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The Big & Dandy Ketamine Thread (Third Injection)

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so why didnt John Lilly have problems with his bladder when he used it flatout for many years?

I mean he only injected it so im thinking maybe when you inject K it bypasess the liver thus being better for your bladder in the long run.
 
Injection does not bypass the liver. When a drug is introduced into the bloodstream it is constantly being moved back and forth between the various organs responsible for it's activity and metabolism This includes the liver.

Like I said, unless you're familiar with how to safely inject drugs, then you're much better off snorting it. Just dont go crazy with the doses and frequency of use and you should be fine.
 
bighooter said:
so why didnt John Lilly have problems with his bladder when he used it flatout for many years?

I mean he only injected it so im thinking maybe when you inject K it bypasess the liver thus being better for your bladder in the long run.
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I'm going to suggest two possible reasons out of many:

1) he was only injecting once or twice a day. The bladder issue seems to arise from chronic abuse (which in turn results in higher tolerance / faster conversion of ketamine into norketamine). Lilly may have avoided some issues simply by not succumbing to addictive tendencies.

2) Lilly started using ketamine and LSD in his mid to late 40's. By that time, chances are any side effects he did notice would have been attributed to age related disorders more than anything else.
 
K

Im experienced in Injecting though as I am currently taking AAS.

But how can I have a high tolerance if I only use 2days a week?
It just seems to me a waste of product, damage to my nose and all for a shitty stimulant buzz that makes me feel wired but wonky aswell.

No my dear friends I want to experience the beautiful tranquility of the K hole which I accidently slipped into once after doing a 250mg line a few months back. I was in my bedroom but in my mind I was in an abandoned, disused, derelict industrial factory I was in some room with a bunch of other spirits sat around and even though I knew these people were all dead I felt at peace even though at first it freaked me out.

That is why I want to K hole so much, I honestly think I'd have to snort at least 2grams to get anywhere near that hole again.
 
K tolerance is a bitch, Hooter. The even better news is that it's all but irreversible, in my (and many other folks') experience. It's one that just won't have it if you abuse it. The less you use it the more rewarding it is. Not always so simple though and two days a week is certainly enough to produce tolerance, unfortunately :\

IM seems to be the best option for holing even with high tolerance. On my last ket binge I was shooting 200mg IV and barely glimpsing the hole but a similar dose IMed was actually more valuable.
 
I really wish someone with K access would give grapefruit juice/cimetidine potentiation with snorted/IM K a try. If I had access, I would give it a go myself.

I personally believe one could partially reverse at least the psychological tolerance from constant use. Perhaps you could reduce tolerance entirely.

Combined potentiators (cimetidine/full spectrum grapefruit juice extract) with nutrient therapy (magnesium, zinc, vitamin C and B12 especially) could reverse or prevent tolerance and increase the effects requiring lower doses on a consistent basis.

Although it's just a hypothesis unless someone tries it out!

[edit]

So I remember reading that Probenecid (a gout medication) was shown to increase plasma concentration and prolong anesthesia with ketamine in rabbits and rats. I was taking a look tonight and it seems that Gauifenesin has a similar (although milder) action as probenecid in higher doses.

Guaifenesin Alone or in Combination with Ketamine or Sodium Pentobarbital as an Anesthetic in Rabbits


Ketamine alone given intramuscularly at 35 mg/ kg in the rabbit has been shown to severely depress the respiratory rate for over 60 minutes, decrease mean arterial blood pressure for 60 minutes and produce bradycardia for 45 minutes (21). In contrast, when ketamine (50mg/kg, IM) was combined with guaifenesin (200 mg/ kg, IV) there was less severe respiratory depression without a significant change in heart rate and mean arterial blood pressure. The ketamine and guaifenesin combination was also able to provide between 30 and 60 minutes of surgical anesthesia in five out of six rabbits with good muscle relaxation. Ketamine alone does not produce surgical anesthesia in the rabbit when given at dosages up to 60mg/kg (19), and animals have muscular rigidity. Ketamine has been combined with guaifenesin and xylazine to produce anesthesia in the horse, swine and dog with minimal or without cardiovascular changes (13,14,22) and it appears that guaifenesin and ketamine behaves similarly in the rabbit
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I have no idea how this equates to humans, let alone how oral administration would affect ketamine. None the less, this is interesting to note and may be something worth looking investigating.
 
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in the book im reading (ketamine- dreams and realities) It says that Magnesium is required in the brain to have an effect so I'd imagine that this could be supplemented.

Could you just use grapefruit juice on its own or does it have to be combined to have effect?
 
bighooter said:
in the book im reading (ketamine- dreams and realities) It says that Magnesium is required in the brain to have an effect so I'd imagine that this could be supplemented.

