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Phenethylamines The Big & Dandy 2C-I Thread - Take Two

And now for a bonus feature: my one 2C-I train wreck. Well, it worked out fine in the end, but Erowid might still classify it as such. I've only had maybe three or four "bad trips", where I really really wanted it to end. For a brief time, this was one of those.

It was a beautiful spring weekend day, and I wanted to visit a friend and trip with him. He had just gotten into a new apartment, and invited me to come see him. I didn't want to trip indoors, and the outdoor areas of his apartment complex were shared with other tenants and rather confined between the buildings. So I suggested we find somewhere more natural to trip. I thought it would be a great idea to drive up the canyon, into a state park where we could do a bit of hiking around and then, when the effects had faded, drive home. There were just two small problems.

It was about 3:30 pm when we found parking at a picnic area that looked like had some room for us to wander from. We dosed (12 mg I think) and then hiked a good distance from the tables onto a small hillside with a nice view. At this point, everything was very pleasant. My friend lit up a cigarette and just stood admiring the scenery. I asked him how he felt. He replied: "I feel awesome!" Ahh, 2C-I. I started to notice the sun getting lower, and my friend commented about how it would be dark soon and we didn't have any lights. I replied: "No worries man, we'll just make our way back to the picnic area and wait until we're down enough to drive home". Problem number 1: the area was officially closed at sunset. Right on time, a pickup truck appeared in the distance. My friend said "uhoh", and I'm like "no need to be paranoid". He giggled at me when it approached and we could see the driver in uniform. It stopped. The ranger told us the park was closing and offered us a ride to our cars in the back of his truck. By this point, the peak effects hit like crazy. The ride was terribly fun (at least for me, my friend says he was wigging out bad), but as we walked out toward the parking area, the ranger shut a gate behind us. We could have just hopped it, but we didn't want to get into it with a park ranger or something worse like actual cops.

So we're sitting in the car, and it's dark now. It was pretty boring, and I didn't want to put the keys in the ignition (for some music at least), lest some cop show up and hit me with a DUI. (I actually hid the keys, just in case.) For a while, I watched the colorful blobs and patterns which were overlaying the now very dark landscape. It was so dark---stiflingly dark. We both were feeling quite paranoid about cops driving by on the road, seeing us, and stopping. (The parking area was just a few spaces right off the road.) I don't recall but I think one of us had weed on our person. (Actually, I think we'd been smoking it too.) Y'all know how insanely 2C-I makes pupils dilate. We were sitting ducks.

And then it happened. Problem number 2: I ran out of water. I sucked on the nipple of my backpack water holder, and got that horrifying sound of the last bits of water mixed with air trickling from it. Under normal circumstances, I had brought plenty of water for a short evening walk in the park, but in my anxious tripping state stuck inside my car, I'd managed to suck it all down and now I *really needed water*. My friend didn't have any to offer me. It was an emergency! I found the keys and started the car. I was going to get us out of there. My friend thought I was nuts. (I was.) He asked me how I could drive with all those crazy visuals. At first, it didn't seem too bad, but it took enormous concentration to follow the lines on the road, which seemed barely illuminated versus the visuals. Then while going around a tight series of complex curve, I felt my hands and arms go completely numb and vanish like in "Spirited Away". I just saw the steering wheel spinning in front of me as we somehow navigated the curves. I considered pulling over, but it was a tight canyon with no pull-outs for miles. Somehow, the part of me that was driving was able to disconnect enough from my tripping self to get us out of the canyon. Once out, the road was straight and well lit, and the rest of the drive was much more relaxed. About 30 minutes later, we got back to his apartment, smoked some weed and chilled for a bit. Then I realized I was hungry and he had no food at all, but the effects had mostly dropped off so I was comfortable driving. I ate one of the most satisfying meals of my life with him.

Some years later, I actually drove that same stretch of road at night again, and even while totally sober it was a bit scary. Something about that particular canyon makes for terrible nighttime visibility and requires constant concentration to navigate the many curves.

So bad trips can happen even with light doses. All it takes is just a little bit of ill preparation. We got started much later than planned and didn't anticipate the park closure. I also didn't bring an extra receptacle of water. If I'd waited things out another 1-2 hours, the drive back would probably have been much less scary. I've driven while lightly tripping on various other occasions but always late into the effects when I don't have visuals or disappearing arms. That somatic hallucination was just crazy!

