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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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Cliron said:
http://www.businesswire.com/news/ho...icals-Receives-FDA-Approval-Generic-Suboxone®

Pretty fecking exciting stuff. The FDA struck down that farce of a citizen's petition R&B proposed. Generic suboxone by early March. Niiiiiiiice.
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isnt subutex generic? my dr. wont prescribe me subutex cuz he thinks that you cant shoot suboxone...and suboxone is fucking expensive..subutex would save me hundreds! so generic would cost me wht like 30 bucks for an rx? compareed to the fucking 200 i spend right now.on top of the dr fee
 
Currently Subutex is generic, Suboxone is not. You can shoot up both. The naloxone in the Suboxone is just there to scare you. Finding a Dr to prescribe Subutex is extremely hard, they'll label you a drug seeker 90% of the time. You may get lucky if you can prove you've never touched a needle or are allergic to the artificial sweetener they put in Suboxone, or can genuinely not afford a Suboxone script.
 
After the patent on Suboxone fell, R&B predicted huge loss in the market. In response they funded a study that found out that their medication had a pediatric risk associated to it. They voluntarily withdrew the medication and at the same time wrote a citizen's petition to the FDA. This was strategically brilliant because when a company voluntarily withdraws its medication the FDA cannot approve any ANDAs (any generic application). They coupled this with a huge campaign trying to get the film off the ground (co-pay reductions, doctor education etc). The film's patent wont expire until 2025 so they had very vested interests in this. Some experts suggested that they just provide the medication in blister packs to prevent exposure to children...they responded that it would take too much time (8months) to approve by the FDA. Instead they wanted the drug fully off the market. Surprisingly, they produce suboxone in blister packs in other worldwide markets.

Also, in regards to a company ethos, they were fined 200k in the UK for anti competitive laws. Their patent for a heart burn medication went out, and so they took it off the market and replaced it with a similar medication of the same name which was still under patent. Since the medication (Gaviscon) had such a household brand, this confused consumers who weren't offered the cheaper version.

As of last week, the FDA struck down this petition and approved Amneal pharma to manufacture generic suboxone. Unfortunately for most patients, this information wont be known to them, so I urge you to discuss this with your physicians and have them specify it on perscriptions. The generic of suboxone is said in that article to be coming out in early March.

It apparently has a nice orange flavour.
 
down508 said:
does anyone else notice that the effects you get from suboxone are pretty erratic? If I do 2mg one day and 2mg the next day I could feel high as shit the one day and not feel anything the next day, just normal. I see no real pattern, just good effects on some days none on the other. been on em for 18 months but cut back from 16mg a day to 4.
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I totally agree....I've been on the subs for four years. I wish I could understand why on some days I can feel so great off of just 2-4mg and then another day, not much at all. I wish I had some kind of explanation and method to the madness, but I don't.
 
On the topic of the binding affinity of Buprenorphine to Naloxone:

Surprisingly few studies have addressed the ability to reverse the respiratory effects of opioids in general and buprenorphine in specific. Just two studies, dating from the 1980s, as well as some anecdotal data, suggest that the respiratory depression from buprenorphine is resistant to antagonism by naloxone.5–7 Relatively low bolus doses of intravenous naloxone have no effect, whereas high doses (2.5 – 10 mg) causes only partial reversal of the respiratory effects of buprenorphine. These results may be ex- plained by the short duration of action of a bolus dose of naloxone (resulting from a rapid elimination), combined with the high affinity of buprenorphine for μ-opioid receptors. Consequently, a bolus dose of naloxone may be unable to displace buprenor- phine from the opioid receptors. The buprenorphine-naloxone data contrast data on the ability to reverse fentanyl-induced respiratory depression, which is considered rela- tively easy. Short naloxone infusions up to 0.4 mg cause full reversal of fentanyl-induced respiratory depression in patients during halothane-N2O anesthesia.8
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Eveline van Dorp, Ashraf Yassen, Elise Sarton, Raymonda Romberg, Erik Olofsen, Luc Teppema, Meindert Danhof & Albert Dahan Anesthesiology 2006; 105: 51-57

So, even if one were to inject a full 8mg suboxone strip (which includes 2mg of Naloxone) Buprenorphines' long duration, and slow separation from the opiate receptors along with its higher affinity, the only thing that might occur would be some of the negative effects reported from high dose buprenorphine.

Its almost always explained by suboxone doctors that the reason Naloxone won't send you into precipitated withdrawal when taken sublingually, is that Naloxone has such a poor sublingual and oral absorption rate. Wile this is true, you got to ask yourself- well how come people sniff their suboxone without any ill complaints (aside from nasal irritation)? Naloxone actually comes in a delivery system that is absorbed through insufflation, so we know its definitely active INTRA-nasally. The whole thing is a bunch of bullshit and like others said before me, a scare tactic. PLUS, I have heard of individuals on pain management who were prescribed Morphine/Naloxone combination (the theory being that as long as the morphine was absorbed orally, the nalxone would have no effect) and DID get sick, taking the drig(s) as prescribed. They should just do away with Naloxone combinations IMO, as well as the recent trend of making incredibly difficult to defeat time release systems for XR medications. When pain pill addicts can no longer use pharmaceutical narcotics most will turn to street opiates (heroin), which is, as an unregulated drug is much more dangerous what with the wide range of purity from batch to batch, as well as a strong likely hood that users will eventually turn to the needle.
 
