Phenethylamines The Big & Dandy 2C-D Thread - Please Insert Second Disc

[Didgital]

Been fortunate enough to have 2c-d in my life again. I have explored it up to 75mg orally.

At high dose, i am very much reminded of both mescaline and mdma, but different. Its extremely tactile, mentally clear, but not erotic AT ALL, if anything it is the opposite.

Like overall, that sort of primal need of mine seems satisfied.

Quite unlike 2cb or 2ci or even mescaline in that sense. I havent taken 2ce in years, but 75mg of 2cd starts to remind me of 2ce but still way less intense than even 20mg of 2ce.

Does anyone else feel like 2cd and mdma have similar qualities?

 

[Didgital]

@Pfafffed no where near the sheer intensity of 2ce, but at very high dose its very reminiscient of 2c-e in its entheogenic qualities except w/o insane body load or psychic stress lol

 

[iom]

Does anyone else feel like 2cd and mdma have similar qualities?

Kind of, yes. I think 2C-D is quite stimulating (at least in the lower end of its range), and has quite a lot of entactogenesis as well. Some data I've seen suggest that when compared with other 2C-X drugs, it may have relatively less affinity for 5-HT2A (psychedelic) compared to 5-HT2B (entactogenic) and Alpha-2 (stimulant). At the same time, I find it has a strong cognitive and mental edge which pulls the experience away from the emotional realm, at least for me.

@Pfafffed no where near the sheer intensity of 2ce, but at very high dose its very reminiscient of 2c-e in its entheogenic qualities except w/o insane body load or psychic stress lol

Except for a single 50 mg dose, all my experiments with 2C-D have been at 20 mg and under. Unfortunately, even at 20 mg, I get a rather heavy body load during the come-up with chills, shakes, sweats, jaw clenching, teeth chattering, muscle aches, and a sour stomach. By the time those effects begin to fade, the trippy headspace essentially fades away too, and I get a kind of smart-drug-like effect I guess. It's actually very pleasant and fun after that crazy come-up, but it isn't really that trippy, or wasn't at 50 mg. Perhaps I'll try working my way back up there and beyond, but to be honest, I kind of like what the low doses do for me in so far as it's quite unique and distinct.

Meanwhile, 2C-E continues to amaze me, and except for one occasion in which my body was in poor shape going into the experience, 2C-E has always treated my body quite well. It does seem to be extremely psychedelic to the point that my thoughts can strongly affect how my body feels, but I also feel like I can direct the experience toward the positive as long as the setting is ok. I've never had anything like a bad trip on it, and typically my trips on it are very euphoric.

 

[Didgital]

It's actually very pleasant and fun after that crazy come-up

The 2c afterglow... is sometimes more what im after than the actual trip itself, and 2C-D has a really nice afterglow.

I personally dont get much negative body load from the substance. Maybe a touch of nausea, but im usually drinking beers, which i notice i tend to want less and less as trip progresses

The tail end of my 75mg, was the best part, id stopped drinking beer hours before this (was essentially sober) still had strong enactogenic effects, libido came back, and overall felt great.

2C-E..... first of all, while the trip itself is indescribable, the afterglow is what i truly enjoy, starting around T+8:00 ending around +16:00. Its a very long experience for me, and always fucks up any regular sleep schedule im on. And it has always had very strong body load, more than any other substance including 2C-t2 or 5-meo-met. It usually starts off like im literally getting sick and by hour it starts to smoothe out physically, while the trip is intensifying.

I may never take 2C-E again, last time was 16mg, i swore i wouldnt look at the news. But on that uncomftorable come-up i wanted something to distract me. That was the day COVID global pandemic was officially announced.

Not the best substance to hear that.

 

[Didgital]

At the same time, I find it has a strong cognitive and mental edge which pulls the experience away from the emotional realm, at least for me.

I get that too, at least during the peak experience..

 

[xdrc]

I spent a couple minutes just now questioning why I wrote about 2C-D's entactogenic qualities (or lack thereof for me) in the Social Tripping Thread. Turns out I meant to reply to this thread...

I'm always surprised when I hear about people claiming these sort of effects for 2C-D. For me some of the value of the substance is precisely not an inherent mood altering, but rather a quite neutral feeling which will develop according to the thoughts being pondered. Now while this is a quality which is shared to some extent by pretty much any psychedelic, many of them seem to tinge the mood into on direction or the other. At least subjectively, 2C-D gives me no such impression. In this aspect, 2C-E is quite similar, though it often gives me a feeling of an overpowering neutralness. 2C-E often feels like a divine machinery which keeps on running, with seemingly no discernible intention, and it certainly does not care whether you get stuck in the cogwheels and ground to dust... (all the while giving me a sizable bodyload which I suspect is tainting the nature of the experience significantly - I'm considering combining with ondansetron to get behind this). 2C-D is on a much more personal level and while I do think it is a full blown psychedelic easily capable of inducing ego dissolution at the right dosage and time, despite the lack of mood-enhancing properties it typically feels non-threatening throughout.