Could you just use grapefruit juice on its own or does it have to be combined to have effect?
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I would think grapefruit juice on it's own would be sufficient, the only problem I see with GFJ is that there seems to be some debate over which form is most useful.

I've heard a lot of people say the white grapefruit juice is the only one worth using, while I have also heard that ruby red GFJ (100% juice, none of that from concentrate crap) is good too.

Mainly you just want one with the least amount of other crap in it, all natural low/no sugar GFJ. Drink a large glass or two an hour leading up to the K and then do your K. It has the potential of lengthening or potentiating the K so I reckon it would be a wise idea to start lower (1/2 your dose) to get a feel for the level of potentiation.
 
Just tried K for the first time at the weekend and it was, well for a better word... strange! I was pretty pissed and had took a fair amount of coke. I've tripped loads of times on acid and shrooms but this was like a sort of out of body type experience, very weird, like I was seeing god from memory. I'm looking forward to doing it again but K and nothing else.
 
Hey everyone...is anyone in this lovely thread able to list some of the more common drugs which share a cross tolerance with Ketamine?

On this occasion I am most concerned with amphetamines, but would greatly appreciate any substances that you may be familiar with for future reference.
 
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I like to crush up my k with a mortar and pestel sometimes if its not fine enough and a little gets left behind in the mortar and over the past months there is more and more left behind i was woundering what i could do to get what is left behind. Put water into it and drink it (which i think would just mess up my stomach) or mix it with water and heat it and maybe have powder left over that i could snort or should i just forget about it.
 
From what little information I can find online I noticed that Morphine can diminish certain aspects of the experience while potentiating others (cataleptic).

While I know this is not normally the rule of thumb, I'm going to assume that the lack of information on the topic (in the case of Ketamine only! not RCs) speaks to the fact that Deslyd is probably right.

Edit: If I was to insufflate 75mg tonight would I be able to reach the k-hole without too high of a dose (I only have this much in my possession from a friend's stash and am getting more tomorrow)?
 
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bacondudeman said:
I like to crush up my k with a mortar and pestel sometimes if its not fine enough and a little gets left behind in the mortar and over the past months there is more and more left behind i was woundering what i could do to get what is left behind. Put water into it and drink it (which i think would just mess up my stomach) or mix it with water and heat it and maybe have powder left over that i could snort or should i just forget about it.
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you could always just put a small amount of water in and then pour it onto a dish and evaporate it.

the maximum saturation for water is 200mg/1ml so if you can guest how much is in the mortar, just add the least amount of water so you can pour it onto a dish.

oral Ket requires a lot and is different (quick conversion to norketamine which is more of a anesthetic/pain killer than a psychedelic)
 
Dear ketamine,
We've had some fun times this summer.
A whirl wind romance, truly amazing nights together.

But I've met you your younger sister, 4-meo-pcp.

We're running off together. x
 
Is there any reason why after IMing K, I should have a lot of blood pour out? I made sure I wasn't in an artery or vein, maybe I pierced through or scraped one?

Also, is a tiny bump after IMing normal? I didn't get a bump at first, now I have one.

It certainly doesn't hurt at all, just have a question as to why.
 
bacondudeman said:
I like to crush up my k with a mortar and pestel sometimes if its not fine enough and a little gets left behind in the mortar and over the past months there is more and more left behind i was woundering what i could do to get what is left behind. Put water into it and drink it (which i think would just mess up my stomach) or mix it with water and heat it and maybe have powder left over that i could snort or should i just forget about it.
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m8 do not drink this!!!!!!!!!!!

I mixed 500mg with grapefruit juice before and drunk that......

I was high but it wasnt a psychedelic experience I just felt high and that was the 1st and only time ive had stomach cramps from k
 
bighooter said:
m8 do not drink this!!!!!!!!!!!

I mixed 500mg with grapefruit juice before and drunk that......

I was high but it wasnt a psychedelic experience I just felt high and that was the 1st and only time ive had stomach cramps from k
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Only had k cramps once after 4 weeks of up to a g a day.

After a party i had the cramps, unbelievably painful i just had to roll around my room moaning.

A day or so later i develope a UTI which means i pissed blood and it stung when i did, which i did every 15 minutes or so//

Needless to say i've stopped the K for the time being and am on a course of antibiotics for the UTI, this is day 5 of recovery and im feeling much better.

i think i also had some physchosis in the last days of abuse aswell, very strange feelings for me on K like my face was being pulled of and feeling fucked for hours and hours even after ceasing to dose.

Anyone else had any problems like this?
 
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