For comparison. My other "bad" trips both involved ayahuasca of one form or another.
 
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I honestly never tried it. I have some in cold storage a couple thousand miles away from back in the pre-Web Tryp days, but I've never gotten around to it.

My first research phenethylamine was 2C-I, and I liked it a lot. Then I discovered 2C-E, which I liked more, but I still used 2C-I at times in which I wanted a more "recreational" experience. I'm not saying that 2C-I is necessarily casual. My recent trips with it have not felt so casual, but when I was younger, I often took 2C-I in circumstances in which many people would use MDMA or other non-psychedelics. It gave me tremendous energy and euphoria, and I liked to dance intensely for hours. I also took it more than once to salvage a failed entactogenic experience---once after being disappointed by methylone and another time after being disappointed by MDA. In both cases, I felt much more euphoric after the 2C-I kicked in.

I think it's worth trying, even though it probably won't be your favorite. It can produce a lot of visual fireworks and euphoria, and it doesn't last too long.
 
I honestly never tried it
I highly recommend it.

It recently came back in my life and I might have been hasty but I was excited and I took 20mg. At one point I felt like every single cell in my body was excited, on the verge of orgasm (can cells have orgasms?)

Much more visual than 2c-b imo and much more neon.

Overall it feels like a dream and I'm sad because I can barely describe what happened, but it was one of the most sensationally intense experiences I've had in years. I dont regret it, but next time i will aim for 14-15mg

Then I discovered 2C-E, which I liked more
I found myself comparing it 2c-e more than anything else, and they both leave me with such a wild afterglow. for me, both substances last 16 hrs or more.
 
I highly recommend it.

It recently came back in my life and I might have been hasty but I was excited and I took 20mg. At one point I felt like every single cell in my body was excited, on the verge of orgasm (can cells have orgasms?)

Much more visual than 2c-b imo and much more neon.

Overall it feels like a dream and I'm sad because I can barely describe what happened, but it was one of the most sensationally intense experiences I've had in years. I dont regret it, but next time i will aim for 14-15mg


I found myself comparing it 2c-e more than anything else, and they both leave me with such a wild afterglow. for me, both substances last 16 hrs or more.
I need your opinion on something. What do you think about 2C-C ?
 
It recently came back in my life and I might have been hasty but I was excited and I took 20mg. At one point I felt like every single cell in my body was excited, on the verge of orgasm (can cells have orgasms?)

Much more visual than 2c-b imo and much more neon.

Overall it feels like a dream and I'm sad because I can barely describe what happened, but it was one of the most sensationally intense experiences I've had in years. I dont regret it, but next time i will aim for 14-15mg

I found myself comparing it 2c-e more than anything else, and they both leave me with such a wild afterglow. for me, both substances last 16 hrs or more.

Oh that's funny. I just had a successful trip on 14-15 mg and was thinking about 20 mg for my next time, probably some time in the late autumn or winter. When I was young, 20 mg was a very good level. I also did 25 mg a couple times which had crazy visuals but also felt a bit hard on the body. One of those, I had about half-an-hour of visual meltdown and feeling very disoriented.

Perhaps you are a bit sensitive to these compounds, which may relate to how long your trips last? I've never known anyone to trip for 16 hours on a "normal" size dose, of either 2C-I or 2C-E. Can you give a little more detail on how strong the effects are over time? Like for me, 2C-I typically peaks at 2.5-3 hours and drops off rather abruptly between 5 and 6 hours in, and then there is another 3-4 hours over which I mostly return to baseline for a total trip duration of around 10 hours. With 2C-E, the peak comes about half-an-hour later and the drop is much smoother and later, manifesting about 7 or 8 hours in and being followed by a 3-4 hour return to baseline for a total trip duration of around 12 hours. I get strong after-effects from both which transition into a proper long-lasting after-glow over the next few days.