And it's a super short experience, which is pretty cool! So far I've only gone up to 50 mg though, which is plenty for me, riding the edge between too much and just right.

 

[emkee_reinvented]

Does anyone else feel like 2cd and mdma have similar qualities?

Not me, actually was scared of 2C s till i took 2C-E.
And that made review my thought s, on them and also Tryptamine s.

MDMA and similar acting Empahogen s are past.
Fell in the cooking pot they brew MDMA in.
Put a good track on. And i m in Ecstasy.

So this is 1 hour on MDMA these day s.
https://www.bluelight.org/community...istening-to-today-thread.946319/post-16304284

2C-D also 2C-C even 2C-B to a extent are not high on my list.
2C-E reminds me a bit of MDMA, like it has bit s.

And 2C-T2 is heaven. Not MDMA like as 2C-E, but taken on the comedown.

 

[Didgital]

So... I have taken the 2C-D probably close to 20 times at this point. 2 of those times were 7 years ago, the rest have been in the past 3 months.

Here is my assessment. To start, I quite like it. To me, it's effects are extremely clear headed, slightly visual, and then depending on dosage it can be analytical or empathogenic. If I HAD TO COMPARE, i would say it is more mescaline like than it is 2C-B like.

My very first time w 2C-D (it was the HCL), I had rolled up to the Grand Canyon at night, slept in my car illegally. Upon waking, I snorted 25mg of the HCL salt. The burn was.... enough to kind of put me in a bad mood. I stepped out of the car and saw the canyon for the first time and I immediately felt like an insignificant and temporary piece of dust. So that first trip, was somewhat melancholy, though it kind of improved as the day went on. While it wasn't the most positive trip, as a psychonaught and explorer of 2Cs I was intrigued.

A few months later, I had organized a Shulgin appreciation party in honor of his bday (2018?). Everyone at that party was tripping on different substances. I chose to take 50mg 2C-D orally (it was the very last of the 2C-D HCL that I had). This experience was so much smoother. Not only did things get extremely colorful, communication flowed well, conversation was quite fun, and in that moment there was quite a bit of euphoria. Everyone had a great time. We had people come in for this small gathering from around the country. I was proud. Went home and slept like a baby. My intrigue grew.

--------------------------FAST FORWARD TO 2025.

I had hoped that I would encounter 2C-D again, but after 7 years I hadn't. So I decided to take matters into my own hands, and lets just say I made it available for the rest of my life.

First trial this run was 37mg. All of these experiences are with 2C-D Hemisulfate, so it is slightly less potent than the HCL, but not by much.
I took it and ran to a concert at a local park. I was surprised at the level of visuals, and also the heart opening effect. I came home so happy.

2nd trial was eyeballed but I would say it was close to 75mg. At this dosage, it resembled mescaline more than any other 2C that ive tried (ive tried most). I had kind of hoped that it would be erotic enhancing, but it did the opposite. I felt so spiritually satisfied that the idea of sex or orgasm just wasn't in my mind (not the case with 2C-B or 2C-I) in that sense it felt more like 2C-E, but a lot gentler. I was actually reminded of MDMA during this experience. The visuals were there but never overwhelming.

Since then, I have only taken microdoses, and the effects while arent quite as pronounced, are still obvious. I've taken it as low as 3mg and still seem to feel it, tho my preffered dosage is probably around 10mg. It never approaches MDMA, 2C-E, or Mescaline effects at this dosage. Its something different. Its like a more entheogenic and less stimulating adderal. Every day that I did take a small dose of 2C-D was just amazing. I achieved my daily goals w ease. Even on days that i woke up feeling doubtful or hungover, I would take 5-15mg and my day would be so much better. I did this maybe a dozen times or so and mostly, " results were similar.

Last night I took 7.5mg and went to a Choctaw fire ceremony. We wrote on 2 pieces of paper. On one we wrote some something we want to leave or exit our lives, on the other we wrote something we want in our lives. I didn't tell anyone that I had taken the 2C-D. The leader of the ceremony though seemed to notice anyway. I had met him prior to the beginning of the ceremony and we both exchanged knowing glances. Throughout the ceremony in between songs he would call me out and say "HEY! what do you think of this ceremony. I threw my intentions into the fire and replied "Thank you for bringing us together". I left the ceremony ended, got home and slept like a baby. I think 2C-D's after effects linger. More than 2C-B or 2C-I

 

[iom]

This is a great retrospective. I too have noticed a subtle connection between 2C-D and mescaline, but I still think 2C-D comes with a kind of 2C-X-base effect, if that makes sense.

