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The Big & Dandy Medication/Supplement Interaction Thread

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Booze with Wellbutrin would be a no-no. Wellbutrin slightly increases one's risk of seizures and when combined with alcohol your risk is further increased. Wellbutrin with yayo or any other strong stimulant would be of course an idiot idea and you'd be asking for a high blood pressure and pulse. Wellbutrin with MJ has seemed fine to me, though, yeah, I've heard of some people who get panicky from the combo. As far as 2Cxx's and other psychedelics none of these would be completely safe with Wellbutrin. You'd be taking 2 substances that both can raise your pulse and blood pressure and cause other stimulant side effects. If you just quit your Wellbutrin for a day or a few days it prob. would be out of your system anyway. Also since you take such a low dose of Wellbutrin tripping or toking might be fine with it. Though, I still wouldn't recommend you try even a low dose of Wellbutrin with booze or blow.
 
Well like I said I took the 2c-x substance the other day (suspected 2c-b fly) and I'm just planning on doing that again tonight, with maybe a small amount of alcohol for the come down. I'm prescribed benzos as well, so my seizure threshold really isn't that high (not on xanax anymore). Anyway, I highly doubt I will be doing much tonight other than what I stated, and thanks for the information.
 
I think 2C-B-fly is really long acting, no? Isn't that the unsaturated alpha-unsubstituted analogue of Bromo-Dragonfly? I think so...

I would the dihydrofuran analogues of any PEA, to be quite honest. They're exceptionally potent, and knowing that they can cause seizures, and that wellbutrin can do the same, I'd be careful.

And, as you say, your seizure threshold "isn't that high" anymore (quitting xanax will lower it).

I think that was a typo, though. You meant to say that your seizure threshold is high, right? High = harder to have seizure, Low = easy to reach and cause seizures.
 
Oops! Sorry for the bad advice then. But what are the odds of welbutrin and bud actually causing a problem? I have a friend whos taking welbutrin and he smokes pot all the time and I haven't noticed any strange behavior.
 
Ive heard some people get jacked by terrible side effects while others are relatively unscathed. There are reports on erowid of cactus/huasca, or "tricocehuasca" or something. I'd say it's a little more dangerous though, than tryptamines.
 
Well I have some personal experience in the matter albeit not with 2Cx's. LSD, MDMA, 5-MeO-DiPT, marijuana all fine, weed a little intensified, but go at your own risk, particularly with amphetamine-type things (most phenylethylamines) as your seizure threshhold is considerably decreased, risky risky. Tread carefully, start low and go slow.
 
mugabe said:
hi, i have just been prescribed prozac for depression and i started today, but i am having a few people over and we r gonna do some of my 2CI, will the prozac effect the 2ci much or at all,
sorry i kno i have seen the answer to this before but i cant remember what it is and i cant find the thread that its in so no flaming please
Click to expand...

If you just started prozac - and are taking nothing else - I doubt prozac would have much effect. Chronic prozac should however downregulate your sensitivity to medicines that must trigger a 5HTP subreceptor before making you trip.

Why not keep us updated both long and short term?

All I could find is discouraging for the chronic prozac user:


Pander Bear said:
The recreational drugs and anti-depressants FAQ
Click to expand...
Quote:
Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2,DPT, DMT etc, Salvia): These drugs can be safely combined with the SSRIs. Most people report that they need to take MORE of a hallucinogen to get normal effects. Thus, if you are taking an SSRI, you will probably need more of the drug to reach threshold effects. Some people find that they need to take more LSD, but that shrooms affect them normally.

according to erowid.org
Quote:
SEROTONIN-SELECTIVE ANTIDEPRESSANTS:
*Fluoxetine* (Prozac) -- even at doses of this antidepressant ranging from 2mg/day to 40 mg/day, there was an overall decrease in most effects from LSD (no matter how much acid people took), as well as a decrease in response to ketamine. There was no change in response to psilocybin. There does seem to be a decrease in the response to MDMA.
*Sertraline* (Zoloft) -- the effect with this antidepressant seems to be dose-dependent. At 50 mg/day, there was no effect on the response to LSD nor to psilocybin. However, at 100 mg/day, there was a decrease in response to both LSD and MDMA.
*Paroxetine* (Paxil) -- decrease in response to LSD.
*Trazodone* (Desyrel) -- decrease in response to LSD.