First Post, I have been on suboxone for a year and a half, no opiates since, my only problem is the needle, today is my first day trying to get off that habbit, i'm addicted to the process now, and I'm getting ready in the next few months to come off suboxone. First step is to stop the stupid addiction of the needle. Wish me luck, i know how bad needles are, and I still feel like a junky, only a legal junky, anyone know how easy it is to stop the needle itself, any adice, i know this is most likely to go to another page, but i'm new to bluelight.
 
Patrickenergy said:
First Post, I have been on suboxone for a year and a half, no opiates since, my only problem is the needle, today is my first day trying to get off that habbit, i'm addicted to the process now, and I'm getting ready in the next few months to come off suboxone. First step is to stop the stupid addiction of the needle. Wish me luck, i know how bad needles are, and I still feel like a junky, only a legal junky, anyone know how easy it is to stop the needle itself, any adice, i know this is most likely to go to another page, but i'm new to bluelight.
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So you've been IV'ing your suboxone this whole time then?
 
Does anyone feel that the suboxone films/strips don't work as well as the tablets? I always heard they were better and faster, but when I tried them they seemed to have like no effect on me. I switched back to the tablets, even when my main pharmacy told me they stopped making them. I went to a different pharm simply because they still had the tablets in stock. I use my sub as directed, under the tongue. Is there something I'm doing wrong? I really don't feel any of the normal suboxone feelings (ease of w/d, slight pupil constriction, etc) when I use a strip instead of a tablet. It is so frustrating because now my doctor won't even write a script for the tablets because all anyone has is strips.
 
Blind Melon said:
I can't remember if I've asked this before (benzos), but does Kratom work with buprenorphine in your system?
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yea but to an extent nothing to special u wont get sick try like 4 mgs of kratom it will make u feel well bupe feel like a opiate hell u might nod .lol. when i take 8mg sub 4 mg klonopin a couple mgs of kratom it works have fun i always end up fkked up passed out aahahhaha in the grass faster than that xanax ,i chewed up to fast lol sorry man but yea
 
Forgot to ask something, I just started back on Suboxone maintenance a few days ago at 4mg/day. Prior to getting back on maintenance I was buying Suboxone on the street when I couldn't afford heroin and 2mg IV would get me well. I really want to stop injecting bupe and just take it sublingually, for health reasons and for the longer duration. However, because the bioavailability of bupe when taken SL is only 30% as opposed to 100% when IV'd, I would technically need to take 8mg SL to get 2.4mg (30%) into my system, correct? At the moment I pick up 2x 2mg Suboxone tablets daily from the pharmacy and I have been IV'ing them, somewhat out of habit and somewhat because I don't trust 2-4mg taken SL is enough to hold me, if my tolerance is 2mg IV to relieve withdrawal symptoms. Ideally I want to be on as low a dose as I can get away with, but 30% of 2mg is 0.6mg when taken sublingually. That seems like way too low a dose of bupe to hold me.

Thoughts?

A. <3
 
Ashley said:
Me too, both IV and sublingual. I don't notice any difference between the film and the tablets. Though, I do find Subutex feels stronger than Suboxone, specifically IV.

Ash. <3
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Are you filtering with a micron filter? The brand name Subutex tablets are smaller and weigh less (hence less inactive ingredients) than the Suboxone tablets.

Ashley said:
Forgot to ask something, I just started back on Suboxone maintenance a few days ago at 4mg/day. Prior to getting back on maintenance I was buying Suboxone on the street when I couldn't afford heroin and 2mg IV would get me well. I really want to stop injecting bupe and just take it sublingually, for health reasons and for the longer duration. However, because the bioavailability of bupe when taken SL is only 30% as opposed to 100% when IV'd, I would technically need to take 8mg SL to get 2.4mg (30%) into my system, correct? At the moment I pick up 2x 2mg Suboxone tablets daily from the pharmacy and I have been IV'ing them, somewhat out of habit and somewhat because I don't trust 2-4mg taken SL is enough to hold me, if my tolerance is 2mg IV to relieve withdrawal symptoms. Ideally I want to be on as low a dose as I can get away with, but 30% of 2mg is 0.6mg when taken sublingually. That seems like way too low a dose of bupe to hold me.

Thoughts?

A. <3
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2mg IV is way too high of a dosage. How much full agonists were you using prior to Suboxone? Were you doing like huge high dosage opiates for a long time?
 
Captain.Heroin said:
Are you filtering with a micron filter? The brand name Subutex tablets are smaller and weigh less (hence less inactive ingredients) than the Suboxone tablets.
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Of course, I always use a micron filter (0.22um) when injecting any kind of pill or suspect compound. ;)

2mg IV is way too high of a dosage. How much full agonists were you using prior to Suboxone? Were you doing like huge high dosage opiates for a long time?
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Yeah, I have been using high doses of opiates for around 6 years now with no real period of abstinence (maybe 3 weeks, at most). I was injecting 32mg/day of Subutex for about 4 years up until about a year ago, when I jumped off maintenance and got back on heroin. So, over the last year I have been using heroin, oxycodone (I need about 120mg of oxy to get a decent result), and Suboxone purchased on the street when I couldn't afford H, and I would usually buy an 8mg tablet and make four 2mg shots out of it. Generally that would last me two days, sometimes four. I usually have two 2mg shots of bupe throughout the day.

Ash. <3
 
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