I find 2C-I and 2C-E to be quite distinct. I find 2C-I to be much more casual and hedonistic. It basically puts on a good show for me. I find 2C-E to be much more truly psychedelic in the sense that the trip doesn't just happen in front of my eyes (so to speak). Instead, I experience my mind directing it. With 2C-E, I am much less likely to have visuals "just because", but if my mind is sufficiently involved, I can conjure up some incredible stuff that 2C-I can't touch. I also think 2C-E has a lot more emotional depth and more feeling of intensity (for lack of a better term). Even very low doses of 2C-E can somehow feel almost overwhelming to me in terms of sensory and emotional amplification. Yet another difference is that 2C-I seems to have a particular stimulating quality, particular over the first 4 hours or so. Presumably this is an adrenergic mediated stimulation. On the other hand, 2C-E seems to bring a lot more psychedelic / serotonergic body energy / body load than 2C-I, and this could be viewed as a different sort of stimulation. I do plan to continue using both.

I need your opinion on something. What do you think about 2C-C ?

In my opinion, 2C-C is even more casual than 2C-I and is also not really stimulating. My main gripe is that the stronger effects barely lasted an hour for me, and most of the rest of the trip was rather weak. Between this and its low potency, I felt that high doses were a waste of money and material. I ended up mostly using it at around 20-30 mg for daytime outings like hikes or museums when I wanted some "enhancement" while being able to drive not too long after taking it, and then it ran out. When the opportunity arose to replace it, I opted instead for more 2C-D which I find to be more interesting for short trips, even if my come-ups are quite rough.
 
Very surprised there isn’t more 2C-I around. It’s always been a wonderful ally. Low chance for overdose, very safe, dose same as 2C-B. It’s easier to handle than LSD and doesn’t last as long. The synth is almost identical to 2C-B.

Very similar to 2C-B although I find it’s less in the body.

One of my favourites along with 2ct7. In many ways, although not as ethereal and smooth as 2ct7, it has far less body load.
 
Oh that's funny. I just had a successful trip on 14-15 mg and was thinking about 20 mg for my next time, probably some time in the late autumn or winter. When I was young, 20 mg was a very good level. I also did 25 mg a couple times which had crazy visuals but also felt a bit hard on the body. One of those, I had about half-an-hour of visual meltdown and feeling very disoriented.

Perhaps you are a bit sensitive to these compounds, which may relate to how long your trips last? I've never known anyone to trip for 16 hours on a "normal" size dose, of either 2C-I or 2C-E. Can you give a little more detail on how strong the effects are over time? Like for me, 2C-I typically peaks at 2.5-3 hours and drops off rather abruptly between 5 and 6 hours in, and then there is another 3-4 hours over which I mostly return to baseline for a total trip duration of around 10 hours. With 2C-E, the peak comes about half-an-hour later and the drop is much smoother and later, manifesting about 7 or 8 hours in and being followed by a 3-4 hour return to baseline for a total trip duration of around 12 hours. I get strong after-effects from both which transition into a proper long-lasting after-glow over the next few days.

I find 2C-I and 2C-E to be quite distinct. I find 2C-I to be much more casual and hedonistic. It basically puts on a good show for me. I find 2C-E to be much more truly psychedelic in the sense that the trip doesn't just happen in front of my eyes (so to speak). Instead, I experience my mind directing it. With 2C-E, I am much less likely to have visuals "just because", but if my mind is sufficiently involved, I can conjure up some incredible stuff that 2C-I can't touch. I also think 2C-E has a lot more emotional depth and more feeling of intensity (for lack of a better term). Even very low doses of 2C-E can somehow feel almost overwhelming to me in terms of sensory and emotional amplification. Yet another difference is that 2C-I seems to have a particular stimulating quality, particular over the first 4 hours or so. Presumably this is an adrenergic mediated stimulation. On the other hand, 2C-E seems to bring a lot more psychedelic / serotonergic body energy / body load than 2C-I, and this could be viewed as a different sort of stimulation. I do plan to continue using both.



In my opinion, 2C-C is even more casual than 2C-I and is also not really stimulating. My main gripe is that the stronger effects barely lasted an hour for me, and most of the rest of the trip was rather weak. Between this and its low potency, I felt that high doses were a waste of money and material. I ended up mostly using it at around 20-30 mg for daytime outings like hikes or museums when I wanted some "enhancement" while being able to drive not too long after taking it, and then it ran out. When the opportunity arose to replace it, I opted instead for more 2C-D which I find to be more interesting for short trips, even if my come-ups are quite rough.
I found 2C-D to be even more neutral than 2C-I. Apparently at higher doses around 60mg it’s very entactogenic.