WZ
 
prozac abd zoloft are 2 SSRIs I would never give someone, I have seen those two drugs make people wacked out of their gourd, it just changes some of the people I have met.... hopefully this is not the case for you, let us know.... DONT MIX BOOZE WITH IT, every time I see someone who is on SSRIs and gets drunk they act waaaaaaaaaaay different then they were drunk before the SSRIs
 
^True, about the alchy thing. But yeah mugabe a search would have revealed a lot.... anyway, you'll be fine to trip; I don't find the effects reduced much and I take zoloft.
 
MAOI and psychadelics

I am sure the info is out there somewhere but I am having a hell of a hard time finding it.
I am on Nardil, an old irriversable MAOI. I am wondering what the situation is with it and shrroms and acid. I have read some reports saying it potentiates it, some that it nearly abolish's all effects.
 
AFAIK, it largely potentiates the experience and makes it peak harder and the opinions are up in the air of whether or not it makes it longer or shorter.

BTW, this topic has been covered MANY times. Do a search and you will find HUGE amounts of info on the topic and legthy conversations and whatnot.

You may be thinking of SSRIs such as Prozac which diminish the effects of serotenergic psychs like LSD.
 
MAOI's STRONGLY potentiate most psychedelics and change the character of the trip in difficult-to-quantify ways. Please do not dose unless you are very experienced and also very aware of what the effects are going to be, the experience will be a no-joke, full-on, hard-core shamanic <whatever>. FOTM is right, though, this has been done many times on this forum and others, have a search in here and on Trip Reports, also check out Erowid, you should find plenty of info.
 
something you might only find once if you looked hard is that it's possible that MAOIs decrease the effects of psychedelics. This could hypothetically be caused by a downregulation of serotonin receptors. Your receptors, having been chronically exposed to increased amounts of serotonin, may not be as sensitive to serotonergic type chemicals anymore. Granted, the MAO-inihibitory action should theoretically counteract this.

There's really no telling what will happen. One thing is for sure. full blown old-style MAOIs shouldn't be combined with highly stimulating psychedelics like mdma or mescaline.

Any other interaction is unlikely to be dangerous. Obviously start out with a lower dosage than normal, and then build up.
 
So if I understand Newmoonrecord correctly, there might be a difference in potentiation between taking an MAOI once (huasca style) and taking an MAOI daily (antidepressant style). The potentiation would be less, or might even be absent, when you take them daily?? This would explain the sometimes contradicting reports on MAOI potentiation.
 
One little point I think you should consider - unless you can be totally sure of the purity of the stiff you're taking, there's a chance you might just get something that is really ugly if all your MAO-A has been knocked out (like DOB/DOC thinking you're getting acid; that's only one example from a huge list I can think of).

A distressing trip combined with a hypertensive crisis headache (then a trip to an A&E dept in an ambulance). Not my idea of mind-expansion
 
The Big and Dandy Psychotropic Medication Interactions Thread

This will be a place to discuss the interactions between psychedelic drugs and pharmaceutical psychotropic medications (i.e., anti-depressants, anti-psychotics, benzodiazepines, and so on) which people may be prescribed for one reason or another, or may combine with psychedelics.
 
Sertraline and lsd question

alright, so im on sertraline (generic zoloft) for 200mg a day. How long should i wait from the last dose of sertraline until i could fully appreciate the lsd?
In other words, how long shoiuld i stop taking the zoloft so it doesnt block the effects of lsd anymore?

thanks.

p.s. i only have half a tab of acid of which im estimating the contents being 40-80 mcg. So i need to make the most of it.
 
^ putting this in the new B&D psychotropic med interactions thread. go to the first page or search within this thread and you will find copious amounts of info on your question.
 
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