To change the subject, I'm somewhat curious about a 2C-D + psilocybe mushrooms combo. Anyone tried that before? My thinking is that the 2C-D might add energy and clarity to the mushrooms, or perhaps the mushrooms would provide some grounding and depth to the 2C-D. I also think they have at least roughly similar timelines and durations with the mushrooms perhaps setting in a little faster and lasting a little longer.

 

[Didgital]

This is a great retrospective. I too have noticed a subtle connection between 2C-D and mescaline, but I still think 2C-D comes with a kind of 2C-X-base effect, if that makes sense.

To change the subject, I'm somewhat curious about a 2C-D + psilocybe mushrooms combo. Anyone tried that before? My thinking is Allthat the 2C-D might add energy and clarity to the mushrooms, or perhaps the mushrooms would provide some grounding and depth to the 2C-D. I also think they have at least roughly similar timelines and durations with the mushrooms perhaps setting in a little faster and lasting a little longer.

All I said was... out of all of the 2C's ive taken... 2C-D at high dose is more like mescaline than another 2C...

On your side note... I have also explored 2C-D as a potentiator like sasha described. I've combined it with very low levels of 5-Meo-DMT and 5-Meo-MIPT
Um...

They potentiate eachother..

specifically with 5-meo-mipt.
(7.5mg of 2C-D orally) I hit the residue of a pipe that I'd previously smoked and carefully weighed out 2.5mg of 5-meo-dmt and 7.5mg of 5 meo-mipt...

The 2C-D is ever present. is this the psychedelic tofu that sasha mentioned?

 

[xdrc]

Very cool, interesting read and I like to see this compound appreciated. I'm currently all out of it. I intended to trip with it this week, but then realised that some microbial contamination has gotten to the aq. solution. I had previously just hoped it would keep clean, starting from distilled water without preservatives trying to minimise handling. Unfortunately I'm all out of good luck on that front. Fortunately it was only a few doses, like 100 mg at most. I've been making the switch to propandiol. I do have great hope I'll come across a significant quantity again though.

I am aware that everyone is different, but one of the qualities I like about 2C-D is the entire lack of entactogen-ish qualities. It is a very clear and insightful headspafe for me without any hedonistic distractions, which I really appreciate about it.

@Didgital I'm curious, how long does a full dose aft for you? Also, I think (still not) addressed in the social tripping threads, but how do you respond to low doses (~ < 10 mg)? Do they interfere with everyday life, rational thought, learning, or does it enhance this for you?

PS: From what I remember in the pharmacology notebooks I think Shulgin kept the dosages rather small, which may be the reason for his assessment.

 

[iom]

I looked at Erowid and couldn't find any report of mushrooms combined with 2C-D. I did find a handful of reports of mushrooms combined with other 2C-X and 2C-T-X. Only a few were especially informative, but the better reports suggest neutral to favorable results. One report for (IIRC) 2C-B + mushrooms expressed frustration because they didn't seem to really potentiate each other---"it was like having two +2 trips at the same time." Reports involving 2C-I and mushrooms were more favorable, suggesting that they synergized in many ways including visually. Reports involving 2C-E and mushrooms suggested this combo could produce trips that were particularly profound, but there were only a few of these.

It seems like the combo may be worth a shot, but I have my reservations. Unfortunately 2C-D and mushrooms both tend to give me rather rough physical come-ups. I'd hate to get stuck with the worst of both worlds there, but who knows. Right now I'm leaning toward just taking some mushrooms tomorrow and saving a combo until I have a bit more "current" experience with both of these things at higher doses. (The last times I had decently strong trips on either of these was over a decade ago.)

 

[Didgital]

I like about 2C-D is the entire lack of entactogen-ish qualities. It is a very clear and insightful headspafe for me without any hedonistic distractions

At high doses +75mg its very enactogenic imo, tho not especially tactile but i do get heart opening and physical tingles.. the heart opening is especially pronounced after the plateu. it never gets super visual, but is still psychedelic, never overwhelming. Colors, lights, maybe some geometric CEVs. Out of all of the compunds ive tried it (including TMA-2) sorta mirrors mescaline (like most 2C-x), the most.

This becomes more apparent at higher doses. I will agree its way less tactile than most common empathogens, and a

Mescaline to me def an enactogenic effect. It feels like a spacier, more visual and slower MDA.

2C•D has smooth stimulant/ light psychedelic/ and empathogen all rolled into one to me.

It does have minor tactile effects and one observation of mine, is that duration def increases w dosage. W the 4 alkyl 2C-x's i have tend to have a particular afterglow effect, that after im done tripping, im still high. At high doses of 2C-D, i feel altered for a good 10 hrs . At lower doses, (less than 35mg) im usually 95% back around 5 hrs. Microdoses of 7.5mg i still feel for approx 5 hrs.

