Yes,
@TripSitterNZ , I completely agree.
And the fact that we know there are impurities like iso-lsd and other ergolines present in sub 99.9% is what I think contributes to these less-desirable effects.
Even if these impurities are not “active at that level,” no one can say they don’t have any altering effect on the parent compound itself.
I know from personal experience (hundreds of trips thru the late 80s to present day), always tripping on pure WoW by NS (lived a couple miles from him!).
The one time I obtained a sheet from someone else, due to his absence, we all complained about the gritty comedowns, speedy and tweaky effects of that sheet.
The thing is, I didn’t tell folks this was different, because it was still WoW (and lsd is lsd, right?), but uniformly I received the same complaints. Must/could have been tornado juice, or lavender laid or something.
So until someone can irrefutably prove that these otherwise inactive iso’s and other impurities/ergolines simply cannot have a mechanism of cascading or synergistic effects either on the lsd itself, or on our body chemistry - I’m going to posit that the diffs I and many others feel and report (maybe we’re just too sensitive to these things or overly so), must/could have a causal relationship to effects felt other than dosage, set and setting. Now I agree that those are chief players in the outcome of any trip, but I allow room in my thinking for the potential of these impurities being capable of altering the experience.
Don’t hate on me folks, I’m no scientist and I know this opinion will be met by a chorus of “here we go agains,” but ask yourself this: can YOU actually PROVE and KNOW this is all just placebo?
One day, double-blind trials may prove one side right; until then, it’s up for respectful debate.