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The Big & Dandy Medication/Supplement Interaction Thread

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SOMA and LSD?

I searched Google but couldnt found any information.
Does anyone know if this combo would work an how?

Thanks in advance.
 
What do you mean by "work?"

I would imagine the soma would mellow things a bit and give you strange bodily sensations. It also might dampen the trip a bit. I do not think a really untoward reaction would be likely, though.

I don't know much about Soma though.
 
Soma will definitely dampen the trip due to it's benzo-like actions. It will also decrease any body tension you may have because it is a strong muscle relaxant.
 
ok thanks; so SOMA its a drug more to combine with .. say Diazepam, Lorazepam and Tramadol right? all would mellow the LSD right?

I asked this in first place because when I did Hydrocodone and LSD I felt damn good, and last time I took a bit of Tramadol a felt similar, I was wondering if SOMA would feel good too with LSD.

Thanks again.
 
Soma is fucking incredible. My favorite downer of all times. I've used just about every common downer and a few unusual ones (methylprylon, and methprobamate, phenobarbital and another *barbital(at the hospital)) and SOMA is the only one I still have dreams of.

I mean, I'm not 1/4 addicted to painkillers as I am to Soma. Fortunately I don't have any SOMA, but I still dream about it constantly.

I start thinking about how wonderful it is and then I write rants like this one. OMG... I want some really bad right now.
 
You know, I bought 100 soma a little while back, and I tried it out every which way to see about its abuse potential. But, I didn't really like it that much. I kept a few to potentiate opiates should I pick some up, but I won't be abusing soma by itself anymore.
 
I bought 300 tablets and ate them in 2.5 months... well, 3.5 if you don't count the time I was in an MMT program that tested for it.
 
Just wake up from 300mg Tramadol, 6mg Lorazepam and 12mg Melatonin, and just had a weird dream about my mother founding out me with my friends and my doujins (¿?)
I dont think its a coincidence.
 
Moclobemide and psychedelics

Hi,

I already asked this question, but I was adviced to move over here.

I'm on 150 mg moclobemide a day. I take it in the morning. I quit drugs because I'm too scared for interactions, but I see VelocideX saying it's ok 24h after release. BUT if i read the anti depressant faq it says you can't take drugs up to two weeks after treatmant. What's up with that, I mean the half-life is low and everything? I have been taking it since last May, I did 2 mg methamph which goes fine, as well with 4.5 mg dextro-amph (under supervision of my shrink), I use without problems hashish, ghb, modafinil, gbl, 1,4 bdo, nitrous, methaqualone, ketamine, cannabinoids, bromazepam, lorazepam and valium (although they work longer). I also did 30 mg of E about 16 hours after ingestion, it gave a slight love feeling.

a. I wonder if i leave 48h in between, what things I could use?
b. How would the effect be?
c. Dosage?
d. Other people here on moclobemide that have experience with using psychedelics?
e. Will one or two experiences have negative influence on my therapy? (I'm taking this since may 2007 and according to my psychiatrist I probably have to take it up to one or two years)

I might better not using stimulating psychedelics (just to be sure), so these are a few compounds I'm taking in consideration:

Psychedelics:

- n,n dmt (smoking)
- met
- dpt
- mipt
- 5-meo-tmt
- amt
- 4-aco-mipt
- 4-aco-dmt
- mushrooms
- lsa-containing seeds
- Fly agaric
- LSD, pro-lad, ethyl-lad, ald-52

Others:

- Alprazolam (I'm not sure if this is safe to combine)
- Clonidine
- Barbital
- Kratom
- Kava kava
- Dilaudid


I'm also curious what a small amount of a phen would do (aleph-x, do-x, tma-x, 2c-x, 2c-t-x, buthylone.) and if anyone has experience with this?

Please note I'm not an irresponsible user, I'm well aware of the dangers this could include, but I really miss tripping and I'd like to have one or two trips during my time on moclobemide.


Thanks in advance.
 
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you can trip on pretty much anything on moclobemide. there are a few research chemicals that are advised to avoid, but i dont remember which (i never use rcs). i would just say avoid synthetic PEAs, because some of them are rough as is.

but there is a long history of native use of mescaline and dmt with MAO-A inhibitors like moclobemide.

as you have already seen, if you've safely taken speed with it, you're pretty much out of the woods. I take moclobemide from time to time and ive never avoided any specific drugs except dxm and synthetic opioids.

avoid dxm and opiates that are based on the piperadine structure (fentanyl, tramadol, demerol, meperidine, and methadone). these, along with SSRIs and possbly MDMA is all i would recommend against with moclobemide. these can/will cause dangerous interactions.

also use the search engine. there are a buttload of posts about this topic, many of them mine

clonidine would be fine, fly agaric would be fine, dilaudid and kava would be fine


AVOID KRATOM. Kratom increases noradrenaline, which is prevented from being broken down by the moclobemide. This would result in excessive stimulation and jitteryness.

