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The Big & Dandy Methoxetamine(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) Thread

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I think those are great questions that people should as themselves everyday in order to live a happier life.

Im pretty sure swim will have 250mg of this to try tomorrow or the day after. anyone have any preferences/advice as to safe experimenting with this material? swim plans to dose sublingually with 35-40mg, in a comfortable and tranquil, meditative type setting in swims bedroom
 
^Sounds good to me, haven't tried sublingual yet but it is said to come up faster so you could start a little lower and see how you feel from there.
Have fun and let us know how you get on.

No need to swim here we know it's you :)
 
lmao okay, I havent been posting on here for very long. rather be unnecessarily discreet than get banned by accident. yeah the only reason i wanna do a lil more than the average sublingual dose is because Ive done quite a bit of DXM. not recently but i tend to need a shit ton more of everything to have an effect on me as well. sucks balls. so expensive. :(
 
calculateddesign said:
lmao okay, I havent been posting on here for very long. rather be unnecessarily discreet than get banned by accident. yeah the only reason i wanna do a lil more than the average sublingual dose is because Ive done quite a bit of DXM. not recently but i tend to need a shit ton more of everything to have an effect on me as well. sucks balls. so expensive. :(
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Don't measure this compound by others - really, start low and see how it goes - you can always up it at a later date but word has it to resist redosing as the half-life's long :)
 
Problem is half life appears longer than experience so it might lead up to an additive effect. Not as bad as the stimulated mania after 3-MeO-PCE etc sessions.

Dark, tranquil and comfortable setting sounds perfect. I actually found out that the chances for having spiritual enlightening experiences are much bigger if invest some time in preparing the experience. Actually, I fully understand what cosmic-ape means. Experiences appear to wary wildly, from boring to highly spiritual, this even happening within the same subject. Somehow this compound needs the same careful treatment likes a 5-HT2 psychedelic.

And wait Jam until you shoot 40mg i.m., forget thats its an opiate, it foremost is a dissociative.Dosed once in a very close time frame a similar amount of K and if have taken blindly , Idon't know...Btw I never had itchings (which I already get from >50mg Desmethyltramadol.) A comparable dose of 40mg Methoxetamine would be maybe 100mg Ketamine altough there appears more lucidity/mobility possible with Methoxetamine. But direct comparisons are anyway moot as its a different compound.
 
im not redosing with it, ew. just trying to get a good hit right the first time and visit methoxetamineland. 35mg isnt a high dose but it seems like a quite pleasant level of intensity. my dxm tolerance crossed over to ketamine which i tried the first time about 3 weeks ago.
 
Can anyone explain to a relative idiot the nature of half life and how it relate to addictiveness?
 
calculateddesign said:
im not redosing with it, ew. just trying to get a good hit right the first time and visit methoxetamineland. 35mg isnt a high dose but it seems like a quite pleasant level of intensity. my dxm tolerance crossed over to ketamine which i tried the first time about 3 weeks ago.
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My first time with this chem I was cautious and started at 10mg snorted and bumped another 10 mg every 15-20 mins till i hit my level (50mg) after an hour or so.
The second time I jumped right in with 50 and it didn't really hit me any harder or faster so don't feel you have start with a big dose to get the full effects, you can start low and work your way up without diminished effects.
The reason I was advising caution is because there are not many reports on sub lingual administration at the moment and I haven't personally tried it, if you were snorting i wouldn't hesitate to say 50mg should be fine.
 
this is NOT always true but in general it seems as if if substances which have shorter half lifes that cause a "crash" to be moreish and addictive (crack, meph) while things with longer half lives like LSD tend not to be addicting. Im comparing radically different drugs here but its just trying to get my point across. i.e. longer acting drugs like DXM, PCP or whathaveyou (doesnt have to be a dissociative) have relatively longer half lives but can still induce addictive tendencies. Honestly its a mixture of the half-life and the affinity the molecule has for dopaminergic receptors as well, these receptors have been implicated in desire to repeat the experience.
 
^I thought ketamine only bound to mu receptors at anesthetic doses. I always figured it was the it's non-committal high and the ability of users to use it to escape various types of psychological and physical pain that was predominately responsible addiction to it.

Is it possible that those with high tolerance take enough to induce mu agonism without being anesthetized?
 
A friend analyzed a sample of "methoxetamine", it was not from the original vendor that does not deal with US customers. Here is what he told me:

I performed GC/MS on the sample and it is definitely NOT methoxetamine as it definitively contains a thiophene (M-85). It seems to be TCM that is a 1-thiophene-cyclohex-1-N,-methylamine (MW 195). Again you can't tell with certainity without NMR but based on my experience with related compounds I'd bet a large sum that is what it is. There is some serious mis-marketing going on. It did seem to be of high purity though.
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Someone seriously needs to identify these vendors by full name and address in the appropriate forums in some kind of verifiable and certain way so that they're less apt to pull this kind of shit. They need to fear customer's vengeance.

So is M-85 a thiophene derivative then? From my hasty ignorant searches it ostensibly looks like a sigma 1 receptor agonist.

This is what wiki says about sigma receptor (1 and 2 I presume) agonist's physiological effects:
Physiologic effects when the sigma receptor is activated include hypertonia, tachycardia, tachypnea, antitussive effects, and mydriasis. Some sigma receptor agonists--such as cocaine, a weak sigma agonist--exert convulsant effects in animals. Behavioral reactions to sigma agonists are rather heterogeneous: some individuals find sigma receptor agonists euphoric with significant anti-depressive effects. Other individuals, however, experience dysphoria and often report feelings of malaise or anxiety.

Recently selective σ–receptor agonists were shown to produce antidepressant effects in mice.[7]
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^ I assumed that "M-85" refers to point on the analysis graph, and that the substance in question would be "TCM", which if I'm not mistaken is effectively the N-methylated analogue of Tiletamine. I'm not sure how GC/MS works in terms of accuracy but I wouldn't be surprised if it is, in fact, Tiletamine, as I have reason to believe N-methylated cyclohexamines (eg. K) are even more difficult to synth than ones with other alkyl groups. Chemists please correct me if I'm wrong :).

Oh: And about mu-antagonism, well 3-MeO-PCP supposedly has more affinity for that receptor than K, yet it is not anaesthetic at any currently-known dose.
 
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Oh I see. My search had come up with this:
The thiophene derivatives show high selectivity for the σ1 receptor over NMDA, 5-HT1A, 5-HT6, 5-HT7, α1A, and α2 receptors...
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http://pubs.acs.org/doi/abs/10.1021/jm8007739

So I assumed when ham said "a thiophene" that that indicated there is a class of compounds referred to as thiophenes, and that the mystery compound is one of them.
 
Works well with 5-HTP, noticeable change in effects with this week's 25mg test compared with last week's test of the same dose.

Anyone combined this with MDMA, are there any possible risks theoretically?
 
I kinda suspected something like this when all these glowing reports starting coming out, with dissociatives it's prudent to be weary about sources and possible mis-labeling. Mainly because there's less known about them, but there's also less mental content to distinguish them from one another like with 5-HT psychedelics. Especially while in the dissociated state or afterglow stages, reading and comparing reports goes something like: "So is my mental card-deck being reshuffled the same as these other people's decks?" ...You guys know what I mean :P It sometimes takes a while to tell what's what, especially with substances of unknown half-lives.

At the same time I'm still very interested in what everyone has to say about "mystery dissociative X" and will be curious to find out what it really is, if not methoxetamine. Whatever happened to good old fashioned ketamine and morphine? I kid, I kid...
 
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