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RCs The AH-7921 (Ah7921) Megathread (v1)

Has anybody else noted that you don't get 'pinned' pupils? I have little tolerance & felt it (but nothing euphoric) but eyes were not affected. Two real junkie mates shot 150mg each and said 'couldn't FEEL it but I didn't rattle for 12 hours'.

So maybe it's got a use since it seems less abusable than methadone.
 
i used to need 300 mg to feel anything. Ive tapered down to 35 now. I took 150mg last night as a treat/relapse/call it what you will.

Astonishing euphoria and a big warm mellow high off just 150mg last night, along with some etiz and noids. Almost up to odt levels. I reckon my opiate receptors and endorphins have apprecaaited the lower level of caining ive subjected them to in recent weeks. They thanked me for it last night. it was wonderful......

Id steer clear unless u hvae very low tolerance, or your using it for tapering or w/e. Its so good to have knocked that tolerance on the head. The jumping off part doest seem so straightforward now tho.

the fact that ive finally got a tolerance low enough to be able to actually get high off it, makes it harder to quit. What a fuckin carry om. Honestly.
 
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But what is 35mg? I don't think I would have felt 35mg four years ago when my opioid receptors were practically virgin. It's placebo! :D
 
Hey guys,

mdb: Like I suggested, I would switch from the AH to Kratom and then taper down that way. Was the easiest of my WD-trys regarding symptoms, even if I only made it 4 days...

knock: with a low tolerance 75mg sublingual was my standard dose to be pleasantly buzzed and productive. But yeah, oral it would need around 125-150mg.
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Damn, day 11 and I could easily start again next week. Which I won't.
 
I always IM'd 75-200mgs. I have a natural tolerance to opi's unfortunately. I can't say i've found much from AH, though admittedly i've only used it about twice alone. I always combined it with MXE into the IM shot. It surely was a crazed come up, great for the pain I was/am in. Thinking of getting more for that reason. Seriously miss the proper +ODT that certain RC compaines with brillant reps had. Oh well though, probably for the best because AH isn't nearly as compulsive as ODT.
 
knock said:
But what is 35mg? I don't think I would have felt 35mg four years ago when my opioid receptors were practically virgin. It's placebo! :D
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Can you be certain of that ? Certain that it doesnt give the opiod receptors just enough of what they need? That could be all they need. We dont know the active doses to we ?

Admittedly, all this is sounding more and more like clutching at straws. 35mg must be at least borderline placebo if not the mildest possible dose. I believe it'll be singnificantly easier to jump at 5 mg than 35mg though.

You missed the good bit of my post about how my opi tolerance has dropped so much. That 150mg last night was so nice. Did 150 tonight, no where near as pleasurable an experience. Isnt it weird.

Ze Taper must continue tomorrow as planned ! Might not be too bad as if you are correct ive just had a very low dose two night binge, which shouldnt trigger much in the way of WDs, youd have thought, in theory ?

Hope im making sense. Hows my bitcoin doing.......
 
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I was trying to encourage you by showing you how small your problem was ;) You've done well though, no doubt.

AH has always been a bit hit or miss for me, 300mg should get me nodding, but sometimes I've barely felt it. I think stomach contents have a lot to answer for.
 
I most certainly have pin point pupils right now from AH, I done a 175mg +/-5mg shot IV and it is a really pleasant buzz, much better than codeine, but much worse than brown. Directly in the middle of both those I would say...
 
adrandell116 said:
I have some food for thought.... If AH-7921 is around 80% strength of Morphine
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You need to take those numbers with a large grain of salt. The % Str figures are generated in a test tube using pieces of Guinea pig intestine. The %str is a relative measure of how much the opiate inhibits the contractions of the intestine segment, as this is an indirect indicator of Mu-receptor biding affinity [I think the Guinea pig intestine does not express the other opiate receptor subtypes].

At best, the %Str number is a measurement of the relative constipation induced by the opiate.
Based on what I've read/seen, the %Str is also a good predictor of analgesia induced by the opiate (and the %Str is often validated in animal pain studies).

But I think the correlation is very weak between that number and how euphoric or intoxicating a compound is.
 
Hey I'm a long time user of AH-7921, I posted on some of the first few pages of this thread last year, suggesting sublingual administration as the best ROA. I lost my bluelight L/P/email though :(

Anyways, for those who are IV'ing this compound, could you describe how you're able to solubilize it? I'm working with the freebase, and in contrast to other recent posts, I find acid doesn't work to keep it in solution (A hot, solubilized solution will still precipitate upon cooling). Also, I thought I would share some solubility data that I obtained from a professional neuroscience company that is studying it.

For longterm storage,we suggest that AH 7921 be stored at -20C where it should be stable for at least two years. AH 7921 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of AH 7921 in these solvents is 11, 3, and 10 mg/ml respectively.

Ah 7921 is only sparingly soluble in water-based buffers. For maximum solubility in aqueous buffers, AH 7921 should first be dissolved in ethanol, and then slowly diluted with the aqueous buffer of choice. AH 7921 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:saline (phosphate buffered pH 7.2) using this method. We do not recommend storing the diluted solution for more than one day.
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Psychedelic Jay said:
This seems like a waste of time...

Who really knows the true strength?
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That's what human Guinea pigs are for. This GP and others posting to this thread have reported 100-200mg to be a reasonable dose (in my case I prefer SL). It only burns the underside of my tounge the first time I use it. My skin peels off sort of like when I burn the roof of my mouth on something hot.