The empathogenic effects seem to present themselves at higher doses, while the stimulant side never gets... worrying in any way

While i say its an amazing psychedelic, i would refute the pihkal entry that says its just as psychedelic as 2c-b, tho i believe that entry was 150mg, Ive only taken hapf that dose, and i dont think i need to take more than that again

Ive mostly taken it 7.5-15mg. Its wonderful... i insufflated 10mg the other day, i prefer it orally...

 

[xdrc]

While i say its an amazing psychedelic, i would refute the pihkal entry that says its just as psychedelic as 2c-b, tho i believe that entry was 150mg, Ive only taken hapf that dose, and i dont think i need to take more than that again

I've missed your post earlier, thanks for your further comment. Personally I believe 2C-D to be the deeper pond than 2C-B, but I rarely dose what is high to me: 2C-B I've dosed up to 44 mg or 25 mg rectal, 2C-D up to 50 mg (two trips at that dosage). The 2C-D proved to be much more valuable at providing deep insights and I believe under the right circumstances full ego dissolution is possible to occur within the 20 - 60 mg dose window for myself.

After running out of the material (some spontaneously converted itself into the NBOH, some was lost to what seemed bacterial contamination in an aq. solution), I've been reunited with the compound for now. To celebrate the occasion, I took a dose today.

(with 20 mg) "Smooth and fast come-up with characteristic electrifying head tingles at 20 min. While showering, some valid criticism and analysis of a certain flaw of mine, showcasing a significant introspective push of the material even at low dosages. I'm made aware of some tension in the neck region and shoulders, which is resolved by stretching. Shortly before peak effects, there is a minimal amount of nausea, barely noticeable, but only for about 5 min. Later during the experience, some food intake did not present any troubles. Music is augmented fabulously, going about chores while dancing, good mood, mild stimulation, but no significant inebriation - there would likely be utility to use in this dosage range as a "concert dosage" during events where sobriety is expected and desired. Smooth and swift comedown at the third hour to a refreshed mind, "mental menthol" arrived at as apt description. No hangover or after-effects. This material is the clear-headed, analytical pendant to the warmer, more intoxicating 2C-B. An absolute ally and love of mine. An alternative to 2C-E with much less of a commitment."

 

[emkee_reinvented]

Retrospective started with 2c-B 10/ 20 mg doses then 2c-T2. Few times 20 mg.
Then 2c-C and -D at ~ 15/ 30 mg. Followed last not least by 2c-E 10/ 15 mg.

-T2 and -E were excellent. Felt 'warm' Kinda like described by @iom. While -C and -D had no cognitive gain s, only aggravated body-load less psychedelic. For me !

2c-B was odd. In the middle. As its head-space was not persee friendly but prank-y. cartoon ish, a shared theme people mention. That feel s in line with mine.
Challenging but worth it. C en D i don t plan to revisit.

The other 3 gladly. Still got some DOI but didn t like it. Body-load very present, and x times the duration. Still got some 2c-E stashed as it was so good. Thought it would be hard core. but not for me. Very pleasant chemical. To trip on.

 

[xdrc]

I am quite curious @emkee_reinvented , arguably 2C-C and 2C-D, especially at those dosages would be considered milder. What turned you off with them?

 

[perpetualdawn]

Still got some 2c-E stashed as it was so good. Thought it would be hard core. but not for me. Very pleasant chemical. To trip on.

I think if you keep the dose tame, 2C-E is very pleasant and nothing like it's hardcore reputation. For me 10-12mg is the sweet spot although I'd like to try it at 14-16mg again. It seems like 20mg+ is just too much for this one and it has a very steep dose response curve

 

[xdrc]

It seems like either Michael Schlichting (I think more likely given age) or Hanscarl Leuner took the material not up to 150 mg, not 200 mg, but 250 mg! Don't repeat at home.

 

[iom]

That's just nuts considering I get a heavy body load on only 20 mg.

 

[TheLightBringer]

Kind of, yes. I think 2C-D is quite stimulating (at least in the lower end of its range), and has quite a lot of entactogenesis as well. Some data I've seen suggest that when compared with other 2C-X drugs, it may have relatively less affinity for 5-HT2A (psychedelic) compared to 5-HT2B (entactogenic) and Alpha-2 (stimulant).

Damn that kinda sucks to hear if thats true, high 5HT2B agonism means its likely extremly cardiotoxic with repeated use and can cause valvulopathy. Luckily people rarely use high doses of 2C-D with high frequency.

I just want to comment that Shulgin himself had to get heart surgery to replace a defective valve. He never made the connection himself but I wonder how much his use of potential 5HT2B agonists influenced this, as most of his compounds dont have proper research on their receptor affinities…


Ill look into 2C-Ds pharmacology later and edit this if I see that its 5HT2B agonism seems insignificant