Never had enough 2C-D around to try the higher doses.
 
Substances that are more common usually have to do with what precursors a chemist can get their hands on.
But doesn't it have more to do with demand than supply? I mean if there is demand for 4-MMC, the market will shift towards it. Just look at Germany, 4-MMC has exploded all over the scene there, in the clubs and festivals.

Not only is it relatively safe compared to cocaine, it's more fiendish than MDMA. The demand is huge. Lol definitely the devils drug. :p

But with 2C-I and 2C-B, they are amazing, sure, but you're not going be having people buy it every week like 4-MMC/3-MMC.

It's bigger in Europe more so than when it was even legal 15 years ago. It's easy for the large syndicates to setup a shop anywhere these days.
 
Substances that are more common usually have to do with what precursors a chemist can get their hands on.
I was under the impression that many of the 2c-series along with mescaline had similar synthesis route sharing precursors, but I've not looked into it recently. I suspect it's more supply and demand. 2cb became popular before it was banned. The rest of the series did not.
 
2CE and 2CI were really easy to get in the DNM golden age ~5 years ago. I wonder if they just didn't sell much. I don't remember being too impressed with 2CI compared to 2CB, but 2CE was a nice change
 
A long long time ago in the States, we could get all kinds of 2C-X except 2C-B because 2C-B was the only one that was scheduled. I was super stoked when I saw 2C-I available because I'd always wanted to try 2C-B and figured that 2C-I was as close as I could get. I didn't know better and thought 2C-I was excellent. I figured Shulgin et.al. preferred 2C-B because of the shorter duration, but it turns out that both 2C-I and 2C-C are quite different from 2C-B. I do think more people would probably prefer 2C-B over 2C-I than the reverse, but I think 2C-I is still worthwhile on its own.

It's true, but 2cb, 2cc, even t2 I'm relaxed and I fall asleep. Not the the same with 2c-i or 2c-e

So are you judging duration by how long you have to wait to sleep?

I suspect both 2C-I and 2C-E have more adrenergic action than the others you mentioned. Have you tried 2C-D? I tend to think of 2C-D as also one of the more stimulating (possibly adrenergic) ones.
 
So I've taken 2C-I twice since my last post here, both times in combination with 2C-B.

1st go was 10mg of 2C-I and 5mg of 2C-B. The stimulation was still present although at a much less degree then 20mg of 2C-I alone. I remember sitting down to pee and my knees were just shaking. I prolly had a few beers as well knowing me. The visuals were immaculate. Neon still, but the B clearly changed the character.

The 2nd go was at a music festival and it was with 5mg 2C-I and 10mg 2C-B. This was the least stimulating of the 3 experiences and probably actually my favorite. It was primarily a 2C-B trip with an extra flare of visuals and tactile sensation. At the end of the night I smoked a small amount of DMT (30mg?) with a lady I met and we went and laid down afterwards and just snuggled and touched eachother. This was on the the tail of a trip (prolly 7 hours in) and it was as much if not more enactogenic than MDMA in a similar setting. It was amazing. She didn't want to go past snuggling (she had a boyfriend) though it would have been no problem for me to do the deed and enjoy it. A few days later she told me she had such a great experience snuggling with me that she broke up with her bf.

Whoops, not the first time Ive caused a breakup.

I do think that 2C-I is best taken in a somewhat active environment (concert, bed with a lover, etc). Taking it alone is ok, but I find the stimulation is much more noticeable and uncomfortable.

It's a shame it's not common at all these days, because I do think it's a wonderful molecule.

I probably won't be trying again soon, 3x in 3 weeks is a bit much for me, but if I develop any new insights or opinions I will post them here.
 