LSD would also probably be fine, given that mushrooms, dmt, and mescaline are fine.
 
Hi,

Thank you for your answer. Do you take moclobemide just recreationally or therapeutically? Ain't there a diference between taking it sporadically and on a constant base? I'm prescribed moclobemide for manic-depression and it's a really good medicine and I'm really greatful for it, my life is finally nice and not crazy and chaotic anymore.

I still worry if this could affect my biochemistry-household and have a bad influence on my therapy. I really hope someone could give me an answer on that.

Yeah, I thought that about kratom, I'm also aware of the dangers with dxm, ssri's, sri's, snri's, opiods.

I even take my dex-amph together with it. I can't exceed 6 mg tho or it becomes too heavy. I use it cos I have chronic tiredness syndrome. Meth-amphetamine is more gentle, but it's not prescribed here, so I can't get it. It's mixed with aegris-extract in case my heart would make overwork. I think that would be a nice supplement to take with a psychedelic. Also, what about the usual extra's, for example 5-htp ... do I need to take them in consideration?

I want to take kava kava instead of benzodiazepines and hashish (wich i use almost every night against FMS-pain).

also use the search engine. there are a buttload of posts about this topic, many of them mine
Click to expand...

I did that, read most of it, but most of them seem to be for recreational use and I wanted to be a bit more specific about some things, for daily users that is.

Thanks again.
 
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I just wiki'd kava kava and I'm not sure this is safe to take:

Pharmacology

Kava's active principal ingredients are the kavalactones, of which at least 15 have been identified and are all considered psychoactive. Only six of them produce noticeable effects, and their concentrations in kava plants vary. Different ratios can produce different effects. Kava has some abuse potential and some experts recommend cycling use over 1 to 3 months.[2]

[edit] Pharmacodynamics

Desmethoxyyangonin, one of the six major kavalactones, is a reversible MAO-B inhibitor (Ki 280 nM)[3] and is able to increase dopamine levels in the nucleus accumbens. This finding might correspond to the slightly euphoric action of kava.[4]
Kavain in both enantiomeric forms inhibit the reuptake of noradrenalin at the transporter (NAT), but not of serotonin (SERT).[5] An elevated extracellular NA level in the brain may account for the reported enhancement of attention and focus.
Click to expand...
 
--> B&D interactions thread, where you will find much on this topic
 
Ugh, I'm still not satisfied after reading half the internet.

I still have concerns bout my therapy and dosage.
 
wolvenkind said:
Ugh, I'm still not satisfied after reading half the internet.

I still have concerns bout my therapy and dosage.
Click to expand...

yeah i've looked into it plenty, believe me (im cautious as hell), but ive come to the conclusion that there isnt really that much good info on moclobemide out there with regards to recreational drug use while taking chronic moclobemide.

you'll probably just have to take the leap and try some things for yourself if you want to find out how they affect you. if you stay away from the previously mentioned substances you're not going to die. start low and go slow (as far as dose is concerned). but remember also moclobemide is probably the safest maoi out there. and even if anything bad were to happen (unlikely), the mao inhibition only lasts a few hours, so if you were to start having some kind of bad reaction, you would be able to just ride it out and it would go away on its own. if it were a traditional maoi, then you'd have to go to the hospital because they last for 2 weeks or so.

since you asked - i use moclobemide to potentiate psychedelics, and to substitute for uppers when i take breaks from stimulants. also sometimes as an anti anxiety when i have too much anxiety. the main difference between daily use and occasional use is that you gain tolerance to its stimulant effect with regular use, and the effect of increased serotonin ends up stimulating nerve growth (which is thought to relieve depression).

pm me if you have real specific question about a certain med. those "14 day washout periods" are confusing and often apply to other older maois.

you should follow a 14 day washout period when discontinuing drugs with long half lifes that increase serotonin, before starting maois.

and you should follow a 14 day washout period when discontinuing traditional maois before starting any serotonin increasers.

moclobemide however leaves your system entirely within about a day or a day and a half, so there is really no post-maoi washout period to deal with.
 
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