After that, the burning doesn't happen again with repeat dosing, unless I take a few weeks off.
 
raybeez2 said:
Hey I'm a long time user of AH-7921, I posted on some of the first few pages of this thread last year, suggesting sublingual administration as the best ROA. I lost my bluelight L/P/email though :(

Anyways, for those who are IV'ing this compound, could you describe how you're able to solubilize it? I'm working with the freebase, and in contrast to other recent posts, I find acid doesn't work to keep it in solution (A hot, solubilized solution will still precipitate upon cooling). Also, I thought I would share some solubility data that I obtained from a professional neuroscience company that is studying it.
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Lemon juice or ascorbic acid. The only issue being, as soon as the solution cools down, the AH precipitates and re-forms it's freebase form and separates from the water in the pin. Just suck it up and wack it while it is still hot, the chemicals in the blood stream will then ensure it stays in a liquid form and stop it precipitating back once again. I encountered your issue when I made up a dig and then went to get a drink, came back and it had separated (this took about 2 or 3 minutes to happen)!

I find 175 mg the perfect dose via this ROA too by the way. As for my opiate tolerance, it is rather small at the moment. 200mg street H, but very rarely.

Also, I have been drinking 3 or 4 pints of lager during my sessions on AH the last few times and it does really improve the euphoria a lot...
 
^ Thanks for this. I have some new interesting experimental data to report.

Subject's tolerance:
Tapering down from an IV H habit that he picked up ~3 months ago. Has cut back from 6 bags(~200-300mg)/day to 3 bags/day in a single shot. The H doesn't get him high, just gives him a dizzy rush ~10min and stops him from getting sick. Last use of H was 20 hr ago (3 bags). Subject sublingually dosed AH-7921 as follows: 50mg 8 hrs ago, and 100mg 2 hrs ago.

Dissolving Method:

Two diff IV preps were made side-by-side. Method A as described ^^^ above by adrandell116, using sterile IV-grade saline and vinegar. Method B - 50mg AH-7921 was placed in a sterile cooker, and 0.20 ml containing 0.10ml 70% isopropanol and 0.10 ml sterile IV-grade distilled water. A bit of powder dissolved immediately without heating. Then 0.80ml distilled water was added (total 1ml) and the mix heated.

Of note , the powder in Method B dissolved before the liquid was boiling, where the powder in method A required a full boil. Just to be safe, Method B was cooked to boiling also.Method B was chosen to proceed with. The mix was injected hot, but very gradually. Only 0.8 ml was used, 0.2 ml left behind.

Of note, after the injection was finished, I glanced over at the two mixtures. Mixture A had come out of solution. Mixture B was still perfectly clear. Either the distilled water, the isopropanol, of the combination made a HUGE difference to the solubility.

Effects:
IV'd 40 mg of AH-7921. It produced a STRONG rush - more intense than the 3 bags of H he's been doing, and DEFINITELY more Euphoric. There is also an ever so slight trippy quality. Tracers seen around trees blowing in the wind outside. 15min later and back baseline (== feeling the 100 mg dose of AH that done sublingual ~2h ago == no where close to nod-land.)
 
Raybeez2, do you mean that all 6 bags would amount to 200 - 300 mg? That is one and a half bags for me locally if it is the higher weight margin, so I bloody hope not! It would be cheaper for you to pack up and move home down to where I am and maintain your habit, than it would if you were to keep buying 4.5 bags extra to get the same amount of brown where you live. Haha.

Off topic I know, but I had to get an answer to this... :/
 
DickTate said:
Hey guys,

mdb: Like I suggested, I would switch from the AH to Kratom and then taper down that way. Was the easiest of my WD-trys regarding symptoms, even if I only made it 4 days...
Damn, day 11 and I could easily start again next week. Which I won't.
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can you remember how much ah you were taking when you switched, and how much kratom did u take to taper, and was it a quick taper from then on in ? Sorry to bombard you with all these questions. I'll be back down to 100mg tonight i think, then 50mg the next night. Hopefully the cunts at the prescribing clinic will have changed their mind and will give me some subs (i think theres been a bit of arse kicking going on behind closed doors there - the way im suddenly being asked to try thrm again) - theyve seen what happens whgen they dont help - i hit a brick wall and relapse. I'll speak to them tomorrow.
 
mydrugbuddy said:
can you remember how much ah you were taking when you switched, and how much kratom did u take to taper, and was it a quick taper from then on in ?
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I was on ~75mg sublingual when I switched to ~7g of Maeng Da Kratom. And yeah it was quick. Over 3 or 4 days only Kratom and then jumped off. One day was pretty bad but the rest was mild compared to my recent cut off from 0,4mg Buprenorphine. Restlessness & Insomnia being the main symptoms and a little diarrhea but nothing serious.

No problem with your bombardement, I'm glad to help :)

Btw: Day 12. I should not frequent OD so much...
 
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DickTate said:
I was on ~75mg sublingual when I switched to ~7g of Maeng Da Kratom. And yeah it was quick. Over 3 or 4 days only Kratom and then jumped off. One day was pretty bad but the rest was mild compared to my recent cut off from 0,4mg Buprenorphine. Restlessness & Insomnia being the main symptoms and a little diarrhea but nothing serious.

No problem wich your bombardement, I'm glad to help :)

Btw: Day 12. I should not frequent OD so much...
Click to expand...

Aye, you dont want to be triggered. 7g is about 2 heaped tbsps isnt it ? was that per day ? ive got some thai red veined kratom. 3rd night running ive been on non taper doses of ah. Shit. Ive still got a bit left over which im not seeing going to waste.
 
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