The 6-APB (that may be 6-APDB but probably isn't) Train Wreck of a Thread

[freaktech]

Is something known about the neurotoxicity of this chem? some study of Nichols in this area?

 

[stom10]

I honestly would be happy if someone could kill my argument here...

Re-read the clause. 'one or more univalent substitutions'

This is a single, divalent substitution. This is independent from a univalent alkoxy substitution, and is therefore legal as it isn't listed separately with the other divalent compounds.

Though it wouldn't surprise me if one of these terrible new vendors started marketing something that was still illegal because they didn't understand the chemistry of the laws.

 

[Skyline_GTR]

The other 36 simply fall outside the catch all - look carefully, they must be named to be illicit...

These are 2 of the 36:

What makes them fall outside of the catch all clause, but 6-APDB falls inside of it?

 

[Skyline_GTR]

Re-read the clause. 'one or more univalent substitutions'

This is a single, divalent substitution. This is independent from a univalent alkoxy substitution, and is therefore legal as it isn't listed separately with the other divalent compounds.

Though it wouldn't surprise me if one of these terrible new vendors started marketing something that was still illegal because they didn't understand the chemistry of the laws.

"One or more *other* univalent" to be precise - "other" being to key word as it impies the previous term refers to univalent too.

 

[nuke]

Is something known about the neurotoxicity of this chem? some study of Nichols in this area?

Pretty sure this one's neurotoxic given it's likely a monoamine releaser and a serotonin agonist. Not sure Nichols assayed it for toxicity, though.

 

[bonbon]

"One or more *other* univalent" to be precise - "other" being to key word as it implies the previous term refers to univalent too.

Grammatically, you're right. And I would agree with you completely had the law not made reference also to alkylenedioxy together with the other alkyl, alkoxy, or halide substituents mentioned.

The problem here is that no matter which definition you follow, alkylenedioxy is NOT univalent so the word "other" cannot be referring to that earlier part of the sentence detailing alkyl, alkoxy, alkylenedioxy or halide substituents. If you insist that the law must make sense, then you cannot substitute the ring with alkyl, alkoxy, alkylenedioxy or halide substituents at whatever valence and in addition to that, you may not further substitute by other univalent substituents.

Of course you can say "the law is just being stupid..." or "it's an oversight" and I would agree with you but the court wouldn't.

Heck - it would be great to get some 6-APDB on high street. But if you advocate that it's legal, you may convince people to get themselves into serious trouble. I imagine that TICTAC are reading this, debating and perhaps adding 6-APDB to their database only days after we post it here.

 

[bonbon]

Pretty sure this one's neurotoxic given it's likely a monoamine releaser and a serotonin agonist. Not sure Nichols assayed it for toxicity, though.

Here's a wee quote from Nichols 93

These compounds also proved to lack completely any serotonergic neurotoxic properties even when given in repeated doses over 4 days.

Sounds like a wonder drug to me!

 

[bonbon]

These are 2 of the 36:

What makes them fall outside of the catch all clause, but 6-APDB falls inside of it?

You're right I stand corrected - I have edited out that remark from my post.

 

[freaktech]

Here's a wee quote from Nichols 93



Sounds like a wonder drug to me!

Source of these information please! What compounds exactly he´s referred? (sorry if the question is bad formulated, my english isn´t good...)

 

[Stormin' Norman]

My interpretation of the UK law and the definiton of a compound by name. This appears to be defined by mathematics: sets.

A beta-ketone contains the amphetamine skeleton but is not by definition an amphetamine; it is greater than that.

A beta-carboline contains the tryptamine skeleton but is not by definition a tryptamine; is is greater than that.

The odd one out:
A dihydrobenzofuran (or benzofuran) which contains the amphetamine skeleton is not by definiton an amphetamine; it's name is defined by the dihydrobenzofuran (or benzofuran) ring structure.