I was under the impression that many of the 2c-series along with mescaline had similar synthesis route sharing precursors, but I've not looked into it recently. I suspect it's more supply and demand. 2cb became popular before it was banned. The rest of the series did not.
Halogenated 2,4,5-trisubstituted phenethylamines are much easier to make than alkylated ones. Especially 2C-B and 2C-C, 2C-I can be notoriously tricky to get the iodine attached to for some reason. 3,4,5-trisubstituted phenethylamines like mescaline, allylescaline and the sort are relatively trivial to whip up but they're also much weaker by mass and don't really blast peoples' asses the way 2C-B does. I think 2C-B won the capitalist game by being good for partying without making people introspect too much, having a quick come up, good visuals and body feel, and by being one of the simplest to produce alongside a solid mass-to-potency ratio, personally.
 
Halogenated 2,4,5-trisubstituted phenethylamines are much easier to make than alkylated ones. Especially 2C-B and 2C-C, 2C-I can be notoriously tricky to get the iodine attached to for some reason. 3,4,5-trisubstituted phenethylamines like mescaline, allylescaline and the sort are relatively trivial to whip up but they're also much weaker by mass and don't really blast peoples' asses the way 2C-B does. I think 2C-B won the capitalist game by being good for partying without making people introspect too much, having a quick come up, good visuals and body feel, and by being one of the simplest to produce alongside a solid mass-to-potency ratio, personally.
I'm just glad there are still people synthesising mescaline when 2C-B is clearly where the money is. Would 2C-E fall somewhere between 2C-B/C and 2C-I in terms of complexity then? If so I love that they're alphabetical.
 
I'm just glad there are still people synthesising mescaline when 2C-B is clearly where the money is. Would 2C-E fall somewhere between 2C-B/C and 2C-I in terms of complexity then? If so I love that they're alphabetical.
There's almost nobody synthesizing mescaline at all, it's dramatically cost ineffective compared to an insane variety of other drugs, and it's even cost ineffective compared to just running bath tub sized extractions on San Pedro/Bridgesii, which is where the majority of (and 100% of North American/South American) mescaline on DNMs is currently sourced from. I've only seen synthetic mescaline coming out of Europe, where access to mescaline containing cacti is scarce. Reducing any phenethylamine (including butanamines, amphetamines, N-benzylations require a SECOND reduction even, etc.) is inherently pretty dangerous due to the risk of the reaction running out exothermically, and on top of that mescaline synths involve not only the use of alkylating but ALSO halogenating reagents, there's a reason that allylescaline, proscaline, and isoproscaline are still being conjured in beakers around the world but mescaline is just being pulled out of cacti, it's both safer and more cost effective when the latter three require less than 50mg for a full dose and mescaline's demanding 10 times more for what's the same synthetic procedure but varied by a single reagent.

2C-E, as well as other alkylated 2,4,5-Trisubstituted phens like 2C-iP, 2C-P, 2C-D, etc., are marginally trickier to work with than 2C-I but not a ton, in fact there's a lot of overlap. There have been people who've found a handful of weird back-handed routes to 2C-I/DOI/Other 2,5-Dimethoxy,4-Iodo compounds, but for the most part none have been cost effective enough to justify continued clandestine production or they involve wacky ass precursors that just aren't very accessible nowadays but were back in Shulgin's era. 2C-I Also received generally unfavorable reviews compared to 2C-B and 2C-C, so given that 2C-B and 2C-C are by far the easiest ones to make, the best selling, AND the easiest to acquire reagents for, I think capitalism just chose which we have for now. Given 2C-C's weakness by mass as well, 2C-B obviously won out in that regard. I wish more DOC and DOB made it on the street frankly, if 2C-B/2C-C are being made then a single reagent swap in the process alters whether you get a 2C-x or a DOx. I just think it's tricky to keep unethical street dealers from selling DOB/DOC as acid and killing people, like they did with the N-benzylated phenethylamines (which are, imo, some of the most beautiful psychedelics to have ever existed).
 
There's almost nobody synthesizing mescaline at all,
This is not true at all. 2024 is the year of mescaline. Plenty of people are making it.
it's even cost ineffective compared to just running bath tub sized extractions on San Pedro/Bridgesii,
Also not true at all.
mescaline synths involve not only the use of alkylating but ALSO halogenating reagents
What are you even talking about? Mescaline requires neither halogenating or alkylating agents. You are clearly confused. Read pihkal again.

Regardless, this forum and this thread in particular is not suitable for synthesis discussion, so please keep on topic or i will start snipping. There are better forums for that anyway.
 
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