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Stimulants of the Future II

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4-phenyl-5-methyl-pyrroli-2-one
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Why?

IMO it would be much more interesting without that oxygen there. Kinda like a cyclic ethylamphetamine, or phenmetrazine sans the oxygen...
 
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/navarone/ said:
Amphetam:
4-phenyl-5-methyl-pyrroli-2-one
MDPM
4,5-MethyleneDioxy-PhenMetrazine
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where's the face slapper when I need it. Why not provide some rationale instead of posting random IUPAC-ish names?

1-(Acetoxy)pyrrolidine-2,5-dione
 
Well Hammy, put aside the face slapper and i'll give you all the rationality i have to offer.

Amphetam is a hypotetical racetam amphetamine analogue, very similar to Carphedon (phenyl-piracetam) which also showed some stimulant like properties. I posted a thread about it a few months back on ADD and many agreed that it could indeed have stimulating effects apart from being a potent nootropic.

The second 'random IUPAC-ish' name is the 4,5 MD version of phenmetrazine.
If you don't know what phenmetrazine is:
http://en.wikipedia.org/wiki/Phenmetrazine
Most of what I know about phenmetrazine is stated in wikipedia. Anyway it is conidered by many as the 'Best' (both for effects and low neurotoxicity) stimulant synthetized so far.

Now could you share your rationality on that 'thing' you mentioned above?
1-(Acetoxy)pyrrolidine-2,5-dione? I hope its a joke mate...
 
Phenmetrazine was a good looking compound, although its not clear to me why adding a MD would be a good thing.

Do you have any good reason why you would want to do this?
 
Probably because it's the magic substitution which makes any substance unbelievably orgasmatic.

Here, let me do my part. Why not add it to cocaine?

mdcoca.png
 
I think I agree with vecktor in that it's going to be hard to beat methamphetamine as far as ease of synthesis and bang for the buck, unless you're into tropanes, and then the possibilities appear to be extensive.

I still don't see why aromatically chlorinated amphetamines such as
3,4-dichloromethamphetamine and 3,4,5-trichloroamphetamine are necessarily any more intrinsically toxic than, say, sertraline, 2cc, or doc however.
 
I still don't see why aromatically chlorinated amphetamines such as
3,4-dichloromethamphetamine and 3,4,5-trichloroamphetamine are necessarily any more intrinsically toxic than, say, sertraline, 2cc, or doc however.
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Think about parachloroamphetamine. That one is hideously neurotoxic already, and you would add more chlorines into it? This is the logic of "two wrongs make a right" or what?
 
Is it possible that stimulant prodrugs with low scheduling and easy availibility (doctors, internet) combined with OTC CYP450 inhibitors/inducers will become popular in the future, as combining opioids like Codeine, Hydrocodone, Methadone etc with CYP450 inducers/inhibitors has become?

Specifically, Benzphetamine (Didrex) [into Amphetamine/Methamphetamine] and Phendimetrazine (Bontril) [into Phenmetrazine]?
 
The FDA said the same thing about bupropion for 20 years, and look at it now.

im a know it all im the smartest man around
 
Propylhexedrine (Hexahydro-Methamphetamine) is a widely available, cheap resource in the US.

Anything interesting about it? (Other than it being a depressing leftover from the era of Benzedrine and putting euphoric stimulants in huge doses in easily abused OTC products). It comes up every so often on crank-centered synth forums, where it is quickly shouted down as a pointless and useless chemical.

In the theoretical realm, are there modifications to make this compound less toxic/unpleasant and more likely to become.. recreational? Let alone hit the RC market?
 
In the theoretical realm, are there modifications to make this compound less toxic/unpleasant and more likely to become.. recreational?
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Yeah, replace the cyclohexane with a benzene.
 
I imagine it's already been made, but what about the benzofuran analogues of AMT and AET?

(Is there some kind of thing online where you can just enter a structure in SMILES or IUPAC and it checks references for its mention? I should probably know this being a chemist, haha...)
 
Sure,

the FDA refused for 20 years to approve bupropion for sale in the US b/c of the aromatic chlorine on a cathinone issue, but during this time period bupropion was being widely used by Europeans.

Today Wellbutrin/Zyban is a blockbuster drug in the US too, and has been for years.

Hope that's the elaboration you were looking for.
 
The differences between para-chloro-amp and 3,4-dichloroamp are quite large. IIRC, 4-halo (excepting fluoro) amps are potent serotonergic neurotoxins, but the 3,4-dihalogenated amps are more dopamine selective.

Just my recollection, as I admit, I paid little attention to these. The 3,4-dichloro analogues of so many of these stimulants are really potent though, often the most potent of the various chems in the various series.
 
Has anybody considered the effect of MDPV in reduced form (w/o beta-keto)?

Obviously it would be longer lasting for one (MDPV is quite short-acting).

The reaction is theoretically easy enough, one has a choice of Clemmenson or Wolff-Kishner conditions.

I was thinking the MD might fall prey to some kind of spurious (unintentional) side reaction though.
 
Has anybody considered the effect of MDPV in reduced form (w/o beta-keto)?
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That would be methylenedioxy-prolintane.

And it should be doable, if you first change the ketone into a hydroxyl and then replace it with a chlorine, then cleave away the chlorine. The methylenedioxy ring would probably be unaffected.


Btw I'd like to see the 4-carbon version of MDPV. There's already a 3C (MDPPP) and 5C (MDPV) so why not a 4C one?
 
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Smyth said:
Has anybody considered the effect of MDPV in reduced form (w/o beta-keto)?

Obviously it would be longer lasting for one (MDPV is quite short-acting).

The reaction is theoretically easy enough, one has a choice of Clemmenson or Wolff-Kishner conditions.
Click to expand...

Clemmenson won't work without a little modification, strong acids in reflux react with the methylenedioxy group. I have a feeling it could be a pain in the ass. But er, no synthesis discussion!

And it should be doable, if you first change the ketone into a hydroxyl and then replace it with a chlorine, then cleave away the chlorine. The methylenedioxy ring would probably be unaffected.
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That's a pretty indirect way and you're missing a step.

My thoughts on the compound: Probably not all that interesting, although it may increase the potency and enhance its affinity for DAT/lower its affinity for NET.
 
Is there a substituted propylhexedrine that's been found to be active in animals?
 
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