life form power plant. Perhaps, and really I’m just as skeptical. But if this supposed Pangea Supercontinent did actually exist, and all these pyramids that keep appearing in patterns that would suggest that perhaps 144,000 of them built on the lay lines of the earth, dealing with the global energy
Thats what I took from it, why pyramids? Scientifically they do give off detectable energy.
Maybe earth was perfect till it collided with the moon. And only God can intervene in cataclysm.
So in order for survival, the man must free himself of earthly bonds and understand the nature of cataclysm, chaos, gravity, and time.
Maybe this is just nonsense, It just came to me. I Imagine earthquakes
Enjoy, ridicule, whatever, I thought it was interesting and shared it. A bitt too intense
Typing is hard on MXE
 
Hello, I suffer pretty severe tinnitus, and right now, pre-hole MXE dosage is causing my normally monotone ringing in my ears, to pulsate, rather than one note continuing. Hmmm now the pitch and timbre are changing in intensity and pitch. Guys this is really freaky, my 20 years of ringing ears turned into some pulsing tweaky theremin symphony. If only you would hear what I’m hearing, how do I introduce this into dr conversation? But realls y’all, if you got tinnitus, maybe there’s a genius somewhere that could benefit from MXE’s effects on it?
 
I dabbed with MXE. Heres my post from the 11th chapter, crazy to see how we're on 18th:
I had a fair time with MXE over the course of a month. I had in posession 1gr MXE and I would orally dose 10mg durning my first days. It provided a "mind booster"-high that made me content and very nice. I would redose to around 30mg and that'd provide for a interesting experience.
About a week later with little MXE use, I had a lot of days for myself and I'd insufflate MXE starting with 15-20mg every hour. This increased to 30mg an hour at the end of the month, where I did most of the MXE. These low doses were nice because I was still socially able to function, but also felt different, better almost, free of depression. This "glow" would linger for up to 48 hours.

I never crossed the 60mg line, though my biggest bump must've been 40-50mg and that got me really dissed. The effects can be described as watching yourself from third person and can be really "odd". Sound is really enhanced, but it's a flat sound and not really "better" and after a night of gaming on MXE and smoking weed, I would be so annoyed by my PC's noise that I decided to sleep. Slept easily, but laying in this "anaestethic" state in your bed, like you're lavitating, is interesting and scary at the same time.

I can say that the drug is incredibly fiendish, but seems physically benign. I had no adverse effects from daily use. I always dosed low and got a bit of tolerance it.

Tl;dr Good chem with likable effects. But I always dosed low (20-30mg bumps) and I never got quite into being dissed for several hours, but the 20 min opiate high makes you redose like mad.
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Since then, I've done MXE a few times. Still absolutely love it. The contentedness and the bliss are very nice effects. I still haven't holed and I don't intend to. I have 3 grams coming in soon; I can't wait. I absolutely despise alchohol, it has such gnarly side effects and especially after effects. On MXE, I can function normally, while being very happy and feeling very well. Walking amongst nature is the best. I will still do 20-35mg bumps.

Only negative, as poster above mentioned, is the extreme sound amplification. My PC fan drives me nuts, although headphones sort of fix that, but I'm not a headphones guy as I prefer speakers (Audioengine A5+ HYYYPE). Anywho, I'll let you guys know when it arrives (tomorrow, wee! Hopefully..) and how my dosages work and how the effects work.
 
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