phase_dancer
Bluelight Crew
I haven't really looked much past the role of melatonin, but the role of CREB ( cAMP response element binding protein) is important in melatonin production.
I wonder if adreno responses are reduced as eyesight deterioates with age, and if so, would this then have effect on cAMP levels asosciated with the pathway.
Below is taken from Angelfire (advertising on link so no URL)
Figure 1.1. Schematic representation of the pathway from the eye to the pineal gland. SCN- suprachiasmatic nucleus; PVN – paraventricular nucleus; UTC – upper thoracic spinal cord; SCG – superior cervical ganglion; A-R – alpha adrenergic receptor; B-R – beta adrenergic receptor; CREB – cAMP response element binding protein; V – Ventricles of the Brain; C – Capillaries. The arrow behind cAMP indicates an increase in its concentration following stimulation of A-R or B-R by norepinephrine.
I wonder if adreno responses are reduced as eyesight deterioates with age, and if so, would this then have effect on cAMP levels asosciated with the pathway.
Below is taken from Angelfire (advertising on link so no URL)

Figure 1.1. Schematic representation of the pathway from the eye to the pineal gland. SCN- suprachiasmatic nucleus; PVN – paraventricular nucleus; UTC – upper thoracic spinal cord; SCG – superior cervical ganglion; A-R – alpha adrenergic receptor; B-R – beta adrenergic receptor; CREB – cAMP response element binding protein; V – Ventricles of the Brain; C – Capillaries. The arrow behind cAMP indicates an increase in its concentration following stimulation of A-R or B-R by norepinephrine.
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