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Stimulants of the Future II

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tametraline is an intresting one, but who the hell added the sertraline part? It's completely nonsensical. Pretty sure I know who...
 
I found a russian site describing the synthesis of 4-propoxy-3-methoxyamphetamine. Apparently it and the isopropyl analogue are stimulant/entactogen type compounds.

Sounds very interesting...
 
And are there any human reports of beta-methyl-PEA effects?
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Personal experience with beta-methylPEA (2-phenyl-1-propylamine) was that it's an almost inactive CNS stimulant (went up to 100mg with no real noticable effect). Good topical vasoconstrictor, but I think it's lack of CNS activity may in the most part be because it's easily deaminated by monoamine oxidase


4-propoxy-3-methoxyamphetamine. Apparently it and the isopropyl analogue are stimulant/entactogen type compounds.
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Read something that said the same thing, but no idea of source - sorry. If it is active, I'd bet that it's dose range would be up in the several hundreds of milligrams
 
Read something that said the same thing, but no idea of source - sorry. If it is active, I'd bet that it's dose range would be up in the several hundreds of milligrams
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Actually it seems to be active at 100-200 mg. By the reports I read (the english ones, can't read or speak russian) it seems to be more of a mood enhancer than anything else. It might become more of a stimulant, entactogen or psychedelic at higher dosages, though.

After reading the site a bit more, it seems that 4-benzyloxy-3-methoxyamphetamine has psychedelic activity. 4-isopropyloxy and 4-allyloxy seem to be mood enhancers similar to the propoxy.
 
funniest chemistry retort i ever heard, well done :)


nuke said:
Here is my submission, froganamine. I believe you will find the methylenedioxy ring as well as dual 2-phenylethylpyridine rings absolutely of the utmost functional quality for producing DA and NE release.

p.s. Please stop posting unsubstantiated crap.
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Anyone have information on this DRI, known as Mesocarb. It is interesting looking:

620px-Sidnocarb.svg.png
 
It was widely used in USSR, decades ago, and was taken off due to problems of abuse in early 90s. Until 2006 it was precribed by psychiatrist, it was an only stimulant in Russia. After 2006 the only factory i St. Petersburg was closed and now here is no Mesocarb.
As for effects it was prone to stimulant psychosis, for example if you use amphetamine for 5 days then on a fifth day you'll get no euphoria from same dose - only dirty stimulation, but Mesocarb is another thing, it will give your all positive effects of a stimulant, but also chances of a psychosis are skyrocketed. It was manufactured in a 5 mg pills.

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According to this book they are stimulants:

Meeting Name: International Symposium on Amphetamines and Related Compounds, Istituto di ricerche farmacologiche Mario Negri, 1969.
Main Title: International Symposium on Amphetamines and Related Compounds. Editors: E. Costa [and] S. Garattini.
Published/Created: New York, Raven Press [1970]
Description: xiii, 962 p. illus. 25 cm.
ISBN: 0911216081
 
^for those who don't know it: The symbol "Ø" is used to abbreviate a benzene-ring.

Thozalinone looks aminorex-like. Wonder what the potency is compared to its better known parent?

The 3rd compound is pyrovalerone.

- Murphy
 
Interesting statements from the book:

Prolintane and 84 F/1983, the two pyrrolidine derivatives, have been claimed to "promote well-being" and increased drive and spontaneus activity in anergic patients.

Generally speaking, the activity spectrum of this group of drugs differs from that of amphetamine in the lack of production of tolerance and psychotomimetic effects on chronic administration. Anorexic and cardiovascular properties were either greatly attenuated or abolished. This was particularly true in the case of the piperidine and isoxazolidine derivatives, but less so for the pyrrolidine compounds.

Meeting Name: International Symposium on Amphetamines and Related Compounds, Istituto di ricerche farmacologiche Mario Negri, 1969.
Main Title: International Symposium on Amphetamines and Related Compounds. Editors: E. Costa [and] S. Garattini.
Published/Created: New York, Raven Press [1970]
Description: xiii, 962 p. illus. 25 cm.
ISBN: 0911216081


I have bioassayed 4 compounds of these classes, 4-methylaminorex, MDPV, methylphenidate and prolintane, and I agree with this statement except in the case of MDPV and methylphenidate. 4-methylaminorex and prolintane didn't produce "psychotomimetic" effects i.e manic or psychotic episodes. And 4-methylaminorex didn't produce tolerance, I'm not sure if prolintane produces, because I did it only a couple of times.

Here is the whole chapter:

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