 

[Black]

5-IAI is a poor 5HT2A/C agonist if I remember correctly. The neurotoxic effect is thought to also be a product of temperature dysregulation and elevation produced by serotonin agonism. From the structure and reported activity this is very likely to be a strong serotonin agonist in the right places. The numbers on reuptake looked good for 5-IAI but it seems part of the MDA/MDMA magic lies within its ability to agonize 5HT2A/2C receptors (MDMA more indirectly through its active metabolite).

you got a point there.
agonism at certain 5-HT receptors seems to play a role for mdma to work it's magic. but why only 5-HT2A/C and not others like 5-HT2B? (this paper is interesting in that respect)
with active metabolite you mean MDA?

edit:
what about an own thread for legality of 6-APDB in the uk?

 

[pharmakos]

what about an own thread for legality of 6-APDB in the uk?

that would go in a whole different forum.

 

[bonbon]

There are two separate threads interleaved here - one about legality and one about neurotoxicity... they're both kinda interesting but it would make things easier if they were split in two.

 

[FlippingTop]

Very interesting read, I ope to aquire some of this soon but the majority of suppliers I have seen are either blatent scammers, or just sites that have popped up to make a quick $...

Does anyone know how this should respond to any of the reagents in EZ complete, or another ay of double checking that what I get is actually (atleast in part...) what I think it is.

Then I can do more reading and maybe put it aside for another time

 

[Black]

Does anyone know how this should respond to any of the reagents in EZ complete, or another ay of double checking that what I get is actually (atleast in part...) what I think it is.

no, we have no idea up to now. the first people to receive their shipment will be the first to see the colour reaction.
it'd be great if someone with a test kit tested the "promo" stuff they've received if they have any 6-apdb left. that way we could compare if the samples sent out up to now are indeed the same stuff that's going on sale in a few days.

 

[Saucy]

well 6-apdb might be neurotoxic aswell but it can't be metabolized to alpha methyl dopamine which causes some of mdma's neurotoxic properties so it should be less neurotoxic to some degree

I'm guessing the lack of an oxygen on carbon 4 makes it more metabolically stable? Have all of the immediate and secondary metabolites of 4D-MDA been studied for toxicity as well as the chemical itself?

 

[rickolasnice]

i'm guessing the lack of an oxygen on carbon 4 makes it more metabolically stable? Have all of the immediate and secondary metabolites of 4d-mda been studied for toxicity as well as the chemical itself?

EDIT: wrong thread

 

[greenmeanies]

not necessarily more metabolically stable, just the metabolite(s) cannot be a-methyldopamine due to the carbon in position 4 instead of an oxygen there.

cleaving the ether bond should give 3-hydroxy, 4-(2-hydroxyethyl)-amphetamine as a possible metabolite of this one, no?

 

[Scoobysnacks]

mates 39th birthday on july 7 th , gonna book weekend off from work/home lol, ive done a lot of reading and think 6-APDB is the3 one im going for, found a vendor , bit expensive but if a gram will do three guys, all roughly same height , age and weight, 5,8" 37- 39 years and 10 and a half stone.

i dont drink alcohol but my mates definitly will, i will be smoking weed ( i do constantly as i need some habit),, we will be sitting in and listening to tunes , ya know catching up , not been home since xmas as wife doesnt let me go often haha, i was wondering in this situation is there another rc which would enhance the experience, ive not touched anything other than weed for years so my tolerance will be very low, what shd our doses be, we will all prefer to bomb and not snort, any help will be appreciated

 

[hx_]

mates 39th birthday on july 7 th , gonna book weekend off from work/home lol, ive done a lot of reading and think 6-APDB is the3 one im going for, found a vendor , bit expensive but if a gram will do three guys, all roughly same height , age and weight, 5,8" 37- 39 years and 10 and a half stone.

i dont drink alcohol but my mates definitly will, i will be smoking weed ( i do constantly as i need some habit),, we will be sitting in and listening to tunes , ya know catching up , not been home since xmas as wife doesnt let me go often haha, i was wondering in this situation is there another rc which would enhance the experience, ive not touched anything other than weed for years so my tolerance will be very low, what shd our doses be, we will all prefer to bomb and not snort, any help will be appreciated

We can't really give you any advice since the only human testing known has been in the last couple of weeks with two randomers on the internet trying it at the same dose (90mg).

What would definitely not be advisable would be to more than triple their dose and mix it with alcohol.