• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

The Big and Dandy AMT Thread - 2nd incarnation

Status
Not open for further replies.
Does anyone notice thier sweat gets a rather unpleasent smell when they're on this drug? I tried it for the first time and it could have just been the taste of the chem coming up my nasal passages from heaving it out at the 1.5 hour mark but just in my own mind I smelled horrible! def similar to the drugs smell itself (mothbally)

Felt pretty cool but it took 4 hours before the nausea subsided (30 mg dose) and I had a good time, I would have really enjoyed this drug at certain times of my life but I'm due for a break from 95% of substances for a bit this trip told me.
 
Tunnelfission said:
Does anyone notice thier sweat gets a rather unpleasent smell when they're on this drug? I tried it for the first time and it could have just been the taste of the chem coming up my nasal passages from heaving it out at the 1.5 hour mark but just in my own mind I smelled horrible! def similar to the drugs smell itself (mothbally)

Felt pretty cool but it took 4 hours before the nausea subsided (30 mg dose) and I had a good time, I would have really enjoyed this drug at certain times of my life but I'm due for a break from 95% of substances for a bit this trip told me.
Click to expand...

Cant say i've notice my sweat smelling but i have sweated quite profusely on it. Next time i will have a whiff. One thing i did notice which i thought was a bit odd is that after administering rectally, i could actually taste the substance about an hour or so into the experience. very odd - not sure if i really tasted it or it was because i had a sniff of the smelly stuff and i was 'remembering' what i had smelt.
 
Well i did 80mg hcl saturday topped up with another 30mg and a gram of weed, 5 hours after ingestion - proper fucked. Me and the missus were just chatting repetitive shit for several hours, forgetting what we'd said just 5 seconds ago. Good buzz initially. Then got a bangin headache for half hour and fell asleep for 27 hours(10 hours after ingestion)!
 
Would taking some vitamin E before I dosed lessen the alleged "neurotoxicity" of this chemical, or does that only apply to MDMA?
 
I don't think this chemical is particularly neurotoxic in comparison with MDMA. I'd definitely go with your usual drug preparations though; I found working out beforehand and making sure my stomach was completely empty really lessened the body load and made the whole experience a lot smoother.
 
Alright, thanks. Yeah, I might as well take it, it's not like it's going to hurt. Might help counter some free radical damage too, if it has a similar action to MDMA that is.
 
AMT & dramamine (anti-nausea drugs)

i would advise against mixing AMT (or almost any drug for that matter) with anti vomiting drugs.
my reason being that vomiting is a useful function of the body for avoiding dangerous overdoses. for example: no one would take gravol to combat vomiting from alcohol because its dangerous to not be able to puke.
AMT in specific as well as many other RC's are often highly variable in effects. 40mg may be just enough to trip for one person, while that same dose may be a nightmarish overdose for another person. which makes loss of the vomiting function extremely risky...
the lesson here is to start small and don't be afraid to vomit.
 
commander-blue said:
i would advise against mixing AMT (or almost any drug for that matter) with anti vomiting drugs.
my reason being that vomiting is a useful function of the body for avoiding dangerous overdoses. for example: no one would take gravol to combat vomiting from alcohol because its dangerous to not be able to puke.
AMT in specific as well as many other RC's are often highly variable in effects. 40mg may be just enough to trip for one person, while that same dose may be a nightmarish overdose for another person. which makes loss of the vomiting function extremely risky...
the lesson here is to start small and don't be afraid to vomit.
Click to expand...

Well said that man
 
33Hz said:
Alright, thanks. Yeah, I might as well take it, it's not like it's going to hurt. Might help counter some free radical damage too, if it has a similar action to MDMA that is.
Click to expand...

Any antioxidants could only be a good idea I think. FYI, AMT does release monoamines like MDMA does... in fact it releases serotonin, dopamine, and norepinephrine. But it does so very slowly over its long duration and so it does not cause anywhere near the damage or depletion that MDMA causes, at least not with responsible use. MDMA releases a bunch all at once which is why it's more dangerous. And if I recall correctly, MDMA also metabolizes into alpha-methyldopamine, which is neurotoxic to serotonin neurons, and AMT does not.

Someone please correct the above information if it's wrong... I am too lazy to look it up right now but from what I recall with discussions with some intelligent and knowledgeable Bluelighters, that's the deal.
 
Xorkoth said:
Any antioxidants could only be a good idea I think. FYI, AMT does release monoamines like MDMA does... in fact it releases serotonin, dopamine, and norepinephrine. But it does so very slowly over its long duration and so it does not cause anywhere near the damage or depletion that MDMA causes, at least not with responsible use. MDMA releases a bunch all at once which is why it's more dangerous. And if I recall correctly, MDMA also metabolizes into alpha-methyldopamine, which is neurotoxic to serotonin neurons, and AMT does not.

Someone please correct the above information if it's wrong... I am too lazy to look it up right now but from what I recall with discussions with some intelligent and knowledgeable Bluelighters, that's the deal.
Click to expand...

Thanks for that. I'm going to be taking some later this evening with a close friend of mine. Bearing in mind that this is our first time, would 40mg (after an allergy test) be too high a dose to start off with? Both of us have a good deal of experience with the 2c's, shrooms/4aco-dmt, and LSD to a lesser extent.
 
commander-blue said:
i would advise against mixing AMT (or almost any drug for that matter) with anti vomiting drugs.
my reason being that vomiting is a useful function of the body for avoiding dangerous overdoses. for example: no one would take gravol to combat vomiting from alcohol because its dangerous to not be able to puke.
AMT in specific as well as many other RC's are often highly variable in effects. 40mg may be just enough to trip for one person, while that same dose may be a nightmarish overdose for another person. which makes loss of the vomiting function extremely risky...
the lesson here is to start small and don't be afraid to vomit.
Click to expand...

good advice, and thank you.

But can i ask why not vomiting is risky?

You would not be vomiting the drug out, since by the time you are feeling nauseas or tripping it has already made its way into your bloodstream and vomiting or not vomiting wont make the slightest bit of difference to your trip (except re-leaving nausea).
 
Isn't 5HT3 agonism correlated with nausea and anxiety? It sounds like an improvement to me. I agree that when first finding your dose you shouldn't take them in order to reserve the potential to puke up an overdose, but once you get your bearings sail away.
 
^Actually, there is anecdotal evidence that 5-HT3 antagonism may potentiate psychedelics with 5-HT2A agonism. The reports are mixed, but most at least agree that it effectively abolishes nausea.

Mescaline - Experienced - "Soul annihilating overdose"

Though this is merely conjecture, the high concentration of 5-HT3 receptors in the gut could potentially sequester the active compound and prevent it from getting to the brain. Therefore, filling these receptors with an antagonist would not only alleviate nausea, but would also increase the amount of compound that enters the brain. That's just my completely unsubstantiated theory. There are also 5-HT3 receptors in the brain, including the nausea center (chemoreceptor trigger zone), which may also help explain the antiemetic properties. Nausea from psychedelics likely reflects 5-HT3 agonism, not toxicity, so prevention of vomiting should not be dangerous.

Other roles for 5-HT3R are unclear, but the receptor is present through the CNS, with high concentrations in the neocortex and amygdala. Interestingly, ondansetron has been shown to mitigate some of the physiological signs of opiate withdrawal.
 
Status
Not open for further replies.
Top